Articles tagged with Embryos
Researchers at MIPT have synthesized an antitumor compound that can target and kill chemoresistant ovarian carcinoma cells. The new agent was found to destroy microtubules, which are involved in cell division, making it a potential treatment for this aggressive form of cancer.
University of Florida researchers found a trio of mutations in a genetic switch that controls limb development, leading to the loss of legs in snakes. The study reveals that pythons and boa constrictors retain rudimentary leg structures, while completely limbless snakes show more extensive decay of the Sonic hedgehog enhancer.
Researchers developed a neurodevelopmental chick model that demonstrates fetal death and brain damage similar to microcephaly caused by the Zika virus. The study suggests that identifying critical windows of susceptibility could lead to therapeutic innovation.
Researchers at the University of Adelaide have developed a new technique to choose the best embryo for implantation, boosting IVF pregnancy success rates. The method uses digital imaging and mathematical modeling to analyze differences in embryos not visible under a microscope, helping embryologists make more informed decisions.
A randomized trial found that IVF culture media affect embryo quality, implantation rates, pregnancy rates, and birthweights. The study suggests that the exact composition of culture media should be listed to ensure transparency.
Scientists have created embryos with 'heteroplasmy,' a presence of both maternal and paternal mitochondrial DNA, allowing them to study potential treatments for mitochondrial diseases. Researchers found that inhibiting two proteins can prevent the removal of paternal mitochondrial DNA from embryos.
A study of 1,508 infertile women with PCOS found that frozen embryo transfers had lower rates of ovarian hyperstimulation syndrome and pregnancy complications compared to fresh embryo transfers. Women with PCOS who received frozen embryos also had higher rates of live births and better birth weights.
Scientists at EMBL discovered that cell contraction strength determines whether cells move inwards to form the embryo or stay on the surface to become the placenta. The study found that unequal inheritance of apical proteins affects cell contraction, leading to the formation of either embryonic or placental tissues.
Studies on nonhuman primates spark debate over ethics of infection challenges, with experts arguing for stricter safeguards to balance human need with animal welfare
Scholars propose five guidelines to prevent disputes over frozen embryos, including clear contract language, requiring a binding agreement, and anticipating potential tragedies. These recommendations aim to provide clarity for the estimated million frozen embryos in the US, reducing uncertainty and shifting terrain of varying state laws.
Researchers identify Cloche, a bHLH-PAS transcription factor, as the key gene controlling blood vessel and blood cell development in embryos. The discovery, made after 20 years of searching, has significant implications for regenerative medicine and personalized stem cell therapy.
A study by researchers at University of Miami Rosenstiel School found that weathered oil from the Deepwater Horizon spill affects heart, eye, and neurological function in mahi-mahi embryos and larvae. The findings suggest that this type of oil poses a significant threat to developing fish.
A UC Riverside-led study found that weathered oil affects developing heart, eye, and neurological function in Mahi embryos and larvae. The researchers used novel bioinformatic methods to identify gene signatures and predict biochemical targets where the oil causes harm.
Researchers developed a novel synthesis method for glaziovianin A from parsley and dill seeds, inhibiting human tumor cell growth. The compounds also showed promise in testing human cancer cells, with the parent compound being the most active anti-tubulin agent.
Researchers discovered that red-eyed treefrog embryos use a unique mechanism to escape deadly snakes, rapidly releasing enzyme-degrading substances from specialized glands on their snouts. This process allows the tiny escapees to wriggle through an aperture created in the egg membrane, ensuring survival.
Red-eyed treefrog embryos, thought to be helpless, are found to have evolved a quick-release mechanism to escape the egg prematurely. The study reveals that tadpoles can hatch up to two days ahead of schedule and use enzymes to create a hole in the egg membrane before escaping.
The US policy on mitochondrial replacement therapy (MRT) is at a standstill due to a contradiction between the National Academies' recommendation and a legislation enacted by President Obama's administration. MRT aims to replace disease-causing mitochondrial DNA in human embryos, providing new cures for previously untreatable conditions.
Researchers at IBS Center for Genome Editing demonstrate Cpf1's superior specificity in precision genome editing, generating mutant mice with targeted mutations. The study reveals that Cpf1 has virtually no off-target effects, opening up new possibilities for therapeutic treatments and agricultural products.
Researchers have found a blastoporal organizer in sea anemone embryos, using the same signaling molecules as vertebrate organizers. This principle existed in the common ancestor of vertebrates and sea anemones over 600 million years ago.
