Articles tagged with Bone Formation
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The team's detailed study reveals that clusters do not form a clearly defined intermediate step in the growth process, but instead are part of a gradual growth process. This new understanding completes the theory by describing alternative pathways for crystal formation.
Researchers at Penn Vet have identified a new pathway for stimulating bone growth using the protein Jagged-1. This discovery has the potential to treat bone fractures and improve outcomes for patients with rare metabolic conditions like Alagille syndrome.
Artificial bone created using stem cells and lightweight plastic can heal shattered limbs by encouraging real bone growth. The implant's honeycomb structure allows blood to flow through it, supporting the attachment of patient-derived stem cells.
A new study reveals how tiny holes in bones can weaken them, but also shows that strengthening osteocalcin could lead to stronger bones. Researchers suggest that increasing vitamin K intake through foods like spinach and broccoli may help prevent bone fractures.
Researchers found that teenage girls who smoke accumulate less bone during a critical growth period and carry a higher risk of developing osteoporosis later in life. The study suggests that strategies to help prevent osteoporosis should focus on preventing smoking, particularly among adolescent girls.
Sanford-Burnham researchers found that two microRNA families, let-7 and miR-18, regulate germ layer formation by dampening the TGFβ signaling pathway. This discovery provides a paradigm for whole-genome screening and its use in identifying molecular signals controlling complex biological processes.
Researchers at Western University have made a breakthrough in understanding diffuse idiopathic skeletal hyperostosis (DISH), a common form of arthritis affecting six to 12 percent of North Americans. The team discovered a mouse model that resembles DISH, pointing to the role of adenosine in causing abnormal mineralization.
Scientists have developed a new tantalum nanotube coating that enhances the integration of joint implants with existing bone, promoting improved biocompatibility and reducing the risk of failure. The coating also encourages bone growth and makes the implant more elastic like natural bone.
A newly discovered neural pathway in the autonomic nervous system reaches bones and regulates bone density during adolescence, affecting fracture resistance throughout life. The finding could lead to new therapies for osteoporosis and neural disorders, such as depression and Alzheimer's disease.
A two-year study found that consuming a Mediterranean diet with olive oil increased serum osteocalcin concentrations, suggesting a protective effect on bone. The study also showed no significant changes in serum calcium levels among participants taking olive oil.
A new study published in the Journal of Clinical Endocrinology and Metabolism found that even minor physical activity can benefit bone health in premenopausal women by reducing sclerostin and enhancing IGF-1 levels. The study involved 1,235 premenopausal women who were followed for eight weeks, with those engaging in more than two hour...
Georgia Tech researchers have created a new way to simulate and control movement of computer-generated characters without a skeletal structure. This technique allows for unparalleled control of digital creatures, enabling amateur animators and young children to manipulate their movements with simple point-and-click commands.
A genetic screening approach has identified nine new genes associated with bone health, providing clues to the cause of bone disorders such as osteoporosis. The study used a collaborative effort between specialist skills in mouse gene deletion and bone measurement, assessing the strength of bones in 100 mutant mouse lines.
A team of scientists led by Robert Young is working on developing small molecule compounds and nano-medicines that stimulate bone regeneration, aiming to improve understanding of bone renewal biology and promote bone repair and regeneration. The grant is part of a $7 million funding package targeting bone health research.
Researchers at the University of Granada have found that ibuprofen has beneficial effects on bone repair following a fracture or surgery. The study shows that a therapeutic dose of ibuprofen does not inhibit osteoblast cell proliferation and synthesis, which is crucial for bone development and growth.
A study of 1,978 Spanish adolescents found that those who ate more frequently had lower accumulated fat rates, regardless of physical activity. Eating breakfast daily was particularly beneficial for young men who did not exercise.
Researchers emphasize the need for standard bone age measurement to interpret growth status and improve treatment outcomes for children with Crohn's disease. Up to 80% of patients exhibit compromised growth, and bone age is crucial for predicting remaining growth potential and guiding therapeutic decisions.
Researchers at MIT have developed a new coating for hip implants that promotes bone growth, creating a stronger seal between the implant and the patient's own bone. This coating could prevent premature failure and reduce the risk of infection, allowing patients to walk and perform physical therapy during the healing process.
