New coronavirus (SARS-CoV-2) mapped out
Researchers at IBS South Korea successfully dissected SARS-CoV-2 RNA genome, mapping subgenomic RNAs to viral proteins. The study reveals dozens of unknown RNAs with potential roles in immune evasion.
Dna Sequencing
Articles tagged with Dna Sequencing
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World's first next-generation protein sequencing device to accelerate the study of diseases and pandemics
The Quantum-Si ecosystem enables sensitive and accurate research tools and diagnostics through digital proteomics, transforming the study of proteins on a large scale. The company's platform offers a complete solution for sample preparation, sequencing, and data analysis, reducing costs and increasing accessibility.
DNA from ancient packrat nests helps unpack Earth's past
A new study analyzes ancient packrat middens for DNA, revealing a mix of bacterial and eukaryotic organisms, including plants and vertebrates. The findings provide valuable insights into past ecosystems and the impact of human-caused climate change.
University of Utah Health launches fast DNA testing to speed care of critically-ill babies
The University of Utah Health is launching a project that uses rapid whole genome sequencing to identify genetic disorders in newborns, aiming to cut diagnosis time to 72 hours or less. The goal is to personalize treatment and improve outcomes for critically ill infants with genetic-related diseases.
Some genetic sequencing fail to analyze large segments of DNA
A recent study found that clinical whole exome sequencing at major commercial labs inadequately analyzes more than a quarter of genes, affecting the accuracy of genetic disorder diagnoses. The reanalysis revealed stark inconsistencies in gene coverage across different labs, with some testing only 34% of genes.
Nanopores can identify the amino acids in proteins, the first step to sequencing
Scientists have developed a method to identify all 20 amino acids in proteins using nanopores, a major breakthrough towards protein sequencing. The technology allows for precise differentiation of modified forms of amino acids, potentially identifying hundreds of modifications.
Scientists identify harmful bacteria based on its DNA at a very low cost
A new method called ON-rep-seq enables the precise identification of bacteria using selective, strain-specific fragments of the bacterial genome. This approach reduces analysis time and costs to less than $2 per bacterium, increasing accuracy to over 99%.
Early DNA lineages from Finland shed light on the diverse origins of the contemporary population
A genetic study of ancient bone samples in Finland discovered separate populations during the Iron Age, influencing modern Finns' gene pool. The study found lineages typical of hunter-gatherers and European farmers coexisted in different regions.
New portable DNA sequencer quickly and accurately diagnoses wheat viruses
A new portable DNA sequencer has been developed to rapidly diagnose wheat viruses with high accuracy. The technology has been tested on four wheat samples from western Kansas and detected three different viruses, including a new strain. This breakthrough has broad applications for plant disease identification and field diagnostics.
NIH funds new All of Us Research Program genome center to test advanced sequencing tools
The All of Us Research Program awards $7 million to HudsonAlpha to evaluate leading-edge DNA sequencing technologies. The project aims to generate genetic data on 6,000 participants, revealing elusive genetic variations associated with rare diseases.
New diagnostic method finds aggressive tumors
Researchers have developed a new genomic method, CUTseq, that can assess the amount and type of copy number alterations in tumors, helping identify highly heterogeneous and aggressive cancers. The technique is cheaper than existing technologies and can be applied to multiple biopsies or small tissue sections.
Whole genome sequencing could help save pumas from inbreeding
Using whole genome sequencing, scientists can pinpoint populations that need an influx of new genes or identify the best pumas to move between populations. This approach may help prevent inbreeding and its consequences, such as health defects.
First genome of spotted lanternfly built from a single insect
The US Department of Agriculture's Agricultural Research Service has published the first genome of the invasive Spotted Lanternfly, obtained from a single caught-in-the-wild specimen. The genome sequencing was made possible by Pacific Biosciences' new platform that produces 10 times more data from a single run.
New method for imaging biological molecules
Researchers have created a new method for imaging biological molecules in cells or tissue samples using DNA snippets, allowing for the study of molecule abundance and distribution. The 'DNA microscopy' approach enables rapid screening and analysis of specific molecules within larger materials.
Brown trout genome will help explain species' genetic superpowers
The completed brown trout reference genome will enable scientists to identify sub-species and understand the genetic roots of this highly specialised species. This knowledge will facilitate targeted conservation efforts, particularly in light of rapid climatic change.
