Articles tagged with Gene Identification
Researchers created the first detailed cell-by-cell description of how the coronal suture develops, identifying new genes and cell types involved in generating stem cells that grow skull bones. The study aims to advance new interventions for patients with craniosynostosis.
A USF Health study found that deleting a single gene, Foxo1, promotes the growth of functional lymphatic valves in both young and adult mice. This discovery offers a promising early treatment approach for hereditary lymphedema, a chronic condition characterized by fluid accumulation under the skin.
Researchers have discovered an enzyme that enables the accumulation of p-hydroxybenzoic acid in plant cell walls, a potential game-changer for sustainable industrial chemical production. By controlling the expression of this enzyme, plants can be engineered to produce more of this valuable chemical building block.
Scientists have identified nearly 300 gene variations that influence reproductive lifespan in women. Manipulating key genes in mice extended their reproductive lifespan, providing insights into the biology of reproductive ageing.
The KAUST Metagenomic Analysis Platform (KMAP) enables researchers worldwide to analyze massive microbial data, eliminating the need for advanced bioinformatics skills. KMAP allows scientists to identify proteins and enzymes with potential applications in various industries, such as agriculture and pharmaceuticals.
Researchers identified a novel lncRNA, Teshl, which plays a crucial role in the development of Y-bearing sperm and regulates sex chromosome gene expression. The study provides new insights into sex ratio variations and suggests that genetics may be a key factor in human male infertility.
Researchers developed a machine learning tool, BoostDM, that evaluates the potential contribution of mutations in genes to cancer development. The tool helps understand how tumors are caused at the molecular level and can facilitate medical decisions regarding therapy.
Researchers have identified the VC1 gene as the source of faba bean's anti-nutrients vicine and convicine. This discovery enables the breeding of low-anti-nutrient varieties, improving food safety and sustainability. The study provides a crucial step towards a global switch to plant-based diets.
Researchers have identified the gene responsible for faba bean's production of vicine and convicine, two compounds that cause favism in susceptible individuals. The team has also found a specific mutation within this gene that reduces synthesis, leading to low vicine and convicine content in certain varieties.
Biologists have identified 71 new 'imprinted' genes in the mouse genome, which tend to be more active in one parental version than the other. The discovery sheds new light on epigenetics and its importance in health and disease.
Researchers at Virginia Tech have identified a novel gene, Per2AS, that controls the sleep/wake cycle in mice, revealing the importance of non-coding genes in regulating biological processes. The study's findings could lead to breakthroughs in understanding internal body clocks and their role in various diseases.
A study found that travellers who returned from abroad acquired and spread destination-specific antimicrobial resistance genes in their gut microbiome. The diversity of these genes increased significantly after travel, with high-risk genes resistant to common antibiotics identified.
Scientists have identified a set of microbial genes that play a crucial role in converting bile acids into beneficial forms. This discovery could lead to the development of therapeutic strategies to enhance gut health and prevent diseases associated with unbalanced bile acid levels.
Finnish researchers have identified the LOXHD1 gene as the cause of nonsyndromic early-onset hereditary canine hearing loss in Rottweilers. The study's findings have implications for breeding practices, allowing dogs to be tested for the defective gene and preventing deafness in puppies.
A new computational approach identifies genes most likely linked to autism spectrum disorders (ASD) and predicts patient IQ using rare mutations. Researchers analyzed de novo missense mutations in a cohort of patients with ASD and their siblings, revealing that most genes are mutated only once.
Research identified specific genetic variants associated with COVID-19 risk, including the ABO gene and others like SLC6A20 and ERMP1. These variants can increase the chances of developing COVID-19, highlighting the importance of genetic factors in disease susceptibility.
Researchers have identified a complex network of genes controlling sleep cycles that can be understood and potentially changed. This knowledge could lead to medicines for individuals with disrupted circadian rhythms and improved crop production.
A team of University of Michigan researchers identified many genes crucial for fruit fly neuron development, including three previously unknown ones. The discovery provides insights into the complex process of neurogenesis and may lead to new approaches for understanding human brain development and regeneration.
UC Riverside researchers identified a gene, RCB, that enables plants to sense heat and respond accordingly. This discovery is crucial in developing heat-tolerant crops to address the impact of global warming on crop yields by one-third by 2050.
A UC Riverside geneticist has won a $1.7 million grant to study how barley has adapted to survive thousands of years, with the goal of understanding its future survival in extreme weather conditions. The project will also train undergraduates in agricultural science and computational techniques.
