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Life Sciences

Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.

447,757 articles | 2542 topics

Health and Medicine

Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.

431,843 articles | 751 topics

Social Sciences

Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.

260,756 articles | 745 topics

Physical Sciences

Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.

257,913 articles | 1552 topics

Applied Sciences and Engineering

Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.

225,386 articles | 998 topics

Scientific Community

Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.

193,043 articles | 157 topics

Space Sciences

Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.

29,662 articles | 175 topics

Research Methods

Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.

21,889 articles | 139 topics

Mathematics

Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.

3,023 articles | 113 topics

Do genes respond to global warming?

A recent study published in PLOS Biology found that climate change can shape genetic diversity in mammals. Researchers analyzed fossil samples and contemporary data from two mammal species, the Montane vole and northern pocket gopher, and discovered that climate-induced habitat alterations influenced variation in genetic diversity.

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Battle between bubbles might have started evolution

Researchers find that simple vesicles with genetic material grow and compete for resources, challenging current theory on cell evolution. The study suggests that the presence of RNA is key to driving cellular growth and competition.

Millennia still mean early days for newly identified sex chromosome

Researchers have found that the threespine stickleback fish has a genetic sex-determination system similar to other vertebrates, with females having XX chromosomes and males having XY. The study provides evidence for the early formation of sex chromosomes in this species, offering insights into the evolution of sex chromosomes.

Using statistics to decipher secrets of natural mutation

Researchers developed a new analytical approach to understand naturally occurring mutations, revealing patterns that distinguish between mutational mechanisms. By analyzing genome sequences from 19 mammalian species, they identified regular clock-like fashion of CpG mutations and shed light on factors influencing evolution.

Prions act as stepping stones in evolution

A team of researchers discovered that prions can have a beneficial effect on the evolution of yeast cells, allowing them to survive in new environments. This occurs when prions alter the reading of genetic information, leading to changes in the cell's phenotype.

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Evolvability could be a driving force in drug resistance

A computer simulation by Rice University scientists suggests that the ability to evolve can itself be favored through natural selection. This idea challenges traditional views and provides insights into the evolution of drug resistance in bacteria, immune system cells, and higher-order organisms.

Study suggests humans can speed evolution

A study by J. Todd Streelman found that human-induced disturbance accelerated the evolutionary process of cichlid fish, leading to two genetically distinct populations with distinct color patterns. The findings suggest a potential for rapid speciation and highlight the impact of human activity on evolutionary processes.

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Insecticide resistance: A constraint on evolutionary change

Research reveals that mosquitoes like Aedes aegypti are less likely to develop high levels of insecticide resistance due to a silent genetic mutation. The study found that only one base mutation is needed for some mosquito species, like Anopheles gambiae, but two adjacent mutations are required in others, including Aedes aegypti.

UAB creates the first Internet server to search for genetic diversity

Researchers at Universitat Autonoma de Barcelona have developed the PDA web service, allowing scientists to analyze genetic diversity in different individuals and species. The server enables the search for small variations in genomes, providing valuable information for studying illnesses with a genetic origin.

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Study reveals evolution on the (butterfly) wing

Researchers at Duke University uncover how two genes control the evolution of line and eyespot patterns in butterflies and moths. The study, published in Current Biology, sheds light on the developmental basis of wing patterns and their connection to biodiversity.

Harnessing DNA-based technology for drug discovery

Researchers have developed a genetic code that enables the evolution of synthetic molecules, revolutionizing drug discovery. By creating a library of nonbiological origin compounds, scientists can identify novel drugs and disrupt cellular processes.

Scientists discover new role for tiny RNA in plant development

Researchers at Rice University and MIT found that microRNA miR164 plays a crucial role in regulating gene expression and controlling basic organ development in plants. The study reveals abnormal development of leaves and flowers when miR164 regulation is absent or overexpressed.

Why grandparents prefer certain kin to others

A study published in the Journal of Personality and Social Psychology found that maternal grandmothers are closer to their grandchildren than other grandparents. The researchers discovered that preferential investment stems from genetic uncertainty, with maternal grandmothers being the closest followed by paternal grandfathers.

