Articles tagged with Tissue Regeneration
Researchers at BWH have engineered human mesenchymal adult stem cells with internal depots that can slowly release agents to influence cell behavior. The cells demonstrated controlled differentiation into bone cells, even affecting distant cells.
Researchers found that R-spondin1 reduces GVHD by protecting intestinal stem cells, which help regenerate damaged tissues and reduce inflammation. The study's results suggest a potential therapeutic approach for human bone marrow transplant patients.
Researchers found that Taxol, a cancer drug, can aid in the regeneration of nerve cells after spinal cord injuries. The drug stabilizes microtubules and prevents the production of inhibitory substances in scar tissue, allowing for better nerve cell growth.
Researchers at Arizona State University have developed a material that can detect and heal cracks in structural materials, increasing toughness by 11 times. The innovative 'autonomous adaptive structure' uses shape-memory polymers to mimic biological systems' healing traits.
A study by Northwestern Medicine found that CD34+ cells can stimulate new blood vessel formation in ischemic limbs, reducing the risk of amputation. The treatment also showed significant repair of cardiac and vascular tissues, providing evidence for its potential to treat previously irreversible conditions.
Researchers are developing a manufacturing platform to produce biodegradable frames that mimic nature's fine-grained details, including vasculature. The goal is to grow replacement cardiac tissues for people who have suffered a heart attack, and create better systems for growing and studying cells in the laboratory.
A large randomized clinical trial found FGF-2 to be effective in regenerating human periodontal tissue destroyed by periodontitis. The study showed substantial restoration of tissues with positive outcomes over the long term, making it an attractive approach for restoring lost tissues.
Researchers at Children's Hospital Los Angeles identified PDGF as a key factor in epicardial cell proliferation and transformation. Blocking PDGF signaling impaired epicardial cell proliferation and coronary blood vessel development.
Biologists at Tufts University have discovered that sodium plays a key role in initiating a regenerative response after severe injury, enabling the regeneration of injured spinal cord and muscle. A specific drug-based treatment triggers an influx of sodium ions into injured cells, breaking new ground in biomedicine.
Researchers demonstrate that rationally guided human adult stem cells can effectively heal, repair, and regenerate damaged heart tissue. The study shows improved heart function recovery, reduced scars, and increased survival rate in mouse models with heart failure.
Researchers at Stanford University School of Medicine successfully replicated the ability of newts to regenerate tissue in mouse cells by blocking the expression of two tumor-suppressing proteins. This breakthrough may lead to future regenerative therapies for humans, and could involve sending us back down the evolutionary tree.
BioSET Inc. has been issued a patent for improved second-generation technology to design synthetic peptides that communicate growth signals to cells, fostering efficient healing. The technology has applications in numerous tissue repair cases, including orthopedic markets and sports medicine injuries.
Researchers discovered a way to boost nerve growth in peripheral nervous system, offering potential treatments for diabetes and traumatic injuries. Blocking PTEN molecular brake increased nerve outgrowth, providing hope for recovery from nerve damage
Scientists have developed a multilayered, nano-sized film containing alpha melanocyte stimulating hormone to regenerate dental pulp, potentially revitalizing damaged teeth and reducing the need for root canal procedures. The film has anti-inflammatory properties and increased the number of fibroblasts in dental pulp.
A Yale University-led team of scientists has made an important breakthrough in regenerating fully functional lung tissue that can exchange gas. The researchers successfully implanted cultured lung cells into rats, which efficiently exchanged oxygen and carbon dioxide, mimicking the natural lungs' function.
Bioengineers at the Wyss Institute have developed a new technology to regenerate heart and other tissues by replicating natural design principles. The resulting protein nanofabrics can be customized to generate specific properties, making them ideal for tissue engineering scaffolds and high-performance textiles.
Researchers at Henry Ford Hospital successfully treated lab animals with a synthetic version of the naturally occurring peptide Thymosin beta 4, promoting the creation of new blood vessels and repairing damaged nerve cells. The study's findings hold significant promise for treating clot-induced strokes in humans.
The University of Pittsburgh will conduct human trials for three innovative regenerative medicine programs aiming to replace scars and defects with healthy tissues. The projects, if successful, could lead to interventions benefiting civilians as well.
Researchers investigated the efficacy of acellular dermal matrix (ADM) in intestinal elongation. The study found that grafts were completely absorbed within two to three months, with severe adhesions and inflammation hindering their use. Despite these findings, ADM is believed to have potential as a scaffold for tissue regeneration.
Researchers at the University of Nottingham have identified a key gene, Smed-prep, essential for regenerating a planarian worm's head and brain after amputation. This discovery could one day lead to understanding human organ regeneration and tissue repair.
