Articles tagged with Bone Formation
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A recent study published in NPJ Regenerative Medicine found that large bone injuries trigger a repair strategy recapitulating elements of skeletal formation in utero. The gene Sonic hedgehog (Shh) plays a necessary role in healing central regions, while small-scale fractures heal through a distinct program.
A Kyoto University study has discovered that c-type natriuretic peptide facilitates intracellular calcium signaling in chondrocytes to stimulate long bone growth. This finding may lead to the development of new bone growth-stimulating agents for treating developmental disorders.
Researchers at Lehigh University developed a new method to accurately gauge healing progress of bone fractures using 3D models. The model identifies the cutoff point between soft tissue and bone, allowing for more precise predictions of bone behavior during the healing process.
A study by Kyoto University researchers reveals that human fetuses develop slower shoulder growth before birth, alleviating complications during delivery. This adaptation allows for a safer passage through the birth canal, reconciling the incompatibility between wide shoulders and narrow pelvis.
An international team of engineers has successfully bioprinted bone along with two growth factor encoding genes that help incorporate cells and heal defects in rats. The researchers used gene encoding PDGF-B and BMP-2, which encouraged cell multiplication and migration, resulting in a 40% increase in bone tissue creation.
Scientists at Texas A¼M University have created water-stable, 2D covalent organic framework nanoparticles that can guide human mesenchymal stem cells to form bone tissue. The new technology has the potential to impact the treatment of bone regeneration and improve drug delivery.
Researchers create transgenic lettuce that expresses a bone-stimulating hormone, which could help prevent osteopenia in astronauts and resource-limited areas on Earth. The lettuce would need to be consumed daily by astronauts to get a sufficient dose of the hormone.
Researchers led by Joan Richtsmeier are exploring the development of the lower jaw, focusing on Meckel's cartilage and its role in mandibular growth. The study aims to understand how mid-portion of Meckel's cartilage influences mandibular length, mineralization, and disappearance.
Researchers uncover the pleiotropic functions of hnRNPK in regulating skeletal muscle cell differentiation, including inhibition of myoblast differentiation and suppression of genes involved in endoplasmic reticulum stress. The study suggests that targeting hnRNPK could be a potential therapeutic strategy for treating human disorders.
Researchers found physical differences in femur, dental structures across specimens suggesting re-categorization into three groups or species. Two new species, T. imperator and T. regina, are proposed based on analysis of 37 Tyrannosaurus specimens.
Scientists created new material design principles by studying the complex structure of starfish skeletons. The unique lattice architecture offers mechanical protection, enabling high strength and flexibility while maintaining buoyancy regulation.
Prunes have been found to help prevent or delay bone loss in postmenopausal women by reducing inflammation and oxidative stress. This is due to their potential to alter the gut microbiome, which can lead to lower levels of pro-inflammatory cytokines and markers of oxidative damage.
Sophie Paczesny's research aims to validate biomarker panels that help doctors predict chronic GVHD risk and adjust immune suppression treatments accordingly. The study uses machine learning algorithms to analyze stored plasma and blood cell samples from over 1,300 BMT recipients.
Researchers discovered that the IL-6 family of proteins is required for maintaining and regenerating cartilage in joints and growth plates. The study found that blocking this gene could lead to severe cartilage and skeletal changes, particularly in females.
Researchers have developed a combination of materials that can morph into various shapes before hardening, similar to the natural process of bone development in the human skeleton. The soft material can be used to create microrobots that can inject themselves into complicated bone fractures and expand to form new bone.
Fibrodysplasia ossificans progressiva (FOP) may be rooted in impaired and inefficient muscle tissue regeneration, which enables unwanted bone growth. This discovery could lead to new therapies targeting both extra-skeletal bone formation and muscle function.
A new study reveals that medieval warhorses were bred for success in various functions, including tournaments and long-distance raiding campaigns. The research, published in the International Journal of Osteoarchaeology, found that breeding and training were influenced by biological and cultural factors.
Researchers from the Crump Lab created a series of atlases to study the molecular decisions of cranial neural crest cells, identifying genetic signs that point to specific destinies. Their findings reveal a new approach to understanding head development and regeneration in vertebrates.
Researchers at INRS have developed a bioactive coating that mimics bone tissue using chitosan, collagen, and copper-doped phosphate glass. The coating promotes healing and reduces the risk of rejection, paving the way for improved orthopaedic implant success.
Researchers found that theropods strengthened their jaws through time, with expanding rear jaw portions and evolving different jaw shapes depending on diet. This allowed them to exploit a wider range of food items and minimized bone fracture risk.
