Articles tagged with Bone Formation
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Research highlights early life factors influencing osteoporosis risk, emphasizing importance of prevention throughout life course. Early growth and nutrition play significant roles in determining bone mass and density.
Researchers discovered a specific gene variant linked to fragile bones in mice with Hajdu-Cheney syndrome, a rare inherited disorder. The study suggests that overactive bone-absorbing cells contribute to the disease's characteristic bone loss and fractures.
Researchers found that adding NELL-1 to BMP2 therapy produces tightly woven trabecular bone within the defect area, whereas BMP2 alone leads to adipose tissue interspersed with sparse trabecular bone. The combination treatment inhibits adipogenesis and promotes osteogenesis.
Researchers found a combination of adult stem cells and parathyroid hormone significantly increased new bone formation in laboratory animals. The therapy also showed enhanced stem cell migration to the area of bone fractures, leading to improved bone density.
The study describes for the first time the developmental processes that differentiate Neanderthal facial skeletons from those of modern humans. The researchers found that Neanderthals' faces grow with extensive deposits by osteoblasts without a compensatory resorption, leading to a prognathic maxilla.
Researchers found Activin-A as a candidate drug target for treating Fibrodysplasia ossificans progressive (FOP), a genetic disease where bone grows in soft tissue. The study uses induced pluripotent stem cells and suggests that inflammation could be the key to preventing diseased bone growth.
Researchers at Harvard developed a new technique to control stem cell differentiation into bone cells, mimicking the viscoelasticity of living tissue. The method increased osteogenic differentiation and allowed cells to grow into bone cells weeks after initial differentiation.
Scientists at Children's Research Institute discovered a secondary, emergency blood-formation system activated in the spleen during times of hematopoietic stress. Blood-forming stem cells migrate from bone marrow to spleen, where they form new blood cells under normal circumstances.
A new study on the fossil bone growth of Ophiacodon, a distant relative of mammals, reveals that it was at least partly 'warm-blooded', challenging the long-held theory of its origin. The findings suggest that mammalian endothermy evolved earlier than previously thought, dating back to the late Carboniferous period.
Paleontologist Matthew McLain discovered a tyrannosaur bone with teeth marks indicating it was gnawed by another tyrannosaur. The grooves found on the bone suggest that the eating occurred after the animal had died, adding to evidence of cannibalism among tyrannosaurs.
A new study from the University of Manchester found that children treated with growth hormone for deficiency show varying rates of growth depending on their latitude and summer daylight exposure. The study of 118 children aged 5-11 from 14 countries suggests a complex relationship between sunlight, genetics, and bone growth.
Researchers found no association between cesarean delivery and lower at-birth fracture rates in infants with osteogenesis imperfecta. The study, involving 540 patients, used large sample size to evaluate multiple covariates, revealing no differences in fracture rates based on delivery method.
Scientists studied the evolution of jerboas' remarkable limbs to understand processes controlling limb development and bone growth. They found that evolution controls individual bone size, suggesting complex genetic regulation.
The Department of Defense has awarded a nearly $6 million grant to Houston Methodist to further bone fracture repair research. Researchers aim to develop technologies that can help mend broken bones faster and more efficiently.
A study of 50 Maiasaura tibiae fossils revealed bird-level growth rates and a six-year window of peak physical fitness. The researchers also found that sexual maturity occurred within the third year of life and the average adult mass was 2.3 tonnes in eight years.
Researchers have found two different types of fat cells in bone marrow, regulated and constitutive, which store different types of fat molecules. The discovery paves the way for more research on how marrow fat influences the body and its role in diseases like osteoporosis.
Researchers at Children's Hospital Los Angeles found that vertebral cross-sectional dimensions in newborn females were 10.6% smaller than males, indicating a predisposition to osteoporosis and scoliosis later in life. This difference may be mitigated with exercise and nutrition.
Scientists created synthetic material from silicon that shows potential for improving soft tissue function and interface between electronic devices and biological tissues. The new method involves pressure modulation synthesis to promote the growth of silicon nanowires.
Researchers discovered a statistically significant increase in osteoblast formation when human mesenchymal stem cells were treated with the compound SR2595, which targets PPARy. The findings demonstrate a new therapeutic application for drugs targeting PPARy and may have broader implications for treating metabolic and bone diseases.
A recent study by Evan Saitta found that Stegosaurus had two types of plates: tall and wide. Contrary to previous claims, these were not separate species or ages, but rather males and females. The plates likely played a role in attracting mates and displaying sex.