Indigenous scholars confront the power, limitations of genomics
The SING workshop brings together Indigenous and non-Indigenous scientists to discuss genomic tools and their social and political ramifications. Participants learn about the limitations of genomics research and its applications in health and environmental policy.
Bloodsucker discovered: First North American medicinal leech described in over 40 years
A previously unrecognized species of medicinal leech has been discovered in North America, with specimens found in freshwater wetlands from Georgia to New York. The new species, Macrobdella mimicus, is less than 50 miles from the National Museum of Natural History and is closely related to other native leeches.
Advanced data analysis enhances precision medicine application in clinics
A novel open-source computational framework promotes affordable and routine NIPT applications in clinics, detecting fetal trisomies and parental chromosome origin from maternal blood samples. The framework incorporates machine learning methods to estimate euploidy or trisomy for each studied chromosome.
Machine learning for damaging mutations prediction
Scientists developed a machine-learning method to analyze protein structures and predict pathogenic mutations. This approach helps identify disease-associated amino acid substitutions in membrane proteins, which account for 25-30% of all cellular proteins.
New diagnostic method for fungal infections could combat a major global health risk
A new study demonstrates dual DNA barcoding improves diagnosis of invasive fungal diseases, enabling faster treatment and reducing morbidity and mortality. The technique uses two specific regions of DNA to identify fungal pathogens, increasing accuracy and speed of diagnosis.
Looking out for the little guys
Researchers found high genetic diversity within and between baitfish assemblages from different locations around Bermuda. The study suggests that the island's baitfish species are highly mixed populations with limited gene flow to other regions.
Researchers embrace imperfection to improve biomolecule transport
University of Illinois researchers discovered that tiny defects formed during fabrication can be used to direct molecules into membrane pores. Their findings could lead to devices that quickly sequence DNA for personalized medicine, increasing capture throughput by several orders of magnitude.
Finnish people's unique genetic makeup offers clues to disease
A study of Finns with their similar DNA identified 26 potentially harmful genetic variations relevant to cardiovascular and metabolic health. These variations are more common in Finland than elsewhere in Europe, making them a valuable resource for understanding disease risk.
Mouse genetics influences the microbiome more than environment
A recent study published in Applied and Environmental Microbiology found that genetics has a greater impact on the microbiome of mice than their maternal birth environment. The researchers tested two different inbred laboratory strains of mice and found that the offspring's microbiomes were similar regardless of which parent was black ...
Scientists hope genetic research will lead to new breakthroughs in weed control
A recent study published in Weed Science has made significant progress in understanding the genetic basis of sex determination in Palmer amaranth and waterhemp. The researchers were able to distinguish between male and female plants with a high degree of accuracy, paving the way for new control strategies.
Illinois study advances possibility of genetic control for major agricultural weeds
Researchers at the University of Illinois identified genetic signatures that distinguish male from female waterhemp and Palmer amaranth plants, a crucial step in developing genetic control. The discovery aims to introduce genetically modified male plants that would contain a gene drive to control the damaging weeds.
First hi-res images of active CRISPR enzyme will help improve genome editing
Scientists have captured atomic-level images of active CRISPR enzyme Cas9, providing new structural information on its mechanism. The images show how the enzyme cuts DNA strands and reveals the importance of domain movement during reaction, which could lead to improved genome-editing tools.
Archaeological mystery solved with modern genetics
Researchers analyzed Y chromosome sequences of modern Japanese men to estimate ancient human population size around 2,500 years ago. The study revealed a significant decrease in ancestral Jomon DNA before the arrival of the Yayoi people, supporting an actual population decline.
Breakthrough in the discovery of DNA in ancient bones buried in water
A recent study published in Nature reveals that ancient bones found in a Finnish lake contain DNA from the modern Sámi people, dating back to around 500-700 AD. The discovery contradicts previous theories about local populations and sheds light on the colonization history of Siberia.
Research overcomes key obstacles to scaling up DNA data storage
Researchers developed DNA Enrichment and Nested Separation (DENSe) techniques to label and retrieve DNA data files, increasing estimated file names from 30,000 to 900 million. The system uses nested primer-binding sequences and molecular tags for efficient data retrieval.