Researchers investigate stem cells and adult tissue in the kidney, suggesting a possible mechanism for regeneration. The study suggests that ACE inhibitors may be used to aid repair and regeneration of injured kidney tissue.
A study published in Cell Transplantation has found that using ICG to label human embryonic stem cell-derived cardiomyocytes substantially improves efforts to optically track stem cells after transplanting them into heart tissues. The labeling procedure did not impair the viability or functional integrity of the cells.
Researchers found that a specific subpopulation of heart muscle cells near the injury site contribute to regenerating heart muscle. The study also showed that these new cells integrate into the wound, replacing the injury clot, and form normal electrical coupling with the surrounding muscle.
A new multifunctional polymer material can rapidly neutralize both biological and chemical toxins, including bacteria, viruses, and nerve agents. The material has been shown to be effective in restoring enzyme activity after exposure to toxins.
Researchers from The Wistar Institute demonstrate that mice lacking the p21 gene can regenerate lost tissue, forming a blastema and replacing damaged cells with healthy ones. This discovery provides evidence of a link between cell division control and tissue regeneration, opening up possibilities for accelerating healing in humans.
Researchers identified a molecular repair pathway that involves white blood cells called macrophages responding to tissue injury by producing Wnt7b, leading to tissue regeneration and repair in injured kidneys. The study suggests the pathway may be important for tissue repair in other organs.
Researchers propose a model of adult stem cell regulation that explains how coexistence of quiescent and active stem cell populations supports tissue renewal and regeneration. The new model suggests separate functional roles for both sub-populations, which may also contribute to cancer drug resistance.
A team of UBC researchers has identified a new type of cell that can produce both fatty tissues and scar tissue, potentially leading to breakthroughs in treating muscle diseases. The discovery could also lead to the development of treatments for other diseases characterized by fibrosis.
Researchers found that male hormones can help vessels around the heart regenerate, potentially explaining why men experience worse heart attacks earlier in life. Androgen replacement therapy might one day be used to treat men at risk for heart disease.
Researchers at WPI are working on advanced prosthetic limbs that can be fully integrated with the body and nervous system, enabling more independent lives for those with amputations. The $1.6 million allocation will fund work on neural control for prosthetics, aiming to regenerate nerves and connect limbs directly to the brain.
Researchers at UC San Diego are developing new regenerative therapies for heart disease using adult stem cells and supportive materials. The study found that cells placed in these materials differentiate into cardiac muscle more effectively, offering a promising solution to treat cardiovascular diseases.
A multi-institutional team is using genomic tools and the Mexican axolotl salamander to understand regenerative capacity after spinal cord injury, stroke, and other neural conditions. The goal is to tap unused human capacities to treat these conditions.
Researchers at Salk Institute discover essential cellular pathway in zebrafish that enables limb regeneration by activating genes required to build a copy of the lost limb. Histone demethylation switches cells from inactive to active state, turning on genes needed for regeneration.
Researchers at Tel Aviv University have developed a biologically active scaffold made from soluble fibers that can help replace lost or missing bone. The technology, which has shown promise in animal models, could also be used to regenerate other types of human tissues, including muscle, arteries, and skin.
The National Institutes of Health has awarded Clemson University a five-year, $9.3 million grant to establish a Center of Biomedical Research Excellence (COBRE) for Tissue Regeneration. The center will focus on tissue regeneration through cell-biomaterials interactions to restore functional tissues and address the growing need for rege...
Research supports potential for new anti-cancer agent as loss of p53 and ATR severely disrupts tissue maintenance in mice, leading to rapid deterioration and fatal outcomes. Cells without ATR persisting in tissues cause blockage of regeneration, while absence of p53 worsens tissue degeneration.
Researchers at MIT have successfully generated blood vessels near damaged tissue using enhanced stem cells equipped with genes producing growth factors. The breakthrough could lead to new treatments for infarctions and induced blood supply for engineered tissues.
Researchers identified critical biochemical pathways linked to human muscle aging, revealing that old human muscle stem cells can be restored to youthful vigor with the right mix of biochemical signals. The study provides promising new targets for preventing muscle atrophy and other tissue degenerative disorders.
Researchers found that wntP-1 gene expression occurs at all wound sites, triggering regeneration polarity in planaria. Blocking the gene results in heads regrowing instead of tails.
A Clemson University bioengineer has developed an injectable biomaterial gel that promotes the growth of neural stem cells at the site of a traumatic brain injury, structurally repairing damaged brain tissue. The procedure shows promise for treating head injuries caused by car accidents, falls, and gunshot wounds.