Research suggests that early growth in the womb and first few years of life is positively related to total hip bone size and mineral content. Stronger hips can protect against future hip fractures, leading to optimized early growth strategies to reduce osteoporotic fracture risk.
Research shows exercise in early 20s improves bone development and may reduce fractures later in life. Regular physical activity between ages 19-24 increases bone density, especially in hips, arms, and legs.
Researchers have developed modular growth factors that can stimulate bone and blood vessel growth in sheep, showing promise for treating orthopedic injuries and defects. The approach uses flexible proteins to activate specific signaling pathways, reducing the risk of unwanted side effects like cancer.
A study found exemestane significantly worsens age-related decreases in bone mineral density by three times, even with adequate calcium and vitamin D intake.
A novel technique enhances bone growth by guiding stem cells to the bone surface, increasing bone density and preventing age-related bone loss. The study successfully tested this approach in mice with osteoporosis, paving the way for human trials.
Researchers found early childhood growth influences adult bone density, with significant contributions from birth size and height growth. Childhood nutrition plays a crucial role in preventing adult bone disease like osteoporosis.
A six-month growth hormone replacement study found increased bone formation, muscle mass, and decreased abdominal fat in abdominally obese women. The results suggest growth hormone as a potential treatment for postmenopausal osteoporosis.
A recent study found that applying mechanical forces to a wound site immediately after healing began can disrupt vascular growth and prevent bone healing. However, delaying the application of mechanical stress until later in the healing process can enhance functional bone regeneration through adaptive remodeling.
Researchers at IRCM identified a new gene modulating bone mass and potentially leading to osteoporosis. This breakthrough may help identify individuals with a greater predisposition to the disease.
Researchers develop salubrinal to treat weakened and broken bones by strengthening protein-producing machinery. Studies show accelerated healing in as little as a week, with potential for FDA approval.
A new study published in the Journal of Bone and Joint Surgery found that knee replacement patients are at a higher risk of developing clots, particularly those with cardiovascular disease, smoking history, or advanced age. The study suggests extending blood thinner therapy into weeks following surgery to minimize this risk.
Researchers discovered that moles' extra 'thumb' develops from a single bone that forms later than the real fingers. This adaptation allows for increased digging efficiency.
Research funded by USDA suggests that blueberry polyphenols, found in blueberries' powerful antioxidant compounds, may aid in building strong bones. The investigation showed that animals fed rations containing 10% freeze-dried blueberry powder had significantly more bone mass than their counterparts.
Dental implant technology could be improved by studying the surface structure at both micro and nano levels. Researchers found that increasing the active surface area and changing conductivity can speed up healing, reducing discomfort for patients.
Researchers developed a stem cell treatment enriched with insulin-like growth factor-I (IGF-I) to mend non-healing bone fractures. The study showed that the treated cells became bone cells and helped repair fractures in animal models.
Researchers at the University of North Carolina discovered that the pelvis continues to widen as people age from 20-79, leading to an estimated three-inch increase in waist size. This finding suggests that pelvic growth contributes to increased body weight and body fat accumulation over time.
Researchers identified the Lrp5 gene's crucial role in bone growth and density, providing a new strategy for treating diseases like osteoporosis. The study also found that targeting mature bone cells might increase bone mass and treat conditions like osteogenesis imperfecta.
A new study published in the journal Sleep has found that infants who experience irregular bursts of sleep have significant growth spurts in their body length. The study suggests that longer sleep corresponds to greater growth, and that increased sleep episodes increase the probability of a growth spurt by up to 43%.
A study found that nitroglycerin ointment increased bone mineral density and decreased bone resorption in postmenopausal women. The researchers also observed increases in bone-specific alkaline phosphatase and decreases in urine N-telopeptide, markers of bone formation and resorption.
Researchers found that osteocalcin enhances testosterone production, leading to improved sperm count and reproductive success in male mice. The study suggests that low osteocalcin levels may contribute to male infertility in humans.
Researchers found that osteocalcin produced in bone enhances testosterone production in testes, supporting sperm survival. This discovery links the skeleton to male fertility and may provide insights into unexplained infertility cases.
Researchers have discovered Largazole's potential to stimulate bone growth and repair damaged bones. The compound blocks the body's natural bone resorption process, offering new hope for treating bone diseases.
A study by Columbia University researchers found that pre-menopausal Chinese-American women have greater bone strength than Caucasian women due to a higher plate-to-rod ratio in trabecular bone. The study used advanced 3-D imaging analysis technique Individual Trabeculae Segmentation (ITS) to analyze bone microstructure.
