Research suggests that heat shock protein (HSP90) overexpression contributes to dopaminergic neuronal death and muscle abnormalities in PD. Exercise training has been shown to inhibit HSP90 overexpression, making it a potential therapeutic target for treating PD-related skeletal muscle issues.
A study published in JCI Journals suggests that estrogen replacement therapy can suppress binge-eating behaviors in mice. The effect required the presence of estrogen receptors in serotonin neurons, and direct delivery of an estrogen conjugate also reduced binge eating in these animals.
Scientists use the most sensitive device ever created to measure the quantum jitter of space itself, probing the limits of the universe's ability to store information. The Holometer experiment could reveal whether we live in a holographic universe with 2-D encoded information.
A new study found that surgery for hip fractures yields significant savings in lifetime medical costs, with total societal savings exceeding $16 billion for older patients. Surgery also improves physical function and reduces mortality risk.
The 2009 H1N1 outbreak at Washington State University provided valuable data for researchers to study the rapid spread of the virus. A computer model revealed that only a few initial infected individuals sparked the outbreak, with a high transmissibility rate among close-knit student communities.
Researchers have developed a new method using laser-induced breakdown spectroscopy to distinguish between gutter oil and safe, edible oil. The technique uses principal component analysis and artificial neural networks to detect toxic substances like bacteria and heavy metals.
A new high-resolution bedrock map for the Antarctic Peninsula provides detailed insights into the region's geology and ice thickness. The study reveals that 34% of the ice volume is grounded below sea level, with a potential to raise global sea levels by 69mm.
A study found that many hospitals in low- and middle-income countries have insufficient stocks of sterile gloves, eyewear, and other protective equipment. This is particularly concerning in the context of the current Ebola outbreak.
A collaborative care intervention that included patient and parent engagement and education resulted in greater improvement in depressive symptoms among adolescents with depression. The study found that 68% of intervention youth had a 50% or greater reduction in depressive symptoms, compared to 39% among control youth.
Researchers have devised a new way to separate cells by exposing them to sound waves as they flow through a tiny channel, overcoming existing cell-sorting technologies' limitations. The device successfully recovered about 71 percent of breast cancer cells from white blood cells in tests.
Researchers have developed dynamic nanoparticles that can be used as contrast agents for MRI and PET scans, deliver chemotherapy directly to tumors, and respond to light to destroy tumor cells. The particles are biocompatible, non-toxic, and can be easily made, making them a promising tool in cancer treatment.
Scientists at Vienna University of Technology have managed to explain how a laser pulse can change the electronic properties of glass, making it conduct electricity. The effect happens so quickly that it can be used for ultra-fast light-based electronics.
Researchers used GPS technology to study sheepdog behavior, finding that they employ two basic rules: collecting dispersed sheep and driving aggregated ones forward. This model can be applied to various fields like livestock management, environmental cleanup, and robotics.
The NSF has awarded two grants to expand its National Innovation Network through the I-Corps program, supporting innovation education, research, and infrastructure in Southern California and Texas. The new nodes will join five existing regional hubs, fostering mentorship, research, and entrepreneurship.
A new report by Princeton University researchers suggests that expanding the age of eligibility for measles vaccination from 12 to 15 months could significantly increase coverage in Africa. The study found that increasing the age range would have the most impact on countries with high rates of unvaccinated children.
Researchers found that administering EPO immediately after birth significantly reduces brain damage in premature babies. This study builds on previous research showing EPO's neuroprotective effects and holds promise for preventing long-term consequences of preterm birth.
Fever is triggered by prostaglandin signaling substance produced in the brain's blood vessels. A new study confirms this origin, shedding light on inflammation symptoms and potential drug targets.
A new study from Princeton University and the University of California-Irvine finds that future coal-fired and natural-gas power plants will commit the world to decades and billions of tons of greenhouse gas emissions. The 'commitment accounting' method assigns all future emissions to the year a facility begins working, revealing a sig...
Researchers used same-beam VLBI technology to monitor the Chang'E-3 rover's movement, measuring sensitivity of 50-100mm. The technique precisely tracked the rover's position relative to the lander and Earth.
A new study finds that loyal customers feel they are more likely and deserving than others to win perks from businesses, even in randomly given out contests. This 'lucky loyalty' effect is driven by people's sense of deservingness, believing they have earned special treatment.
