Articles tagged with Gene Identification
Researchers have identified a set of genes responsible for producing the deadly toxin botrydial in gray mold, and found that shutting off this gene can stop toxin production. The discovery offers hope for finding natural ways to eliminate gray mold without using expensive fungicides.
A team of researchers led by University of Georgia's Wayne Parrott is using a jumping gene in rice and radiation to identify key genes in soybeans that can be used to produce a better bean. This project aims to improve soybean yield, disease resistance and nutritional content.
Purdue University researchers are working on a new technique called MAGIC to identify gene combinations that increase disease resistance and stress tolerance in crops. By analyzing the genetic diversity of maize, they aim to engineer plants that can withstand most diseases and improve crop yields.
Researchers aim to identify undiscovered genes involved in early breast cancer stages by studying genetic information from thousands of breast samples. The technique could help monitor women at higher risk due to inherited gene defects, reducing mortality from breast cancer.
A genetic mutation in Dalmatians causes high uric acid levels leading to bladder stones, a problem also affecting humans. Researchers identified the SLC2A9 gene responsible and plan to offer DNA testing for breeders to eliminate the trait.
Researchers at NYU's Center for Genomics and Systems Biology identified approximately 300 genes that break phenotypic robustness when knocked out, leading to physical differences in the species. These findings provide new understanding of how organisms develop and function reliably despite environmental changes.
A team of scientists has discovered unusual differences in the natural mechanisms that turn off genes in corn, providing new insight into how the crop protects itself from damage. The research found an extra layer of protective small RNAs in corn, which play a key role in repressing repetitive sequences, including mobile DNA elements.
Researchers have discovered a novel marker for colon cancer, revealing differentially expressed genes that can help identify diagnostic and therapeutic targets. The study's findings provide new insights into the progression of colon cancer and may lead to improved patient outcomes.
Researchers at the University of Minnesota identified a gene mutation linked to exercise-induced collapse (EIC) in Labradors, affecting up to 30% of the breed. A genetic test has been developed to confirm diagnosis and prevent inheritance of the mutated gene.
Researchers discovered specific mutations in the JAK2 gene associated with Down's syndrome-associated acute lymphoblastic leukemia, which could lead to new treatment options. Children with this type of leukemia are younger at diagnosis and have a better prognosis when treated with JAK2 inhibitors.
A study by Stanford University scientists reveals that type 1 diabetes may not be caused by bad genes but by how normal genes and gene variants are expressed. Researchers found differences in gene expression between two groups of mice, suggesting a role for environmental stimuli in triggering the disease.
Scientists identify a gene mutation in SLC17A8 that causes a previously unknown form of hereditary hearing loss, diminishing ability to hear high-frequency sounds. The mutation affects varying severity and onset age among individuals, highlighting the need for families and doctors to be alert for inherited hearing problems.
Researchers have identified approximately 2000 genes that contribute to the increased drought tolerance of two Andean potato clones. The study found up-regulated genes involved in osmotic adjustment, detoxification, and cell communication and signaling, as well as increased solute concentrations to induce water uptake from drying soils.
Research has found a significant association between the tachykinin receptor 3 gene and both alcohol and cocaine dependence. The study, conducted in European American families, identified seven DNA sequence variations within the TACR3 gene as having a strong link to AD and co-existing cocaine dependence.
A study published in Proceedings of National Academy of Sciences identifies the erythropoietin (EPO) gene as a contributor to increased risk of severe diabetic eye and kidney diseases. The research highlights the importance of considering blunting EPO's effects in future therapeutic strategies, such as anti-VEGF therapy.
Researchers Philip A. Beachy and Clifford J. Tabin received the 2008 March of Dimes Prize for their work on hedgehog genes and their role in embryonic development, including limb formation and organ development.
Researchers develop a technique to detect the ancestry of disease genes in hybrid human populations, identifying inherited genes that cause diseases. The algorithm is more powerful and accurate than standard methods, allowing researchers to pinpoint the origins of disease-causing genes and explore potential treatments.
A new algorithm ranks abnormal genes according to their likelihood of contributing to cancer. The study found that a specific gene plays a crucial role in regulating tumor growth and that its loss triggers a shutdown of a key pathway, leading to unchecked cell proliferation.
Scientists have identified 20 new regions of the genome linked to human height, adding to the growing understanding of genetics and growth. These discoveries may shed light on diseases such as osteoarthritis and cancer, and could lead to new avenues for treating various conditions.
The journal highlights a method for ENU mutagenesis to screen the mouse genome, allowing researchers to identify genes important in specific tissues or processes. A second featured protocol provides a step-by-step process for selecting the proper method for analyzing evolutionary relationships between genes.
