A recent study identified specific RNA biomarkers linked to gastrointestinal symptoms in children with autism. The findings could lead to the development of personalized treatments to ease the pain of these individuals. The research has implications for precision medicine, enabling healthcare providers to track medication effectiveness...
SourceUniversity of Missouri-Columbia·JournalFrontiers in Psychiatry·TypeCase study·DateFeb 25, 2022
Researchers found that certain transfer RNAs are dysregulated in human cancer, leading to a worse clinical course. Re-silencing these molecules in preclinical studies halted tumor growth, suggesting they could be attractive targets for next-generation drugs.
SourceJosep Carreras Leukaemia Research Institute·JournalMolecular Cancer·TypeExperimental study·DateFeb 17, 2022
Researchers found that women who experienced childhood sexual abuse developed blunted cortisol profiles, associated with health problems like depression and anxiety. Epigenetic age acceleration also contributed to these effects. The study aims to understand resilience to trauma and develop interventions for those affected.
SourcePenn State·JournalPsychoneuroendocrinology·TypeObservational study·DateJan 13, 2022
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Researchers at TUM and MPIMG decipher the molecular mechanisms responsible for deactivating genes in genomic imprinting. By removing known epigenetic 'off switches', they discovered that DNA methylation and Polycomb enzymes play a crucial role in silencing genes.
SourceTechnical University of Munich (TUM)·JournalDevelopmental Cell·TypeExperimental study·DateJan 12, 2022
Researchers developed a single-cell epigenetic aging clock to profile biological age in individual cells. The technique revealed mechanisms driving aging, attenuation, and early embryogenesis-related rejuvenation, opening possibilities for clinical applications in mammalian cells.
SourceBrigham and Women's Hospital·JournalNature Aging·TypeExperimental study·DateJan 6, 2022
Researchers mapped genetic interactions in C. elegans to identify new genes influencing lifespan and their human equivalents. The study reveals that most key longevity genes belong to transcription factors and metabolic genes.
SourceBabraham Institute·JournaliScience·TypeMeta-analysis·DateDec 21, 2021
Scientists used single-cell sequencing to analyze over 150,000 cells from 11 tumor samples, discovering novel mechanisms of tumor development and identifying potential targets for therapy. The findings may lead to personalized medicine and improved treatment options for gynecologic cancers.
SourceUNC Lineberger Comprehensive Cancer Center·JournalMolecular Cell·TypeExperimental study·DateDec 2, 2021
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A Swedish twin study discovered epigenetic differences in twins with one developing type 2 diabetes. The researchers found lower levels of microRNA-30, a gene that regulates glucose uptake, in the affected twins' fatty tissue.
A recent study reveals that child maltreatment is associated with altered oxytocin gene methylation, leading to atypical brain structures and function. This finding suggests a potential biological mechanism for targeting during adolescence to improve the lives of victims of childhood abuse.
SourceUniversity of Fukui·JournalTranslational Psychiatry·TypeObservational study·DateNov 18, 2021
Researchers discovered that a single protein, Kr-h1, responds to socially regulated hormones to orchestrate the complex social transition in Harpegnathos saltator ants. The study reveals important roles for gene regulation and hormone response in controlling animal brains' plasticity.
SourceCell Press·JournalCell·TypeExperimental study·DateNov 4, 2021
A team of scientists developed a drug-like molecule that can counteract the effects of mutated epigenetic regulators, which are known to drive certain types of cancer. The molecule targets the 'reader' CBX8, which is critical for the proliferation of cancer cells, but more dispensable in healthy cells.
SourceKeck School of Medicine of USC·JournalCell Chemical Biology·TypeExperimental study·DateOct 29, 2021
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Mangroves have evolved a remarkable resistance to stress in harsh ocean environments. Researchers decoded the genome of Bruguiera gymnorhiza and found that it regulates genes to cope with stress, using adaptive epigenetic changes to survive.
SourceOkinawa Institute of Science and Technology (OIST) Graduate University·JournalNew Phytologist·TypeExperimental study·DateOct 25, 2021
Researchers at Queen Mary University of London have discovered a new way to analyze diseased and healthy cells from the same patient, revealing potential targets for individualized treatments. The study's findings could also help predict patient response to current drugs, leading to improved survival rates.
SourceQueen Mary University of London·JournalNature Communications·DateOct 21, 2021
A new study found a significant increase in adverse outcomes for COVID-19 positive pregnant women, including gestational diabetes, low white blood cell counts, and heavier bleeding during delivery. Respiratory complications were also witnessed in their babies, highlighting the importance of vaccinating all pregnant women against COVID-19.
SourceTaylor & Francis Group·JournalThe Journal of Maternal-Fetal & Neonatal Medicine·DateOct 10, 2021
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Researchers discovered a microRNA, miR-766-5p, that targets super-enhancers and reduces MYC expression in cancer cells, inhibiting growth rates. The study suggests this molecule could be used as an anti-cancer therapeutic to fight MYC-driven cancers.