Researchers at UC Berkeley developed a faster and more efficient CRISPR-Cas9 editing method for mice, using electroporation instead of microinjection. The new technique resulted in higher success rates and reduced embryo damage.
The report shows that ICSI use is approaching 100% in some regions, despite being developed for male infertility. The editor highlights the need to make decisions based on evidence, warning against unnecessary and costly care.
A new UVM study examines the trade-offs between IVF financial savings and medical complications from multiple embryo transfers. The research found increased rates of cesarean-section deliveries, premature births, and low birth weight with two or more embryos transferred into the mother at one time.
A new study confirms BPA's detrimental impact on IVF success, with embryo death rates increasing linearly as BPA exposure grows. The findings support decades of research suggesting BPA's role in reproductive toxicity, emphasizing the need for regulation and control of this chemical.
Researchers discovered that entire sets of maternal and paternal chromosomes can segregate into different cells in embryonic development, leading to chimeric embryos. This finding provides a new mechanism for chimerism and may improve embryo selection approaches for IVF preimplantation genetic diagnosis.
Researchers developed a mouse model of aneuploidy to investigate the fate of abnormal cells in early-stage embryos. They found that even when half of the cells are abnormal, the embryo can fully repair itself through programmed-cell death.
A recent study found that epaulette shark embryos can withstand ocean acidification conditions predicted for the year 2100, but may be vulnerable when gills are still developing. This suggests that sharks may be more resilient than previously thought, but their survival depends on maintaining healthy habitats.
A new research essay in Cell journal suggests that the US can follow the UK's approach to regulate germline editing and mitochondrial replacement therapy. The authors argue that the UK's experience with MR therapy provides a well-drawn regulatory framework for evaluating the safety and ethics of germline editing.
A new study by Stanford bioengineers and physicians finds that measuring the rigidity of an hour-old fertilized egg can predict its viability more accurately than current methods. The technique, published in Nature Communications, could improve the success rate of single-egg IVF and ultimately benefit both mothers and babies.
Researchers at Cornell University discovered triggers that could reduce congenital heart defect risk in newborns by regulating embryonic heart and valve formation. They found cyclic stretches activate enzymes that coordinate biological responses, leading to proper valve maturation.
A study published in the Proceedings of the National Academy of Sciences reveals that micronuclei structures can cause aneuploidy and lead to mosaic embryos. This discovery may provide early non-invasive detection of aneuploidy, improving the chances of success for infertile couples who rely on medically assisted reproduction methods.
Scientists have developed a new light sheet microscope that can record the first two to three days of a mouse embryo's life. By tracking each cell's daughters, grand-daughters, great-granddaughters, and so on, they identified a crucial turning point in the embryo's development.
For the first time, a litter of puppies was born through in vitro fertilization, thanks to work by Cornell University researchers. The breakthrough enables conserving endangered canid species and study genetic diseases, as dogs share more than 350 similar disorders with humans.
Researchers at EMBL used a new technique to prevent cell contraction, identifying crucial cells for ventral furrow formation. The shape of the tissue dictates the direction of contraction, not internal programming.
A new study reveals that certain 3D printed parts are highly toxic to zebrafish embryos, causing lower survival rates and malformations. Treating the parts with UV light may reduce some side effects, emphasizing the need for safe disposal strategies.
Researchers found that parts from both types of 3D printers were toxic to zebrafish embryos, with liquid-based printer parts being the most toxic. A post-printing treatment using ultraviolet light reduced toxicity levels.
Researchers have discovered that cell division mechanisms involve an excitable cortex that participates in the process. This excitable state allows for precise control of contractile proteins and enzymes to assemble at the right place and time during cell division, enabling accurate and adaptive management of the cell's shape.
Researchers analyzed 640 pregnancies in 142 mares to understand the impact of maternal lineage on gestation length and foal characteristics. The study found that certain maternal lineages produce more female foals, with young and older mares contributing to this trend. These findings have implications for horse breeding practices.
A new UNSW report shows that frozen embryo IVF cycles are just as successful as fresh embryo cycles, with a 23-27.5% birth rate. The report also found a significant increase in the use of frozen embryos and improvements in techniques such as vitrification and blastocyst culturing.
Researchers discovered a network of transporters involved in controlling hormone ABA transport to seed embryos, ensuring optimal germination timing. This knowledge can be integrated into breeding programs to prevent premature germination and reduce economic losses.
Researchers found male seahorses play a crucial role in nourishing and protecting embryos during pregnancy, delivering energy-rich lipids and calcium. Their gene expression during pregnancy was also similar to that of humans, suggesting a common genetic mechanism for managing pregnancy across species.
