Articles tagged with Epigenetics
A new study reveals that depression and antidepressant use are associated with an increased risk of all-cause mortality in postmenopausal women. Epigenetic age acceleration, measured by GrimAge DNA methylation age acceleration, partially mediates the relationship between antidepressant use and increased mortality risk.
Research at Helmholtz Munich found that a father's body weight can affect the weight of their child and increase susceptibility to metabolic diseases. The study suggests that paternal diet influences gene expression in early embryos, affecting the development and health of offspring.
A new molecular test WID-qCIN detects significantly more cancers and precancerous stages than current methods, identifying 100% of invasive cervical cancer and 93% of serious precancerous lesions. The test reduces the need for colposcopy examinations by 40%, improving the effectiveness of screening programs.
Researchers discuss therapeutic opportunities for hypermutated urothelial carcinomas that are resistant to immunotherapy, including the potential of targeted therapies. High TMB is associated with defects in mismatch repair proteins and can lead to increased sensitivity to cancer treatments.
Researchers found associations between inflammatory and metabolic biomarkers and accelerated aging, with GlycA and GrimAge showing robust correlations. The study provides insight into the relationship between aging and cardiometabolic health, potentially informing vulnerable populations.
A new study found that experienced firefighters have different epigenetic modifications linked to prostate cancer risk compared to new firefighters. Chemical exposure to PFAS is associated with these changes. The research team investigated fire department data and found a link between PFAS exposure and increased prostate cancer risk.
A study by Mount Sinai researchers has identified several pathophysiological mechanisms underlying perianal fistulae in Crohn’s disease. The findings highlight key transcription factor binding events and epigenetic phenomena that contribute to the higher rates of complications in African American patients. The research provides avenues...
Researchers found a link between Fontan circulation and accelerated epigenetic aging, which can cause complications like osteoporosis and renal impairment. The study suggests this acceleration starts in childhood and continues into adulthood, with potential new treatment opportunities to delay progression.
Researchers from the University of Southern Denmark have identified specific groups of cells driving resistance to chemotherapy in TNBC, offering new biomarkers and alternative treatment options. The studies shed light on the mechanisms behind chemoresistance and its epigenetic control.
A study by Dr Manel Esteller and colleagues identified an epigenetic signature associated with a good clinical response to hypomethylating drugs, enabling early detection of resistant patients. The research found single genes that facilitate the development of biomarkers and rescue strategies for non-responder patients.
A new study published in Nature Communications reveals that the Kdm1a protein is essential for preserving neuronal identity, and its loss or natural aging triggers the expression of genes that normally should not be expressed in neurons. The researchers found that eliminating this protein accelerates neuronal aging at an epigenetic level.
Researchers found associations between prenatal vitamin and metal exposures and epigenetic aging biomarkers in early life. A one standard deviation increase in essential metals was associated with lower Horvath EAA at birth, while arsenic was linked to greater EAA at birth and in childhood.
A new study from Stockholm University found that pesticide linuron causes significant physiological impacts in frogs, including changes in DNA, growth, metabolism, and reproductive systems. The research highlights the profound transgenerational consequences of environmental pollution on amphibian populations.
Researchers investigated the impact of senolytic treatments on DNA methylation clocks and epigenetic age. Results showed significant increases in epigenetic age acceleration with Dasatinib and Quercetin treatment, but not with Fisetin addition.
A recent study published in Nature found that smoking has a lasting effect on the immune system, with certain defense mechanisms persisting for up to 10-15 years after quitting. The research used a large cohort of healthy volunteers and identified three key factors: smoking, latent cytomegalovirus infection, and body mass index.
Parents who received nutritional epigenetics education reduced ultra-processed food consumption and increased whole organic foods intake, leading to improved behavior and cognition in their children. The education intervention also reduced heavy metal exposures and dietary deficits that disrupt gene function.
Researchers develop epigenetic clocks based on regional disorder of DNA methylation patterns, identifying common responses and critical differences from canonical clocks. These findings suggest a fundamental decoupling of epigenetic aging processes.
Researchers have identified mechanisms of resistance to tazemetostat in epithelioid sarcoma and rhabdoid tumors, leading to the development of a combination therapy strategy. The therapy uses an epigenetic treatment approach to target specific mutations that drive cancer growth.
Researchers discovered a link between single cancer cell mutations and clinical response to epigenetic therapy in myelodysplastic syndrome. Patients showing treatment benefits had decreased mutation counts in stem cells and immature granulocytes, suggesting early tumor elimination is key to therapy success.
Research in mice reveals that epigenetic status controls cancer cells' behavior at metastasis sites, with some cells entering dormancy while others grow into tumors. The study identifies DNA methylation as a key factor in this decision.
