Articles tagged with Epigenetics
A study found that biological age in humans and mice increases rapidly in response to diverse forms of stress, only to reverse after recovery. The researchers used DNA methylation clocks to measure changes in biological age, revealing transient changes in response to stressful stimuli.
A study by Brigham researchers reveals that childhood trauma and biological sex are associated with epigenetic changes in functional movement/conversion disorder. Female patients and those with an history of childhood trauma show distinct profiles of epigenetic changes linked to this condition.
Researchers at Johns Hopkins University discovered how histone H3 controls cell specialization in worms, offering insights into cell differentiation and potential links to diseases. The study used CRISPR gene-editing technique to track the role of histones in development.
A new case series study found that an 8-week methylation-supportive diet and lifestyle program reduced biological age by 4.60 years, with five of six participants exhibiting significant age reversal. The study suggests that this intervention may favorably influence biological age in both sexes.
Researchers found that severe herpesvirus infections can strongly activate host cellular immunity, leading to a therapeutic effect on refractory adult T-cell leukemia/lymphoma. This activation may play an important role in the survival of patients with this intractable disease.
Researchers found 270 distinct differentially methylated regions (DMRs) in AD brains compared to normal controls, validating their key findings using an independent cohort. The study offers a novel approach to investigating the relationship between DNA methylation and gene/protein expression.
A recent study found that metformin users had distinct DNA methylation profiles compared to non-users, potentially revealing its role in longevity. The research identified several pathways related to delirium and aging, highlighting the need for further investigation into metformin's mechanism of action.
A recent study published in the Journal of Clinical Investigation found that PAX5 is strongly associated with impaired insulin secretion in type 2 diabetes. The research team identified 94 previously known genes and discovered many new genes differently expressed in individuals with type 2 diabetes.
Researchers examined three epigenetic age acceleration measurements and found inverse associations with lung cancer risk in men and younger participants. However, these findings did not support a positive association between epigenetic age measures and lung cancer risk in the study.
Researchers at Scripps Research found that a 'poisoned' form of the DNA methyltransferase 3B protein can promote cancer growth by allowing cancer-causing genes to turn on. A new drug candidate, DBIC, was developed to revert the protein to its normal form, preventing tumor formation in mice with colon cancer.
Researchers at Helmholtz-Zentrum Dresden-Rossendorf developed a new strategy to increase target molecules for radionuclide therapy in pheochromocytoma tumors, delaying tumor growth. The combination of valproic acid and decitabine prior to therapy doubled the radiation dose absorbed by the tumor.
Researchers at NYU Langone Health and the University of Toronto have developed a new AI tool called ZFDesign, which enables customizable protein editing for treating genetic diseases. The tool promises to accelerate gene therapy development on a large scale, offering a potentially safer alternative to CRISPR.
A new study finds epigenetic aging is associated with aberrant neural oscillatory dynamics serving visuospatial processing in people with HIV. Participants showed accelerated biological age and different brain activity patterns compared to controls, suggesting a link between biological aging and neural function in PWH.
A 16-year longitudinal study found associations between DNA methylation-based measures and neuropsychologically-validated cognitive decline in midlife. The results suggest that these measures may serve as biomarkers for a molecular aging mechanism, potentially identifying individuals at risk of cognitive impairment and dementia.
Researchers developed a new epigenetic biomarker, GrimAge version 2, which leverages two DNAm-based estimators of plasma proteins to predict mortality risk. The study found that GrimAge 2 outperforms existing clinical biomarkers in predicting mortality across multiple racial/ethnic groups and associations with age-related conditions.
The study reveals that SETD1A overexpression is associated with poorer disease-free survival in pancreatic cancer patients. Artificially cultured cells showed increased cell growth and migration when SETD1A levels were overexpressed, while knocking down SETD1A expression led to decreased RUVBL1 gene expression.
Researchers describe results using cladribine-based combination epigenetic and immunotherapy in MCL, achieving an increased overall survival greater than 40 months with durable remissions without relapse for longer than 5 years. The approach is promising in the treatment of MCL and potentially other previously treatment-refractory canc...
Researchers at Florida State University have found that aspartame, a common artificial sweetener, can cause anxiety-like behavior in mice. The study, published in the Proceedings of the National Academy of Sciences, suggests that aspartame's effects extend up to two generations from exposure, affecting male mice and their offspring.
Research found that male rats exposed to ifosfamide during adolescence had offspring and grand-offspring with increased incidence of diseases, including kidney and testis problems. The study's epigenetic analysis revealed changes passed down through sperm and ova, indicating a potential risk for future generations.