A team led by Otger Campàs and Jérome Gros aims to measure the map of forces generated by embryonic cells as they build limbs. They plan to use a new technique to study mechanical forces in living tissues and explore their role in cell differentiation.
A new study published in the journal Bone found a strong link between lean muscle mass and healthy bone development in children aged six and seven. The research, led by Dr Rebecca Moon, suggests that higher muscle mass is associated with larger, denser bones and reduced risk of osteoporosis.
A newly developed drug may also be effective in treating brittle bone disease, a rare genetic disorder that affects bone formation. The therapy has shown promising results in young mice with the condition, with no reduction in midshaft bone strength after treatment stopped.
Researchers at Duke University Medical Center have identified a link between gene mutations in the IDH gene and the formation of benign cartilage tumors that can evolve into cancerous chondrosarcomas. The study provides insights into the potential development of new treatments using drugs designed to block IDH function.
A study on newborn mice reveals a previously unknown mechanism involving bone growth and muscle contraction that rapidly realigns fractured arm bones. This finding could lead to alternative approaches for treating fractures in adults, improving treatment outcomes by reducing side effects like muscle atrophy.
Researchers have discovered an enzyme therapy that improves bone growth, mineralization, and strength in a mouse model of neurofibromatosis type-1. The treatment, asfotase-alpha, reduces fractures by clearing accumulated pyrophosphate, a strong inhibitor of bone mineralization.
A team of researchers has developed a 'self-fitting' material that can precisely fill bone defects in the head, face, and jaw, providing a potential solution for reconstructing facial features after injuries or surgery. The material, made from a shape-memory polymer, expands with warm salt water to conform to irregular defect shapes.
Researchers found a teeth protein that signals bone growth and enhances tissue formation in rat models, offering potential for synthetic bone grafts. The breakthrough could benefit patients with osteoporosis or bone fractures.
Researchers at the University of Liverpool developed a new method to target bone growth, increasing density by 30 percent in weaker regions. The method uses miniature muscle pacemakers to produce contractions in targeted areas, showing promise for effective treatment of bone disease and fragility.
A team of scientists has discovered that the colon has a safety mechanism to restrict adenoma formation and growth. The study found that an increase in BMP production limits the self-renewal capacity of adenoma stem cells, thus impeding rapid development.
Researchers at UT Southwestern Medical Center have found that orexin proteins play a crucial role in both promoting and blocking bone formation. This dual regulation may provide new targets for treating osteoporosis, particularly by inhibiting orexin receptor 1 or activating orexin receptor 2.
Researchers have discovered a new pathway between the gut, liver, and bone that regulates bone mass. Vitamin B12 deficiency leads to stunted growth and osteoporosis in offspring of mice, but supplementation restores bone health.
Researchers have discovered a new target, human plastin 3 (PLS3), that may be critical for the treatment of osteoporosis. Injection of PLS3 or related proteins in zebrafish where it has been suppressed can replace its loss and repair bone development anomalies.
A study by North Carolina State University and Microsoft Research found that game developers value communication, teamwork, and creative skills. The research highlights the importance of including non-programmers in computer science projects and developing interpersonal communication skills.
Researchers studied embryonic development in 134 species, discovering that brain size affects cranial bone formation. Individual bones develop in different phases characteristic to each species.
A new gel coating has been developed to promote bone growth on implants, allowing for improved integration and reduced rejection. The coating, made from a protein that encourages bone formation, can be released slowly in response to calcium ions, stimulating bone growth on the implant.
A genetic variant in SCN10A modifies cardiac expression of SCN5A, essential for conduction. An inflammatory feedback loop activates STAT3, repressing miR-34a and promoting EMT in colorectal cancer cells. Insulin resistance in bone disrupts glucose homeostasis through decreased active osteocalcin.
Scientists at Washington University School of Medicine have discovered a potent stimulator of new bone growth, which could lead to new treatments for osteoporosis. The study found that the WNT7B protein enhances bone formation through the mTOR pathway.
Researchers developed a new way to study bone disorders and bone growth using stem cells from patients with a rare genetic bone disease. The approach identified a cellular mechanism driving abnormal bone growth and found chemicals that can slow it, potentially guiding future drug development.
Researchers found tumor-suppressing genes Rb1 and Rb2/p130 regulate fat tissue formation and function. Dysregulation can lead to overproduction of fat tissue, causing obesity-related diseases such as diabetes and cancer.
Researchers found that chloroquine treatment increased TRAF3 levels in osteoclast precursor cells, limiting osteoclast generation and bone resorption. The study suggests that therapies targeting TRAF3 may help prevent bone loss in individuals with osteoporosis.
