Articles tagged with Tissue Regeneration
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Researchers at Burnham Institute for Medical Research discovered how two signaling pathways control epigenetic modifications that regulate muscle stem cell growth and differentiation. The study highlights potential pharmacological avenues for selective gene expression control in regenerative medicine.
Researchers studying Holothuria glaberrima found that sea cucumbers can rapidly regenerate lost body parts by healing wounds with similar cellular mechanisms. This discovery may lead to new insights into repairing human tissues.
Researchers in Australia identify two markers to isolate mesenchymal stem-like cells from endometrial tissue, which can differentiate into various cell types and repair prolapsed pelvic floors. The study opens up possibilities for using these stem cells for pelvic floor prolapse surgery and other gynaecological applications.
Scientists have identified unique stem cells within adult tendons that can proliferate and self-renew, regenerating tendon-like tissue in an animal model. This breakthrough could lead to the development of new treatments for tendon injuries caused by overuse and trauma.
A research group led by Dr. Cato T. Laurencin has received a $2 million NSF grant to explore novel methods for musculoskeletal tissue regeneration. The project aims to engineer new material surfaces that will allow a range of tissues to grow, potentially leading to breakthroughs in regenerative medicine and tissue engineering.
Researchers at Forsyth Institute have identified a novel mechanism controlling adult stem cells, highlighting the importance of direct cell-to-cell communication. The study's findings suggest that gap junctions play a critical role in regulating stem cell behavior and tissue regeneration.
Researchers developed a silk-based scaffold, SeriACL Graft, to regenerate or re-grow anterior cruciate ligament (ACL) tissue in goats. The study demonstrated the safety and efficacy of the device in promoting ACL regeneration, with 95% of animals returning to normal gait by 6 months.
A team of surgeons at Washington University School of Medicine has found that using motor nerves to repair damaged muscles yields better results than traditional sensory nerve grafts. The study used a novel approach, where intact motor nerves were used as grafts in rat models, resulting in significant improvements in muscle function.
A new study from Harvard Medical School identifies p63 as the master regulator of epithelial stem cells, which are essential for tissue regeneration and have implications for cancers such as breast, prostate, and skin. The findings show that p63 imparts 'stemness' to regenerative cells, maintaining a steady pool of these cells.
Researchers identified a regenerative process in the sea squirt that could be applied to humans, allowing damaged organs to repair themselves. This breakthrough has major implications for regenerative medicine, potentially treating conditions such as missing limbs and scarred hearts.
Xuejun Wen aims to repair spinal cord nerves using tissue engineering and implantable bridging devices. His research has the potential to improve lives and generate commercial interest.
Using adult bone marrow stem cells, researchers successfully regenerated healthy liver tissue in patients, doubling the liver growth rate and allowing for earlier surgical resection. This therapy has potential as a treatment for regenerating livers damaged by other chronic and acute diseases.
Biodegradable PolyHIPEs have been successfully used as tissue-engineering scaffolds for craniofacial reconstruction due to their rigid foam structure and ease of fabrication. This technique allows for the creation of interconnected pores, enabling efficient cell migration and tissue regeneration.
Researchers have developed a method to produce enamel-like tissue in culture, using epithelial cells extracted from developing teeth and seeded onto collagen scaffolds. This breakthrough could lead to the regeneration of whole teeth and treatment of damaged or missing enamel, revolutionizing dental care.
Dr. David Mooney is recognized for his groundbreaking work on tissue engineering and tissue regeneration, including blood vessel and bone regeneration. He will receive the IADR Isaac Schour Memorial Award, a prestigious honor acknowledging outstanding scientific contributions in the field.
Researchers find unique mode of whole body regeneration (WBR) in sea squirts, which arises from systemically induced signals and may travel through circulation. RA signaling plays a vital role in WBR, with overexpression leading to accelerated regeneration.
Scientists at Forsyth Institute successfully induced frog tadpole tail regeneration using gene therapy and electric fields. This breakthrough discovery may hold key to regenerating human spinal cord tissue, providing insights into the role of bioelectricity in regeneration.
Researchers have made progress in restoring bone function using bone tissue engineering, which uses stem cells to regenerate bone tissue. This technique has shown success in animal studies and holds promise for clinical applications, but further research is needed to overcome existing challenges.
Scientists at The Forsyth Institute have discovered that programmed cell death is necessary for regeneration to occur. Apoptosis plays a critical role in development and a novel role in regeneration, allowing medically therapeutic regeneration. The study uses the Xenopus tadpole as a model organism.