A team of Canadian and French researchers has identified the TDP-43 gene as a significant cause of ALS (sporadic amyotrophic lateral sclerosis), a neuromuscular disorder affecting motor neurons. The study, published in Nature Genetics, found that up to five percent of ALS patients have genetic mutations in this gene.
A standard sampling regime is being developed to identify superbug genes in intensive care unit environments. The technique uses polymerase chain reaction (PCR) to characterise micro-organism genes and spot antibiotic resistance, allowing for the detection of MRSA and other drug-resistant bacteria.
A collaborative effort by over 90 researchers from 40 centres analysed genetic data from 70,000 people to identify differences in the genetic code that make some individuals more susceptible to type 2 diabetes. The study found six new genes contributing to the risk, bringing the total to sixteen, and provides valuable insights into the...
Researchers have developed a new method to identify mutated genes in human diseases by analyzing gene expression data. The study identified candidate genes for 81 diseases, including epilepsy and muscular dystrophy, paving the way for a better understanding of disease mechanisms.
Researchers discovered a higher frequency of vitiligo in a Romanian community compared to surrounding populations, suggesting a genetic component. However, the disease's onset required environmental triggers, indicating that genetics alone may not be enough to explain its development.
Researchers at Karolinska Institutet have discovered a network of genes that lower blood cholesterol levels and prevent the development of atherosclerotic plaques. The findings suggest that targeting these genes could be an effective way to combat atherosclerosis, the main cause of myocardial infarction and stroke.
Researchers at Ohio State University have identified a key gene, SUN, controlling the elongated shape of tomatoes. This discovery sheds light on the genetic basis of fruit shape variation in various crops, including peppers and cucumbers.
Researchers identified a new gene associated with autosomal dominant juvenile cataract and renal glucosuria, highlighting the importance of monocarboxylate transporters in eye and kidney health. The discovery may lead to new non-surgical treatment options for age-related cataracts.
A unique DNA gene, matK, has been identified as a potential 'barcode' for plants, allowing for easy identification and cataloging of different species. This discovery could lead to new methods for identifying plant ingredients in traditional medicines and monitoring endangered species.
A powerful new gene-networking model has been developed to identify disease-causing genes, allowing for faster and more efficient discovery. The technique was tested in nematode worms, where it identified new genes involved in tumor development and extended life span by 55 percent.
Researchers at Scripps Research Institute identified a nonsense mutation in the Coronin-1A gene that suppresses lupus development in mice. The study suggests that this mutation and other disease-suppressing genes may play a crucial role in modulating autoimmunity.
An international team of scientists discovered 480 genes that regulate human cell division and identified over 100 genes with abnormal patterns of activation in cancer cells. These findings provide insights into how cancers develop and potentially lead to new treatments.
A comprehensive gene atlas has been created to understand drug addiction, revealing five molecular pathways common to four different addictive substances. The atlas is based on an integrative meta-analysis of scientific literature and provides a more complete picture of the genetic factors underlying addiction.
The Baumann lab has identified the long-sought telomerase RNA gene in a single-cell research model, providing a critical tool for studying telomerase in human cells. This breakthrough sheds light on the correlations between telomere shortening and various diseases, including cancer and coronary heart disease.
New research identifies a second gene, TRIM22, that exhibits rapid evolutionary adaptation to defeat retroviruses, suggesting alternate defense mechanisms over time. The study suggests that both TRIM5 and TRIM22 have played roles in protecting humans against retroviral infections.
Scientists at Einstein College of Medicine identified two genes crucial for packaging fat into lipid droplets. Overexpressing these genes led to a significant increase in lipid droplet formation, while suppressing one of the genes resulted in a drastic reduction. This discovery could lead to new strategies for treating obesity and rela...
Researchers have identified a gene variant associated with increased alcohol consumption in mice, which may provide new targets for developing treatments for alcohol dependence. The study suggests that glutamate pathways play a critical role in addiction and may be targeted by future drugs.
Researchers have identified a key Lupus gene that increases risk by 50%, prompting a need for more patient DNA samples. The OX40L variant is crucial in the immune system and may hold the key to diagnosing and treating the disease.
Scientists at Baylor College of Medicine created a database of molecular profiles for blood cells, identifying unique 'lineage fingerprints' that mark different cell types. They found two genes that, when overexpressed, drove the differentiation of specific blood cells.
UC Riverside scientists will use genomic technology to develop new and improved cowpea cultivars with drought tolerance and resistance to pests and diseases. The goal is to benefit resource-poor African farmers by increasing yields and income generation.