Researchers have identified seven genes essential for normal cell division, allowing a synthetic cell to grow and divide uniformly. This breakthrough aims to engineer synthetic cells for various applications, including drug production, disease detection, and computing.
Researchers discovered a rare genetic variant that dampens innate immunity to COVID-19, increasing the risk of severe disease in younger men. Genetic testing and interferon treatment may benefit affected individuals.
A genetic defect has been identified as a key factor in the development of MacTel, an eye disease that can lead to vision loss and blindness. The discovery provides new insights into the condition and may enable clinicians to better diagnose and treat it.
Researchers found 300 genes associated with neural oscillations, including hub genes that control separate gene networks. Surprisingly, several of these hubs were active in glial cells, which support and protect nerve cells. This discovery provides an entry point for further research into the underpinnings of human memory.
Researchers at Earlham Institute created a new automated workflow using liquid handling robots to identify the genetic basis of preventing plant pathogens. The new technology screened 2,880 mutants in just 11 hours, identifying a gene cluster linked to growth inhibition of the common potato pathogen.
A new software tool called scfind allows researchers to quickly query datasets generated from single-cell sequencing, identifying which cell types any combination of genes are active in. This enables swift analysis of multiple datasets containing millions of cells by a wide range of users.
Researchers have identified 40 genes that suppress axon regeneration in central nervous system cells, hindering recovery from brain and spinal cord injuries. By editing out one gene, they restored axons in mouse models with glaucoma, suggesting a potential new approach to treating neural damage.
Hypertrophic cardiomyopathy (HCM) is a complex disease characterized by thickening of the left ventricle. Researchers have identified patient-specific protein networks using RNA-seq and tissue samples from HCM patients. This study offers a path toward individualized medicine for treating HCM.
A new 523-gene panel has been developed to diagnose and treat acute myeloid leukemia (AML), identifying more genetic mutations and potential treatment targets. The panel has shown high sensitivity and specificity in detecting AML and has the potential to improve patient outcomes.
Researchers at NUI Galway have contributed to a significant international study identifying nine specific genes linked to breast cancer risk. The study, published in the New England Journal of Medicine, used DNA samples from 2,000 Irish patients and controls to uncover key genetic associations.
Researchers discovered a gene that shows butterflies and flowers independently evolved to make the same chemical compound for different purposes. Male butterflies use this pheromone to repulse competitors and attract females only once.
Researchers identified key gene networks controlling sugar and organic acid metabolism in watermelon fruit, shedding light on its sensory quality. The study's findings have important implications for improving watermelon breeding levels in China and the development of the watermelon industry.
A study on lettuce reveals that the genetic basis of leaf heading is controlled by a single gene, LsKN1, which promotes compact head development and prolongs shelf life. The researchers found that a transposon insertion in this gene elevates its expression, leading to heading in crisphead lettuce.
Biologists from RUDN University identified polymorphisms in six genes that determine flaxseed oil's fatty acid composition and shelf life. The study found specific gene variations that extend the shelf life of flaxseed oil, improving genetic selection for new flax breeds.
Researchers have identified the BICRA gene as a new disease gene involved in neurodevelopmental disorders. The study found that mutations in the BICRA gene can cause disease in humans and flies, and may provide new insights into how to develop individualized medical plans for patients with similar conditions.
Researchers at Harvard University have identified a key gene POPOVICH responsible for floral nectar spur development, a crucial innovation in plant evolution. This discovery provides insight into the origin of this trait and its role in promoting biodiversity among flowering plants.
The study analyzed over 591,000 chemical-gene interactions and found that almost every well-known molecular pathway is sensitive to chemicals to a certain degree. The researchers identified genes and pathways most sensitive to chemical exposures, including aging, lipid metabolism, and autoimmune disease.
A new tissue screening assay for human cerebral organoids identified 25 additional candidate genes for microcephaly, nearly doubling the number of currently known genes linked to the rare neurological condition. The CRISPR-LICHT technology revealed these genes associated with both known and previously unknown microcephaly-driving pathw...
Researchers identified 28 new genes associated with developmental disorders, including 500 families, using the largest genetic resource available. The study estimates that another 1,000 genes linked to these conditions remain undiscovered.
Researchers at the Donald Danforth Plant Science Center have identified a novel seed dispersal gene in wild green millet, which could lead to more efficient crop production. The discovery was made through the analysis of nearly 600 genome sequences and confirmed by gene editing studies.