Researchers at the University of Toronto have identified the process of endocytosis as a key driver of rapid embryonic healing, which coordinates cell movement to close wounds. This discovery holds promise for developing more efficient treatments for human wound repair.
A study published in JAMA found that using frozen donor eggs for IVF is linked to lower live birth rates compared to fresh eggs. The study analyzed data from over 11,000 cycles and found that per started cycle, the live birth rate was 43% with frozen eggs vs 50% with fresh eggs.
A new study has found that rising ocean temperatures and acidification have a significant impact on the survival and development of Antarctic dragonfish. The research reveals that warmer waters can accelerate embryonic development, but also lead to increased mortality rates.
Research aims to understand how Antarctic fish will respond to rising ocean temperatures, which could impact the food web and ecosystem. The study will focus on embryo viability, development rate, and temperature stress response in two species, and provide data for informing climate change strategies.
A large study found no benefit in IVF from routinely freezing all embryos before transfer, even among normal responders. This challenges the move to adopt a freeze-all strategy in IVF.
A study by Dr. Marta Devesa found that IVF cumulative live birth rates decline significantly with age, especially in women using their own eggs, with a 3% chance of success at 44 and over. In contrast, egg donation shows higher success rates, making it a viable alternative for older patients.
Researchers discovered that cells in early embryos 'dance' as they compact, a process controlled by cell contraction. The study used new methods to measure forces and tensions within the embryo, revealing that adhesion acts as an anchor rather than an engine of compaction.
The rate of ectopic pregnancy following IVF has decreased significantly over the past 12 years, from 20 cases per thousand cycles in 2000 to 12 cases per thousand in 2012. This decrease is largely attributed to advancements in ART techniques and a reduction in tubal factor infertility.
Researchers found that pregnant pipefish males supply relatively low oxygen levels to their embryos, averaging 51% in well-oxygenated water and as low as 32% in poorly oxygenated conditions. Despite this, the fathers' care allows the young to survive and thrive, with a focus on nutrient supplementation and waste removal.
Researchers found that paternally contributed centriole proteins can persist up to ten cell generations, raising the possibility that centrioles may be a non-genetic information carrier. This discovery has profound implications for biology and disease treatment, particularly for understanding centriole-related diseases.
A team of researchers has found a new connection between physical forces and limb development in embryos, using live imaging and computer models. Their study could lead to simulations that help repair deformed limbs, potentially creating a drug to alter mechanical stress on cells.
Researchers at Cincinnati Children's Hospital Medical Center found that the size and patterning accuracy of an embryo depend on the amount of reproductive resources invested in by mothers before eggs leave the ovary. The study used fruit flies to develop a mathematical model, TEMS, which links core pieces of the developmental picture. ...
Researchers have discovered that a specific set of molecules, known as transcription factors, trigger DNA errors and slow down cell division in embryos. This finding provides new insight into the mechanism behind the 'midblastula transition', where the embryo takes control of its genetic expression.
French scientists have discovered that vertebrate formation is guided by a pattern present from early development stages, with folds along boundaries of elastic contrast forming the final shape. This finding explains how complex structures like vertebrates emerged during evolution.
A recent study revealed that surrogate mothers in Indian fertility clinics lack knowledge about embryo transfer risks, while doctors make unilateral decisions. The existing laws need stricter regulation to ensure rights of all parties are protected.
Researchers used a new whole-genome sequencing method to detect potential disease-causing mutations in human IVF embryos, detecting 82% of single base de novo mutations. The technique, which uses DNA barcodes and advanced sequencing technology, can help identify the cause of congenital disorders such as intellectual disability and autism.
Researchers at the University of Manchester have identified a possible cause of IVF failure in some women, which may be treated with therapies targeting microRNA-145 and its effects on IGF1R. The study's findings suggest that manipulating this biological process could lead to improved rates of embryo attachment during implantation.
The study reveals that dam-induced changes in riverine sediment transport lead to reduced oxygen levels, causing hatched pallid sturgeon embryos to die. The research provides vital information for pallid sturgeon conservation and is a significant breakthrough in understanding the species' decline.
A recent study by MSU-led researchers found that oxygen-depleted dead zones between dams in the upper Missouri River are directly linked to the failure of endangered pallid sturgeon hatched embryos to survive to adulthood. This is a major breakthrough in understanding the decline of this species, which can live up to 100 years.
Children born after IVF have fewer preterm births, low birth weight issues, and stillbirths. The study found that transferring only one embryo per cycle improves single baby health.