Articles tagged with Gene Identification
A new study suggests that genetic variations in the APOL1 gene are responsible for population disparities in kidney failure, particularly among persons of African and Hispanic heritage. The findings highlight the importance of identifying genetic mutations associated with increased risk of chronic kidney disease.
A groundbreaking study published in BMC Medical Genomics found significant changes in gene expression due to cigarette smoke exposure. The research, involving 1,240 individuals, identified over 323 unique genes whose expression levels were correlated with smoking behavior, revealing a sobering link between smoking and gene expression.
U-M researchers identified a DIAPH3 gene mutation that causes over-production of a diaphanous protein, leading to hearing loss. The discovery will aid in developing genetic tests for auditory neuropathy, a rare disorder previously difficult to diagnose.
Scientists combined new and classic approaches to identify a single genetic mutation causing metachondromatosis, a disorder characterized by bony growths. The study demonstrates the power of whole-genome sequencing technology in efficiently identifying genes responsible for Mendelian diseases.
Researchers identified a previously unknown genetic location on chromosome 2p causing familial focal segmental glomerulosclerosis (FSGS), a common cause of kidney failure worldwide. The discovery may provide clues to disease mechanisms and lead to identification of specific and less toxic therapies.
A new study published in Genetics found that mutations in 10 different genes of worms can extend lifespan without reducing oxidative stress. This discovery challenges the long-held notion that oxidative stress is responsible for aging and suggests a slow rate of metabolism may be key to increasing longevity.
Researchers have developed an animal model that demonstrates the initial stages of atherosclerosis can be predicted by disturbed blood flow. The study identifies genes turned on or off in response to disrupted flow, providing new insights into how exercise may protect against the disease.
Researchers found rare genetic changes called copy number variants (CNVs) in nearly 2,300 people, which could account for up to 3.3% of autism cases. The study identified three new genes and pathways contributing to autism susceptibility.
The DOE JGI's new QC tool, GenePRIMP, helps check the quality of microbial genomic DNA sequences, reducing errors in gene annotations. With its ability to identify and correct anomalies, GenePRIMP facilitates comparative analysis and improves the overall accuracy of structural annotations.
Researchers found that genetic mutations affecting cilia function may predispose older individuals to pulmonary diseases. A simple nitric oxide testing can identify patients at risk of abnormal ciliary function.
A team of international researchers has identified 20 genes associated with osteoporosis and bone weakness, including 13 genes never previously associated with the disease. The study, published in Nature Genetics, provides new insights into the genetic mechanisms that control bone strength.
The GREAT algorithm allows scientists to analyze vast amounts of DNA sequencing data to reveal control regions for nearly any gene. Researchers can input a list of binding sites and receive an analysis of which genes are likely to be moderated by the transcription factor, including those far away from the coding sequence.
Researchers have identified a new breast and ovarian cancer susceptibility gene, RAD51C, in a German study. The gene is associated with a high risk of breast and ovarian cancer, particularly in familial cases.
A new method has been developed to identify genetic mutations in active genes, enabling studies of disease effects and improving diagnostic accuracy. This technique allows researchers to study specific cellular processes and identify minority cells in tissue samples.
Researchers found that bees with artificially reduced insulin receptor substrate (IRS) in abdominal fat cells preferred pollen over nectar. This suggests an alternative mechanism for insulin's impact on eating behavior beyond the brain.
Researchers at EMBL identified almost 600 human genes involved in mitosis through high-throughput imaging and computer analysis. The study provides a rich resource for scientists to investigate the molecular workings of cell division.
A new study proposes that slow-growing animals waste energy in two ways, making too much protein and then discarding excess. Fast-growing oysters, on the other hand, are more efficient at protein production, according to USC marine biologists.
Researchers have discovered a gene linked to a newly recognized multisystem autoimmune disorder affecting Amish children, characterized by chronic diarrhea, enlarged organs, and developmental delays. The ITCH gene plays a crucial role in regulating the immune system, and identifying it may lead to effective treatment for these children.
Researchers at CSIRO Australia have successfully produced hand-drawn threads of artificial honeybee silk, rivalling the strength of natural silk. The breakthrough is a significant milestone towards developing biomimetic materials for various industries.
Researchers found similar connectivity between genes in normal individuals and schizophrenia patients, but a significant link between aging and gene expression patterns was discovered. Age-related aberrant regulation of developmentally related genes might explain at least part of the manifestation of schizophrenia.
