Articles tagged with Dna Sequences
A team of researchers identified a molecular mechanism that defends the human genome against mobile DNA sequences. The study found that abnormalities in this mechanism are linked to DiGeorge syndrome, a rare disease caused by chromosome microdeletion. The research aims to develop new therapies for the disease.
Scientists at Scripps Research Institute have found a way to apply powerful new DNA-editing technology more broadly than ever before. They report their breakthrough in using designer TALE proteins that can target any DNA sequence, enabling precise gene manipulation for biotech and medical applications.
A team of scientists has identified a potential mechanism for cellular memory, which allows cells to recall the order of transcription factor binding. This discovery sheds light on how cells maintain gene regulation and may have implications for understanding diseases such as cancer.
The study reveals a large block of genes from wild relatives are present in domestic tomatoes, affecting the genome in unexpected ways. Genes associated with fruit color and drought tolerance show rapid evolution among domesticated and wild varieties.
Researchers have developed a faster method to identify Salmonella strains, reducing the time it takes to detect outbreaks from one to three days. The new approach, called CRISPR-MVLST, is comparable in accuracy to existing methods and has the potential to be much cheaper.
Scientists at Arizona State University have discovered an enzyme that allows DNA sequences to be transcribed into a simpler molecule called TNA, which can then be reverse-transcribed back into DNA. This breakthrough offers clues about the origins of genetic code and has potential applications in molecular medicine.
Researchers unveil public domain DNA sequences and statistical models to engineer microbes with precision, increasing reliability and accuracy. This technological foundation enables more precise genetic engineering in the future.
A new checklist of Cucurbitaceae from India brings up-to-date information on the family's evolution, diversity, and distribution. The list includes 94 species, 79% of which have DNA sequences available in GenBank.
EMBL-EBI researchers develop a DNA storage method that stores at least 100 million hours of high-definition video in about a cup of DNA, overcoming challenges of writing and reading DNA. The new method uses short strings of DNA and error-tolerant coding to ensure data retrieval without errors.
Researchers found a clear role for regulatory 'tags' in mediating genetic risk for rheumatoid arthritis, an immune disorder affecting 1.5 million American adults. The study identified 10 DNA sites tagged differently in RA patients and associated with disease risk.
Researchers found a significant link between herbivore activity, phenotypic plasticity, and epigenetic changes in European holly. The study suggests that plants can quickly respond to environmental changes through epigenetic modifications, making them more resilient.
Researchers sequenced DNA molecules directly without library preparation, using less than one nanogram of DNA. The technique has potential for fast and efficient identification of organisms in hospitals and healthcare settings.
Researchers at Emory University School of Medicine have obtained a detailed molecular picture that shows how glucocorticoid hormones shut off key immune system genes. The finding could help guide drug discovery efforts aimed at finding new anti-inflammatory drugs with fewer side effects.
A new article provides simple guidelines for establishing basic authenticity and reliability of fungal ITS sequences, targeting traditional DNA sequencing. The guidelines aim to assist researchers in sharpening their datasets and reducing noise in public sequence databases.
Researchers identified a whole new class of arenaviruses in snakes with Inclusion Body Disease (IBD), a deadly condition causing bizarre behavior and eventual death. The discovery could lead to development of treatments, vaccines, diagnostics, and prevention policies for IBD.
Scientists are investigating the genetic components of song expression in singing mice, a species known for its melodic trills. By analyzing the FOXP2 gene, researchers aim to gain insights into the neural mechanisms underlying vocalization and potentially shed light on human language disorders.
Recent studies from Northwestern University's Physical Sciences-Oncology Center report significant methodological advances in gene expression regulation. The breakthroughs enable better comprehension of gene transcription in both normal cells and cancer cells.
A large international consortium has successfully sequenced the tomato genome for the first time, revealing its genetic code and potential applications in improving crop yields, flavor, and aroma. The achievement is expected to have significant implications for food production and culinary innovation.
Researchers have created a method to sequence epigenetic marks 5hmC and 5mC in DNA at single base resolution, improving our understanding of gene regulation and cell development. This breakthrough has major implications for regenerative medicine and stem cell research.
Researchers developed a method to derive DNA information from RNA, allowing for identification of individuals in massive research repositories. This technique raises questions about DNA and RNA data bank privacy issues, and may enable tracking of individual characteristics like age, sex, and disease risks.