Researchers have developed a new sea coral-based material that considerably improves the outcome of bone grafts in 16 patients. The material, called coralline hydroxyapatite/calcium carbonate (CHACC), has been shown to biodegrade after two years and promote natural bone healing.
Researchers at the University of Iowa have created a bio patch that can regrow bone by delivering DNA instructions to cells. The patch successfully regenerated bone in test animals and stimulated new growth in human bone marrow stromal cells. This breakthrough technology has potential uses in dentistry, including rebuilding bone for de...
Researchers found that osteocalcin, a bone-derived hormone, plays a powerful role in prenatal brain development and cognitive functions such as learning, memory, anxiety, and depression. Osteocalcin promotes the birth of neurons, increases neurotransmitter synthesis, and affects behavior in adult mice.
A literature review found that one in four people develop hip arthritis before age 85, contributing to groin pain. Contributing factors include sports-related injuries, prior surgery, and traumatic occupational history. A detailed medical history and examination are crucial for diagnosing the source of groin pain.
Nanodiamonds have been found to promote bone growth and deliver proteins to treat osteonecrosis, a debilitating disease that causes bones to break down. The tiny diamonds can be administered non-invasively, potentially revolutionizing dental implant procedures.
Researchers at the University of Sheffield have developed a new treatment for children with brittle bone disease, finding that oral risedronate significantly reduces the risk of fractures. The study showed rapid action, with curves for fracture risk diverging after just 6 weeks of treatment.
Researchers identify CTHRC1 as a key molecule linking bone resorption and formation, suggesting potential treatment targets for osteoporosis. Mice with deficient CTHRC1 secretion exhibit lower bone mass, highlighting the molecule's role in age-related bone loss.
Researchers have identified prolactin as a potential treatment for inflammatory joint disease, reducing chondrocyte death and associated cartilage degradation. A protein called CTHRC1 has also been linked to bone health, suggesting it could be a target for osteoporosis treatment.
Researchers in Granada have successfully generated bone tissue from umbilical cord stem cells using a novel biomaterial. The breakthrough could lead to the development of new treatments for bone and cartilage lesions, as well as the regeneration of bones in patients with osseous system pathologies.
Researchers at RI Hospital found that the absence of Shp-2 enzyme near specialized cartilage cells can lead to multiple benign cartilage tumors in mice. These tumors can become malignant in humans and are a rare condition known as metachondromatosis.
University of Oklahoma Norman campus researchers received $135,000 OCAST grants for three-year health research projects. The recipients will study advanced treatments for bone defects, viral RNA structure to develop new drugs, and the control of mosquito-transmitted diseases.
A team of scientists studied Psittacosaurus dinosaurs to understand their growth patterns. They found that arm bones grew fastest during the first few years of life, while leg bones experienced a massive growth spurt, eventually becoming twice as long as the arms.
Researchers found reversal cells covering 80% of resorbed bone surfaces that gradually mature into osteoblasts during the reversal phase. Biopsies from postmenopausal patients with osteoporosis showed a high proportion of arrested cells, associated with bone loss.
Researchers have identified a gene, GPR126, linked to adolescent idiopathic scoliosis (AIS) across Asian and Caucasian populations. The study reveals that the gene is involved in spinal growth during childhood.
A recent study found that zoledronic acid, a common osteoporosis drug, not only slows bone loss but also increases levels of sclerostin, a biomarker that inhibits bone formation. This suggests that combination treatments may be needed to effectively treat osteoporosis and increase bone mass.
A team of scientists from Canada, Taiwan, and Australia excavated over 200 bones from embryonic dinosaurs, providing a rare glimpse into their growth patterns. The fossils, dating back over 100 million years, show evidence of protein structures, suggesting that dinosaurs moved around inside their eggs.
A study has uncovered a rare congenital deformation in an early human skull from China, suggesting high levels of inbreeding among our ancestors. The finding provides valuable insights into human evolution and population dynamics, revealing unusual population dynamics likely caused by high levels of inbreeding.
A new study elucidates the reproductive strategy of bone-eating worms, shedding light on their postembryonic development and sexual maturation. The researchers observed the duration of the larval stage, male dwarfism, and rapid female spawning, enabling effective reproduction in a food-rich but isolated habitat.
Researchers at Tel Aviv University found a clear genetic connection between fat and bone mass, which can impact body composition and overall health. The discovery highlights the importance of considering both factors in treatment plans to avoid negative side effects.