Researchers developed a reporter system to permanently mark cells infected with chikungunya virus, revealing that marked cells containing most of the persistent RNA can survive for at least 112 days. Treatment with an antibody reduces the number of marked cells in muscle and skin.
A new study published in Science sheds light on how our ancestors fed themselves, dramatically changing the world to grow food. By 3,000 years ago, intensive farming was common, reshaping environments for human sustenance.
A RAND Corporation study highlights the need for innovative approaches to address the fentanyl crisis, which has worsened dramatically with tens of thousands of deaths annually. The study suggests that supply disruption, creative supply-side strategies, and increased access to novel treatments are crucial in reversing the tide.
Scientists have identified a Y-chromosome linked gene called Maleness-on-the-Y that determines male sex in several major fruit fly pests. The discovery could lead to the development of more effective genetic control strategies for these destructive agricultural pests.
A new study published in Climate of the Past reveals that Burgundy wine grapes have been picked 13 days earlier on average since 1988 than in the previous six centuries. This accelerated warming trend is consistent with a hotter and drier climate in recent years, which has become more common in the past 30 years.
Post-opioid overdose interventions are emerging in the US to provide support to survivors and reduce future overdose risk. The interventions often involve collaboration between emergency departments, law enforcement, and public health departments.
Researchers have sequenced the microbiome within crown gall tumors of grapevines, providing a database to assess disease stage and paving the way for new advances to combat the debilitating disease. The study sheds light on the complex interaction between the grapevine and its microbial community.
Fuzhong Zhang receives nearly $2 million NIH grant to investigate metabolic diversity and its relation to antibiotic persistence in bacteria. He aims to understand what causes cells with different metabolic activity and develop strategies to control these differences.
A new species of prehistoric murine has been identified from fossils in Lebanon, providing the first physical evidence of initial Asian-African mouse dispersal. The findings suggest that Progonomys manolo is one of the earliest representatives of Progonomys, which spread out of southern Asia 16 million years ago.
Research reveals that Christian churches can provide essential support to Chinese international students in the US, addressing cultural shock, language barriers, and academic challenges. The 'Chinese Home Church' community offers a welcoming environment for students to share their experiences and emotions.
A new gene therapy has been developed to specifically reduce fat tissue and reverse obesity-related metabolic disease in obese mice by targeting a fatty acid metabolism gene. The therapy resulted in a 20% reduction of body weight and improved insulin resistance and inflammation after just six weeks of treatment.
Researchers found that Id4 controls whether stem cells remain in a state of rest or enter cell division, with increasing age leading to hyperactive signaling pathway inhibiting cell division.
Tropical Depression Erin's strong northwesterly vertical wind shear pushed most of its clouds and thunderstorms southeast, weakening the storm. The cyclone strengthened into a tropical storm despite the wind shear, but weakened back to a depression by 11 a.m. EDT.
Researchers from MIPT created a second-order memristor that stores information and forgets it over time, mimicking natural memory. The device is based on hafnium oxide and has potential applications in designing analog neurocomputers.
Researchers at São Paulo State University discovered that breaking time-reversal symmetry creates molecules with spin-polarized orbitals, allowing for the encoding of information. This phenomenon could be exploited in quantum computing and spintronics to develop faster, more efficient devices.
A new study found that children in preschool have unique interactions with teachers and peers, with some interacting more with their teacher than others. The study used video cameras to capture the class environment from each child's perspective.
A new study finds that waist size, not overall obesity, is a significant predictor of coronary artery disease in postmenopausal women. The study, published in Menopause, found no association between body mass index and obstructive cardiovascular disease.
A new mechanism was discovered that induces programmed cell death in cancer cells by disrupting ion homeostasis, leading to increased reactive oxygen species and endoplasmic reticulum stress. This approach has been shown to strongly inhibit tumor growth in animal models.
A large international study led by TU Wien demonstrates climate change's influence on river flood magnitude. Regional patterns show changes in flood severity and frequency, with northwestern Europe experiencing increasing floods and southern Europe seeing decreasing flood levels.
A new DNA sequencing method can detect early-stage wheat diseases with high accuracy, addressing the limitations of traditional methods. This portable technology can also identify unknown pathogens and diagnose unexpected diseases, saving time and money in agricultural biosecurity monitoring.
Researchers have visualized the atomic structure of the metabolic enzyme transhydrogenase (NNT) using cryo-electron microscopy. The study reveals the enzyme's channel gating mechanism and has implications for understanding metabolic regulation and developing novel therapies.