Scientists at the Max Planck Institute discovered that newt heart cells can re-differentiate after damage, allowing for complete repair and restoration of function. The researchers found that Phospho-H3 protein marks the G2 phase of cell cycle and indicates regeneration without stem cells.
Researchers found that zebrafish have progenitor cells and an epicardium that can restore wounded heart muscle. The study's findings suggest that these mechanisms could be utilized for therapies, potentially improving the regenerative capacity of mammalian hearts.
Researchers developed a method to construct scaffold libraries made from controlled polymer blend compositions, which can predict the behavior of thousands of possible tyrosine-derived blends. This innovative line of research aims to develop rapid and inexpensive methods to optimize biomaterial properties.
Researchers at Rice University and Baylor College of Medicine have been awarded a $2.9 million NIH grant to develop a stem cell repair therapy for stroke damage. The project aims to regenerate damaged brain cells and blood vessels, providing a new source of neural and vascular cells that can be transplanted into the damaged brain.
Rutgers scientists have developed a polymer-based drug delivery system to kill bacteria that attack gum tissue during periodontal disease, promoting healing and regeneration of tissue and bone around teeth. The system treats bacterial infection, inflammation, and pain with pharmaceuticals incorporated into the material itself.
A UCF study found that coral tissue damage cannot heal near pollution sources on land, leading to reef decline and increased hurricane risks. The loss of coral harms natural ecosystems and the tourism economy, while also protecting coastal areas from storms.
Researchers have found that protein-coated dental implants can induce bone formation and promote tissue regeneration. In laboratory tests, the protein-induced bone growth nearly completely regenerates lost tissue around teeth.
Researchers at Penn School of Medicine successfully manipulate cells to regenerate damaged heart tissue using cyclin A2. The findings hold promise for future therapy and treatment of heart disease, potentially leading to less surgery and medicine.
Researchers will explore ways to harness the body's natural healing process to heal deep wounds, including bone, muscle, nerves, and soft tissues. The goal is to develop regeneration of tissue in humans, inspired by the salamander's ability to fully restore lost tissue.
Scientists at OHSU School of Medicine found that bone marrow-derived cells fuse with intestinal stem cells in both normal and diseased tissue, promoting tumor growth and cancer development. This discovery has implications for understanding the balance between rapid regeneration and cancer risk.
Researchers have made significant breakthroughs in developing biohybrid lung devices, regenerative potential of stem cells, biomechanical training of tissue constructs, and artificial esophagus using extracellular matrix scaffolds. These advancements aim to restore function of damaged or diseased tissues and organs.
Researchers are conducting a trial to use mesenchymal stem cells (MSCs) to repair damaged heart muscle after a heart attack. The MSCs can be grown in large numbers and stored for years, allowing a single donation to treat thousands of patients.
Researchers have found a naturally occurring mutant chicken called Talpid with a complete set of teeth, similar to those of crocodiles. The team successfully induced teeth growth in normal chickens by activating dormant genes, paving the way for potential applications in tissue regeneration and tooth replacement.
Researchers at Rice University developed a new method to coax bone cells into producing up to 75 times more calcium, paving the way for regenerating healthy bone. The study, led by undergraduate Néha Datta, uses adult stem cells and a novel growth medium approach.
Researchers discover smedwi-2 plays critical role in regulating daughter cell differentiation for tissue maintenance. Silencing this gene leads to animal death, despite intact stem cells, highlighting early specification of progeny
Scientists study flatworms to understand how adult stem cells regenerate tissues, finding key genes involved in the process. Researchers discovered that a specific gene, piwi, plays a crucial role in producing daughter cells capable of restoring damaged tissues.
A new study has identified a key regulator of spindle orientation in mammals, essential for neural development. The discovery sheds light on the complex process of neural stem cell division and its impact on brain structure and function.
Researchers at Forsyth Institute discover that gap junctions play a crucial role in planarian regeneration by facilitating long-range signaling. By closing down gap junctions, the team found that cells can adopt radically different fates, leading to the growth of complex structures.
Researchers have discovered that neural stem cells in adult mice can respond to Shh signaling and give rise to other neural cell types, including glial cells. The study also found that quiescent stem cells can self-renew after a year, with implications for tissue repair and cancer progression.
Massachusetts General Hospital has been designated as a Specialized Center for Cell-Based Therapy for Heart, Lung and Blood Diseases. The center aims to develop new ways of regenerating or repairing damaged tissues using stem cell biology and tissue engineering.
