Articles tagged with Gene Identification
Researchers identified 102 genes associated with autism spectrum disorder (ASD), including 49 linked to developmental delays. The large international cohort of nearly 12,000 ASD participants enabled the team to increase the number of associated genes from 65 in 2015.
Researchers at UNIGE discovered a new gene linked to blindness and cardiomyopathy, which causes a deficiency in taurine. Administering a taurine supplement halted the progression of eye disease and treated cardiac disease in two children.
A new study identified Gemin3 as a molecular 'bridge' between genes causing amyotrophic lateral sclerosis (ALS), a neurodegenerative disease. The research holds promise for developing treatments effective for a broad range of ALS patients.
Researchers have identified a second gene, BSND, which determines the severity of kidney disease in patients with Joubert syndrome. The discovery has significant implications for diagnosis and treatment of genetic kidney diseases, offering hope for personalized therapies to reduce disease severity.
A study in Scientific Reports presents a genetic model that accurately estimates lifespans of different vertebrate species by analyzing 42 selected genes and their CpG sites, which are correlated with lifespan. The 'lifespan clock' reveals high predictive power for various species, including extinct ones.
A recent study identified distinct gene signatures associated with memory creation, found in cortical and subcortical regions of the brain. These genes play crucial roles in memory processes, immune signaling, neuronal generation, and mRNA production.
A study identifies 5 genetic markers near the EGLN1 gene linked to high-altitude adaptations, suggesting natural selection in these populations. These markers were found at higher frequencies among 429 Quechua people from Peru compared to lowland populations.
By blocking the expression of c-Answer, a newly identified gene, researchers found that tadpoles can no longer regrow lost tails or limbs. The loss of this gene may have led to the evolution of appendage regeneration in cold-blooded animals.
A new gene, NPSR1, has been discovered that promotes natural short sleep and prevents memory deficits associated with sleep deprivation. The researchers found that the mutant version of NPSR1 is easier to activate and better at switching on other proteins involved in wakefulness.
Researchers have developed a novel way to identify previously unrecognized antibiotic-resistance genes in bacteria using machine learning and game theory. The approach determined the presence of antibiotic-resistant genes in three different types of bacteria with high accuracy.
Researchers from King's College London and UCL have identified 44 genes linked to age-related hearing loss, offering a clearer understanding of the condition's development. The study's findings may lead to new therapies for millions worldwide affected by hearing loss as they age.
Cetaceans lost genes for saliva secretion and lung function to adapt to aquatic life. They also shed melatonin production genes, leading to novel sleep patterns where one brain hemisphere stays awake to generate heat as needed.
A highly predictive genetic risk score is being developed by Paul Tran to identify children at significant risk of developing type 1 diabetes. The algorithm uses a feedforward neural network to analyze thousands of gene variants associated with the disease, aiming to predict with five times better accuracy than current systems.
Brazilian researchers used computational tools to analyze blood cells from patients infected with chikungunya virus, identifying genes associated with the disease and potential biomarkers of predisposition to chronic joint pain. The study suggests that certain gene signatures can be explored as therapeutic targets.
Researchers have identified a new gene, ADRB1, that regulates sleep duration, found in individuals requiring significantly less sleep. The gene's variant was shown to alter the receptor's function, leading to shorter sleep periods.
A study identified genes associated with heart regeneration in neonatal mouse hearts. Genes related to immunity and developmental programs were found to promote regeneration. Enhanced post-MI regeneration was observed in mouse hearts overexpressing the RNA-binding protein IGF2BP3.
Scientists used an epigenetic clock to explore the molecular mechanisms of aging in humans and identified a gene, NSD1, that is closely linked to the process. This research could lead to a better understanding of how aging works and its relationship with various conditions.
Researchers at Tel Aviv University have identified genes that safeguard against Zika viral infection and resuscitate infected cells. The study found that the IFI6 gene provides high levels of protection against the virus, potentially leading to the development of a novel antiviral therapy.
A newly discovered gene in rice renders the crop resistant to several widely used beta-triketone herbicides. The HIS1 gene encodes an oxidase that detoxifies herbicide compounds, offering potential value in breeding new herbicide-resistant crops for efficient global food production.
Huda Zoghbi, MD, is recognized for her contributions to the field of human genetics, including discoveries of genes responsible for Rett syndrome, spinocerebellar ataxia type 1, and other conditions. Her work has enriched the development of human genetics and its applications in science, medicine, and health.