SourceTokyo Medical and Dental University·JournalCancer Research·DateOct 5, 2021
A study published in the EMBO Journal identified DNA methyltransferase 1 as a crucial enzyme in preventing autoinflammation. Reduced DNA methylation leads to cGAS-induced autoinflammation, causing genomic instability and activating the immune system.
SourceMedical University of Vienna·JournalThe EMBO Journal·TypeExperimental study·DateOct 5, 2021
Researchers will investigate the genetic and epigenetic factors controlling variation in health, with potential implications for combating cancer, obesity, and other diseases. The team aims to identify new sets of disease-related genes, delineate subtypes of disease, and understand the complex interaction between genetics and epigenetics.
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Researchers found a genetic regulation profile associated with improved overall survival and reduced disease relapse in patients treated with CAR-T cells. The epigenetic pattern is typical of young T lymphocytes, suggesting they may be ideal for selection and administration.
SourceJosep Carreras Leukaemia Research Institute·JournalJNCI Journal of the National Cancer Institute·TypeExperimental study·DateOct 4, 2021
A nationwide team of researchers will investigate epigenetic therapies for cancer, with a focus on exploring new targets and investigating novel combinations. The project aims to improve current epigenetic therapies and enhance existing approaches such as immunotherapy.
Researchers at RIKEN Cluster for Pioneering Research have found that Kleefstra syndrome, a genetic disorder leading to intellectual disability, can be reversed after birth. Postnatal treatment with artificially induced GLP production resulted in improved brain and behavioral symptoms.
Five innovative research projects tackle fundamental questions of environmental and earth science, including the origins of Earth and life on Mars. The studies aim to advance our understanding and lead to important scientific breakthroughs.
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A new study has identified RNF5 as a key player in acute myeloid leukemia, regulating gene expression through its interaction with protein RBBP4. Inhibiting RNF5 may improve treatment outcomes for AML patients by increasing sensitivity to existing targeted therapies.
SourceSanford Burnham Prebys·JournalNature Communications·TypeExperimental study·DateSep 13, 2021
Researchers identified distinct epigenetic patterns associated with heart disease in diverse populations, offering potential early warning signs. The study analyzed genome data from four cohorts and found unique methylation points linked to coronary heart disease.
SourceTexas Biomedical Research Institute·JournalJAMA Cardiology·DateAug 25, 2021
A new study finds that early-life exposure to tobacco smoke is associated with accelerated biological ageing in children. The analysis of over 1,000 children in six European countries revealed that maternal tobacco smoke during pregnancy and indoor exposure to black carbon are linked to an acceleration in epigenetic ageing.
SourceBarcelona Institute for Global Health (ISGlobal)·JournalEnvironment International·DateAug 25, 2021
A CRISPR screening tool identified ZMYND8, an epigenetic regulatory protein, as a potential new therapeutic target for acute myeloid leukemia. Inhibiting ZMYND8 has been shown to leave cancer cells with smaller tumors and better survival in mouse models.
SourceUniversity of Pennsylvania School of Medicine·JournalMolecular Cell·TypeExperimental study·DateAug 19, 2021
New research from the University of Arkansas finds that prior training can accelerate muscle growth and response even after extended idleness. Previously trained muscles in mice responded with more sensitivity and grew more rapidly than previously untrained muscles, thanks to epigenetic changes in DNA.
SourceUniversity of Arkansas·JournalFunction·TypeExperimental study·DateAug 18, 2021
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Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
Researchers analyzed data from five large heart cohort studies to identify epigenetic changes associated with cardiovascular disease. The study found 33 common methylation sites linked to heart disease across diverse populations, providing a potential target for prevention and intervention.
SourceColumbia University's Mailman School of Public Health·JournalJAMA Cardiology·TypeData/statistical analysis·DateAug 4, 2021
Scientists at the University of Copenhagen have discovered that exercise can alter the structure of our DNA, specifically the enhancers that regulate gene expression. This epigenetic rewiring may be responsible for the beneficial effects of physical activity on human health.
SourceUniversity of Copenhagen - The Faculty of Health and Medical Sciences·JournalMolecular Metabolism·TypeExperimental study·DateAug 2, 2021
Researchers from USC Stem Cell discovered a latent regenerative potential in the inner ear's sensory cells. They found that epigenetic modifications regulate hair cell development and identified a key histone decoration, H3K4me1, that keeps supporting cells primed for transdifferentiation.
SourceKeck School of Medicine of USC·JournalDevelopmental Cell·TypeExperimental study·DateJul 30, 2021
Deep Longevity has adapted its blood aging clock to work with saliva samples, improving accuracy from 20.9 years to 4.7 years. The company's solution uses cell-type deconvolution to separate the composition of saliva samples.