Research identifies a key mechanism in bone formation after resorption, revealing the importance of TGF-?1 and skeletal stem cell recruitment. The study suggests that using PTH before antiresorptive drugs could be an effective therapy for osteoporosis treatment.
Researchers at UMass Medical School have developed FlexBone, a synthetic bone material with bone-like properties, to replace traditional bone transplants. The material facilitates tissue repair by absorbing proteins from the surrounding tissue, accelerating healing, and delivering growth factors.
A $1.76 million study at Rensselaer Polytechnic Institute investigates the role of two proteins, osteocalcin and osteopontin, in bone fractures over time. The research aims to develop new methods of diagnosing osteoporosis and treating related bone diseases.
A team of researchers has identified a key player in maintaining bone balance, finding that the protein Maf promotes bone formation and prevents osteoporosis. By understanding this age-related switch in cell type generation, new approaches to treat age-related osteoporosis may be developed.
Researchers developed population-specific identification criteria for the Chilean population to determine stature and biological sex of skeletal remains. This will help identify victims of political violence under Pinochet's regime and aid in contemporary body identification efforts in Chile.
Researchers developed a titanium coating with protein 'flower bouquet' nanoclusters that strengthened implant attachment by 50% compared to standard coatings. The clusters improved bone growth around the implant, enhancing cell adhesion signals and promoting better integration of biomaterial implants into bone.
Researchers have created a material for bone grafts that attracts stem cells and growth factors to promote bone regrowth and integration. The synthetic graft heals similarly to natural bone implants in animal tests, suggesting potential as a replacement for traditional grafts.
Researchers identify neogenin as a crucial protein in skeletal development, which can disrupt cartilage and bone formation if mutated. This finding offers new insight into treating osteoarthritis and provides potential therapeutic targets.
A new study by Johns Hopkins researchers found that insulin is required for normal bone development and may provide a link between bone health and metabolic diseases like diabetes. The study suggests that insulin action in bone provides a critical signal that links metabolism and metabolic disease with bone health.
Two new studies reveal a key molecular link between bone remodeling and metabolism, finding that osteocalcin levels are tied to insulin resistance and glucose intolerance. Osteocalcin treatment improves symptoms in mice with diabetes-like conditions.
Researchers at Columbia University Medical Center discovered that bone resorption plays a crucial role in regulating blood sugar levels. The study suggests that stimulating the release of insulin and improving glucose uptake in cells could be a new target for type 2 diabetes treatment.
Researchers found that raising juvenile salmon at 16°C causes skeletal deformities. Fast growth temperatures disrupt bone and cartilage production, leading to increased deformity rates. The study suggests temperature-induced growth is severely affecting osteoblasts and chondrocyte cells.
A recent study found that subchondral bone mineral density positively predicts cartilage defect development at the medial tibial site, but not cartilage loss. Researchers believe subchondral bone changes and loss of cartilage contribute to osteoarthritis, a condition affecting millions worldwide.
Researchers found a new complication of stem cell therapy: angiomyeloproliferative lesions at injection sites, which can lead to kidney failure and death. The study highlights the need for further research to determine the circumstances that cause these masses to form and strategies to avoid them.
Researchers at EMBL identified microRNAs MiR144 and MiR451 as crucial regulators of efficient red blood cell formation. These molecules help fine-tune genes involved in haematopoiesis, allowing for stable oxygen transport under challenging conditions.
Researchers at Sanford-Burnham Medical Research Institute created a new mouse model of multiple hereditary exostoses, a rare childhood disease characterized by abnormal bone growths. The study reveals the molecular basis of the disease and provides a tool to screen new treatments.
Researchers have identified the location of bone generating stem cells in mice and found factors that control their growth. The discovery opens up avenues for studying bone tumor formation and regenerating damaged or injured bone.
A study found that agave fructans can boost calcium absorption, potentially preventing osteoporosis. Fructans also have anti-inflammatory properties and may help regulate blood sugar levels.
Researchers at Case Western Reserve University have found a way to use the sleeve-like cover on bone to heal serious bone injuries faster and more simply than current methods. They developed an artificial sleeve that spurs fast healing when a car wreck, bomb blast or disease leaves too little cover.