Articles tagged with Dna Microarrays
Researchers discovered how the genome uses competition between proteins to prevent rogue retrotransposon LINE1 from causing damage. The team found that a modified protein NRBP2 marks and disposes of another protein NRBP1, which is no longer functional due to mutations.
Researchers developed a single-assay approach using exome sequencing data to detect large-scale pathogenic mutations, detecting 91 previously undetectable mutations. This shift could enable earlier diagnoses and save the NHS vital resources.
A new study has documented the experiences of women receiving abnormal prenatal chromosomal microarray testing results, revealing a range of negative reactions. The research highlights the importance of providing emotional support and nuanced counseling to help parents navigate the ambiguities of genetic testing.
Researchers used genome-wide array analysis to find that parents of affected children often have previously undetected genetic abnormalities. These abnormalities can increase the risk of having another affected child, and understanding them can help provide better genetic counseling.
Paul Li's new technique combines DNA microarrays with microfluidic devices, allowing for faster and more efficient DNA analysis at room temperature. The method uses gold nanoparticles to separate single strands of DNA, enabling quicker detection and identification of specific genetic sequences.
Cold Spring Harbor Protocols presents high-throughput methods for mapping active gene regulatory elements using DNase-seq, and analyzing DNA synthesis with BrdU-IP-chip. These techniques enable genome-wide identification of genetic regulatory elements and analysis of DNA metabolism.
Researchers have successfully predicted a previously unknown cellular mechanism using mathematical modeling of DNA microarray data. This breakthrough brings biologists closer to understanding and controlling the inner workings of cells, similar to NASA's trajectory prediction capabilities.
Researchers at TGen have found a way to identify possible suspects using small amounts of DNA, even in complex mixes. This breakthrough could help police investigate crimes more effectively and potentially lead to new cost-effective methods for analyzing DNA evidence.
Researchers have invented a new DNA microarray technique that uses electrostatic repulsion to read and evaluate DNA or RNA assays without chemical labeling or sophisticated instrumentation. The technique can be carried out in minutes and has the potential to revolutionize medical diagnostics.
A new DNA microarray chip has been developed to predict severe disability and remission in RA patients, using genetic markers. The chip improves the accuracy of clinical scores in predicting functional impairment and disease remission.
Researchers develop protocols to identify promising molecule/mineral pairs, building on previous findings that many biomolecules can adhere to mineral surfaces. The study uses DNA microarrays and Time-of-Flight Secondary Ion Mass Spectrometry to discover which molecules stick to specific mineral surfaces.
Researchers have developed a new application called spectral self-interference fluorescence microscopy (SSFM) that characterizes the structure of DNA molecules with sub-nanometer accuracy. Using this technique, the team estimated the shape of coiled single-stranded DNA and double-stranded DNA of different lengths.
Researchers at Carnegie Mellon University have developed a new method to identify gene activation in DNA microarrays with greater sensitivity and specificity. This innovation holds promise for improving research on complex biological systems, including stress response, cancer, and embryo development.
The ERCC proposes developing consistent, well-characterized RNA samples to validate gene expression assays. These external RNA controls will help ensure comparable results across microarray and QRT-PCR systems.
A new printing method called Supramolecular Nano-Stamping (SuNS) enables the mass production of complex nano-scale patterns, including DNA microarrays. This could revolutionize diagnostics by making DNA analysis routine and inexpensive.
Researchers at Penn State have developed a coating made of molecules that binds to glass and grabs onto DNA strands, improving DNA retention on microarrays by over 50%. The coating, which is single molecule thick, allows DNA to act as if it were free-floating.
A UC Riverside graduate student has won the Best Poster award at an international conference for his research on clustering binary fingerprint vectors with missing values. His work aims to improve DNA microarray data analysis, which can help classify microorganisms and detect diseases.
GenMAPP organizes gene expression results by biological process, allowing researchers to see coordinated changes in gene expression. The program uses graphical representations of biological pathways to analyze gene expression data, providing a systems approach to interpreting biological data.
Researchers have created protein microarrays that can measure the function of thousands of proteins, enabling rapid screening of small-molecule drug candidates and profiling of enzymes in cells. The technique preserves protein function and functionality, allowing for creation of 'protein snapshots' of cells.