The new method, called Direct Molecular Recognition, uses atomic force microscopy to take nanoscopic pictures of DNA molecules and identify sequence differences. This technique has the potential to be used for sensitive detection of DNA molecules in genomic research and medical diagnostics.
A new web-based program called Spliceman predicts whether genetic mutations will disrupt mRNA splicing, a process crucial for gene expression. The software uses research to show that many disease-causing mutations occur due to faulty splicing instructions.
Researchers at the University of Texas at Austin have developed a molecule that can bind to DNA for up to 16 days, making it a promising step towards creating drugs that can target rogue DNA. This breakthrough could lead to new treatments for genetic diseases, cancer, and retroviruses like HIV.
A team of scientists has discovered that the histone protein CenH3 is both necessary and sufficient to trigger the formation of centromeres and pass them on from generation to generation. This discovery may help develop artificial human chromosomes for gene therapies in medicine.
A new DNA testing method, MEMO, has been developed to detect trace mutant DNA sequences with improved sensitivity. The technique uses 3′-modified oligonucleotides to block normal gene extension while allowing mutated gene extension, increasing detection sensitivity.
Research published in the Journal of Medical Genetics found that faulty intellectual disability genes are largely paternal in origin and more common in children born to older fathers. The study analyzed rare copy number variations (CNVs) in over 3,500 people with intellectual disabilities.
Researchers at Stanford University School of Medicine have developed a new technique that allows them to pinpoint the exact DNA sequences and locations bound by regulatory RNAs. The study reveals the intricate world of gene expression and how RNA molecules control neighboring and distant genes.
Researchers at Salk Institute discover a "hidden" code linked to DNA that allows plants to develop and pass down new biological traits rapidly. The epigenetic code is found to evolve more quickly than the genetic code and strongly influence biological traits.
A new DNA construction software, j5, streamlines the process by identifying cost-effective strategies and automating protocols. This enables researchers to focus on primary interests while reducing labor-intensive tasks.
A new software program, called a DNA compiler, designs synthetic DNA sequences to control protein production in simple organisms. The technology allows biotechnology companies to quickly identify the best DNA sequence for a particular application, increasing efficiency and productivity.
A study by Christopher A. Cullis found that the environment influences helpful mutations in plants, even within a single generation. The experiment showed each strand of flax responded differently to its grown conditions, and the LIS-1 sequence appeared in response to nutrient deficiencies.
Engineers at Vanderbilt University created a 'spongy' silicon biosensor that detects small molecules with high sensitivity. The new sensor's porous structure increases its surface area, allowing it to capture more molecules than traditional sensors.
Researchers have discovered a new group of algae, rappemonads, which thrive in both freshwater and saltwater environments. The findings suggest that these microorganisms may be widespread globally.
Researchers discover two new species of 'leaping' beetles in New Caledonia that feed on previously unknown plants. The study used DNA sequencing to identify the diet of these herbivorous insects, revealing a secret botanical diversity on the island.
A DNA sequence variant, impairing kidney function channels, is associated with an increased risk of heart failure. The variant may be treated with drugs used for high blood pressure.
A new study argues that synthetic life sciences require a global regulator to detect pathogenic agents and ensure approved purposes for DNA sequences. However, current technology is insufficient to create an effective clearinghouse, highlighting the need for improved screening software and procedures.
A bioinformatics team from Virginia Tech and ENSIMAG is using federal guidance to detect the misuse of synthetic biology. The team's work will help gene synthesis companies identify potential threats, improving national security.
Researchers have discovered 2,363 new DNA sequences corresponding to 730 regions on the human genome, representing segments not charted in the reference map. The findings suggest that new genome assemblies based solely on next-generation sequencing might miss many of these sites.
Researchers used DNA barcoding to study the spread and diet of insect pests in Papua New Guinea. The study found that migratory patterns and caterpillar diets are very dynamic, with species showing surprising adaptability across vast distances.
Researchers at Arizona State University have developed a versatile DNA reader that can distinguish between the four core chemical components of DNA. The device uses nanotechnology and scanning tunneling microscopes to detect unique electrical signatures from each base, enabling faster and cheaper genome sequencing.
Scientists are using DNA barcoding to unravel secrets of ancient plant and animal remains, revealing how life on Earth responded to global climate change. The technology is also being used to identify species in gut contents, soils, and marine life, with important conservation implications.