A new study in mice identifies a critical gene for short-term memory that functions in the thalamus, not traditionally associated with memory. Disabling this gene enhances working memory in low-performing mice.
Researchers at UMD discovered that mosquitoes lack a critical gene for proper body segmentation, but a related gene took its place. This finding highlights the importance of caution in genetic studies and offers new potential avenues for targeted mosquito control strategies.
Research reveals genetic differences in fat storage and formation affecting disease susceptibility in men and women. Six genes were identified as potential therapeutic targets for distinct outcomes in each sex.
Researchers identified thousands of rare epigenetic variations in the human genome, linked to abnormal gene expression and Mendelian diseases. The study highlights the significance of epivariations in contributing to a fraction of genetic diseases, including hereditary cancers.
Scientists at Nagoya University discovered two genes, ACE1 and DEC1, that counteract each other to regulate rice plant stem growth. The findings suggest a new approach for genetically modifying rice crops to improve yield and adaptability.
A team of researchers has identified a key gene, POPOVICH, responsible for the development of nectar spurs in Aquilegia. The study used a spurless species to pinpoint the gene and found that it promotes cell divisions in the regions where the spur develops.
Researchers at UC Santa Barbara have identified a gene critical to the development of columbines' iconic spurs, which has led to rapid expansion in the genus. The discovery provides new insights into how key innovations evolve and could shed light on the genetic changes underlying this trait.
Researchers from IRB Barcelona have identified 568 cancer driver genes, play specific roles in cell growth regulation, DNA replication, and more. These genes confer malignant cells rapid reproduction, immune evasion, and invasive capabilities.
Researchers from NUS identified covalently closed circular RNAs (circRNAs) from the ASXL1 gene involved in leukemia development and found that circASXL1-1 regulates BAP1 deubiquitinase activity. The study provides insights into a new mechanism for H2AK119ub levels regulation, which could lead to targeted therapeutic approaches.
A new software program can identify drug-resistant genes in bacteria with up to 90% accuracy. The WSU research team developed a machine-learning algorithm that uses features of AMR proteins to identify AMR genes, providing a more efficient way to predict antimicrobial resistance.
Dr. Jeffrey A. Towbin, a researcher at Le Bonheur Children's Hospital, has received a NIH research project grant to identify modifier genes in cardiomyopathy. The study aims to understand how different genetic backgrounds affect the expression of myopalladin, a gene linked to the severity of cardiomyopathy.
Researchers are collecting DNA data from popular home genetic-testing kits to identify key genes involved in the body's response to Covid-19. The study, called Coronagenes, aims to understand why some people become ill while others remain symptom-free.
Researchers have identified genes implicated in neurodegeneration throughout the stages of Alzheimer's disease using gene-network analysis. The study found that protein domain networks collapse during the progression of AD, leading to neuronal dysfunction and neurodegeneration.
Researchers have identified ATP10B as a novel risk gene for Parkinson's disease, revealing its role in transporting glucosylceramide, a lipid critical to the disease's pathogenesis. Mutations in this gene can lead to neuronal loss and increased sensitivity to environmental risk factors.
A gene switch, excessive number of floral organs (eno), plays a crucial role in boosting fruit size during tomato domestication. Analysis reveals that mutations in eno result in larger flowers and fruits, leading to higher yields.
Researchers found that mutations in gene ydcI cause increased numbers of persisters, a type of bacteria resistant to antibiotics. Persisters have memory loss, leading to abnormal growth and making them difficult to treat.
Researchers found that a specific gene is switched off in alpine plants, allowing them to grow hairs and protect against UV sunlight. The discovery could aid the production of useful chemicals and provide insights into plant evolution.
Scientists from UNIGE and HUG identify monogenic diabetes in 42% of pediatric patients, enabling tailored treatments. The study highlights the need for precision medicine to address chronic hyperglycemia, suggesting a systematic diagnosis approach to minimize long-term complications.
Researchers developed a new database of gene essentiality, providing insight into the causes of rare childhood diseases. The study identifies new mutations likely responsible for these conditions and offers a valuable resource for clinicians and researchers.
Researchers identified 102 genes associated with autism spectrum disorder (ASD), including 49 linked to developmental delays. The large international cohort of nearly 12,000 ASD participants enabled the team to increase the number of associated genes from 65 in 2015.