Surprisingly, inbred isle royale wolves dwindle because of fewer harmful genes
Inbred Isle Royale wolves have fewer harmful genes than expected, with a higher proportion of paired recessive alleles. This discovery has broader implications for conservation efforts, suggesting individuals from smaller populations may be more beneficial due to fewer potentially harmful alleles.
Global Strep A vaccine one step closer
Researchers sequenced DNA of over 2,000 Group A Streptococcus samples from 22 countries to identify common genetic targets for a global vaccine. The study reveals that current vaccine candidates may have limited coverage in low-income areas where Strep A is most prevalent.
Reading the dark heart of chromosomes
Researchers use cutting-edge sequencing technology and microscopy to discover the sequences of all centromeres in the fruit fly Drosophila melanogaster. They found that centromeres contain a high number of transposable elements, including retroelements, which may play a role in centromere function across species.
Lionfish genes studied for clues to invasive prowess
A new North Carolina State University study found that lionfish in the Atlantic and Pacific regions share genetic similarities, suggesting a population near Taiwan as the source of the invading species. The research also revealed that lionfish in the Atlantic exhibit rapid reproductive rates and voracious predation, devastating native ...
Crusaders made love and war, genetic study finds
A recent study of ancient DNA from Crusader skeletons confirms they intermingled with local populations, forming families and fighting alongside them. The researchers found that the Crusaders' genetic presence was short-lived, with no lasting impact on Lebanese genetics.
New eDNA technology used to quickly assess coral reefs
Scientists at the University of Hawaii have developed a technique to measure living coral on reefs by analyzing DNA in small seawater samples. This new method, known as metabarcoding, can track changes in coral reef health and detect rare species.
Prebiotic chemistry: Stable majorities
Scientists discover a simple mechanism that allows prebiotic information-bearing DNA sequences to outcompete shorter molecules, enabling the survival and transmission of genetic information. Templated ligation promotes cooperation among complementary sequences, creating stable majorities through intermolecular assembly and replication.
Scientists construct new family tree for perching birds
Researchers constructed a massive family tree using DNA samples from 221 bird specimens, discovering two African species in a distinct new passerine family and five additional proposed families. This study reveals that global temperature changes and continent colonization were not the sole drivers of passerine diversification.
Tiny DNA reader to advance development of anticancer drugs
Researchers from Osaka University developed a tiny DNA reader using microscopic probes and an electrical current to locate anticancer drug molecules. The technology successfully identified individual molecules in short DNA strands, pinpointing exact insertion sites of trifluridine.
New buzz around insect DNA analysis and biodiversity estimates
Researchers estimate 6856 arthropod species in soil samples, adding over 2500 new DNA sequences to GenBank. Traditional field methods combined with DNA sequencing reveal diverse insect and beetle populations on Hauturu Island.
A new sequencing method to detect DNA modifications of relevance to cancer
A new sequencing method, TET-assisted pyridine borane sequencing (TAPS), detects chemical modifications to DNA that contribute to cancer progression and resistance to therapy. The method is less damaging and more efficient than bisulfite sequencing, enabling the detection of mutations and structural variations.
Huge step forward in decoding genomes of small species
Researchers at the Wellcome Sanger Institute and Pacific Biosciences successfully assembled the genetic code of a single Anopheles coluzzii mosquito, opening doors to understanding genetic diversity in insects. The breakthrough reduces DNA needed for genome sequencing by an order of magnitude, enabling studies on previously inaccessibl...
New technologies enable better-than-ever details on genetically modified plants
Researchers at Salk Institute mapped the genomes and epigenomes of genetically modified plant lines with high resolution, revealing molecular-level changes when foreign DNA is inserted. This study provides new methods for minimizing potential off-target effects in transgenic plants.
DNA tool allows you to trace your ancient ancestry
Researchers developed a new concept called Ancient Ancestry Informative Markers (aAIMs) that can accurately identify and classify ancient populations. The tool enables testing of an individual's similarity to ancient people from various regions, providing insights into their primeval origins.
Producers of white colonies on kimchi surface, mistaken as molds, have been identified
A recent study by WiKim has identified five yeast strains responsible for forming white colonies on the surface of kimchi. The research uses whole-genome sequencing and NGS technology to confirm that these yeasts do not produce toxin-related genes, making them safe for consumption.
