Articles tagged with Gene Identification
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
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Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A highly predictive genetic risk score is being developed by Paul Tran to identify children at significant risk of developing type 1 diabetes. The algorithm uses a feedforward neural network to analyze thousands of gene variants associated with the disease, aiming to predict with five times better accuracy than current systems.
Brazilian researchers used computational tools to analyze blood cells from patients infected with chikungunya virus, identifying genes associated with the disease and potential biomarkers of predisposition to chronic joint pain. The study suggests that certain gene signatures can be explored as therapeutic targets.
Researchers have identified a new gene, ADRB1, that regulates sleep duration, found in individuals requiring significantly less sleep. The gene's variant was shown to alter the receptor's function, leading to shorter sleep periods.
A study identified genes associated with heart regeneration in neonatal mouse hearts. Genes related to immunity and developmental programs were found to promote regeneration. Enhanced post-MI regeneration was observed in mouse hearts overexpressing the RNA-binding protein IGF2BP3.
Scientists used an epigenetic clock to explore the molecular mechanisms of aging in humans and identified a gene, NSD1, that is closely linked to the process. This research could lead to a better understanding of how aging works and its relationship with various conditions.
A newly discovered gene in rice renders the crop resistant to several widely used beta-triketone herbicides. The HIS1 gene encodes an oxidase that detoxifies herbicide compounds, offering potential value in breeding new herbicide-resistant crops for efficient global food production.
Researchers at Tel Aviv University have identified genes that safeguard against Zika viral infection and resuscitate infected cells. The study found that the IFI6 gene provides high levels of protection against the virus, potentially leading to the development of a novel antiviral therapy.
Researchers identified a repeated stretch of DNA as the cause of four rare neurodegenerative diseases, including fragile X tremor/ataxia syndrome and Parkinson's disease. The discovery uses advanced DNA sequencing technology and may lead to insights into other diseases caused by similar mutations.
Huda Zoghbi, MD, is recognized for her contributions to the field of human genetics, including discoveries of genes responsible for Rett syndrome, spinocerebellar ataxia type 1, and other conditions. Her work has enriched the development of human genetics and its applications in science, medicine, and health.
Researchers have identified the HvAST gene as the cause of variegation in albostrians barley, a breakthrough that sheds new light on chloroplast biogenesis. The discovery provides novel insights into the molecular mechanisms underlying chloroplast development and has significant implications for plant biology.
A corn gene identified from a 118-year-old experiment at the University of Illinois can boost yields by an average of 4.6 bushels per acre, requiring no additional fertilizer inputs. The gene, NAC7, controls senescence and stays green longer, allowing plants to continue photosynthesizing and producing grain.
A joint Australian-Indian study has identified a new genetic variation associated with schizophrenia, found in over 3000 individuals. The research highlights the importance of studying diverse populations to understand the complex causes of the disease.
Researchers from University of Copenhagen identify genetic variant on chromosome 2 that increases the risk of fainting. The study analyzed data from over 400,000 individuals and found that women under 35 are more likely to faint due to this gene variant.
Researchers have created a pan-genome that captures genetic information of 725 cultivated wild tomatoes, revealing nearly 5,000 new genes. This resource promises to help breeders develop more flavorful and sustainable varieties, potentially reducing the need for pesticides.
A new bioinformatics tool analyzes CRISPR pooled screen data to identify candidate genes involved in diseases, outperforming existing methods. The web-based tool is quicker and more user-friendly, empowering non-bioinformaticians to analyze data.
Researchers have identified 34 genes associated with an increased risk of developing the earliest stages of ovarian cancer. The study uses alternative splicing analysis to pinpoint these genes, which can help identify women at high risk and pave the way for new therapies.
Researchers have discovered a new genetic defect that causes intellectual disability, affecting around 3% of the global population. The newly identified gene target will help improve screening programmes and aid in accurate diagnoses worldwide.
A new genetic test accurately identified over 200 disease-causing gene variations in the Old Order Amish and Old Order Mennonite communities. The test could help reduce morbidity and mortality by detecting asymptomatic newborns with rare genetic disorders.
A large-scale screen of mouse mutants revealed 38 new genes involved in hearing loss, including those related to metabolic pathways and regulatory processes. These findings provide a rich source of therapeutic targets for the restoration of hearing.
A large-scale study of mouse mutants identified 38 new genes involved in hearing loss, revealing molecular pathways and regulatory processes. The findings provide a rich source of therapeutic targets for restoring hearing and suggest therapies may need to be directed at common molecular pathways.