Researchers identified genes required for stem cell function and regeneration in planarians, providing insights into human development and health. The study used RNA interference to analyze gene function in intact animals and on proliferation of adult stem cells.
Scientists have identified 35 genes essential for regeneration in planarians, a discovery that could lead to new insights into human regenerative biology and the development of potential treatments for diseases. The study also highlights the potential of planarians as a genetically sound model for human biology.
Scientists used fruit fly larvae to study regeneration and discovered a key gene involved in adapting stem cells to different tissue types. The research challenges old concepts of regeneration and opens new avenues for stem cell research.
Researchers have successfully regenerated the optic nerve in mice using a combination of techniques that prevent the formation of scar tissue. The study, led by Dr. Chen, shows promise for treating eye injuries and potentially improving outcomes for patients with glaucoma and spinal cord damage.
Tissue engineering aims to regenerate human tissue through artificial means, mimicking the body's natural processes. Researchers at U-M School of Dentistry are working on combining therapies to improve tissue engineering outcomes, such as using parathyroid hormone and bone morphogenetic proteins.
A study by Stanford researchers found that the youthful blood of younger mice can revive the regenerative abilities of older mice's satellite cells, which dot muscle tissue. This phenomenon was also observed in livers of older mice connected to younger lab-mates, suggesting a possible role for blood-borne factors in rejuvenation.
Researchers have found a new protein, TAJ/TROY, that acts as part of the receptor complex in neurons responding to growth-inhibitory molecules. This discovery may provide insights into designing therapeutic strategies to block myelin inhibition and promote regeneration of spinal cord or brain tissue after injury.
Researchers have discovered a single human stem cell population derived from the bone marrow that can regenerate myocardium after myocardial infarction. This breakthrough has significant implications for treating heart failure and major morbidity associated with myocardial infarction.
The study suggests that the spleen contains a population of primitive stem cells important for healing several types of damage or injury. These cells may produce an even greater variety of tissues than adult stem cells from bone marrow.
Hair cell regeneration is a promising approach to treating hearing loss and related neurodegenerative disorders. Researchers have discovered that specific genes, including Rb, play a crucial role in halting the cell cycle, allowing for hair cell regeneration.
Researchers at UNC Lineberger identified two proteins, p16INK4a and ARF, that increase dramatically as cells age, suggesting a link between cellular aging and their upregulation. This discovery may lead to new biomarkers for determining the molecular age of people and potentially slow aging.
Researchers have found promising results using olfactory ensheathing cells (OECs) to form myelin around nerve fibers, improving rats' functionality. Tiny beads releasing the enzyme chondroitinase ABC also enhance axonal growth and recovery of function.
Researchers at Northwestern University are using regenerative medicine to help paralyzed people walk again and enable diabetic individuals to lead normal lives without daily treatments or organ donations. The team is focusing on synthetic scaffolds and their interactions with cells, a key component of regenerative medicine.
In a preclinical safety study, adipose-derived stem cells demonstrated a statistically significant improvement in left ventricular ejection fraction (LVEF) at six-months post-infarction. The treated group showed improved heart function compared to the control group, as measured by both 2D echocardiography and cineangiography.
Researchers at Stanford University used Drosophila melanogaster to study wound healing, discovering that distinct genetic programs and signaling pathways control each stage of the process. This breakthrough could help identify molecular underpinnings of wound healing in humans.
Researchers have made significant breakthroughs in growing replacement teeth and dental tissues using tissue engineering techniques. The development of novel regenerative therapies could restore partial tooth tissue loss and minimize restoration failure with traditional dental materials.
Researchers recreated mammalian cell self-organization patterns in a test tube using mathematical formulas dictating cell interactions. This may help improve tissue regeneration methods and understand mechanisms behind birth defects and heart disease.
Researchers have demonstrated that adipose-derived cells can engraft and differentiate into cardiac myocytes, offering new hope for treating heart disease. The study's findings are consistent with previous research and are being further explored by MacroPore Biosurgery.
Scientists have discovered a synthetic chemical called cardiogenol that can selectively differentiate embryonic stem cells into beating cardiac muscle cells. This breakthrough could lead to the development of new treatments for heart disease and other degenerative conditions.
Dr. Anseth's team has developed an injectable scaffold to regenerate cartilaginous tissue using light-activated chemistries, with potential applications in treating Parkinson's disease by injecting stem cells into human brains.
Researchers have created a strain of mouse whose muscle cells continuously produce mIGF-1, leading to significant muscle regeneration and tissue repair. This breakthrough sheds light on how stem cells specialize and integrate into damaged tissues.