A new consensus statement provides recommendations for the diagnosis, management, and care of individuals with achondroplasia across all life stages. The guidelines aim to improve clinical outcomes and quality of life for those affected by this genetic disorder.
A new study by researchers at Mount Sinai found that a specific gene, HHIP, helps regulate the development of the coronal suture, a fibrous joint that connects the front and middle bone plates. The study showed that embryos with a missing HHIP gene had misshapen skulls and fewer mesenchymal cells separating the bones.
Researchers at Hospital Gregorio Marañón and UC3M developed a navigation system combining surgical navigation, three-dimensional photography, and augmented reality to estimate bone fragment positions during surgery. This system has been used on 7 patients with optimal results, reducing dependency on surgeons' experience.
A study suggests that total hip replacement may contribute to sacral insufficiency fracture (SIF), a type of pelvic stress fracture. SIF is more likely to occur on the side opposite from previous THA, and bone loss leading to SIF begins within the first postoperative year following THA.
Research reveals that captive animals on soft food diets may experience weaker skulls and reduced bite effectiveness when released back into the wild. The study found that rats fed softer diets had weaker skulls, but those switched from hard to soft food as juveniles also showed signs of weakened bone growth.
Research suggests that obesity triggers inflammation, leading to an increase in myeloid-derived suppressor cells, which break down bone tissue. This can result in gum disease and tooth loss. The study found a significant link between high-fat diets and increased osteoclasts and alveolar bone destruction.
Researchers at CNIC have identified the essential role of GPR126 in placental development, revealing its critical function in fetal growth and viability. The study also highlights a possible link between GPR126 dysfunction and pregnancy complications such as preeclampsia.
Researchers discovered that mammals developed protruding, flexible noses from reptilian jaws through cellular studies and fossil analysis. This finding explains the origin of mammals' strong sense of smell and provides potential new animal models for studying facial development disorders like cleft palate.
Researchers at University of Virginia Health System have discovered a new treatment target for osteoporosis and bone loss from rheumatoid arthritis. A cellular protein called ELMO1 promotes the activity of osteoclasts, which break down bone, leading to excessive bone degradation.
A recent University at Buffalo study found that patients using proton pump inhibitors (PPIs) for heartburn had smaller probing depths in their gums, indicating less severe gum disease. The researchers suggest that PPIs' side effects may be linked to reduced periodontitis severity.
A subpopulation of mesenchymal stem cells expressing CD73 has been identified as crucial for bone regeneration, displaying enhanced proliferation and differentiation capabilities. This subgroup promotes fracture healing by forming new cartilage and bone cells, contributing to the remodeling process.
Detailed analyses of cremated bone fragments from Tomb of Nestor's Cup uncovered at least three humans with varying life stages, alongside animal remains like goats and dogs. The study sheds new light on funeral practices and ancient Greek culture.
The study found that a specific type of glycosaminoglycan in the scaffold led to greater blood vessel development and immune cell activation. Researchers aim to further understand these interactions to develop biomaterials for bone repair.
A study published in the Journal of Materials Science: Materials in Medicine found that alginic acid improves artificial bones by increasing porosity, compressive strength, and setting time. The addition of alginic acid to calcium phosphate cement enhances its mechanical properties, allowing for more effective bone replacement.
Researchers created the first detailed cell-by-cell description of how the coronal suture develops, identifying new genes and cell types involved in generating stem cells that grow skull bones. The study aims to advance new interventions for patients with craniosynostosis.
A new research project aims to create strong, malleable biomaterials that support stem cell growth for improved skull reconstruction surgeries. The $2.4 million grant will help accelerate bone regeneration and reduce complications.
A substance from Saussurea controversa has been found to promote bone regeneration by stimulating the conversion of stem cells into osteoblasts. The calcium chelidonate was tested in vitro and in vivo, showing non-toxic effects and increased viable stem cells at low doses.
Researchers discovered that physical load stimulates bone growth through the expression of osteocrin (OSTN), a peptide produced by osteoblasts. OSTN is critical to regulating bone growth and physical endurance, with its expression decreasing when load is reduced and increasing with load stimulation.
A study of over 7,500 participants refutes the idea that the 2D:4D ratio is influenced by sex hormones, instead suggesting that finger size differences are related to overall growth patterns. The research found no correlation between total finger length and 2D:4D ratio in men and women across different ages and nationalities.
Researchers at King Abdullah University of Science & Technology (KAUST) create a biomaterial that supports the growth of bone marrow precursor cells and forms tubular blood vessels, mimicking natural bone tissue architecture. This breakthrough enables the development of 3D disease models for tissue engineering and biomedical research.
