Articles tagged with Gene Identification
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
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Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Scientists have identified a key gene that can improve wheat grain yield by increasing the number of spikelets per spike. The discovery provides a promising solution to address the food security crisis and could lead to significant improvements in wheat yields.
Researchers identified Srrm3 as a master regulator gene for photoreceptor cells in the retina, which is critical for visual function. The study found that misregulation of alternative splicing and microexons can lead to devastating health impacts, including vision loss.
Researchers have identified a second gene, CLDN5, as responsible for AHC in two unrelated cases. The mutated protein disrupts the blood-brain barrier's integrity, leading to the condition's characteristic symptoms.
Researchers at the University of Maryland identified AGL62 as the trigger for fruit and seed development in flowering plants. The study showed that AGL62 stimulates auxin production, which regulates endosperm growth and fruit enlargement.
Researchers have identified over 1,500 genetic differences between migratory and non-migratory hoverflies, shedding light on the genetic pathways involved in migration. The study reveals suites of genes being activated in concert, including insulin signalling for longevity and pathways for immunity.
A new statistical method called Association Plot facilitates the determination and analysis of marker genes in single-cell data. This allows researchers to trace back RNA molecules to their cell of origin, providing insights into cell-type specific genes.
Researchers from the Max Planck Institute for Chemical Ecology elucidate the complete biosynthetic pathway of strychnine, a highly toxic alkaloid used as rat poison. The study reveals that the conversion of prestrychnine to strychnine occurs spontaneously, without an enzyme.
The Emu project effectively identifies bacterial species by leveraging long DNA sequences spanning the entire length of the gene under study. This approach facilitates the analysis of key genes in microbiome researchers' efforts to sort out harmful and helpful bacteria.
A Danish research study has made significant discoveries about the CRISPR/Cas9 protein and its gRNA component, enabling more accurate gene modification. The findings aim to optimize the effectiveness of gene editing, addressing concerns over 'off-target effects'.
A novel single-cell RNA sequencing technique, TAS-Seq, has been developed to provide higher-precision data than current methods. The new method detects more genes and identifies highly variable genes, making it a sensitive high-throughput scRNA method.
A new gene, RAP1GAP2, has been identified as a potential contributor to the disparity in heart disease diagnosis and treatment between men and women. The study aims to analyze how this gene affects cardiac disease risks among women of different racial and ethnic groups.
Researchers identify key features of a gene mutation responsible for 15-20% of melanomas, establishing a link between the frequency of specific NRAS mutations and spontaneous melanoma formation. The study could help pinpoint early events required for melanoma formation and develop targeted treatments.
Researchers at the University of Exeter have identified a new gene, TMEM63C, that causes a degenerative disease affecting upper motor neuron cells. The study suggests that MNDs are caused by abnormal lipid processing pathways inside brain cells, which could lead to new diagnostic approaches and treatments.
Researchers identified a three-gene signature in multiple myeloma tumors that predicts a positive response to selinexor-based therapy. The discovery could improve patient selection for targeted agents and expand the use of the drug into patients who haven't failed other therapies.
Researchers identified specific genetic signals in people with severe coronavirus infection using machine learning. They found that more than 1,000 genes linked to the development of severe COVID-19 cases account for three-quarters of the genetic drivers for severe illness.
A new machine learning algorithm called 'ikarus' has found a gene signature characteristic of tumors, distinguishing between healthy and tumor cells in various types of cancer. The algorithm was trained on single-cell sequencing data sets and demonstrated an extraordinarily high success rate in distinguishing between different cell types.
Biologists at the University of Rochester have identified two key systems controlling gene expression related to longevity: circadian networks regulating negative lifespan genes and the pluripotency network controlling positive lifespan genes. This research provides new insights into understanding how longevity evolves and may lead to ...
Researchers have identified the genetic causes of three mitochondrial diseases and proposed 20 additional possibilities for further investigation using a new approach. The study provides a platform to better understand how mitochondria's hundreds of proteins work together, which could lead to improved diagnoses and treatments.
A study led by Tel Aviv University researchers reveals a common mechanism underlying genetic mutations associated with autism, schizophrenia, and other neurological disorders. The discovery points to an experimental drug developed by the team as a potential treatment for these conditions.
Researchers discovered a new gene, ZBTB11, that drives heart muscle cell degeneration in arrhythmogenic cardiomyopathy. The gene's activity induces damage to neighboring heart cells, a key process in the disease.
A new study identified the Cnpy4 gene as a crucial modulator of the Hedgehog signaling pathway, which regulates growth and development during embryonic stages. This discovery could lead to potential new treatments for cancers related to Hedgehog signaling and birth defects involving extra fingers or toes.