SourceDeep Longevity Ltd·JournalFrontiers in Aging·TypeData/statistical analysis·DateJul 28, 2021
Scientists at the La Jolla Institute for Immunology have discovered that Vitamin C and TET proteins can work together to generate stable induced Tregs, which could potentially treat autoimmune diseases. The study reveals an intriguing connection between TET enzymatic activity, Vitamin C and IL-2/STAT5 signaling.
SourceLa Jolla Institute for Immunology·JournalEMBO Reports·DateJul 21, 2021
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Researchers found that castration of male sheep leads to delayed DNA aging compared to intact males, with epigenetic clocks and DNA methylation patterns differing between the two groups. The study's findings also suggest a link between castration, male hormones, and sex-specific differences in DNA aging.
Research reveals that epigenetic changes contribute to the development of type 1 diabetes, with DNA methylation and histone modifications playing a crucial role. The study suggests that epigenetic markers could be used to monitor disease progression and identify potential therapeutic targets.
SourceCactus Communications·JournalChinese Medical Journal·DateJun 17, 2021
Researchers found epigenetic modifications driven by DNMT3A protein determine B cell fate, with implications for understanding diseases linked to B cells' dysregulation. Chronic lymphomic leukemia (CLL) risk arises when these modifications are lost.
SourceMassachusetts General Hospital·JournalNature Communications·DateMay 13, 2021
Researchers discovered HP1a as an epigenetic regulator that establishes the global structure of the genome in early Drosophila embryos. The study used powerful genetics and 3D genome modeling to show that HP1a is required for proper chromatin organization at multiple hierarchical levels during embryonic development.
SourceMax-Planck-Gesellschaft·JournalNature·DateApr 15, 2021
Researchers discovered that HP1a is required to establish proper chromatin structure at multiple hierarchical levels during early embryonic development. The protein plays a central role in maintaining individual chromosome integrity and establishing the global structure of the genome.
SourceMax Planck Institute of Immunobiology and Epigenetics·JournalNature·DateApr 15, 2021
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A study published in EBiomedicine found that epigenetic variations predict COVID-19 severity, particularly in genes related to inflammation and overall health. The 13% of the global population with this signature is considered the group at maximum risk requiring special care.
SourceUniversity of Barcelona·JournalEBioMedicine·DateApr 15, 2021
A study published in eLife suggests that high social status contributes to accelerated aging in male baboons, with higher body mass index and increased physical demands being key factors. In contrast, early life adversity is not a significant predictor of premature aging.
Recent research on epigenetic mechanisms reveals the impact of alcohol on gene expression and biochemical processes. Candidate drugs that counteract these effects are being developed to advance tailored pharmacological treatments.
SourceBentham Science Publishers·JournalCurrent Pharmaceutical Design·DateMar 31, 2021
Scientists at the University of Cambridge have identified a potential new treatment to protect immunosuppressed transplant patients from HCMV reactivation, which can cause serious illness and death. The 'shock and kill' treatment strategy uses epigenetic inhibitors to expose and destroy dormant HCMV infections.
SourceUniversity of Cambridge·JournalProceedings of the National Academy of Sciences·DateFeb 22, 2021
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Researchers develop DNA modifying epigenetic therapy to transform immune killer T-cells into "super soldiers" with enhanced ability to kill cancer cells. The therapy uses available chemotherapy drugs to remove epigenetic tags, turning key genes back on and turbocharging the cells' killing function.
SourceUniversity Health Network·JournalMolecular Cell·DateFeb 19, 2021
A Swedish study found that lifestyle interventions during pregnancy, including physical activity and a healthy diet, led to epigenetic alterations in newborn babies. These changes were associated with increased muscle mass at birth and potentially benefited the children's body composition and growth later in life.
Researchers found that MLL4 controls the production of neurons vital to growth, leading to delayed growth and short stature in patients. Small chemicals mimicking epigenetic actions of MLL4 may help restore GHRH neuron production, offering a potential treatment strategy.
SourceUniversity at Buffalo·JournalNature Communications·DateJan 11, 2021
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Researchers at Tokyo Institute of Technology create kinetic model to study site-specific histone modifications and their impact on chromatin accessibility. The model shows that acetylation increases chromatin accessibility threefold, highlighting the potential for accurate quantification of epigenetic effects.
SourceTokyo Institute of Technology·JournalNucleic Acids Research·DateDec 10, 2020
DeepMAge is an epigenetic aging clock that accurately predicts human age on over 6,000 DNA methylation profiles, outperforming previous clocks. The clock reveals associations with various age-related conditions, including cancer, dementia, and obesity.