Scientists from Trinity College Dublin found that skeletal defects caused by lack of movement in the womb can be partially recovered after movement resumes. The study used chicken embryos and suggests that this finding may also apply to humans.
A Hebrew University study found that ultra-processed foods negatively impact children's skeletal development, leading to reduced bone quality and growth. The research surveyed lab rodents who consumed junk food, showing growth retardation and impaired bone development.
Researchers at Osaka University identified SLPI as a critical mediator in balancing bone build-up and break-down, mediated by parathyroid hormone. The molecule promotes bone formation and suppresses bone loss, suggesting potential new treatments for osteoporosis.
A new study led by the University of South Australia found that inhibiting bone morphogenetic protein (BMP) suppresses growth plate bony repair and prevents degeneration. This could lead to a biological treatment in place of correcting deformities through surgery.
Researchers analyzed ancient bones from A??kl? Höyük to determine the ages of unborn and neonatal lambs. The study reveals that early Neolithic sheep-herders faced high levels of mortality among young animals, with infections, malnutrition, and overcrowding being primary causes.
Researchers have developed an effective method for managing bone defects in diabetes patients using 3D bioprinted bone-repair scaffolds infused with bone marrow stem cells and macrophage. This technique has the potential to accelerate bone repair and improve outcomes for individuals with diabetes.
Researchers have successfully grown a lifelike piece of bone tissue from human stem cells, providing unprecedented understanding of the complex process of bone formation. The new organoid contains two types of cells that are essential for successful bone development and offers promising possibilities for personalized medicine.
A team of researchers from Osaka University has identified a novel mechanism by which the protein Smurf2 regulates bone formation through the BMP signaling pathway. The study found that Smurf2 uses ubiquitination to mark messenger proteins for destruction, leading to reduced bone mass and formation rates in mice without Smurf2.
The UMass team developed a novel biomaterial, demineralized bone paper, that mimics the dense structural matrix of bone. This material supports cellular processes and can be used to model bone remodeling and disease progression.
Researchers identify a unique population of skeletal stem cells that mark a transitional phase in bone growth and maintenance, which may hold clues to preventing osteoporosis. The study's findings provide new insights into the regulation of these cells and their potential role in bone health.
A new study found that gut microbes can affect bone mass and structure in mice, with treatments altering the gut microbiome potentially aiding healthy skeletal growth. The findings suggest that microbes can be inherited or transmitted between individuals and impact skeletal development.
Researchers from UIC have discovered distinct pathways for bone and teeth formation, which can be manipulated to enhance healing processes. This breakthrough has significant implications for developing new treatments to cure dental diseases and bone injuries.
Researchers develop a biomaterial that enhances adult stem cell regenerative ability, repairing large bone defects and reducing inflammation. The material incorporates nanoparticles that activate JNK3, a key driver of children's stem cells' regenerative capacity.
A new ceramic artificial bone coating has been developed with improved adhesion strength, enabling robust coating on metal and polymer surfaces. This breakthrough reduces production cost and time for implant procedures, addressing issues such as inflammation and loose implants.
A new study by researchers at the University of Eastern Finland provides novel insight into the previously unknown effects of factors regulating blood vessel formation. Bone morphogenetic factor 6, BMP6, is shown to regulate blood vessel formation via vascular endothelial growth factor receptor 2 (VEGFR2) and Hippo signalling pathway.
Researchers at University of Helsinki identified mechanism behind bone marrow failure in Fanconi anaemia by finding MYC gene overexpression. This led to stem cell detachment from the bone marrow and development of bone marrow failure.
This study reveals that hypoxic exosomes promote sphere formation and stem-like phenotype in EWS cells by delivering enriched miR-210. The knockdown of HIF-1α led to decreased exosomal miR-210 levels, while inhibition of miR-210 attenuated sphere formation.
Researchers at Radboud University Medical Center have redefined bone formation, finding that it does not require complex biomolecules in collagen. This breakthrough simplifies the production of bone substitutes and biomaterials.
A new study published in Journal of Bone and Mineral Research suggests that women with a history of obstructive sleep apnea (OSA) are at a higher risk of developing vertebral fractures. The study found that OSA was associated with a 2-fold increased risk of vertebral fracture, particularly among those experiencing daytime sleepiness.
Researchers analyzed fossil bones of Panthasaurus maleriensis, an ancestor of modern amphibians, and found phases of rapid and slow growth depending on the climate. The study provides valuable insight into the prehistoric past, with the Indian site showing evidence of both young and adult animals.