Researchers found XRCC1 to have both positive and negative correlations with prognosis across different tumors. The study also revealed associations between XRCC1 expression and DNA methylation patterns, TMB, MSI, immune cell infiltration levels, and immune checkpoint gene expression.
Researchers analyzed genome sequences from over 4,000 tumours to identify patterns of DNA mutations that vary between individuals. They found 13 distinct patterns, with 10 corresponding to different types of tissue, and discovered that the density of mutations in specific genes varies significantly between individuals.
The study reveals that hepatoblasts along the portal vein receive Notch signaling and differentiate into bile duct epithelial cells. Hematopoietic cells fail to transmit signals, resulting in the failure of differentiation. This discovery provides molecular biological support for mathematical analysis results.
Researchers developed a new technique called MAbID to study multiple mechanisms of gene regulation simultaneously, enabling the connection between different gene expression processes. This technology can be applied to various fields, including human development and disease research.
A study by Max Planck researchers has discovered an epigenetic regulator MSL2 that ensures the expression of both alleles of haploinsufficient genes, crucial for human health. This mechanism allows for tissue- and cell-type specificity in gene dosage, opening new directions for understanding diseases and developing potential treatments.
Researchers have identified a new therapeutic target for pulmonary hypertension treatment by discovering an epigenetic pathway mediated via the protein SPHK2 that can reduce and potentially reverse vascular remodeling. This discovery offers new hope for treating pulmonary hypertension, which is a complex and often fatal condition.
Researchers discovered COVID-19 causes epigenetic scars in lung tissue that lead to hyperinflammation and fibrosis. These changes are associated with increased interferons and chemokines, promoting inflammation.
Researchers found that higher alcohol consumption is associated with biological age acceleration and hypertension in middle-aged and older adults, but not in young adults. The study suggests that alcohol consumption may mediate the association between alcohol intake and quantitative traits like hypertension.
Scientists at University of Leicester investigate sleep's impact on ageing epigenetics using jewel wasp model, finding potential reversible effects on DNA methylation. This study aims to understand the molecular basis of sleep-regulated ageing and its potential for therapeutic intervention.
An international team of researchers analyzed 1.7 million cells from 225 samples across 11 different cancer types, identifying regions in the DNA that are differentially activated or inactivated in a cancer-specific manner. These epigenetic changes create a signature for each tumour and correspond to hallmarks of cancer.
Researchers developed a new epigenetic clock that accurately measures biological aging in healthy and unhealthy tissue, outperforming current clocks. The Glasgow-Karolinska Clock showed promise in assessing the impact of chronic kidney disease on aging, even after dialysis treatment.
A study by Washington State University researchers found epigenetic alterations associated with elk treponeme-associated hoof disease, suggesting a systemic impact. The findings also suggest that the disease may be heritable, raising concerns about its transmission and susceptibility.
Scientists have identified a specific process that helps control transposable elements, which destabilize the genetic code and contribute to aging. Strengthening this pathway in Caenorhabditis elegans extended its lifespan.
Researchers aim to study epigenetic modifications of histone H1 to understand its role in gene expression and disease. The project seeks to develop chemical methods to reveal the epigenetic corners of H1, with potential implications for understanding diseases such as cancer and autoimmune disorders.
A new study introduces the concept of a 'noise barometer,' measuring biological age based on epigenetic changes. The researchers found that specific cytosines show increased variability with age, indicating a biomarker for aging and disease. This approach provides a novel perspective on aging research.
Microglial cells age differently in male and female mice, with female microglia displaying a 'middle-aged' phenotype and male microglia switching suddenly to an aged phenotype. The researchers identified key genes and mechanisms contributing to this aging process, including the role of aged-like microglia in cognitive decline.
Researchers discovered that a small subpopulation of AIB1-expressing cells in breast cancer enables invasion and metastasis. The study suggests that these subpopulations play a crucial role in tumor growth and spreading to distant sites.
Researchers found that pregnant mice experiencing copy number variation (CNV) showed similarities to aging, with biomarkers and genetic effects appearing during pregnancy and reversing after delivery. This study aims to revolutionize aging treatment by investigating the mechanisms behind post-labor rejuvenation.
Researchers at Brigham and Women's Hospital have developed a cohesive framework for evaluating biomarkers of aging, providing a robust classification system for the identification and validation of molecular markers. The framework highlights key criteria for evaluation, including age-sensitivity and generalizability across cell types, ...
The editorial discusses epigenetic mechanisms leading to oocyte quality loss, a significant factor in age-related fertility decline. Researchers highlight the importance of understanding this process to address the growing issue of advanced maternal age and its impact on reproduction.
