Articles tagged with Epigenetics
Early epigenetic modifications play a crucial role in determining the fate of neurons during embryogenesis. Deregulation of Uhrf1, a key epigenetic gene, leads to activation of endogenous retroviruses, causing accumulation of retroviral proteins and cell death.
Researchers develop targeted epigenetic approach to treat aggressive forms of leukemia by inhibiting key chromatin regulators. This method demonstrates promising results in reversing leukemia-causing gene activity and promoting normal blood cell development.
Researchers discovered that supplementing an epigenetic cancer drug with vitamin C enhances its ability to impede cancer cell growth and trigger cellular self-destruction. The therapy combines azacitidine with vitamin C, addressing a common deficiency in cancer patients. If successful, the approach may improve the existing therapy for ...
Research reveals that hypoxia, or low oxygen levels, can cause epigenetic alterations leading to cancer growth. Normalizing oxygen supply inhibits these changes, suggesting new anti-cancer drug targets.
A UCLA study finds that Latinos age more slowly at the molecular level, with an epigenetic clock measuring their age as 2.4 years younger than non-Latino women of the same age after menopause. This discovery may help scientists understand how to slow the aging process for everyone.
Autoinflammatory diseases are characterized by recurrent acute inflammatory episodes due to deregulation of the inflammatory process. Researchers have identified epigenetic alterations in cryopyrin-associated periodic syndromes (CAPS), which could lead to the development of novel biomarkers for diagnosis and treatment.
A new study on lactose intolerance may provide insights into the origin of schizophrenia and other complex mental illnesses. Epigenetic factors that build up over time in individuals with genetic predisposition can lead to delayed onset of symptoms.
Scientists at UC Berkeley have identified a key epigenetic switch that increases lifespan in mammals, offering hope for new treatments to improve human metabolic function. The discovery was made in the nematode worm C. elegans and found to be linked to increased lifespan in mice.
Alterations in chromatin structure are essential for cancer development, accelerating cell cycle progression and malignant transformation. Changes in epigenetic factors and histone variants confer to cancer cells the ability to reprogram their genomes.
A recent study found that HIV infection can lead to an average age acceleration of 4.9 years due to epigenetic changes, increasing the risk of mortality by 19%. The researchers suggest that early intervention and healthy lifestyle choices may help mitigate these risks.
Researchers at Lund University developed a new method to predict type 2 diabetes risk by detecting epigenetic changes in specific genes through a simple blood test. The study found that higher DNA methylation levels were associated with increased insulin secretion and lower disease risk.
A new Northwestern Medicine study links a biological age discrepancy to increased cancer risk and mortality. The study found that individuals with an epigenetic age 2.2 years older than their chronological age have a higher risk of dying from cancer.
Research in Child Development Journal explores gene-environment interaction and epigenetics' role in shaping child behavior. Studies link methylation of specific genes to important developmental outcomes from prenatal period through young adulthood.
Researchers at the Max Planck Institute of Immunobiology and Epigenetics found a novel epigenetic switch regulating genes in mice, leading to two distinct phenotypes. This discovery fundamentally alters our understanding of how epigenetics influences gene outcomes and has implications for obesity and other diseases.
Researchers found that DNA methylation plays a key role in regulating social dominance in cichlid fish. By altering gene expression, these fish can change their social status, which is linked to better health and quality of life.
Researchers at Rockefeller University have identified pivotal changes in epigenetic pathway genes required for forming the cerebellum's circuitry. The study reveals that specific epigenetic regulators are crucial for neuronal connections and ion channel expression.
Scientists have identified a new type of epigenetic modification that directly affects the base A in human and mouse DNA. This discovery suggests that many more DNA modifications exist than previously thought, which could impact gene regulation and human health.
Researchers at German Cancer Research Center find that freshwater marbled crayfish exhibit parthenogenesis, a process where animals reproduce without fertilization, and use this as an ideal model for studying epigenetics in cancer. The discovery could lead to new insights into the development of the disease.
A new study reveals how breast cancer cells become desensitized to lapatinib, a common cancer drug, by turning FOXO into an oncogene c-Myc. The researchers hope to develop new tools to fix this adaptation pathway and improve therapy for HER2+ breast cancer.
Research at ASHG 2015 Annual Meeting found that smoking and heavy alcohol use cause epigenetic changes reflecting accelerated biological aging. Moderate alcohol consumption was surprisingly correlated with the healthiest aging outcomes.
