Articles tagged with Epigenetics
Researchers have identified two major sub-types of breast cancer based on DNA methylation profiles, which could help refine cancer classification and predict treatment response. The study also revealed new information about sub-types of breast cancer and the potential for epigenetic therapy.
A recent study published in PNAS reveals the unique role of EZH2 enzyme in cancer, facilitating the development of selective small molecule therapeutics for specific forms of human lymphomas. The research highlights the importance of targeting HMTs in genetically-defined cancer patients with high unmet needs.
UK scientists have reported direct evidence that taking up smoking results in epigenetic changes associated with cancer. A study funded by Cancer Research UK found women who started smoking had a higher risk of acquiring p16 methylation, a type of epigenetic change linked to tumor suppressor genes.
Researchers sequenced the genomes of Jerdon's jumping ant and Florida carpenter ant, revealing clues to their complex social behavior and potential links to human aging. The findings highlight the importance of epigenetics in controlling gene expression, which may influence longevity and behavior.
Researchers found that epigenetic profiles of tumors had a direct association with diet, alcohol, and tumor size, providing new biomarkers for disease subtype and severity. The study's data show promise for tumor epigenetic signatures to provide more detailed tumor staging and prediction of prognosis.
Scientists have discovered a new epigenetic mechanism by which AMPK regulates gene expression, allowing direct control of cellular processes such as sugar storage and insulin production. This finding holds promise for the development of new therapies for diseases like diabetes and cancer.
A study found that smoking is associated with molecularly defined DNA changes and a subtype of colorectal cancer that emerges more frequently among older women. The researchers suggest that epigenetic modifications may play a role in the development of smoking-related colorectal carcinogenesis.
Dr Clare Scott and Dr Marnie Blewitt have been awarded fellowships worth AU$1.75 million to focus on lymphoma and breast cancer, respectively. Their research aims to improve outcomes for cancer patients by harnessing the body's natural killing machinery.
BPA exposure during pregnancy leads to epigenetic changes causing permanent reproductive issues in females, including fertility problems and hormone-related cancers. The study also suggests that early exposure can genetically program the uterus to be hyper-responsive to estrogen.
A new USC study reveals that prenatal tobacco smoke exposure is associated with detectable changes in DNA methylation patterns, which may impact childhood asthma and cardiovascular disease. Researchers found that children exposed to maternal smoke had lower global methylation levels and higher methylation in certain genes.
Researchers discovered epigenetic changes in mice with chronic lymphocytic leukemia that occur before disease symptoms appear. These findings suggest an early methylation test could predict cancer development and delay its onset.
Research suggests that maternal nutrition, protein intake, and fat levels before conception can lead to epigenetic changes that affect fetal development and increase the risk of diseases later in life. Studies have shown that diet before pregnancy can cause abnormal growth, cardiovascular disease, and other health problems in offspring.
Researchers at UNC have redefined the process of X-inactivation, a genetic phenomenon that helps females avoid toxic genes. The new findings suggest Xist gene's role is more nuanced, and its absence may not trigger X-inactivation but rather allow genes to become active again.
A new study published in The FASEB Journal reveals that poor nutrition during pregnancy can lead to permanent genetic changes in the offspring, causing health problems such as diabetes, growth retardation, and cardiovascular disease. The researchers found that rat fetuses receiving inadequate nutrition became genetically primed to be b...
Research suggests that a mother's diet during pregnancy can induce epigenetic changes in her offspring, increasing their risk of developing allergic asthma. The study found that high-methyl-donor diets led to more severe airway disease and increased IgE levels in the blood.
Researchers have determined the 3D structure of UHRF1's Set and Ring Associated domain, crucial for ensuring accurate epigenetic code copying. This breakthrough facilitates a better understanding of epigenetics and its role in cancer development.
Researchers at Norwich BioScience Institute have detected chemical differences in genes that can lead to colorectal cancer. These findings suggest that diet and lifestyle factors may contribute to the development of cancer by altering epigenetic code in healthy tissues.
A new study found that pregnant mothers taking folic acid or genistein supplements can protect their offspring from the negative effects of BPA, a common chemical used in plastics. The study showed that even low levels of BPA exposure can cause epigenetic changes in offspring, leading to increased disease susceptibility.
Researchers demonstrate that a combination of epigenetic drugs can reactivate the expression of over 1,000 genes in primary tumours of breast cancer patients. These reactivated genes play crucial roles in cell proliferation, differentiation, and immune recognition, suggesting increased anti-tumour effects.
Research suggests that embryonic nutrition can impact health outcomes, with adaptations set in place during fetal development potentially leading to benefits later in life. For example, meadow voles have coats thickened or thinned based on day length exposure in early pregnancy, with no immediate survival value but later benefits.
St. Jude researchers successfully cloned embryos from mouse medulloblastoma cells using a reprogrammed nucleus model, demonstrating the potential for epigenetic factors to cause tumors. The study provides valuable insights into the molecular basis of cancer and may lead to new therapies.
Researchers have found a possible association between IVF and an increased risk of Beckwith-Wiedemann syndrome (BWS), a genetic disorder that can predispose children to cancer. BWS is characterized by excessive growth and occurs in about 1 in 15,000 births, with the incidence being significantly higher among IVF-conceived babies.