Articles tagged with Bone Formation
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Researchers have developed a new therapeutic approach to enhance bone healing by delivering additional Jagged-1 protein at the site of injury. In a study published in npj Regenerative Medicine, rodents treated with Jagged-1 showed improvements in skull and femoral bone injuries, unlike BMPs which caused excessive bone growth.
Researchers used intravital two-photon microscopy to visualize interactions between osteoblasts and osteoclasts in living bone tissue. They found that osteoblasts can inhibit bone resorption by direct contact with osteoclasts, demonstrating an important concept for regulating bone homeostasis.
Researchers identified two related genes, Nr2f2 and Nr2f5, that pattern the jaw by regulating stem cell generation of skeletal cells. This study offers clues for understanding craniofacial anomalies in humans, where equivalent gene mutations are present.
The HLF gene plays a crucial role in maintaining blood stem cells in a resting state, protecting them from exhaustion and external damage. This study provides new insights into the regulation of blood stem cell activity and its potential applications in bone marrow transplants.
Researchers found that genes can be activated in human stem cells to initiate biomineralization, a key step in bone formation. The study used engineered silk derived from golden orb weaver spider webs and supercomputers Stampede1 and Comet to model the folding of proteins and predict osteogenesis.
A preclinical study demonstrates the effectiveness of PRO 140, a humanized anti-CCR5 monoclonal antibody, in preventing graft-versus-host disease (GvHD) in bone marrow stem cell transplantation. The study shows that PRO 140 successfully blocked GvHD development without affecting hematopoietic cell engraftment.
A recent study discovered that a bone hormone called osteocalcin regulates appetite and energy expenditure. Researchers found that removing an enzyme responsible for activating osteocalcin reduced mice's appetite and increased blood glucose levels.
Researchers have discovered an Alvarezsaurid dinosaur fossil in Uzbekistan, revealing distinctive characteristics that set it apart from other species. The findings provide evidence for the continent's role in the species' evolutionary history.
A 120-million-year-old bird specimen from the Early Cretaceous exhibits high skeletal fusion in manus and pelvis bones, features rare in most known birds from that era. Osteohistological analysis indicates that the bird reached maturity in approximately one year, similar to modern birds.
Researchers found that saber-toothed kittens were born with more robust bones compared to other felines, contrary to expectations. The study suggests that the growth of feline species is tightly constrained, even among species with distinct bone structures.
A new treatment for osteoporosis has shown significant improvements in bone density and fracture protection. The study found that romosozumab reduced the risk of vertebral fractures by 48% and clinical fractures by 27%, offering better protection against fractures for high-risk patients.
A recent study has overturned a common belief about how bone morphogenetic proteins regulate the formation of nervous system cells during embryonic development. The findings could inform the creation of stem cell-based therapies that restore sensation, particularly for paralyzed patients.
Researchers at Pohang University of Science & Technology have discovered the role of matrix protein Pif80 in nacre formation, a biomineral with exceptional fracture resistance. The study sheds light on the biomimetic materials that can be created using nacre properties.
A study led by Columbia University Medical Center researchers found that boosting blood levels of osteocalcin reverses age-related memory loss in mice. Osteocalcin binds to a receptor called Gpr158 in the brain's memory center, and restoring youthful levels of the hormone improves cognitive function.
Scientists at Sanford Burnham Prebys Medical Discovery Institute propose a therapeutic strategy to suppress formation of bony tumors in multiple hereditary exostoses, a rare disease affecting 1 in 50,000 people. Researchers identify BMP signaling as the culprit and demonstrate success with an inhibitor compound.
Researchers found that environmental factors, such as 'vigorous gaping' behavior in larval fish, can significantly influence the development of their craniofacial bones. This discovery challenges the long-held assumption that genetics is the primary driver of species variability.
Researchers used CRISPR to study dyskeratosis congenita, a rare condition that causes progressive DNA damage leading to blood cell failure. The study reveals new ways to potentially treat the disease by blocking signaling pathways involved in blood cell formation.
A UTA professor has received a grant to design a biomedical device that stimulates bone growth and could be used to treat osteoporosis. The device aims to strengthen bones of people with low bone mass conditions.
Researchers discovered a communication system between the knee joint and developing bones in mice, which controls bone growth during early development and after injury. The study suggests that bone growth is controlled not only from within the bone itself but also by neighboring cells situated in nearby joints.