Researchers identified a link between aging and abnormal gene expression patterns in schizophrenia patients, suggesting that age-related aberrant regulation of developmental genes may explain the manifestation of the disease. The study supports early intervention and treatment tailored to the patient's age.
Researchers at IRB Barcelona have identified a new gene, DOR, that facilitates the formation of autophagosomes and plays a crucial role in the cellular recycling program. The study suggests potential avenues for developing new therapies for cancer and neurodegenerative diseases by modulating autophagy.
Researchers have identified a gene, Kir2.6, underlying the rare genetic disease thyrotoxic hypokalemic periodic paralysis (TPP), which causes temporary muscle paralysis. The finding, published in the journal Cell, illustrates how investigations of rare genetic diseases can drive insights into more common ones.
A recent study published in Political Research Quarterly found that genetics may contribute to an individual's political party identification, challenging the long-held assumption that it is solely shaped by socialization factors. The study used quantitative genetic models to examine the sources of party identification and intensity.
A team of researchers has identified 12 genetic variants in the HSPB7 gene associated with heart failure. The study found a block of 12 genetic variants linked to heart failure in a large group of individuals.
A new study published in the Journal of Periodontology found that nearly 30% of human genes are expressed differently during gingivitis onset and healing. Biological pathways associated with immune system activation were identified as critical to controlling the body's reaction to plaque build-up.
Researchers developed a genetic screen for human cells to pinpoint specific genes and proteins used by pathogens. The study identified new genes essential for host-pathogen interactions, including those involved in diphtheria and E. coli infections.
This study found that variations in plasma glutamyl transferase (GGT) and albumin (ALB) levels are genetically influenced and correlate with cardiovascular disease risk factors. The researchers identified chromosomal regions containing genes that affect GGT and ALB variation, which may also influence cardiovascular health.
Researchers at UAB have discovered the genetic identity of a cellular receptor for the immune system's first-response antibody, shedding light on infection control and immune disorders. The discovery proposes renaming the gene linked to this receptor to better describe its role in early immune responses.
Researchers have identified and grouped the genes responsible for cell wall development in maize, enabling better study of biomass production. The discovery expands their ability to discover ways to produce biomass suitable for biofuels production.
Researchers at the University of Pittsburgh are using a mouse model to identify genes that cause congenital heart defects, which affect up to 1% of live births. The goal is to develop a diagnostic chip that can rapidly identify genetic root causes of specific heart defects.
Researchers found a population of tropical butterflies exhibiting diverging color patterns and reproductive preferences, suggesting the potential emergence of two distinct species. The study provides insights into the earliest stage of ecological speciation, where natural selection drives the divergence of populations into new species.
A new genetic method allows for precise identification of all eight tuna species from processed tissue, helping conservation efforts and trade controls. The analysis of DNA sequence variability enables full discrimination between the recognized species.
A recent study published in BMC Biology identified genetic pathways associated with moderate alcohol consumption, but found no correlation between these genes and alcohol dependence. The research team found that drinking behavior was linked to pleasure and reward pathways in the brain, similar to satiety and appetite for food.
A Virginia Commonwealth University study identified a key gene regulating ovarian follicle development in mice, which may help understand human fertility issues. Female mice lacking the Smad-3 gene showed reduced ability to respond to FSH stimulation, leading to infertility.
Researchers have identified the 'master gene' E4bp4, which drives blood stem cells to produce disease-fighting Natural Killer immune cells. The discovery could lead to new ways to treat cancer and autoimmune diseases by boosting the body's production of these frontline tumour-killing cells.
Researchers at the University of Virginia have identified a gene in cowpea that confers resistance to Striga, a parasitic flowering plant that attacks the roots of host plants. The discovery is significant as it could help develop strategies for improving resistance to Striga in other affected crops.
Researchers at UBC found a mutant gene in freshwater sticklebacks that drives their tendency to relocate instead of adapting to new environments. This 'wanderlust gene' is associated with the loss of bony lateral plates and affects salinity tolerance.
A TGen-led research team has been awarded a $1 million grant by the Melanoma Research Alliance to identify novel melanoma risk genes. The team, led by Dr. Jeffrey Trent, aims to characterize genes influencing melanoma risk and develop targeted screening or prevention efforts.