In a laboratory study led by NIH scientists, broadly neutralizing HIV-specific antibodies (bNAbs) were found to effectively block HIV from entering immune cells. The researchers also demonstrated that these antibodies could completely block HIV replication in infected individuals receiving antiretroviral therapy.
The era of Big Data presents new opportunities for personalized treatments and services, but also introduces challenges in statistical analysis, bias sampling, and measurement errors. Researchers focus on developing new computational infrastructure and data-storage methods to handle massive datasets.
A study found that high-dose EPO administered within 42 hours of birth reduced brain injury and white matter damage in preterm infants. The treatment was associated with improved neurodevelopmental outcomes, including lower rates of encephalopathy of prematurity.
A new study by USC Marshall professor Gerard J. Tellis and colleagues reveals that financial innovations can deliver significant positive returns, particularly in the United States. The research found that radical innovations, such as home mortgages and auto loans, generate higher cumulative abnormal returns due to their ability to cha...
A new study published in Radiology found that using the Wii Balance Board system can induce favorable changes in brain connections associated with balance and movement in patients with multiple sclerosis. The device helps improve balance, reducing the risk of accidental falls and related comorbidities.
A recent study published in Molecular Psychiatry found no statistically significant link between prenatal antidepressant exposure and autism risk after accounting for severe maternal depression. However, an increased risk of attention-deficit hyperactivity disorder (ADHD) persisted even after controlling for factors related to a mother...
The NSF has awarded $10 million to create a cloud computing testbed called Chameleon, enabling researchers to develop and experiment with novel cloud architectures. The testbed will provide persistent infrastructure clouds, 'bare metal' provisioning of hardware, and pre-configured software stacks for users to build cloud services.
Casey Diekman is leading a research effort to understand the biological clock's role in regulating daily behavior patterns. Preliminary results suggest that circadian rhythms are deeply encoded in neuronal electrical programming, influencing hormone production and other physiological indicators.
The study found that age, gender, repair time, repair materials, and the injured nerve are independent predictors of good prognosis. Functional recovery of peripheral nerve injuries is multifaceted and affected by different factors in various patients.
A new study found that robot-assisted radical prostatectomy (RARP) procedures for prostate cancer increased from 0.7% to 42% among US surgeons between 2003 and 2010. RARP adoption was associated with higher volume providers and decreased costs over time.
Researchers have developed the thinnest-possible semiconductor junctions, made in sheets only three atoms thick, allowing for flexible and transparent computing, LEDs, and solar technologies. The discovery enables new kinds of transistors, LEDs, nanolasers, and solar cells to be developed within a single atomic plane.
Kids Konnected and the Breast and Gyn Health Project in California will each receive $8,500 awards to support their work assisting cancer patients and their families. The organizations will also be featured at ASTRO's Annual Meeting in San Francisco.
Researchers at Baylor College of Medicine developed an estrogen-based compound that inhibits binge-like eating behavior in female mice. The study found that the compound, GLP-1-estrogen, works by delivering estrogen to specific brain regions where serotonin neurons are present, reducing binge eating.
Researchers have developed a new method to identify and measure vital molecules that control cell behavior, paving the way for better diagnosis, prediction, and monitoring of cancer. The study identified over 200 protein kinases and created a technique to quantify their levels in biological samples.
Researchers developed algorithms to visualize and predict weak spots in tendons, muscles, and bones prone to tearing or breaking. The new algorithms are 1,000 times more accurate than older methods at quantifying large strains near tiny cracks and tears.
Research at the University of Adelaide found that providing daily contact with boars during lactation stimulates oestrus in sows, allowing for increased piglet weaning age without compromising litter frequency. This could lead to improved post-weaning growth and better welfare for piglets.
Scientists have obtained an atomic-level picture of the intact NMDA receptor, a massive multi-subunit complex that integrates chemical and electrical signals in the brain. The structure reveals how the receptor is regulated and offers new insight into its function, which is tightly controlled and associated with neurological diseases.
Researchers at Southern Methodist University found that elite sprinters use a unique gait feature to maximize speed, delivering a firm and rapid punch to the ground upon contact. The study, which compared data from competitive sprinters to other fast-running athletes, suggests that there is only one way to achieve high speeds.
A Yale School of Environment special issue examines life cycle engineering for a more sustainable manufacturing sector. The study finds that product design and maintenance can significantly reduce environmental impact.
