Articles tagged with Embryos
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Researchers have developed a new CRISPR technique that allows them to target and reduce specific messenger RNA (mRNA) molecules involved in early embryonic development. This approach enables the study of genes that were previously difficult or impossible to manipulate, and has shown promise for understanding infertility and development...
A study published in The BMJ found that freezing embryos for later transfer does not result in a higher chance of pregnancy compared to fresh embryo transfer. Researchers recommend using fresh embryo transfer as the gold standard for women with no immediate risk of ovarian hyperstimulation syndrome.
Researchers at Max Planck Institute for Molecular Genetics discovered that epigenetic regulators control the development of different tissues and organs in early mouse embryos. By analyzing thousands of individual cells, they found that specific regulators have unique functions in every cell, making them difficult to study.
A team of Princeton researchers used optogenetics to activate the Ras/Erk pathway in fly embryos lacking Torso signaling. This allowed them to investigate where and when Ras/Erk signaling is needed for terminal patterning, revealing a surprisingly simple system controlling complex developmental patterns.
A new Oregon State University study using zebrafish found no significant health impacts from 5G radiofrequency radiation. Researchers exposed embryonic zebrafish to 3.5 GHz radiation and observed a modest impact on sound response, highlighting the need for further investigation.
Researchers found that 80% of embryos studied contained at least one aneuploid cell across all cell types and developmental stages. This suggests that embryos with abnormal cells may still develop into healthy pregnancies, challenging the current debate around IVF embryo selection.
A 20-year study found that 16% of cancer patients used their frozen eggs and embryos, with a remarkable 71% birth rate among those who did. Fertility preservation can be effective for young women diagnosed with cancer, with ovarian tissue cryopreservation and oocyte freezing offering good options.
Researchers discover a way to 'tune down' heterochromatin in early embryos, improving artificial cell reprogramming efficiency. This knowledge can lead to the efficient generation of high-quality stem cells for regenerative medicine approaches.
Research found that vitrification technology is safe for embryos, but storing them for longer periods reduces chances of pregnancy and live birth. The study analyzed outcomes from 24,698 patients and found lower implantation, clinical pregnancy, and live birth rates with longer storage times.
The BioRescue consortium successfully extracted oocytes from a southern white rhino female and created four viable embryos through advanced assisted reproduction technologies. This breakthrough procedure has nourished hope for the survival of the northern white rhino species in the near future.
Researchers found that embryo culture is associated with placental abnormalities, preeclampsia, and abnormal fetal growth. Optimizing embryo culture is key to ensuring healthy outcomes for mothers and offspring.
Developing frog embryos damaged by nicotine exposure can be repaired with ionoceuticals that restore bioelectric patterns, leading to normal anatomy and gene expression. The discovery offers a roadmap for exploration of therapeutic drugs that could help repair birth defects in humans.
Scientists have introduced nanodevices into mammalian cells to study the processes governing development and cellular behavior. The tiny devices measure forces exerted within the cell interior, providing insights into how intracellular matter rearranges itself over time.
A study led by Dr. Karl Hansen aims to investigate the health risks associated with two types of frozen embryo transfers used in IVF, one with a natural cycle and the other with artificially stimulated cycles. The research hopes to identify which protocol carries a lower risk of pregnancy complications such as pre-eclampsia.
Women have a good chance of having a second child with IVF, according to new study. The chances of a second ART baby decrease with maternal age, but successful pregnancies are more likely if treatment is continued and frozen embryos are used.
A study at Harvard Medical School found that administering CoQ10 reverses damage to germinative cells caused by BPA exposure. The antioxidants reduced oxidative stress and cell death rates in worms exposed to BPA, suggesting a potential strategy for reversing BPA-induced fertility issues.
Scientists have developed a 'virtual embryo' model of the sea squirt Phallusia mammillata, providing unprecedented insights into early embryonic development. The study describes the gene expression and morphology of every single cell in the embryo, revealing coordinated regulation and reproducible patterns.
Researchers reconstructed 3D models of baby dinosaur skulls, revealing they develop in the same order as modern reptiles. The embryos were found to be fossilized at approximately 60% through their incubation period, much earlier than previously thought.
A new method detects trace proteins secreted by embryos using microfluidic droplets and multicolor fluorescence, predicting developmental potential with high accuracy. The technique improves upon conventional morphological scoring, reducing variability among embryologists.