A study published in Nature Genetics has identified a gene responsible for cadmium accumulation in durum wheat, a toxic metal that poses serious health risks. The discovery enables the rapid development of low-cadmium durum wheats, increasing the quality and safety of pasta and couscous.
A recent study published in JNeurosci has identified genes and molecular pathways associated with higher educational attainment in older adults. The research found that individuals with higher education levels had thicker prefrontal brain regions, which are linked to improved working memory and decision-making.
The study identifies 30 genes associated with schizophrenia, revealing their impact on brain structure and function. These findings could lead to new drug targets for the treatment of the disease.
Scientists at Cold Spring Harbor Laboratory have created a ranked list of genes that are likely to be involved in any disease, allowing researchers to distinguish between these 'usual suspects' and those unique to specific conditions. The study's findings provide valuable context for interpreting gene activity in disease onset.
A team of researchers identified the genes responsible for the hallmark sour taste of many citrus fruits. By analyzing these genes, plant breeders can develop new, sweeter varieties by targeting related genes that reduce acidity. The discovery could lead to the creation of better-tasting citrus fruits.
A study analyzing genetic data from 791 family trios identified 160 genes associated with preterm birth, many related to inflammatory pathways. Candidate biomarker genes were found in the RAB31 and RBPJ genes, implicated in both preterm and very early births.
A study at St. Jude Children's Research Hospital identified MAP3K8 as the most commonly mutated gene in pediatric spitzoid melanoma, driving cancer growth and treatment response. Comprehensive genomic testing revealed novel mutations, including kinase fusions, that may be targeted by precision medicines.
A recent study identified 57 gene regions associated with insomnia symptoms and found a causal link between insomnia and coronary artery disease. The research suggests that genetics play a role in insomnia symptoms and could lead to new therapeutic targets for insomnia treatment.
Researchers identified a gene defect underlying childhood-onset osteoporosis in two Finnish families and four additional families worldwide. The SGMS2 gene mutation causes changes in bone metabolism and mineralisation, leading to severe short stature and disturbed bone development.
A Rutgers University study has discovered that fruit fly wings remain the same shape even when cells are manipulated to change their division pattern, revealing a new way organs form. This breakthrough could lead to improved diagnosis and treatment of genetic diseases like mitral valve prolapse and van Maldergem syndrome.
Researchers pinpointed the premelanosome protein (PMEL) gene as the cause of pigmentary glaucoma, a condition that affects 150,000 people in North America. The study found that mutations in this gene lead to vision loss and blindness if left untreated.
Researchers at the University of Helsinki have identified a genetic defect in dogs that causes a rare metabolic bone disease similar to human hypophosphatasia. The study provides the first spontaneous animal model of the disease and may lead to the development of new therapies.
A Stanford study has identified a set of 20 genes that predict the severity of dengue fever, allowing for more accurate diagnosis and treatment. The researchers used gene expression data from hundreds of patients to develop a predictive model that can identify patients at risk of severe disease.
Researchers identified specific genes associated with AMD using DNA methylation profiling of human donor eyes. The condition affects central vision and has no treatment for 85% of patients. New targets for therapy may help address the unmet clinical need for AMD treatments.
A team of researchers has identified 261 new genes linked to blindness and vision disorders in mice, which could help identify new causes of hereditary blindness in humans. The study uses a large database of gene-knockout mice to accelerate the application of genomics in clinical medicine.
A study of wild baboons in Kenya found that high-ranking individuals have better access to resources and immune system genes. However, the relationship between social status and health differs between males and females, suggesting a sex-specific connection between rank and immune function.
The Okinawa Institute of Science and Technology has unveiled a new web-based tool called ORTHOSCOPE, which quickly analyzes genomic data to estimate gene trees and identify sets of ancestral genes. This allows researchers to infer gene functions and understand species evolution.
A team of scientists at McGill University Health Centre identified three genes responsible for recurrent molar pregnancies, a rare complication that occurs when a non-viable pregnancy with no embryo implants in the uterus. They discovered MEI1, TOP6BL/C11orf80, and REC114 mutations linked to genetic causes of fetal loss and miscarriages.
Researchers have created a groundbreaking cellular atlas of the brain, revealing over 70 different types of neurons, their locations, and functions. This breakthrough technology allows for unprecedented insights into brain organization and behavior.
Agricultural Research Service scientists have identified key genes and transcription factors in plants that allow them to direct nitrogen to their roots, shoots, flowers, and seed heads. This knowledge may enable the breeding of new plant varieties with improved nitrogen use efficiency.