A new gene, GPD1-L, has been identified as responsible for a rare form of cardiac arrest known as Brugada syndrome. The mutation impairs the heart's natural electrical ability to beat in a coordinated manner and maintain a stable rhythm.
A study published in Genome Biology has identified genes associated with alcohol sensitivity in fruit flies. The research team found over 1000 genes that differ in expression between sensitive and resistant flies, including 23 human orthologs that could be linked to alcohol sensitivity in humans.
Scientists have identified a crucial gene, Jhdm2a, that triggers the final step of sperm cell formation. Mice lacking this gene exhibit significant male infertility symptoms. The study provides evidence that Jhdm2a controls expression of genes required for DNA packaging in sperm cells.
Scientists at UCSF have identified naturally occurring processes that allow multiple genes to slow aging and protect against cancer in the C. elegans roundworm. The study suggests that cellular changes leading to longevity antagonize tumor cell growth and highlights a deep evolutionary connection between lifespan and cancer.
Researchers at Weizmann Institute and Teva Pharmaceutical Industries identified genes linked to improved response in MS patients to Copaxone. The discovery may enable personalized treatment and optimize dosage for each patient.
The NIH grant will support research on biological mechanisms of healthy aging, aiming to identify genes contributing to exceptional longevity and prevent age-related diseases. Dr. Nir Barzilai's team will collaborate with experts in gerontology, neurology, genetics, epidemiology, and statistical genetics.
Researchers from the Picower Institute at MIT have identified the gene Ten_m3 as crucial for creating matched projections from both eyes in the brain. In mice with this gene knocked out, visual deficits persisted even when one eye was covered, but blocking the output of one eye restored vision.
Scientists developed a microchip that can identify 56 virulence genes in E. coli bacteria and 54 antimicrobial resistance genes in gram-negative bacteria, speeding up diagnosis and treatment of infections. The chip will enable large-scale monitoring of bacterial pathogens and search for important genes in other pathogens.
Researchers identified genes that are irreversibly activated by smoking, leading to increased lung cancer risk in former smokers. The study's findings provide insight into why former smokers remain susceptible to lung cancer despite quitting.
Researchers found that the MX2 gene is significantly down-regulated in narcoleptic patients' white blood cells, which may contribute to immune system abnormalities. This discovery could help elucidate the pathophysiology of narcolepsy and inform further studies on its functional relationship with the MX2 gene.
Researchers at Duke University Medical Center discovered a novel gene associated with increased susceptibility to multiple sclerosis, which increases risk by 30%. The gene variant affects the function of interleukin-7 receptor alpha, guiding immune system cell development and growth.
A joint research by Dr. Leonid Brodsky and Dr. Milton Taylor identified 37 genes out of 22,000 possible genes which fight the hepatitis C virus. The study's mathematical model can be applied to identify key genes in patient response to treatment, potentially leading to more effective medications.
Researchers at McGill University Health Centre have identified a new gene involved in type 1 diabetes, bringing the total to five genes responsible for the disease. The discovery using high-density DNA microchip technology provides a promising step towards developing effective treatments and prevention methods.
Researchers have identified a new gene mutation in the progranulin gene associated with frontotemporal dementia. The mutation leads to a loss of protein production, which can cause brain cell death. This discovery provides new insights into the disease and may lead to the development of new therapies.
Researchers found antibody levels in African American MS patients were 29% higher than Caucasians, linked to increased disability and shorter disease duration. Genetic background differences may contribute to this disparity.
A team of scientists has identified over 350 immune system genes in the Aedes aegypti mosquito, which transmits deadly diseases like yellow fever and dengue. Understanding these genes' role in virus transmission could lead to new ways of combating these diseases by enhancing the mosquito's immune response.
Researchers compared genes involved in insects' immunity and their ability to spread disease, gaining insights into halting the transmission of diseases like malaria. By analyzing gene sequences with computers, scientists identified key genes to study, paving the way for new experimental research.
A team of Canadian scientists has identified 1,155 genes under the control of Oct4, a master regulator of the stem cell state. These genes help maintain stem cells in a flexible state by controlling DNA packaging, cell division, and signaling pathways.
A new study identifies a genetic 'fellow traveler' that influences the risk of late-onset Alzheimer's disease. The researchers discovered the GAB2 gene, which appears to modify Alzheimer's risk in people with a specific version of the APOE gene.
Researchers identified two DNA regions linked to autism on chromosomes 11 and 17 using a quantitative approach. They found significant linkage to symptoms of autism in families with affected children, which may lead to the discovery of multiple genes contributing to the disorder.