Researchers at RIKEN found that mechanical forces sculpt the embryo, creating a precise fold despite genetic variation and environmental fluctuations. This discovery highlights the importance of mechanical self-organization in ensuring developmental consistency.
Researchers discovered that female swamp wallabies are permanently pregnant throughout their lives due to two uteri, allowing for continuous embryonic development. This unique reproductive strategy enables females to return to oestrus in late pregnancy and conceive new embryos.
Researchers discovered diapause in African turquoise killifish protects against aging consequences without affecting lifespan or fitness. Genes involved in muscle development and chromatin remodeling factors play critical roles in regulating gene expression during diapause.
Researchers have created a new stem-cell model that can grow somites, the blocks of tissue that form vertebrae and muscles in embryos. This model, called gastruloids, has been developed to study complex processes in embryonic development and may enable testing of new drugs for developmental defects.
A study by Karolinska Institutet found that IVF-conceived children had a 45% higher risk of death before 1 year of age than naturally conceived children. The risk varied depending on the type of assisted reproductive technique used and how many days had passed since birth.
A bovine embryo successfully regenerates its placenta-forming cells, demonstrating a high regenerative capacity compared to mice. The study opens up possibilities for genetic testing and breeding cattle with improved qualities.
A Tufts University-led team discovered that embryonic brain signals direct the migration of immune cells to infection sites, significantly improving embryo survival rates. Without a brain, embryos are more susceptible to bacterial infections and succumb quickly.
Researchers at the University of Pittsburgh discovered that mechanical cues can drive goblet cell regeneration on the surface of frog embryonic organoids. The study, published in Nature Communications, shows that changing the stiffness of the environment can induce significant changes in cell behavior. This finding has implications for...
A new study found that fertility treatments cause epigenetic changes associated with rare diseases, while maternal age does not. Researchers used mice to dissociate the effects of technology and aging on gene expression.
Researchers have created a spatial map of gene expression for individual cells in various tissues, including the liver and intestinal epithelium. The new algorithm, called 'novoSpaRc', uses machine learning to track gene activity and reveals new insights into tissue organization and regulation.
A four-year study using advanced computational methods has found that IVF embryos do not have a higher risk of chromosomal abnormalities than naturally conceived children. The study, published in Nature Medicine, analyzed the genetic makeup of live-born children and found no evidence of cell lines with chromosomal aberrations.
Researchers from CRCHUM unveiled a mechanism that likely contributes to the low level of pregnancy success in some fertility clinics. Healthy cells usually have one nucleus, but many fertility clinics transfer so-called 'binucleated embryos' with two nuclei back to patients. The study found that binucleation increases the chances of an...
Scientists from CSIC-UMH have discovered a molecular mechanism that ensures the right equilibrium needed in left-right signaling cascade during development, leading to correct heart positioning. This mechanism involves a transient wave of small molecules called microRNAs that travel along the left-hand side of the embryo.
Using electric shocks accelerates the formation of limb and tail buds in early chicken embryos. The study reveals that concentric rings within the blastula deform in a cascade-like process, inducing each ring to change shape.
Japanese scientists have developed a new method to construct 3D models from 2D images, overcoming several limitations in current methods. The approach uses non-rigid registration and blending of rigid transforms to create accurate 3D reconstructions of human embryos with high success.
Researchers found that turtle embryos move towards warmer ends of eggs and develop into females or males based on the temperature gradient. This study provides a rare 'good news' story about conservation, as it suggests that turtles may be more resilient to climate change than thought.
Researchers found that turtle embryos can move around to find optimal temperatures, influencing their own sex determination. This behavior may help turtles buffer the effects of climate change by producing a balanced sex ratio.
Researchers at Tel Aviv University have made a breakthrough discovery in genetic sex selection, allowing for the production of only female offspring in mammals. The study uses a CRISPR-protein approach to guide gene editing, eliminating male embryos while leaving females unaffected.
Pregnancy rates from IVF and ICSI in Europe have reached a peak, with success rates stabilizing after increasing for conventional IVF cycles. Frozen embryo cycles show the highest pregnancy rate at 30.5%, indicating an upward trend in outcomes.
A large cohort study confirms that blastocyst transfer is linked to a higher risk of preterm birth and large-for-gestational-age rates. The study found a 23% increased risk of being large for gestational age after fresh blastocyst transfer compared to cleavage stage transfer.