Parting genomes: UA biologists discover seeds of speciation

Researchers observe breeding patterns of two closely related fruitfly populations and find genetic changes that suggest they are on the verge of diverging into separate species. The study identifies polymorphism causing male sterility, which is present in every population but at higher frequencies in one geographic region.

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Gene maps of simpler life forms point the way to human disease gene

Researchers have identified a flagellar and basal body proteome that includes the BBS5 human disease gene by comparing the genetic codes of humans and the green alga Chlamydomonas. This discovery sheds light on the complex structure and function of cilia, which are essential for various cellular processes.

Evolution's mirror in a fish's spines

Scientists studying stickleback fish discovered that small changes in gene regulation can lead to rapid skeletal changes without disrupting essential genes. The researchers identified a single region on the chromosome responsible for most of the changes in spine and pelvic morphology, pointing to the key role of the Pitx1 gene.

Puzzle of corn's origins coming together

Corn's genetic origins have been revised after a study found it arose from a serendipitously viable cross between teosinte and gamagrass. Eubanks' research confirms teosinte was an ancestor of corn, with gamagrass contributing key genes.

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Molecular midwives hold clues to the origin of life

Researchers suggest that small molecules, known as molecular midwives, played a crucial role in the production of the first RNA-like molecules. These midwives would have worked together to form RNA by spontaneously mixing with chemical building blocks.

Proven method of bone analysis may clarify human origins

A novel method of three-dimensional mathematical analysis has been developed to quantify bone characteristics of humans and great apes. The results agree with genetic analyses, providing a clear family tree that defines ancestral relationships down to the subspecies level.

NIST-led research de-mystifies origins of 'junk' DNA

The study analyzed data for 10 families of protein-coding genes in multi-celled organisms, resolving a debate over the timing of intron emergence. It found that most modern introns appeared subsequent to gene creation, contradicting the 'introns-early' view.

For some gorillas, local kin may mean local peace

Researchers analyzed DNA from western gorilla fecal and hair samples to find that neighboring social groups are often led by genetically related males. This suggests connections between genetic relationships and group interactions, parallels with human social structures, and clues to the early human social world.

Evolution's twist

A USC study found that human ancestors developed meat-tolerant genes to resist diseases associated with a meat-rich diet, leading to slower aging and longer lifespan. However, the researchers argue that modern-day humans' sedentary lifestyle and lack of moderation may be contributing factors to high cholesterol and vascular disease.

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Refuting Neandertal ancestry

A team of scientists has analyzed the largest sample of Neandertal and early human remains, concluding that Neandertals could not have made a significant genetic contribution to early modern humans. The study's findings challenge the theory of interbreeding between Homo sapiens and Homo Neanderthalensis.

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Gene may be key to evolution of larger human brain

A study led by Bruce Lahn found that the Abnormal Spindle-Like Microcephaly Associated (ASPM) gene shows strong evidence of accelerated evolutionary changes in the primate lineage leading to humans. These changes are most prominent after humans parted ways from chimpanzees, suggesting a possible key role for ASPM in human brain evolution.

Rapidly evolving genes providing new insights in plant evolution

Scientists have discovered that rapidly evolving genes can reveal more historical signals than slowly evolving genes, providing a new perspective on plant classification. This approach has the potential to revolutionize our understanding of plant evolution, ecology, genetics, and biodiversity.

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Chimp vs. human DNA: what's in the 1% difference

A massive gene-comparison project found evidence of positive selection in genes involved in the sense of smell, digestion, long-bone growth, hairiness, and hearing. The analysis also suggested that humans may have an advantage in understanding speech due to genetic differences in hearing genes.

Lifestyle accounts for difference in chimp, human genome

A massive gene-comparison project found evidence of positive selection in genes involved in olfaction, smell perception, and hearing. This suggests that lifestyle changes, such as the shift from a plant-based diet to meat-eating, drove the evolution of unique human traits.