A research team led by Ivano Amelio found that the protein p53 acts as a key to maintaining genomic stability, preventing cancer-promoting mutations. Without p53, cells become more aggressive and prone to acquire genomic instability.
Scientists have discovered that leukemia cells can change their DNA read-out to evade treatment, making them harder to treat. The study identified key genetic changes that allow cancer cells to survive and relapse.
Researchers found that centenarians have a lower epigenetic age than expected, suggesting slowed biological aging. The study used four epigenetic clocks based on small CpG sites to reveal these differences.
A recent study published in The Journals of Gerontology Series A found that men are biologically older than women due to factors such as smoking and body size. Despite the initial sex difference, the gap between men and women has narrowed in recent decades.
A new epigenetics drug, tazemetostat, has been found to stop bladder cancer growth by activating the immune system, not just inhibiting tumors. The drug targets the EZH2 gene and is being tested in clinical trials for late-stage bladder cancer.
Researchers have developed a model of how human embryos are formed, revealing that genes are switched on almost immediately after fertilization. This discovery may also shed light on the origins of cancer, which is often diagnosed at an advanced stage.
Researchers used single-cell gene expression analysis to study DNA methylation's impact on cell fate. They found that maintaining correct DNA methylation suppresses past and alternative cell identities, while removal of methylation allows certain cell types to form.
A new study by UC Santa Cruz researchers demonstrates 'transgenerational epigenetic inheritance,' where epigenetic marks are transmitted from parents to offspring and grandoffspring. This can lead to altered gene expression patterns in tissues, affecting health and development.
Researchers identify two distinct types of obesity with physiological and molecular differences that may impact health, disease, and treatment response. The study reveals new insights into the link between insulin and obesity, as well as the role of epigenetics in shaping individual body types.
Scientists at the University of Freiburg have successfully characterized epigenetic modifications using nanopore analysis. The technique allows for rapid detection of protein fragments with varying levels of acetylation, enabling more accurate diagnosis and treatment of diseases like cancer.
A study led by UMD researchers found that hibernating big brown bats experience slower epigenetic aging, with their biological clock extending by nearly a year. The study established the link between hibernation and longer lifespans in small mammals.
Researchers at the University of Pittsburgh have discovered that even terminally exhausted T cells retain some capacity to function again. They identified approaches to overcome exhaustion by targeting co-stimulation pathways and reprogramming T cells to be resistant to hypoxia, a common tumor microenvironmental signal.
Leukemia cells exploit metabolic pathways to evade programmed cell death, but researchers identified a weak spot in acute lymphoblastic leukemia that can be targeted with experimental drugs. Inhibiting glutathione metabolism induces ferroptosis, leading to the death of malignant lymphocytes.
Researchers at the University of Maryland School of Medicine found that cells lining the heart direct cardiac muscle growth and outlined a complex mechanism regulating this process. The discovery may help develop better techniques for regenerating heart tissue and prevent congenital heart defects.
A new study introduces a novel epigenetic predictor, PCBrainAge, that captures aging heterogeneity across multiple brain regions. The tool demonstrates stronger associations with AD dementia and pathologic AD compared to existing age predictors.
A study of 1,813 older women found that accelerated biological aging is associated with lower odds of living to be 90 years old and maintaining physical and cognitive function. Slower age acceleration was linked to a reduced risk of mortality.
Researchers found that high temperatures induce epigenetic changes in zebrafish embryos, leading to sex reversal and altering the sex ratio. This study provides insights into the mechanisms behind climate change's impact on species with genotype-by-environment sex determination.
Researchers found reduced levels of Histone Deacetylase I (HDAC I) in the brains of patients with Alzheimer's disease, linked to deleterious effects of misfolded beta-amyloid and tau proteins. HDAC inhibitors, currently being tested against mild Alzheimer's disease, may be harming patients rather than helping them.
Researchers found associations between perceived discrimination and epigenetic aging in US middle-aged and older adults. Depressive symptoms were identified as a potential mediator in these relationships, particularly among women and White adults.
A UMass Amherst researcher will investigate the link between ambient environmental factors and male fertility, focusing on air pollution and temperature. Her study aims to identify risks associated with these exposures and inform medical and behavioral interventions for men before fertility treatment.
Researchers analyzed stored blood samples from infected men and found significant age acceleration in DNA epigenetic measures and telomere shortening. The study demonstrates HIV's substantial impact on the body's aging processes within two to three years of infection.