Researchers at Baylor College of Medicine found that infancy's gut development can have lifelong implications on intestinal health. The study discovered that epigenetic changes and the gut microbiome play a crucial role in shaping intestinal stem cells, which control gut physiology throughout life.
Researchers have discovered a novel epigenetic mechanism that causes the mantled phenotype in oil palms, resulting in reduced oil yields and sterility. A leaf-based test can predict the mantling phenotype at an early stage, enabling the exclusive cultivation of high-performing clonal palms.
Geneticists identify a gene called MANTLED, which helps determine the fate of sexual organs and causes male organs to develop instead as female organs. The mutation leads to plants with worthless fruit, resulting in millions of dollars in spoilage.
Researchers used new methods to compare two stem cell types and found one superior at producing retinal cells. The study demonstrates a standardized method for quantifying effectiveness, which could advance treatments for age-related macular degeneration and other vision loss disorders.
Researchers identified a significant association between low DNA methylation scores and radiographic progression in ankylosing spondylitis. Smoking was also found to worsen disease outcomes, with smokers exhibiting more rapid joint damage than non-smokers.
Researchers have identified a new mechanism linking chronic inflammation to cancer progression, revealing the role of MUC1 and p65 in driving pro-inflammatory cytokine gene expression. This discovery offers potential therapeutic targets for developing drugs that can interrupt the cancer-inflammation process.
The University of Illinois College of Medicine will create a Center for Alcohol Research in Epigenetics (CARE) to investigate the impact of long-term alcohol exposure on genes. Researchers will explore how epigenetic changes influence gene expression and behavior, aiming to develop new pharmacotherapies for alcoholism.
A McGill University team has identified a mechanism by which environmental factors influence the expression of genes controlling complex traits. By manipulating DNA methylation levels, researchers were able to create variation in worker ant sizes, shedding light on the interplay between genetics and environment in shaping these traits.
A team of researchers identified a key epigenetic factor EZH2 that plays a central role in controlling tumor growth and metastasis in melanoma. The study found that suppressing EZH2 activity can prevent the growth and spread of cancer cells, offering new hope for cancer treatment.
A novel analytical method enables characterization of epigenetic tags, revealing that the system adapts to the loss of single epigenetic writer and eraser enzymes. The study also finds that biological systems can compensate for the loss of individual functional components by attaching novel acetylation tags at nearby sites.
Researchers found that exposure to diesel exhaust for just two hours can alter DNA methylation, changing the expression of approximately 400 genes. This epigenetic shift can have long-term effects on health, even without noticeable symptoms.
Researchers have developed a novel treatment approach for persistent viral infections like herpes by blocking the activity of host cell protein LSD1, reducing HSV infection, shedding, and recurrence. This epigenetic therapy shows promise as an antiviral strategy to control shedding and reactivation of latent virus.
The Van Andel Research Institute-funded epigenetics dream team will focus on epigenetic mechanisms in cells to control gene expression. The team will move forward with more extensive clinical trials in other cancer types to improve upon the progress already made.
Roberto Bonasio, PhD, receives NIH New Innovator Award to study epigenetic memory in ants and its implications for biological processes. The award supports his research on gene expression controlled by epigenetic pathways that alter chromosome structure.
Researchers used an epigenetic clock to measure the biological age of liver tissues in obese subjects, finding a significant acceleration of liver aging. The study suggests that obesity may contribute to the premature development of age-related diseases such as liver cancer and insulin resistance.
Researchers at MU School of Medicine identified epigenetic protein changes caused by binge drinking, which can amplify liver damage and lead to chronic liver failure. The study suggests that excessive alcohol consumption with a binge drinking pattern is a major public health concern globally.
A new study has found a wide range of epigenetic changes in children with Crohn's disease, which may be related to key environmental exposures. The research suggests that these changes could have early implications for clinical management of the disease.
Researchers found that infants exposed to opioids in utero had more severe symptoms of neonatal abstinence syndrome, with higher DNA methylation levels. This study suggests a link between early exposure and lasting epigenetic changes, potentially affecting future sensitivity to addictive substances.
Scientists have identified key DNA sequences and regulatory proteins controlling blood stem cell fate, revealing a more dynamic process than previously thought. The discovery has implications for developing diagnostic tools, personalized medicine, and regenerative therapies.