SourceDeep Longevity Ltd·JournalAging and Disease·DateDec 8, 2020
Researchers have developed a novel approach to quantify ChIP-seq results, eliminating the need for spike-ins and ensuring reproducibility. The sans-spike-in method defines a physical scale for sequencing results, allowing comparison between experiments.
SourceVan Andel Research Institute·JournalJournal of Biological Chemistry·DateNov 20, 2020
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A study reveals that methylation of the DVDMR region in the IGF2 gene determines its protein expression levels in breast cancer cells and tissues, suggesting a potential novel epigenetic biomarker for BC aggressiveness. The findings imply that IGF2 levels contribute to BC metastasis and chemoresistance.
SourceImpact Journals LLC·JournalOncotarget·DateNov 19, 2020
Researchers found epigenetic biomarkers that indicate chronic stress in commercially raised chickens, potentially leading to improved animal welfare and quality meat. The study suggests a diagnostic tool could be developed to track recurrent stress in production animals.
SourceUppsala University·JournalFrontiers in Genetics·DateNov 10, 2020
Researchers found that methylation of a specific region in the IGF2 gene, known as DVDMR, determines IGF2 protein expression levels in breast cancer. High IGF2 levels are associated with increased BC aggressiveness and metastasis.
SourceImpact Journals LLC·JournalOncotarget·DateNov 10, 2020
A new study by UCLA researchers found that antiretroviral therapy given over two years was unable to completely restore age-appropriate epigenetic patterns in HIV-infected adults. This suggests that even successfully treated HIV-infected individuals are at an increased risk for early development of diseases commonly associated with aging.
SourceUniversity of California - Los Angeles Health Sciences·JournalPathogens and Immunity·DateOct 22, 2020
Children born to mothers with gestational diabetes in pregnancy are at increased risk for accelerated aging and poor health outcomes later in life. The study found a link between epigenetic age and higher weight, body mass index, blood pressure, and cardiovascular risks.
SourceRutgers University·JournalEpigenetics·DateSep 10, 2020
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Researchers studied epigenetic modifications associated with posttraumatic stress disorder (PTSD) in trauma survivors, finding a link to the gene NTRK2 and reduced PTSD risk. The study revealed that epigenetic modification of NTRK2 was predictive of PTSD risk, but its relationship with PTSD is complex and influenced by multiple factors.
SourceProceedings of the National Academy of Sciences·JournalProceedings of the National Academy of Sciences·DateAug 17, 2020
A study found that two blood epigenetic signatures associated with ADNP syndrome have only modest correlation with clinical manifestations. Researchers conclude that these signatures should be carefully evaluated before being considered as biomarkers for predicting behavioral outcomes.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalAmerican Journal of Human Genetics·DateAug 5, 2020
Researchers discovered two possible mechanisms that drive varying degrees of susceptibility and resistance to EMT, a key process in cancer metastasis and therapy resistance. The study's findings suggest that epigenetic feedback and stochastic partitioning during cell division contribute to this resistance.
SourceImpact Journals LLC·JournalOncotarget·DateJul 7, 2020
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Studies from Osaka University revealed that Tet2 and Tet3 proteins play a crucial role in regulating B cell activity and preventing autoimmunity. By knocking out these proteins, researchers found increased serum levels of autoantibodies and organ damage in mice, highlighting the importance of epigenetic control in immune function.
SourceOsaka University·JournalNature Immunology·DateJul 2, 2020
A comprehensive epigenetic study on human tumor organoids reveals their potential as a reliable model for cancer research. The findings validate the use of these samples in biomedical research and pharmaceutical development, opening up new avenues for discovering anti-cancer treatments.
SourceJosep Carreras Leukaemia Research Institute·JournalEpigenetics·DateMay 13, 2020
Scientists used 3D models to study cancer cell DNA behavior, validating the use of these models for cancer research. The research team characterized the epigenetic fingerprint of human cancer organoids, showing that they closely resemble patient tumors and can be used to develop new oncology treatments.
SourceTaylor & Francis Group·JournalEpigenetics·DateMay 10, 2020
Research by RIKEN Cluster for Pioneering Research identifies ATF7 as essential for intergenerational effects on metabolic disorders, such as diabetes. The study found that a male mouse's diet influences the health of future children through epigenetic changes in sperm cells.
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A study of over 6,000 newborn babies found that longer pregnancies are associated with chemical DNA changes in thousands of genes. These epigenetic modifications may influence fetal organ development and potentially affect the health of premature birth children.
SourceKarolinska Institutet·JournalGenome Medicine·DateMar 2, 2020
Researchers at Kyoto University have designed a new compound that can bind to DNA and activate genes, which could lead to new treatments for cancers and hereditary diseases. The compound, called ePIP-HoGu, targets specific DNA sequences and recruits gene-modifying molecules.
SourceKyoto University·JournalChemical Communications·DateFeb 28, 2020