Sport hunting hits evolutionary traits in bighorn sheep

Research reveals that sport hunting depletes genes for big horns and fast growth in bighorn sheep populations, leading to a decline in trophy quality. The study's findings suggest that wildlife managers should explore alternative strategies to minimize further deterioration of the genetic quality of bighorn sheep.

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Changing one gene launches new fly species

Researchers alter a single gene in fruit flies to adapt them to different environments, resulting in distinct pheromones that influence mating behavior. The change leads to potential sexual isolation, a crucial step in the emergence of a new species.

UCLA study sheds new light on island evolution

A recent UCLA study found that Caribbean island lizards share genetic material due to ocean currents, which carry them from one island to another. This challenges the long-held assumption that species on separate islands evolve independently.

Research sheds new light on evolution

Researchers at Michigan State University found that initial changes in genetic makeup can lead to significant adaptations in plants and other organisms. The study used the monkeyflower plant, altering its genome to attract new pollinators, such as hummingbirds.

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Unfaithful songbirds increase offspring fitness

Research on blue tits found that extra-pair copulations with distant males lead to more heterozygous offspring, resulting in improved survival and reproductive success. This study suggests that females can benefit from promiscuity by increasing the genetic quality of their progeny.

Genes that regulate hearing link humans and fruit flies in new way

Researchers found that a mutated fruit fly gene controlling hearing produces similar consequences in humans, including hearing loss and limb deformities. The study suggests that hearing may have evolved earlier than previously thought, linking human genetics to those of fruit flies.

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Danger on chromosome 15

Researchers have discovered four new genes in the most unstable part of chromosome 15 that contribute to Prader-Willi and Angelman syndromes and hereditary spastic paraplegia. These findings can expand genetic diagnosis of these diseases, including prenatal genetic counseling.

University of Chicago scientist wins prestigious Balzan Prize

Wen-Hsiung Li has made seminal contributions to the field of evolutionary molecular genetics, developing widely used methods for inferring phylogenetic relationships and discovering important insights into genetic change rates. His work has improved our understanding of evolutionary lineages and genetic diversity.

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Male baboons recognize and care for their own offspring

Researchers found that male baboons give priority care to their own genetically related offspring, despite multiple males mating with the same female. This discovery raises questions about how male baboons recognize and distinguish between their genetic and behavioral offspring.

Laboratory 'theme park' re-creates RNA world for study

Scientists, led by Bartel, develop RNA enzymes in lab that can replicate and act as enzymes, but still short of the 200-nucleotide goal. The RNA-world hypothesis proposes RNA played both DNA and protein roles in early evolution, with researchers re-creating this system to study its feasibility.

Studies probe rapid evolution of Chinese tallow trees

Biologists at Rice University are investigating the genetic and environmental factors behind Chinese tallow trees' success in Texas. The research aims to understand how the trees' low defenses against insects contribute to their rapid growth and success as an invasive species.

Genes that paint fly derrieres hint at convergence

Researchers found a common gene, Bric-a-brac2, responsible for diverse pattern and color pigmentation across 13 fruit fly species. The study suggests that similar genetic mechanisms govern body plans in related animals.

Borneo elephants: A high priority for conservation

Research reveals Borneo's elephants are genetically distinct from other Asian elephants, suggesting they may have parted ways 300,000 years ago. This classification changes the focus of their conservation, as their habitats are increasingly disrupted by human expansion.

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Models show gene flow from crops threatens wild plants

Researchers at the University of Wisconsin-Madison developed mathematical models to understand the effects of gene flow from crops to wild plants. The models show that crop genes can rapidly take over wild populations, leading to genetic changes, population decline and loss of natural traits.

Biologists find unexpected rapid evolution in Caribbean lizards

Researchers found significant genetic differentiation among Anolis lizard populations on Caribbean islands, revealing unexpected dimensions of biodiversity. The study suggests that multiple species may be present within a single island's ecosystem, and factors such as geography and ecology could be driving the DNA evolution.