Marine species quickly revealed by new 'Go Fish' tool, highlights potential of emerging eDNA science
A new 'Go Fish' tool confirms marine species presence in water samples within three days, complementing traditional monitoring systems. Experts at the first US National Conference on Marine Environmental DNA discuss the potential of emerging eDNA science to enhance ocean management and inform policy decisions.
Population of rare Stone's sheep 20 percent smaller than previously thought
New research by University of Alberta biologists reveals the Stone's sheep population is 20% less common than previously estimated. Genetic analysis shows significant overestimation of certain subspecies due to misclassification, leading to a more accurate estimate.
'Potato gene' reveals how ancient Andeans adapted to starchy diet
Ancient Andean populations adapted to high-altitude environment with distinct genetic changes, including a co-evolution between the potato and humans. The study suggests that these adaptations allowed them to thrive in extreme conditions.
MSU pioneers new course: Digital introduction to biology, evolution
MSU researchers developed a new course 'Integrative Biology: From DNA to Populations' featuring Avida-ED, a digital evolution software program. This approach allows students to engage with biological concepts in a familiar and interesting context, resulting in increased understanding of evolution-influenced topics.
Genes responsible for difference in flower color of snapdragons identified
Researchers at IST Austria identified two genes that determine magenta and yellow flower colors in snapdragons, which are separated by a hybrid zone. The study found that selection favored new variants of these genes, making the flowers more attractive to bees, while also creating barriers to gene exchange.
There's a better way to decipher DNA's epigenetic code to identify disease
Researchers at University of Pennsylvania have developed a new method to sequence epigenetic marks on DNA, allowing for more precise detection of disease earlier and with increased precision. The method uses APOBEC DNA deaminases to differentiate between two common epigenetic marks, methylation and hydroxmethylation.
Scientists use prenatal testing samples to complete the largest genetic study yet in China
Researchers sequenced 141,431 women's genomes using non-invasive prenatal testing data, identifying patterns in ethnic groups' evolutionary history and novel genetic loci linked to height and BMI. The study provides insights into disease risk and epidemiology in Chinese populations.
New Tourette disorder genes come to light
Researchers have discovered new genetic mutations associated with Tourette Disorder, which may disrupt cell polarity and lead to chronic vocal and motor tics. The study's findings provide a deeper understanding of the condition and offer potential insights for developing improved treatments.
Penn researchers: Class of neurological disorders share 3D genome folding pattern
Scientists at the University of Pennsylvania discovered a common thread linking nearly all TNR expansion diseases: misfolded 3D genome patterns. Nearly all unstable repeats are located at genome folding boundaries, suggesting new research questions for diagnosis or treatment.
Scarlet macaw DNA points to ancient breeding operation in Southwest
Researchers found that scarlet macaws sequenced from Chaco Canyon and Mimbres areas in New Mexico shared the same haplogroup, indicating a single breeding population. This contradicts previous theories that ancestral Puebloan people brought birds back from Mexico, as transporting adolescent birds would be logistically difficult.
Deep in the weeds: Using eDNA sequencing to survey pondweed diversity
A recent study using eDNA sequencing identified aquatic plant diversity in ponds, offering a new approach to ecological surveys. The study found that pondweed diversity had been underestimated at a reserve in Ontario, detecting three previously unknown species.
Generating DNA sequence data in the developing world
A recent study demonstrates the feasibility of producing high-quality DNA sequence data at a laboratory in Indonesia. The research shows that molecular techniques like DNA extraction and PCR can be done using relatively simple methods and inexpensive reagents.
NIST builds statistical foundation for next-generation forensic DNA profiling
The National Institute of Standards and Technology (NIST) has developed a statistical foundation for calculating match statistics when using Next Generation Sequencing in forensic DNA profiling. This new data enables labs to generate reliable match statistics, even with partial DNA profiles or mixtures from multiple individuals.
Rethinking existing method opens new doors for cancer diagnostics
Researchers at Osaka University have successfully developed a new method for cancer diagnostics that uses single-molecule sequencing to investigate fluid dynamics of DNA molecules in solution. This method enables the detection of subtle differences in DNA sequences, allowing for more accurate diagnosis and treatment of cancer.
Deep data dive helps predict cerebral palsy
A recent study published in BMC Bioinformatics has found that DNA methylation patterns in circulating blood cells can help identify children with spastic cerebral palsy. The researchers used next-generation sequencing data to analyze these patterns and identified distinct markers that distinguish children with CP from those without it.