Researchers have devised a new method to fix a broken heart by coaxing adult heart muscle cells into reentering the cell cycle, allowing them to divide and regenerate healthy heart tissue. The key ingredient is neuregulin1, which may one day be used to treat failing human hearts.
A growth factor called neuregulin1 can spur heart-muscle growth and recovery of cardiac function when injected systemically into animals after a heart attack. Researchers were able to restart the cell cycle with NRG1, stimulating cardiomyocytes to divide and make copies of themselves - even though they are not stem cells.
Research by Singapore and NC researchers found that reducing p38MAPK levels delays aging of multiple tissues in lab mice. The study also discovered that partial inactivation of p38MAPK improves proliferation and regeneration of islet cells without affecting tumour suppressor function.
Researchers successfully used induced pluripotent stem (iPS) cells to treat heart damage caused by infarction. The treatment restored heart muscle performance, stopped progression of structural damage, and regenerated tissue at the site of heart damage.
Researchers at Tufts University developed a tissue regeneration application that maintains complete root coverage after three years with minimal pain and recovery time. This innovative approach uses platelet concentrate gel instead of traditional grafting methods, resulting in improved esthetics and patient satisfaction.
A new study reveals that three cell-signaling pathways work simultaneously to direct pancreas and liver progenitor cells to mature into their final state. The research provides insight into the basis of tissue development and how it can be manipulated for regeneration and development from embryonic stem cells.
Researchers at Worcester Polytechnic Institute have received NIH grants to advance their work on regenerating damaged hearts using stem cells and preventing urinary tract infections by analyzing cranberry juice's molecular mechanisms. The studies aim to develop new therapies for heart damage and UTIs, potentially replacing antibiotics.
Researchers are developing models to test strategies for treating complex combat injuries, including segmental bone defects and massive soft tissue defects. The center is also investigating ways to protect stem cells during insertion and enhance their healing properties.
A UC San Diego bioengineer has made significant discoveries on the universal need for cells, tissues, organs, and organisms to use common biological modules. The researcher found that despite differences in structure and function, various biological systems respond to forces using similar strategies.
Researchers at the University of Michigan have developed a gene therapy approach that safely regenerates gum tissue. The method uses a localized application of adenovirus to deliver genes directly to the affected area, reducing the risk of systemic reactions.
The CellThera/WPI team will continue their joint efforts in regenerating mammalian muscle tissue under a one-year $570,000 DARPA contract. They aim to reprogram and engineer cells to replace damaged skeletal muscle and restore normal function.
Dr. Christopher McCulloch, a professor at the University of Toronto, is recognized for his significant contributions to understanding mechanisms regulating fibroblast cytoskeleton and collagen remodeling in periodontium.
Dr. Pamela DenBesten, UCSF professor and chair of Pediatric Dentistry, is recognized for her significant contributions to pulp biology and regeneration research. Her studies on the role of matrix molecules in cellular signaling have highlighted key bio-active molecules in regenerative events.
Three researchers have been awarded $75,000 grants to develop novel treatments for periodontal diseases, including a peptide-based hydrogel for dentin-pulp complex regeneration and an optical coherence tomography device for non-invasive diagnosis. The awards aim to improve oral health worldwide through innovative technologies.
Researchers found that the omentum increases liver size by 50% after transplantation, suggesting its role in regenerating damaged liver tissue. The study also identified oval cells as the key players in this process, which may be a promising new treatment for liver disease.
Researchers at Columbia University Medical Center have designed a new way to grow bone and other tissues by co-transplanting hematopoietic and mesenchymal stem cells. This approach results in faster regeneration of vascularized tissues compared to previous methods.
The University of Western Ontario has received $45.5 million in funding from the Canada Foundation for Innovation to develop new methods for growing stronger lab-grown bones and tissue. This will help address conditions such as arthritis, osteoporosis, and traumatic injuries, where current lab-grown materials lack sufficient strength.
A novel protein marker identifies rare adult liver stem cells whose ability to regenerate injured liver tissue has the potential for cell-replacement therapy. The finding offers significant implications for treating chronic liver disease in the future.
Researchers have identified two genes that regulate stem cell function in planarians, which could provide insights into adult tissue maintenance and regeneration. The study also reveals the role of PTEN in controlling stem cell proliferation and regeneration.
Researchers at Mayo Clinic have successfully used stem cells to regenerate heart tissue and repair dilated cardiomyopathy, a genetic defect. The treatment improved heart performance, synchronized electrical impulses, and halted deterioration in genetically altered mice with heritable dilated cardiomyopathy.