Researchers have identified a universal mechanism behind bone cell organization, revealing a quantitative framework to assess bone quality. The study shows that different bone types exhibit varying levels of connectivity but similar efficiency in intercellular transport and communication.
Playing football improves bone development compared to swimming and cycling, particularly after a year of training. The study found that adolescents who played football had better bones than those who engaged in non-weight-bearing sports.
The late adolescent years are a critical period for bone growth, with 10% of bone mass continuing to accumulate after adult height is reached. A study found that bone mineral density develops at different rates in different parts of the skeleton, highlighting the importance of considering growth trajectories when interpreting data.
Researchers at Northwestern University have designed a sugar-coated nanomaterial that promotes bone regeneration by binding to growth factor BMP-2, reducing its need by 100 times. The biodegradable material functions as an artificial extracellular matrix, mimicking natural cell interactions.
Researchers have developed a novel gene therapy method that utilizes microbubbles and ultrasound to promote bone growth and healing in nonunion fractures. The technique, which involves injecting genetic material for a bone growth factor into the affected area, has been shown to completely heal broken bones in pigs within eight weeks.
A new bioactive foam can be molded to fit irregular skull defects, attracting bone cells to naturally regenerate bone. The foam hardens in place, providing a low-cost alternative to current bone grafts.
A new study found that higher levels of vitamin D, insulin-like growth factor-1, and dehydroepiandrosterone sulfate are associated with a lower risk of worsening frailty in men. These findings suggest that targeting these hormones may help prevent frailty development in aging men.
A large study of 309 adolescent boys and girls found that moderate to intense physical activity during growth spurt years significantly increases bone mass and strength. The study suggests a balance between physical activity and recovery time is needed to enhance bone health.
A study published by Pamela Hinton at the University of Missouri-Columbia found that weight-bearing exercises decrease sclerostin, a protein made in the bone, and increase IGF-1, a hormone associated with bone growth, promoting bone formation and increasing bone density.
Researchers discovered that pre-menopausal South Asian women have higher levels of 'urinary N terminal telopeptide', indicating elevated bone resorption, making them more susceptible to osteoporosis and fractures. Fluctuating Vitamin D levels were also linked to increased bone resorption in white Caucasian women.
The study found that distortion of radial glial fibers leads to aberrant neuron localization and formation of periventricular nodular heterotopia (PNH), a brain abnormality in thanatophoric dysplasia. This discovery paves the way for developing therapy using animal models with brain architecture similar to humans.
Research shows that arthroscopic hip surgery is effective in improving running ability, with 96% of recreational and competitive runners returning to their sport within nine months. However, increasing BMI and longer time without running prior to surgery are associated with slower recovery.
A team of researchers developed a new material that regrows quality bone in the affected area without developing scar tissue. The breakthrough could potentially treat patients with severe skull or facial injuries, making painful bone grafting obsolete.
A new method of repairing injured bone using stem cells from human bone marrow and a carbon material with photocatalytic properties has been developed. The research team found that the material accelerates bone regeneration by activating key transcription factors, leading to increased osteoblast differentiation.
Researchers at the University of Missouri found that limiting maternal myostatin levels improved bone strength and density in mice with osteogenesis imperfecta. The study suggests a potential therapeutic approach to treating brittle bone disease.
A new method of repairing injured bones using stem cells and a carbon material with photocatalytic properties has been developed, showing promising results in accelerating bone regeneration. The technique uses red-light absorbing carbon nitride sheets to activate key transcription factors associated with osteoblast differentiation.
Researchers are conducting a £1.5 million trial to test two therapies on 390 people with Osteogenesis Imperfecta, aiming to reduce fracture risk. The six-year study will track participants for five years to assess the combination of teriparatide and zoledronic acid.
A new study of 119 children with osteogenesis imperfecta found that bisphosphonate treatment did not change the radiological appearance of femur fractures.
Researchers at Penn State University have identified Speckle-type POZ Protein (Spop) as a key regulator of bone development. The study reveals that Spop positively regulates Hedgehog signaling during bone formation, leading to reduced bone density and brachydactyly-like symptoms.
Researchers at Kazan University have developed a novel gene therapy approach that combines demineralized bone with genetic material to stimulate blood vessel and bone growth. The treatment shows promise in treating pseudarthrosis and other bone defects, with plans to offer innovative treatments at the Kazan University Clinic.
Researchers are enrolling 60 obese children in an eight-week study to examine the impact of vitamin K supplements on their cardiovascular health. The study aims to determine whether vitamin K can improve insulin sensitivity and reduce lipid levels in the blood, potentially reducing the risk of diabetes and cardiovascular disease.