Black truffles use complex genetic makeup and DNA methylation to regulate jumping genes, adapting to changes in their surroundings. This unique process sheds light on how fungi adapt to environmental changes without an active spore dispersal system.
Researchers at Baylor College of Medicine created a mouse model showing that epigenetic alterations alone can cause cancer. DNA methylation changes led to a higher incidence of spontaneous cancers and reduced survival in the mice.
Researchers have found that disturbed blood flow leads to epigenetic changes in genes lining blood vessels, contributing to atherosclerosis. The study suggests that good blood flow patterns can persist over time due to these lasting changes.
A study published by Johns Hopkins Medicine found that DNA modifications in the blood of stressed mice correlate with changes in brain tissue, providing a valid comparison between the two. The research linked epigenetic changes to altered gene function, shedding light on the relationship between stress and psychiatric diseases.
A new discovery identifies a key protein called PCAF that promotes nerve growth in the central nervous system, leading to increased nerve fibers regrowing. The study suggests that PCAF may be used to trigger nerve regeneration and potentially lead to recovery from spinal cord injury or brain trauma.
A new theory proposes that epigenetic modification plays a key role in the development of endometriosis, a chronic disease affecting 1 in 10 women. The research suggests that alterations in the epigenetic landscape, rather than genetic mutations, contribute to the disease's progression.
Researchers at the University of Adelaide are investigating epigenetics as a tool for understanding oral health. They aim to develop personalized treatments by analyzing an individual's epigenetic profile and environment.
Researchers have discovered a key protein, AP2-G, essential for the development of male and female sexual forms of the malaria parasite. The protein triggers the production of gametocytes, which are infectious to mosquitos, offering clues for identifying transmission mechanisms.
Scientists have identified an epigenetic lesion in the hippocampus of Alzheimer's patients, which regulates tau protein and may contribute to disease progression. This discovery provides a potential new target for future therapies, offering hope for improved treatment options.
Researchers found a correlation between DNA methylation levels and breast cancer risk in high-risk families. High levels of DNA methylation were associated with increased breast cancer clustering within families.
Researchers have determined the molecular structure of a Tet family member from Naegleria gruberi, providing insights into its role in regulating gene expression and potential therapeutic targets for cancer. The study sheds light on how Tet enzymes interact with DNA, enabling scientists to design drugs that manipulate them.
A study at Johns Hopkins Medicine has identified genetic mutations and molecular alterations linked to higher head and neck cancer death rates in African-Americans, revealing potential targets for improved risk assessment, early detection, and targeted therapy.
A $225,000 grant will help map the landscape of epigenetic changes associated with chemotherapy, a new area in cancer research. The collaboration aims to identify novel targets for more effective cancer treatment.
Researchers have identified distinctive epigenetic modifications associated with Parkinson's disease that can be easily analyzed in blood samples. These changes replicate the epigenetic status of brain tissue cells, potentially simplifying early diagnosis of the disease.
Research suggests that fetal stress can disrupt genetic imprinting patterns, leading to chronic disease later in life. The study found high rates of IGF2 gene expression from both alleles in cord blood, associated with increased disease susceptibility.
A study published in Epigenetics suggests that a high-folate diet during pregnancy can prevent the development of an obesogenic phenotype in Wistar rat offspring. The diet has epigenetic effects on hypothalamic mechanisms regulating food intake, leading to reduced obesity.
Researchers found a potential link between homocysteine levels and schizophrenia risk through epigenetic mechanisms. Elevated plasma homocysteine may contribute to gene expression changes that increase the likelihood of developing the disease.
Obese mothers may program their children to develop metabolic problems, but a healthy diet can mitigate this risk. The study found that offspring of obese mothers were more likely to be heavier and develop type 2 diabetes, but a low-fat diet could protect them from overt metabolic disease.
A study led by St. Jude Children's Research Hospital found that epigenetic changes, such as cytosine methylation, are unique to each child with ALL and may be as important as genetic alterations in causing the disease. The research suggests that epigenetic targeted therapies could be developed for patients with ALL.
Researchers found significant epigenetic changes in DNA methylation patterns related to immune function in people with and without schizophrenia. These changes were found to protect against delusion and hallucination symptoms in schizophrenia patients.
Hopkins researchers identify two genes, TTC9B and HP1BP3, that can predict postpartum depression with 85 percent certainty in pregnant women. The study's findings could lead to early intervention and treatment options for the condition.