A review of 52 publications found inconsistent results on the effects of prenatal opioid exposure on childhood outcomes and development. Studies showed some null effects of opioid exposure on cognitive and behavioral outcomes, but behavioral effects emerged as children got older.
Researchers have discovered fungi that flourish in people infected with C. difficile, suggesting a potential new way to treat the disease. The findings suggest that fungal species may contribute to the development of C. difficile infections and could be used as a therapeutic target.
The BC2 Basel Computational Biology Conference aims to bridge the gap between Big Data and clinical applications, featuring renowned experts from precision oncology to infectious diseases. Key takeaways include the importance of single-cell data in cancer research and biological big data analysis methods.
Researchers trained an AI model using human-generated clickbait data, resulting in improved performance compared to other systems. The study found differences in headline creation between humans and machines, highlighting the need for high-quality training data to improve machine learning models.
The American Academy of Neurology has issued a new guideline recommending that people with multiple sclerosis receive recommended vaccinations, including yearly flu shots. The guideline updates previous recommendations and emphasizes the importance of preventing infections through vaccine use in MS patients.
Researchers identify VPS13A gene associated with migratory behavior in golden-winged and blue-winged warblers, shedding light on the complex genetic factors behind bird migration. The study's findings may have important conservation implications for declining populations of these species.
A study found that general probiotic use could save the US healthcare system $1.4 billion annually by reducing acute respiratory tract infections, including influenza-like illnesses. Probiotics were associated with a decrease in doctor visits and sick absences, leading to significant cost savings.
Researchers from the University of Córdoba have discovered that high-virulence strains of PRRSV cause earlier and greater damage than low-virulence strains. This study aims to develop vaccines that reduce mortality in the pig sector by understanding the behavior of the virus in infected animals.
A new underwater gripper developed by researchers at Harvard's Wyss Institute for Biologically Inspired Engineering has successfully caught and released jellyfish without causing harm. The ultra-soft gripper uses hydraulic pressure to wrap around a single jellyfish, then release it, allowing for extensive study of marine organisms.
Researchers at University of Illinois Chicago developed a system to deliver stem cells and provide mechanical stress for new bone formation. The addition of growth factors mimics embryonic bone development, leading to enhanced healing of bone defects in rat models.
Research reveals that horizontal and vertical circulation of carbon-rich ocean water in the subpolar Southern Ocean work together to control carbon storage and release. The study found that large gyres, such as the Weddell Gyre, play a key role in transporting carbon-containing phytoplankton out of the region.
Researchers at Carnegie Mellon University have received a $1.95 million grant to create customizable, ultra-high density neural probes using 3D nanoparticle printing. This new technology will increase accessibility to brain tissue and enable prototype new electrode configurations on-demand.
Researchers developed a DNA vaccine for Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) that completely protects against lethal infection in ferrets. The vaccine induces both neutralizing antibody response and multifunctional T cell immunity.
Researchers have developed a new electrolyte regulation strategy for Li-O2 batteries using hydrophobic silica colloidal particles. The strategy prevents lithium dendrite growth and corrosion, achieving a 980-times better anticorrosion effect and stable long-life electrochemical performance.
Researchers analyze data from Gaia satellite and spectroscopy to find that older stars move more rapidly in and out of the Galaxy's disk. The findings provide insights into the history of our Galaxy and inform theories about star formation and evolution.
A UCI-led team has created the first high-resolution map of ocean surface phosphate, showing that marine phytoplankton are more resilient to nutrient stress than previously believed. This finding holds important implications for climate change predictions, as plankton communities can thrive even in nutrient-deficient environments.
Researchers developed a neural network model using machine learning to predict Universe structure formation. The new model is more accurate than existing analytic methods and efficient enough for large-scale simulations.
Four new species of extinct Paradoxosisyrinae were discovered in Burmese amber, revealing nectar-feeding habits and inefficient proboscis design. Researchers found the insects could not seal their proboscis for effective nectar uptake, limiting their ability to feed on deep-flowered plants.
A new study found that low-cost active teaching techniques, such as group work and worksheets, significantly improve learning in university science classes. Increasing class time dedicated to group work by just 10% resulted in a 3% improvement in student performance.
A review of autopsy reports reveals that early in the HIV epidemic, the average age of death was 36, increasing to 54 by 2010 due to development of antiviral therapies. However, people are still dying predominantly from underlying disease rather than just old age, with infections like pneumonia and hepatitis C contributing to deaths.