A large multicentre randomised trial found no improvement in delivery rates with frozen embryo transfers compared to traditional fresh transfers. The study suggests that a general freeze-all strategy may not be beneficial for women with regular menstrual cycles.
A study found that 94% of patients who underwent embryo genetic testing before IVF were glad to have the information, despite potentially disappointing results. The research suggests that even after a negative outcome, most women value the knowledge gained from embryo testing for reproductive planning.
A Penn study found that cell size controls the timing of genome activation in zygotes, shifting control from maternal molecules to individual cells. This discovery has significant implications for understanding early embryo development and may impact research approaches.
A new article recommends explicit management of conflict of interests, banning exclusive rights to research results, and enhanced informed consent to guide germline gene editing. The author argues that regulation and penalties are necessary to ensure public trust in science.
A new AI approach analyzes time-lapse images of embryos to predict pregnancy potential, improving IVF success rates and minimizing multiple pregnancies. Researchers used a large dataset of human embryos to train an algorithm that can classify embryo quality with high accuracy.
Research at Princeton University reveals that a DNA-building block limitation is key to embryo survival, preventing catastrophic development. Excess material leads to defective offspring.
Researchers found that in 9% of cases, embryos produce males when sperm genetic material is used after fertilization. This unique case suggests that males play a crucial role in helping females produce descendants without contributing their own genes.
A study published in Cell Systems has characterized global phosphorylation and protein abundance changes in response to physical force in Xenopus embryos. The research team identified precise modulatory points in response to force, highlighting the importance of mechanical forces in tissue homeostasis.
Researchers at Karolinska Institutet discovered previously unknown cellular stages of fetal development using gene analysis on individual cells from early mouse embryos. The study revealed a molecular road-map of the events that control cell differentiation, shedding new light on the early development of the embryo.
Researchers at Oregon Health & Science University found that mosaic embryos can adapt to abnormalities and persist in development, resulting in positive IVF outcomes. Mosaic embryos, which contain both normal and abnormal cells, were previously considered non-ideal candidates for IVF transfer due to the risk of aneuploidy.
Researchers developed a new technique called GOTI to evaluate genome-editing tool safety, improving detection sensitivity and accuracy. The method detected off-target effects in CRISPR/Cas9 and base editors, raising concerns about emerging technologies' unpredictable risks.
Researchers at CRCHUM successfully reduced chromosome abnormalities in mouse embryos by half, a major cause of infertility. The discovery could improve infertile couples' chances of giving birth if applied to humans in the future.
A team of biologists and physicists have shown that cells optimize the use of all available genetic code information to position themselves with precision. This study demonstrates a mathematically optimal process in complex biological systems, predicting cell placement accuracy within 1 percent of actual locations.
Estonian scientists have developed a genetic testing technology called TAC-seq, which enables precise analysis of clinical biomarkers at the single-molecule level. This method raises the precision of biomarker analysis and is poised to make it more affordable.
During zebrafish development, a region of the embryo switches from viscous to liquid, allowing it to take shape. The study found that this process is mediated by cell division and regulated by non-canonical Wnt signaling pathway.
A research team from Universitat Autonoma de Barcelona develops a new Double Factor Preimplantation Genetic Testing (DF-PGT) strategy using massive sequencing techniques. This allows for simultaneous diagnosis of genetic mutations and chromosomal alterations, increasing the security of the diagnosis and the viability of embryos.
A study found that random differences in gene expression during fetal development can lead to a survival advantage, potentially contributing to adult health issues. The researchers propose that these epigenetic variations can become more common in individuals exposed to famine or adverse conditions during gestation.
A liquid nitrogen storage tank failure at a fertility center resulted in the loss of over 4,000 frozen eggs and embryos. Researchers argue that a ruling in favor of a couple's wrongful death lawsuit could lead to limits on abortion, stem cell research, and IVF.
Scientists in EMBL's De Renzis group use optogenetics to steer the shape transitions of embryonic tissues, controlling a crucial step in development. This technique allows them to inhibit abnormalities and provide new insights into tissue invagination.
Scientists have developed a smart microscope that provides a 4D view of embryonic development in living mice. The microscope uses algorithms to track the embryo's position and size, creating high-resolution images of its development over a critical 48-hour window.
A study analyzing over 937,000 single embryo transfer cycles found that the proportion of multiple pregnancies is 1.6% and 1.36% result from true zygotic splitting. Factors increasing the risk include frozen-thawed embryos, longer blastocyst maturation, and assisted hatching.