Researchers found global redistribution of histone H3 modifications with time, particularly in intergenic regions and near transcription start sites. Caloric restriction diet feeding reduced the extent of changes occurring during the first year of life in these genomic regions.
Researchers at Gladstone Institutes and Stanford University identified key genes linked to T cell exhaustion. They discovered how to block these genes, resulting in healthier T cells and smaller tumors in mice with cancer. This breakthrough may lead to improved immune-based treatments for cancer patients.
Researchers identified an epigenetic signature, EPIMISC, associated with the development of Multisystem Inflammatory Syndrome in Children (MIS-C) after SARS-CoV-2 virus infection. The study found deregulation of epigenetic cellular programming leading to hyperinflammation in tissues.
Researchers found that tendons, not muscles, are the key site where increased mechanosensitivity translates to better running and jumping capabilities. High expression of the calcium-ion channel mechanoreceptor coincided with wider tendons composed of larger collagen fibrils.
Researchers identified DNA damage-inducible transcript 4 (DDIT4) as a critical factor regulated by histone deacetylase 4 (HDAC4) in skin aging. Overexpression of HDAC4 rescued cells from senescence, while DDIT4 overexpression reversed changes associated with aging.
A study found that a methionine-deficient diet alters gene expression and DNA methylation in liver cells, increasing the risk of non-alcoholic fatty liver disease. A methionine-supplemented diet had the opposite effect, reducing the risk of liver damage.
A study reveals an epigenetic switch that restricts early embryo cells from differentiating into certain tissue lineages. The research identifies PRC2 as a key regulator of gene expression in embryonic development, allowing for better control of stem cell specialization and blastoid formation.
A new study by University of Chicago researchers found epigenetic differences in airway cells of patients with asthma who have asthmatic mothers, contributing to the development of severe asthma. The findings suggest that impaired immune responses may be an underlying cause of lack of therapeutic response to corticosteroids.
A study found epigenetic differences in airway cells of patients with asthma who have asthmatic mothers, suggesting impaired immune responses and potential new therapies for this subtype of asthma. The research was conducted in a diverse population and replicated in independent children's cells.
A new diagnostic marker has been identified that predicts successful and efficient oocyte development. The study found that X-chromosome inactivation and reactivation are critical for normal germ cell differentiation.
The São Paulo School of Advanced Science on Pathogenic Trypanosomatids will bring together experts from different fields to discuss the fight against leishmaniasis and Chagas disease. Researchers will share state-of-the-art science and results of new research on epigenetics, drug discovery, and molecular biology.
Researchers at Wayne State University developed a novel technique to measure the age of male sperm, finding a link between sperm epigenetic aging and pregnancy outcomes. The study suggests that older sperm can be associated with lower pregnancy success rates and shorter gestation periods.
Researchers found that hormone fluctuations, particularly estrogen, shape brain development and behavior. Estrogen influences the growth of brain regions, leading to permanent changes in neural circuitry.
Researchers discovered a novel mechanism for miR-10b activation in high-grade gliomas, implicating topologic reorganization of chromatin and long-non-coding RNAs. This finding suggests new RNA-targeted strategies for glioma therapy and points to the vulnerability of tumor-initiating cells.
Researchers developed a new method, EpiDamID, to analyze single cells and determine the location of modified proteins around which DNA is wrapped. This technique helps understand how PTMs affect gene expression and has implications for early development and disease research.
A genome-wide functional screen identified critical regulators of naïve stem cell reprogramming, enabling the creation of high-quality, stable stem cell populations. The study also uncovered epigenetic factors that hinder or help reprogramming, including the essential PRC1.3 complex and inhibitory HDAC2 protein.
Researchers have identified early-onset epigenetic changes linked to an increased risk of developing type 1 diabetes. These findings offer new opportunities for identifying children at genetic risk, potentially allowing for earlier intervention and prevention.
Researchers have discovered signature epigenetic biomarkers in mothers and fathers of preterm infants, which may lead to a non-invasive test to predict preterm birth. This could help prevent premature births and their related health impacts on infants.
Researchers at the University of Pennsylvania have identified a key factor in T-cell leukemia disease relapse - genome refolding. The study found that cancer cells adapt to targeted therapy by changing the folding of their genome, driven by transcription factor repositioning.
A recent study identified specific RNA biomarkers linked to gastrointestinal symptoms in children with autism. The findings could lead to the development of personalized treatments to ease the pain of these individuals. The research has implications for precision medicine, enabling healthcare providers to track medication effectiveness...