Researchers identified a repeated stretch of DNA as the cause of four rare neurodegenerative diseases, including fragile X tremor/ataxia syndrome and Parkinson's disease. The discovery uses advanced DNA sequencing technology and may lead to insights into other diseases caused by similar mutations.
A corn gene identified from a 118-year-old experiment at the University of Illinois can boost yields by an average of 4.6 bushels per acre, requiring no additional fertilizer inputs. The gene, NAC7, controls senescence and stays green longer, allowing plants to continue photosynthesizing and producing grain.
Researchers have identified the HvAST gene as the cause of variegation in albostrians barley, a breakthrough that sheds new light on chloroplast biogenesis. The discovery provides novel insights into the molecular mechanisms underlying chloroplast development and has significant implications for plant biology.
A joint Australian-Indian study has identified a new genetic variation associated with schizophrenia, found in over 3000 individuals. The research highlights the importance of studying diverse populations to understand the complex causes of the disease.
Researchers from University of Copenhagen identify genetic variant on chromosome 2 that increases the risk of fainting. The study analyzed data from over 400,000 individuals and found that women under 35 are more likely to faint due to this gene variant.
Researchers have created a pan-genome that captures genetic information of 725 cultivated wild tomatoes, revealing nearly 5,000 new genes. This resource promises to help breeders develop more flavorful and sustainable varieties, potentially reducing the need for pesticides.
A new bioinformatics tool analyzes CRISPR pooled screen data to identify candidate genes involved in diseases, outperforming existing methods. The web-based tool is quicker and more user-friendly, empowering non-bioinformaticians to analyze data.
Researchers have discovered a new genetic defect that causes intellectual disability, affecting around 3% of the global population. The newly identified gene target will help improve screening programmes and aid in accurate diagnoses worldwide.
Researchers have identified 34 genes associated with an increased risk of developing the earliest stages of ovarian cancer. The study uses alternative splicing analysis to pinpoint these genes, which can help identify women at high risk and pave the way for new therapies.
A new genetic test accurately identified over 200 disease-causing gene variations in the Old Order Amish and Old Order Mennonite communities. The test could help reduce morbidity and mortality by detecting asymptomatic newborns with rare genetic disorders.
A large-scale study of mouse mutants identified 38 new genes involved in hearing loss, revealing molecular pathways and regulatory processes. The findings provide a rich source of therapeutic targets for restoring hearing and suggest therapies may need to be directed at common molecular pathways.
A large-scale screen of mouse mutants revealed 38 new genes involved in hearing loss, including those related to metabolic pathways and regulatory processes. These findings provide a rich source of therapeutic targets for the restoration of hearing.
A study published in Nature Genetics has identified a gene responsible for cadmium accumulation in durum wheat, a toxic metal that poses serious health risks. The discovery enables the rapid development of low-cadmium durum wheats, increasing the quality and safety of pasta and couscous.
A recent study published in JNeurosci has identified genes and molecular pathways associated with higher educational attainment in older adults. The research found that individuals with higher education levels had thicker prefrontal brain regions, which are linked to improved working memory and decision-making.
The study identifies 30 genes associated with schizophrenia, revealing their impact on brain structure and function. These findings could lead to new drug targets for the treatment of the disease.
Scientists at Cold Spring Harbor Laboratory have created a ranked list of genes that are likely to be involved in any disease, allowing researchers to distinguish between these 'usual suspects' and those unique to specific conditions. The study's findings provide valuable context for interpreting gene activity in disease onset.
A study analyzing genetic data from 791 family trios identified 160 genes associated with preterm birth, many related to inflammatory pathways. Candidate biomarker genes were found in the RAB31 and RBPJ genes, implicated in both preterm and very early births.
A study at St. Jude Children's Research Hospital identified MAP3K8 as the most commonly mutated gene in pediatric spitzoid melanoma, driving cancer growth and treatment response. Comprehensive genomic testing revealed novel mutations, including kinase fusions, that may be targeted by precision medicines.
A team of researchers identified the genes responsible for the hallmark sour taste of many citrus fruits. By analyzing these genes, plant breeders can develop new, sweeter varieties by targeting related genes that reduce acidity. The discovery could lead to the creation of better-tasting citrus fruits.
A recent study identified 57 gene regions associated with insomnia symptoms and found a causal link between insomnia and coronary artery disease. The research suggests that genetics play a role in insomnia symptoms and could lead to new therapeutic targets for insomnia treatment.