Researchers have identified 102 genes associated with autism spectrum disorder (ASD) through the largest genetic sequencing study to date. This study distinguishes between ASD and intellectual disability, providing valuable insights into the genetics of ASD.
Researchers identified a cluster of genes responsible for producing the neurotoxin domoic acid in microscopic plants. The knowledge will allow scientists to track the development of bloom toxicity at the genetic level and predict toxin production before it occurs, helping to mitigate harm from algae blooms.
Researchers discover gene H19 has a unique protective effect against the development of overweight and related diseases. Genes from mothers primarily lead to the development of brown fat tissue, which has a protective effect against obesity.
A team of scientists has identified 25 genetic mutations associated with longer lifespans in humans and primates. These findings provide insights into the complex process of aging and may lead to new therapeutic targets for age-related diseases.
A Danish study has estimated 10-year absolute risk of dementia by age, sex and common APOE gene variation, identifying high-risk individuals who may benefit from early preventive interventions. The research found that a combination of these factors could lead to a 7-24% risk of developing dementia by age 80.
The NSF's EDGE program has awarded $10 million to develop genomic tools that will enable researchers to identify mechanisms determining gene function in organisms. This research aims to advance efforts to predict phenotype by developing enhanced genomic tools and infrastructure, contributing to understanding the rules of life.
The NSF's EDGE program awards $10 million to develop genomic tools that can identify mechanisms determining how genes affect organisms' physical and functional characteristics. Researchers will create innovative tools to predict phenotype, contributing to 'Understanding the Rules of Life' and various societal benefits.
Researchers identified genetic mutations associated with increased risk of breast cancer in Nigerian women. The study found that nearly half of patients were diagnosed with triple-negative breast cancer, an aggressive subtype with poor prognosis.
Researchers at Tohoku University have identified the retrotransposon insertion in a floral homeotic gene responsible for greenish orchid mutations. This discovery paves the way for genetic modification of orchids to produce more flowers.
Researchers at Tokyo Institute of Technology have identified an enzyme, GPAT1, as a promising target for increasing biofuel production from red algae. The study found that TAG productivity could be increased by more than 56 times in a strain overexpressing GPAT1 without negative effects on algal growth.
Researchers have identified 85 genes essential for fission yeast cells to maintain their ability to divide after being starved of nitrogen. The study sheds light on the genetic network required for resting cells like cancer stem cells to reactivate and has potential applications in developing new therapies to treat cancer. This discove...
Researchers have discovered new genes that may contribute to the development of Alzheimer's disease, a complex condition characterized by neurodegeneration and memory decline. The study identified rare variations in genes associated with an inflammatory response and changes in protein production.
A new computational approach has identified genes that may enable microbes to colonize the human gut and survive in its harsh environment. The researchers found thousands of genes across different species that are prevalent in the gut, including those specific to this environment.
Researchers developed a novel approach to identify microbial genes specifically present in the gut, accounting for ancestral relationships between bacteria. The analysis uncovered thousands of genes associated with bacteria prevalent in the gut and those linked to Crohn's disease.
Researchers discovered that gene CD36 is unusually active in older cells, causing them to stop dividing. This effect can spread to nearby cells, leading to senescence. The study highlights the importance of understanding cellular aging and its implications for age-related diseases and cancer.
Researchers have identified novel genes associated with childhood-onset schizophrenia, a rare form of the disorder. The discovery is expected to aid in diagnosis and the development of treatments for this severe condition.
Researchers used fruit flies to test the effects of TBX2 genetic variants in patients with congenital heart defects and skeletal abnormalities. The study found that the variants moderately affected eye development, retinal function, and lifespan in flies, suggesting their pathogenic potential.
Scientists deciphered the biosynthetic gene cluster for furanosteroid demethoxyviridin, a nanomolar-potency inhibitor of phosphatidylinositol 3-kinase (PI3K). The research group identified key enzymes involved in the biosynthesis pathway.
Scientists at Karolinska Institutet have identified the cell types underlying schizophrenia, providing a roadmap for developing new therapies. The findings suggest that certain cell types contribute to the disorder and may require separate treatments.
The researchers have identified a gene called Ankrd16 that prevents the production of harmful protein aggregates in neurological disorders such as Alzheimer's and Parkinson's disease. Elevating levels of Ankrd16 protects specific neurons from dying, while removing it leads to widespread buildup of abnormal proteins.