Abaloparatide stimulates bone formation without affecting resorption, reducing fractures in postmenopausal women with osteoporosis. The study's preclinical data are promising for continued development of abaloparatide as an osteoporosis treatment.
Researchers identify SIK2 enzyme as key to improved osteoporosis treatment, reducing bone breakdown and stimulating formation in animal model. A new compound YKL-05-099 mimics PTH effects, safely stimulating bone growth while suppressing bone resorption.
Paleontologists discover dinosaur bones and trackways in Denali National Park, providing new insights into the region's ancient ecosystem. The finds are significant as they confirm the presence of dinosaur fossils in the area, supporting the hypothesis that a distinct polar fauna existed during the Late Cretaceous Period.
A new study from the University of California, Berkeley, reveals that calcium plays a major role in regulating bone growth and development. By understanding the signaling mechanisms involved, researchers hope to develop regenerative therapies for conditions such as Treacher Collins Syndrome, which can lead to dozens of surgeries during...
A new technique developed by Tokyo Medical and Dental University has improved bone regeneration by using double-layered cell constructs that can be transplanted onto bone defects. The technique increases the speed of bone repair and provides flexibility and durability ideal for surgical applications.
Researchers at Tokyo Medical and Dental University have successfully stimulated local bone augmentation in mice jawbones using a protein/peptide combination carried by an injectable gel carrier. The study demonstrates the potential for non-surgical treatment of alveolar bone loss, which may lead to tooth loss.
Researchers have developed a new approach to limit side effects of stem cell transplants by stimulating the formation of regulatory T cells in recipients. Pretreating mice with STAR2 protein protected them from developing GvHD, while donor-derived cells retained their ability to kill recipient's tumor cells.
Researchers at Thomas Jefferson University found that cold plasma can promote bone formation by enhancing cell/matrix attachments and increasing focal adhesion kinase activation. The study suggests that the technology could be used to improve bone healing in various medical applications.
A new study suggests a dual-targeting drug candidate could treat both type 2 diabetes and bone disease by expanding bone formation and turnover. The compound has shown promise in increasing bone mass regardless of body mass index.
Researchers developed an index to predict bone loss in women during menopause by considering both bone formation and breakdown. The Bone Balance Index was found to be a stronger predictor of bone loss than a measurement of bone breakdown alone.
Researchers developed a technique to coat polymer implants with a bioactive film that significantly increases bonding between the implant and surrounding bone. The coating improved bone formation, density, and toughness of the implant, leading to better implant fixation.
A study published in Cell Metabolism found that osteocalcin, a bone-derived hormone, increases muscle performance during exercise. Osteocalcin levels naturally decline with age, affecting men and women differently, with the decline occurring about 15-20 years sooner in women.
Researchers identified Pf-POU3F4, which promotes Aspein and Prismalin-14 expression in oyster shells. The study provides new perspectives on biomineralization and its similarities to bone and tooth formation in mammals.
The discovery of a young Rapetosaurus dinosaur provides insights into the early lives of sauropod giants. The findings suggest that these animals developed quickly to function on their own, similar to birds and herding mammals.
Researchers have identified a key action of a watershed gene crucial to bone formation and the evolution of vertebrates. The Sp7 gene emerged about 400 million years ago, expanding life diversity and programming bone-secreting cells.
Researchers found that loss of specific genes induces osteochondroma formation in mice, identifying a population of cells responsible. The study suggests therapeutic strategies targeting these cells could treat related skeletal diseases.
A team of researchers from the University of York conducted a first-of-its-kind study on Zanzibar's formation and fauna extinction. The study, which analyzed mangrove sediments and animal remains, found that large mammals like zebras and buffalo disappeared after sea levels rose and coastal cultures inhabited the island.
A single dose of zoledronic acid inhibited bone loss in HIV-infected patients and reduced the risk of fractures. The study found a significant reduction in bone loss with treatment, while men showed greater protection against bone loss than women.
Researchers at the University of Rochester Medical Center have identified a population of stem cells capable of repairing skull formation and craniofacial bone repair in mice. This discovery contributes to an emerging field involving tissue engineering that uses stem cells to replace damaged bones in humans.
Researchers at UCLA have discovered a protein combination that significantly improves clinical bone restoration, offering potential therapeutic treatments for osteoporosis and bone skeletal defects. The combination of NELL-1 and BMP2 stimulates bone production while inhibiting fat cell formation.