Researchers identified a gene defect underlying childhood-onset osteoporosis in two Finnish families and four additional families worldwide. The SGMS2 gene mutation causes changes in bone metabolism and mineralisation, leading to severe short stature and disturbed bone development.
A Rutgers University study has discovered that fruit fly wings remain the same shape even when cells are manipulated to change their division pattern, revealing a new way organs form. This breakthrough could lead to improved diagnosis and treatment of genetic diseases like mitral valve prolapse and van Maldergem syndrome.
Researchers at the University of Helsinki have identified a genetic defect in dogs that causes a rare metabolic bone disease similar to human hypophosphatasia. The study provides the first spontaneous animal model of the disease and may lead to the development of new therapies.
Researchers pinpointed the premelanosome protein (PMEL) gene as the cause of pigmentary glaucoma, a condition that affects 150,000 people in North America. The study found that mutations in this gene lead to vision loss and blindness if left untreated.
A Stanford study has identified a set of 20 genes that predict the severity of dengue fever, allowing for more accurate diagnosis and treatment. The researchers used gene expression data from hundreds of patients to develop a predictive model that can identify patients at risk of severe disease.
Researchers identified specific genes associated with AMD using DNA methylation profiling of human donor eyes. The condition affects central vision and has no treatment for 85% of patients. New targets for therapy may help address the unmet clinical need for AMD treatments.
A team of researchers has identified 261 new genes linked to blindness and vision disorders in mice, which could help identify new causes of hereditary blindness in humans. The study uses a large database of gene-knockout mice to accelerate the application of genomics in clinical medicine.
A study of wild baboons in Kenya found that high-ranking individuals have better access to resources and immune system genes. However, the relationship between social status and health differs between males and females, suggesting a sex-specific connection between rank and immune function.
The Okinawa Institute of Science and Technology has unveiled a new web-based tool called ORTHOSCOPE, which quickly analyzes genomic data to estimate gene trees and identify sets of ancestral genes. This allows researchers to infer gene functions and understand species evolution.
A team of scientists at McGill University Health Centre identified three genes responsible for recurrent molar pregnancies, a rare complication that occurs when a non-viable pregnancy with no embryo implants in the uterus. They discovered MEI1, TOP6BL/C11orf80, and REC114 mutations linked to genetic causes of fetal loss and miscarriages.
Researchers have created a groundbreaking cellular atlas of the brain, revealing over 70 different types of neurons, their locations, and functions. This breakthrough technology allows for unprecedented insights into brain organization and behavior.
Agricultural Research Service scientists have identified key genes and transcription factors in plants that allow them to direct nitrogen to their roots, shoots, flowers, and seed heads. This knowledge may enable the breeding of new plant varieties with improved nitrogen use efficiency.
Researchers have identified 102 genes associated with autism spectrum disorder (ASD) through the largest genetic sequencing study to date. This study distinguishes between ASD and intellectual disability, providing valuable insights into the genetics of ASD.
Researchers identified a cluster of genes responsible for producing the neurotoxin domoic acid in microscopic plants. The knowledge will allow scientists to track the development of bloom toxicity at the genetic level and predict toxin production before it occurs, helping to mitigate harm from algae blooms.
Researchers discover gene H19 has a unique protective effect against the development of overweight and related diseases. Genes from mothers primarily lead to the development of brown fat tissue, which has a protective effect against obesity.
A team of scientists has identified 25 genetic mutations associated with longer lifespans in humans and primates. These findings provide insights into the complex process of aging and may lead to new therapeutic targets for age-related diseases.
A Danish study has estimated 10-year absolute risk of dementia by age, sex and common APOE gene variation, identifying high-risk individuals who may benefit from early preventive interventions. The research found that a combination of these factors could lead to a 7-24% risk of developing dementia by age 80.
The NSF's EDGE program awards $10 million to develop genomic tools that can identify mechanisms determining how genes affect organisms' physical and functional characteristics. Researchers will create innovative tools to predict phenotype, contributing to 'Understanding the Rules of Life' and various societal benefits.
The NSF's EDGE program has awarded $10 million to develop genomic tools that will enable researchers to identify mechanisms determining gene function in organisms. This research aims to advance efforts to predict phenotype by developing enhanced genomic tools and infrastructure, contributing to understanding the rules of life.
Researchers identified genetic mutations associated with increased risk of breast cancer in Nigerian women. The study found that nearly half of patients were diagnosed with triple-negative breast cancer, an aggressive subtype with poor prognosis.