Researchers have developed a yeast model to identify genes that contribute to cancer growth. The study found that point mutations in just a few genetic loci are responsible for the faster growth of cells, rather than aneuploidy. This discovery could help guide the search for new cancer genes in humans.
Researchers identified the hSDH5 gene as mutated in a hereditary form of paraganglioma, a rare neuroendocrine tumor. The study found that individuals with the mutation are at risk for developing tumors, and genetic testing can help identify those at risk.
A new gene, RCP, has been identified as a potential breast cancer-promoting gene, with overexpression causing tumor cell characteristics and metastasis. Targeting RCP may provide a way to inhibit the known tumor-promoting pathway through activation of the RAS signaling pathway.
A recent study published in JAMA Network has found a network of altered genes that appear to play a crucial role in the development and progression of brain tumors. The researchers identified seven landscape genes that are associated with patient prognosis and survival.
A network of 31 mutated genes has been identified as the driving force behind glioblastoma growth. Annexin A7, a vital guard gene, is lost in most cases, allowing tumors to flourish. The discovery offers new therapeutic targets and potentially extends patient survival.
Researchers have identified 20 genes involved in cholesterol regulation, including 12 previously unknown genes. This discovery may lead to new treatments for cholesterol-related diseases and help fight heart disease.
Researchers identified backup genes with similar sequences that can replace failed master genes, explaining experimental results and highlighting the robustness of cells as computational devices. The study found that removing a master gene and its immediate backup has little effect, but removing both has significant consequences.
A study published in BMC Biology has identified 59 genetic mutations in 57 genes that impact the behavior of fruit flies. Researchers found that certain mutations increase aggression, while others make the flies more placid.
Researchers at Northwell Health have identified a new risk factor gene, REL, associated with rheumatoid arthritis. The study found that this gene is common in people in North America and may confer an important survival advantage.
Researchers have developed a method to quickly identify shRNA that turns genes on and off, enabling complex genetic screens at minimal cost. The tool has the potential to revolutionize the study of gene function in mammals, paving the way for targeted therapeutics.
Two genes have been identified as key regulators of female sexual maturation, with their variants associated with earlier onset of menstruation. The study's findings suggest a genetic basis for the links between early menstruation and body mass index and height.
Researchers have identified a potential genetic link to vesicoureteric reflux (VUR), a common cause of urinary tract infections and kidney failure in children. The study found that the VUR susceptibility gene is located on chromosome 12 and may be inherited in an autosomal recessive fashion.
The SLC25A38 gene is responsible for congenital sideroblastic anemia, a rare disease characterized by ringed sideroblasts in bone marrow. Researchers identified the causal mutation in zebra fish, showing its role in hemoglobin synthesis.
A team of scientists from Canada, Spain and the US identified a key gene that allows plants to defend against environmental stresses like drought, freezing and heat. They discovered a receptor that activates abscisic acid (ABA), a hormone helping plants survive drought.
Researchers at the University of Liverpool have developed a new method to identify genes that help protect the body from age-related changes. The study analyzed over five million gene measurements across multiple tissue types in animals and humans, highlighting key biological mechanisms that allow the body to adapt to aging.
Scientists at the University of Cincinnati have identified the RGS17 gene as a major suspect in familial lung cancers. Further investigation may lead to genetic testing for high-risk patients, enabling early detection and treatment.
Researchers at Ben-Gurion University have identified two genes that increase plant tolerance to heat, salt, and drought. The collaboration will help identify additional candidate genes for developing stress-resistant crops.
Researchers at UCLA have identified a gene mutation responsible for short-rib polydactyly syndrome, a deadly disorder that kills newborn babies. The discovery will allow for earlier testing of embryos at risk for the disease, potentially saving lives and reducing the emotional burden on families.
Researchers identified 14 gene variants associated with prolonged QT interval, a known risk factor for sudden cardiac death. Individuals with the top genotype scores were found to have a higher risk of prolonged QT intervals and increased mortality.
Researchers have identified 10 genes linked to changes in QT interval duration, a key factor in sudden cardiac death. The discovery could help identify individuals at risk and aid pharmaceutical companies in developing safer drugs.
Two University of Alberta researchers have discovered eight genes directly related to disc degeneration, providing valuable insights into its biological mechanisms. The study's findings may lead to effective interventions for individuals prone to spine problems, such as those with obesity or genetic susceptibility.