A DuPont-Lehigh University team has developed a DNA-based method to sort and separate specific types of carbon nanotubes (CNTs) from a mixture. The new method utilizes tailored DNA sequences that can recognize individual types of CNTs and purify them with sufficient yield for fundamental studies and application development.
A team of Penn State scientists has identified unique patterns in the DNA sequences surrounding insertions and deletions, suggesting mechanisms that may have generated these mutations. The findings could influence genetic counseling for couples seeking to have children.
A study in Zoonoses and Public Health confirms Chronix's potential for early disease detection, identifying signature sequences in serum DNA before clinical symptoms appear. The findings advance the company's ability to apply these results to laboratory tests for routine clinical use.
A new tool, developed at North Carolina State University, allows researchers to visually represent DNA sequences and identify minute genetic variations. This enables the detection of genetic patterns that can lead to diseases such as cancer and Huntington's disease.
Researchers at the University of Minnesota have developed a new genome engineering tool to make model crop plants herbicide-resistant without significant DNA changes. This approach has the potential to provide sustainable solutions for producing food, fuel and fiber while minimizing concerns about genetically modified organisms.
Researchers propose an operational definition of 'epigenetics' to address confusion in the scientific community. They define it as stably inherited phenotypes resulting from changes in chromatin without altering DNA sequences. The proposed definition highlights three signals involved in establishing a heritable epigenetic state.
Researchers developed a new theoretical model to explain protein-DNA interactions, revealing optimal concentrations of binding proteins and auxiliary binding sites. The findings provide insight into gene regulation and its connection to diseases like cancer.
Researchers have devised a novel method to identify functional elements in non-coding DNA by surveying the landscape of DNA structure. This topographical approach reveals that about 12% of non-coding DNA appears functionally important, twice as much as detected using sequence comparison.
Researchers from Max Planck Institute and 454 Life Sciences Corp. have completed a draft version of the Neandertal genome, providing insights into their genetic relationship with modern humans. The study reveals significant differences between the Neandertal and human genomes, shedding light on how our species diverged.
A team of researchers from the University of Arizona has discovered a new method for protein-DNA interaction, where proteins can identify specific sequences on DNA using indirect readout. This breakthrough has implications for the development of designer drugs and could lead to a better understanding of diseases.
Researchers at McGill University have discovered that plants can forget epigenetic silencing, a process crucial for breeding enhanced crops. This 'molecular amnesia' varies depending on genome position, offering new avenues for understanding gene regulation and developing cancer treatments.
The new journal Epigenetics & Chromatin publishes research on heritable changes in gene expression without altering DNA sequence. High-quality studies on human telomeres and the RNAi pathway have been published, shedding light on epigenetic inheritance and chromatin-based interactions.
Researchers have released the world's most extensive collection of kiwifruit DNA sequences, which will help breeders create new varieties with improved nutritional content and desirable traits. The data is expected to speed up the development of new kiwifruit varieties through Marker Assisted Selection.
The Early Bird Project, a five-year study funded by the National Science Foundation, has collected DNA sequence data from 169 bird species. The research revealed that birds adapted to diverse environments multiple times and that distinctive lifestyles evolved independently. The study's findings will be published in Science on June 27.
A study published in PLOS ONE estimates that both island species were isolated around the same time, approximately 250,000 years ago. The researchers suggest that a moderate-sized ancestral population could reconcile differences in gene divergence patterns among the species.
The January issues of Biophysical Journal feature studies on the ultra-fast biological motion of Vorticella, which contracts like a spring, and sequence-dependent variations in nucleosome stability. Researchers also explore the biomechanical perspective of vesicle transport regulation in cells.
A recent study by McGill researchers has identified that small genetic variations can significantly affect the way genes produce proteins, resulting in diverse physical characteristics. These changes may contribute to the development of diseases such as cystic fibrosis and Type 1 diabetes.
Researchers found a gene named JAK that disrupts DNA activity, leading to cancer in fruit flies and potentially affecting offspring. The study shows epigenetic information can be passed from parent to offspring, even if the mutation itself is not present.
A University of Delaware-led team is working to advance scientific understanding of the rice epigenome, which regulates gene expression. The four-year project uses novel 'deep sequencing' technology to decode millions of DNA sequences and shed light on similar mechanisms in corn and other cereal grains.