Researchers found that inducing inflammation triggers an epigenetic response in Tas2r genes, leading to a decrease in sweet taste preference and potentially affecting appetite and medication tolerance. This study has significant clinical implications for understanding behavioral aspects of illness and developing effective bitter blockers.
A new study by Weill Cornell Medicine researchers found that severe COVID-19 infection can alter the immune system's response, causing long-lasting changes to gene expression in immune system stem cells. This can lead to symptoms of prolonged inflammation and 'long COVID' in affected individuals.
Researchers at Michigan Medicine have discovered a potential treatment for diffuse midline glioma, a type of childhood brain tumor with no effective treatments. The compound ONC201 nearly doubled survival rates in patients with the disease, and the underlying mechanism behind its success has been explained.
Researchers propose a novel theory of aging that suggests cell competition is a key factor in the process. The selective destruction theory (SDT) proposes a mechanism of aging that is independent of accumulating damage and consistent with epigenetic rejuvenation.
Rice University chemist Han Xiao has won a $3.2 million research grant from the National Cancer Institute to develop an epigenetic inhibitor targeting bone metastasis. The drug, based on existing bisphosphonates, aims to prevent cancer cells from spreading to other organs without affecting normal tissues.
Scientists discovered epigenetic signatures in immune cells that allow for rapid activation of key genes, enabling quick recall of antigens. This rearrangement is accompanied by changes in the 3D distribution of DNA in the nucleus, which affects gene expression and could lead to new therapies for autoimmune diseases.
Professor Coppedè's appointment aims to enhance the journal's focus on cutting-edge genomics research, covering topics like genome sequencing and functional genomics. He will lead Current Genomics to greater success by staying at the forefront of genomics discoveries and advancements.
A recent study suggests that Black Americans experience accelerated biological aging compared to White Americans, primarily due to lower socioeconomic status and exposure to air pollution. The findings highlight the significant impact of environmental factors on epigenetic aging disparities between racial groups.
Researchers used proteomics and small RNA sequencing to analyze 103 human blood plasma samples, identifying 21 proteins and 315 small RNAs associated with aging. Combining protein and miRNA data improved age predictions (R2 = 0.70 ± 0.01), suggesting a broader range of age-related physiological changes.
A new study from the Van Andel Research Institute reveals that loss of two key 'protector' proteins, TET and RYBP, transforms healthy lung cells into cancerous ones through epigenetic changes. The research found that deficiency of these proteins leads to widespread aberrant methylation and malignant transformation.
A new study by CNIC researchers reveals that low-grade systemic inflammation triggered by subclinical atherosclerosis accelerates epigenetic aging in otherwise healthy young individuals. The study found a strong association between atherosclerosis progression and accelerated biological age, with potential reversibility through lifestyl...
A recent study published in JAMA Network Open explores the association between adverse childhood experiences and epigenetic aging in midlife. The research found that early life experiences can accelerate biological aging, which may contribute to various health outcomes in middle-age adults.
Researchers developed a new biological age indicator, DNAmFitAge, that incorporates physical fitness parameters, showing a correlation with lower mortality risk, coronary heart disease risk reduction, and improved disease-free status in physically fit individuals.
A new study found that living in urban environments with material and social inequities is associated with premature biological aging. Depressive symptoms also accelerate epigenetic age acceleration, regardless of neighborhood deprivation. The researchers used DNA methylation-based estimators to examine aging at the cellular level and ...
A study by Dr. Manel Esteller's team has identified a key epigenetic alteration in liver cancer that makes tumors more vulnerable to a specific class of anticancer drugs. This discovery may lead to improved treatment options for patients with liver cancer, particularly those with intact NSUN7 gene function.
A study reveals a unique epigenetic biotimer mechanism controlling floral meristem termination and stamen development in Arabidopsis thaliana. The team discovered that AGAMOUS serves as a master conductor orchestrating gene expression through cell cycle-coupled H3K27me3 dilution.
Research found that children of obese or diabetic mothers developed epigenetic alterations that predisposed them to diseases such as diabetes, obesity, and cardiovascular problems. Longitudinal follow-up revealed persistent effects on health status and metabolic condition beyond childhood.
Researchers from the ALFA Score Consortium explore how nutrition and physical exercise can positively impact the aging process by modifying epigenetic changes. They find that healthy aging is associated with more tightly condensed chromatin, fewer histone post-translational modifications, and greater regulation by non-coding RNAs.
A new study reveals a shared molecular response to nanoparticles, linking immune activation and particulate matter exposure. The findings propose a solution to the 'one-chemical-one-signature' problem in chemical safety assessment.
A recent study published in Cell Metabolism found that biological age increases with stress from surgery, pregnancy, and severe COVID-19, but can be reversed upon recovery. The study used 'biological clocks' to measure the health of cells and tissue, revealing a dynamic relationship between stress and biological aging.