Researchers at MIT have designed a robotic thread that can navigate the brain's blood vessels using magnets, aiming to improve endovascular procedures for treating stroke and aneurysms. The thread can be functionalized to deliver drugs or break up blockages with laser light.
Researchers have developed a hydrogel-based carrier that can deliver siRNAs directly to tumors, overcoming the challenge of rapid degradation and limited cellular entry. This innovative technology has the potential to improve the effectiveness of siRNA-based cancer treatments and enable more efficient delivery of biologics.
A global study found that satisfaction is the most popular metric for marketing decisions worldwide. The study analyzed over 4,000 marketing plans from 1,600 companies across 16 countries, revealing a significant relationship between total metric use and marketing performance.
Researchers at UNIGE have discovered that brain progenitor cells can recover their past skills and rejuvenate when transplanted into a young mouse embryo. This finding sheds light on how the brain constructs itself and opens up new possibilities for cortical neuroregeneration.
Researchers discovered a remarkably complete 3.8-million-year-old cranium of Australopithecus anamensis in Ethiopia, revealing new insights into human evolution. The fossil finds contradict the long-held notion of a linear transition between A. anamensis and its descendant species A. afarensis.
Women who used oral contraceptives during adolescence are more likely to develop depression as adults, according to a new study published in the Journal of Child Psychology and Psychiatry. The research found that teenage birth control pill users were up to three times more likely to be clinically depressed in adulthood.
A review of current land surface models highlights the need for more accurate infiltration predictions, which affect erosion control and water supply. The authors recommend increasing attention to soil structure, moisture, temperature, precipitation, terrain, and plants in these models.
A new clinical trial from Penn Medicine found that administering arginine vasopressin to trauma patients with severe bleeding can significantly reduce the need for blood products, a promising way to save lives. The study, published in JAMA Surgery, showed that patients treated with AVP required less than half the usual volume of blood ...
Researchers challenge widespread misconceptions about nighttime eating and weight gain, finding protein consumption before bed has no effect on belly fat metabolism or whole-body fat burn in active women. Contrary to previous beliefs, a high-protein snack at night can actually have beneficial effects on fat release and metabolism.
Nearshore corals, which grow faster than offshore counterparts due to warmer temperatures, have experienced a decline in growth rates over the past decade. Climate change and coastal development are believed to be major contributors to this decline, with far-reaching implications for global coral reefs.
Researchers uncover remarkably complete cranium of Australopithecus anamensis, a 3.8-million-year-old early human ancestor. The discovery contradicts long-held notions of human evolution, revealing that Lucy's species and its ancestor coexisted for at least 100,000 years.
Studies find that older Chinese Americans with depressive symptoms experience increased functional disabilities, mobility issues, and comorbid chronic health conditions. Comorbidity increases emergency room visits, hospitalizations, medical costs, and mortality rates among this population.
A new study identified a transcriptional signature in B cells that correlates with protection from SIV or HIV infection in five independent trials of HIV-1 vaccine candidates. The gene expression signature was found to be associated with the only human HIV vaccine trial that previously showed modest efficacy, RV144.
Research from Washington State University reveals that hiring star employees alongside founders can stall product innovation efforts due to conflicting influences. The study advises start-ups to establish clear chain of command, hire experienced start-up employees, and adapt to change as the organization evolves.
Research from University of California - San Diego found a significant association between tramadol use and an increased risk of developing hypoglycemia. The study analyzed over 12 million reports and identified a 10-fold greater risk compared to other opioids, with methadone being the only other drug with comparable effect.
University of Kansas researchers have developed a new technology that could improve subsurface fracture characterization, visualization, and diagnostics of unconventional reservoirs. The innovative approach uses smart microchip proppants that generate real-time data to optimize well spacing and completion design, potentially reducing e...
A recent study published in Clinical Psychological Science found that parental burnout can lead to increased neglect, violence, and thoughts of escape. The research suggests that self-care is essential for parents and that health professionals need to be aware of parental burnout to provide accurate diagnosis and care.
Researchers analyzed strontium, carbon, and nitrogen isotopes in jaguar scat to identify prey habitats. The study found that jaguars in Belize were not competing with livestock for resources, providing reassurance for conservation efforts.
NASA's Terra satellite captures images of Hurricane Dorian near St. Thomas on August 28, 2019, confirming its Category 1 status. The storm is expected to continue strengthening over the Atlantic waters, posing a threat to the U.S. and British Virgin Islands, Puerto Rico, and other regions.