Researchers identified a tumor vessel-specific protein, L1, as a potential therapeutic target to reduce tumor growth and metastasis. Loss of L1 in mouse pancreatic cancer models reduced tumor angiogenesis and promoted vessel normalization.
A new study estimates that more than 40% of global waste is burned in unregulated fires, releasing pollutants such as particulates, carbon monoxide, and mercury. These emissions have been linked to serious medical issues, including decreased lung function and cancer.
A new study by Yale University authors found that consumers are more likely to purchase a product if it is perceived as environmentally friendly due to unintentional design changes rather than intentional eco-friendly efforts.
Researchers found that increased safety signaling is associated with improved REM sleep consolidation and better management of fear conditioning in individuals with PTSD. This suggests that addressing sleep disturbances before treating daytime symptoms may lead to more beneficial outcomes for exposure-based treatments.
A study of 634 couples found that frequent marijuana use by both spouses predicted lower levels of intimate partner violence. The relationship between marijuana use and reduced partner violence was most evident among women without prior antisocial behavior.
Scientists have discovered two separate phases of ferromagnesian silicate in the lower mantle, one containing nearly no iron and the other rich in iron. This finding has significant implications for seismology and the study of earthquakes, highlighting the need to reconsider existing models.
Researchers have identified chemical changes in DNA that could screen people for Crohn's disease and reveal possible targets for new treatments. These genetic changes can be detected in blood samples, opening the door to a simple test for the condition.
A 15-year study has revealed astonishing cryptic diversity in the New Zealand kanuka genus Kunzea, with 10 new species identified. The discovery challenges a long-held assumption that a single species was mistakenly merged with Australian relatives.
Researchers at the University of Illinois have created a new optical amplifier design that combines plasmonics and optical microresonators to produce laser-like light emission. This breakthrough enables power-on-a-chip applications with improved speed performance and reduced energy consumption.
A quality improvement audit found that a volume-based system increased EN volume intake, calories, and protein delivery in mechanically ventilated ICU patients, improving nutrition outcomes.
Continuous positive airway pressure (CPAP) is an effective treatment for obstructive sleep apnea (OSA) in older people, reducing daytime sleepiness and healthcare costs. The study found that CPAP can improve quality of life and reduce the risk of road accidents, heart disease, and other conditions associated with OSA.
Experts say 14th century Venice's response to the plague holds lessons on how to mitigate the consequences of today's emerging threats. The city's use of resilience management, including physical movement management and quarantine measures, can inform strategies for dealing with highly infectious diseases like Ebola.
Hurricane Marie has extended hundreds of miles from its eye, causing heavy rainfall and hurricane-force winds on nearby Socorro Island. The storm is also generating dangerous surf along the western coast of mainland Mexico.
Chronic drinking is associated with a reduced CD8 T cell response to the influenza virus, leading to increased disease severity. However, some effector functions of CD8 T cells remain intact, suggesting that alcohol may have distinct effects on the immune system.
A study in Journal of Consumer Research finds that former churchgoers experience deep identity crises due to the loss of morality and day-to-day guidance. As they navigate a broader marketplace, they must assume personal responsibility for their choices and reassemble their lives from new ideas, experiences, and services.
A new study in Journal of Consumer Research found that consumers' perception of time categories influences task initiation. By categorizing deadlines as similar to the present, consumers are more likely to start tasks and achieve their goals.
A UCLA study found that men with low prostate cancer knowledge experience increased decisional conflict and lower perceived effectiveness of treatment. Doctors can help by providing educational information before consultations to increase patients' comprehension and reduce regret.
A study by the University of Liverpool found that a fiber-based dietary ingredient can lead to lower food intake at both lunch and dinner. The product, Weightain, consisting of viscous hydrocolloid and whole-grain corn flour, was shown to produce significant effects on appetite across the day.
A new study found that weight loss surgery can improve cognitive function and reduce altered brain activity associated with obesity. Bariatric surgery may contribute to a reduced risk of Alzheimer's disease in obese people, according to researchers.
A study found that India's Total Sanitation campaign increased latrine availability and reduced open defecation, but did not improve child health outcomes. Despite limitations, the results highlight the need for continued efforts to expand global understanding of sanitation's impact on child health.
Researchers monitor blood pressure of 47 volunteers on Mount Everest and find a progressive increase in blood pressure with altitude. Telmisartan is effective in counteracting the effects of high altitude up to 3400 meters, but not at 5400 meters.