A study comparing whole genomes of several mustelids, including the tayra and wolverine, identifies multiple sources of genomic variation contributing to species-specific traits. The research sheds light on how these adaptations evolved in response to different ecological challenges.
Researchers have identified a cork-like substance called suberin that helps protect rice roots from floods and drought. By understanding how suberin is produced, they hope to use gene editing or selective breeding to make the crop more resilient to climate change.
Researchers at King Abdullah University of Science & Technology (KAUST) have identified a stem rust resistance gene in Aegilops sharonensis and transferred it to common wheat. The new transgenic wheat lines show high levels of resistance to the stem rust pathogen, providing hope for mitigating the devastating effects of climate change.
A new study suggests that up to 1 in 4 cases of congenital hydrocephalus may be linked to genetic mutations affecting neural stem cell growth, leading to underdeveloped brains and enlarged ventricles. This paradigm shift could lead to targeted therapies such as gene editing or drugs to optimize neurodevelopment.
Brazilian researchers have discovered two novel enzyme families in the capybara's gut, which can accelerate the utilization of agroindustrial waste. The enzymes have biotechnological potential and can be used to produce biofuels, biochemicals, and biomaterials.
A research team from the Max Planck Institute for Terrestrial Microbiology has identified 1,000 biosynthetic gene clusters, over half of which are previously unknown. These natural products have been found to be eukaryotic proteasome inhibitors that suppress the immune system of insects, as well as other virulence factors.
Researchers developed a computational technique to predict favorable gene sequences that make Rubisco, a key plant enzyme for photosynthesis. The study found promise for developing faster and more efficient Rubisco enzymes to increase crop yields and adapt to hot, dry future conditions.
Researchers analyzed genomic profiles of over one million cells from 1,000 people, identifying a link between specific genes and immune cell types in autoimmune diseases. The discovery could lead to tailored treatments and refine clinical trials.
A study published in Ophthalmology identified the genetic spectrum behind foveal hypoplasia, a rare condition affecting vision development. The research combined data from over 900 cases across the globe and revealed relationships between genetic defects and the degree of arrested foveal development.
Researchers fill in gaps in Human Reference Genome, discovering repetitive sections are a major source of human variation and genetic diversity. The Telomere-2-Telomere project reveals complex architectural features with significant consequences for understanding human evolution and biological function.
The T2T consortium's completed human genome has shown significant improvements in DNA sequencing accuracy, correcting tens of thousands of errors and revealing millions of genetic variations. This new reference genome can support the analysis of over 200 genes of medical relevance, potentially propelling research into genetic disorders.
Researchers use stem cells from people with extra X chromosomes to identify key genes contributing to symptoms like infertility and intellectual disability. The study's findings could lead to new treatments for these conditions.
A team of researchers identified a stem rust resistance gene from wild goat grass species Aegilops sharonensis, which can be cross-bred into wheat for immunity against deadly crop pathogens. The genetic potential of this hardy relative has been largely unexplored and holds promise for reducing the threat of the stem rust disease.
Researchers examine the value of studying underutilized crops and identify specific genes that underpin their adaptive traits. The review advocates for extensive genome sequencing to breed favorable varieties with mainstream potential.
Researchers used single cell RNA-sequencing to identify specific cells and genes in maize roots responsible for nitrate uptake. The study provides valuable insights into optimizing root nutrient uptake ability in crops.
Researchers at the University of Birmingham identified a new gene, Highlander, that regulates self-incompatibility in plants. The discovery opens up new avenues for improving crop yields and resistance to disease.
Researchers have identified 79 ASD-associated genes and found that many of them alter behavior in fruit flies, providing functional evidence for their consequences. The study also uncovered a new form of rare disease due to the GLRA2 gene, highlighting the importance of de novo genetic variants in autism.
Researchers developed a novel genetic barcode system to mark cancer cells with different gene modifications and image their characteristics. The Perturb-map platform identified specific genes controlling lung tumor growth, immune composition, and response to immunotherapy, offering new approaches for targeting anti-cancer drugs.
Researchers have identified a key gene that confers stripe rust resistance in bread wheat, providing hope for improving crop yields and ensuring global food security. The discovery was made possible by the assembly of the highest-quality genome to date for bread wheat using advanced DNA sequencing techniques.
Researchers found that the Klotho gene can suppress glioblastoma cell viability and induce apoptosis, leading to a significant decrease in tumor growth. The study contributes to the development of new diagnostic and treatment approaches for malignant brain tumors.
Researchers at Johns Hopkins Medicine discovered a critical step in the molecular circuitry of immune cells that mobilizes the immune system to fight off foreign invaders. The findings, published in iScience, shed light on subtle genetic variations among human populations that may explain individual responses to infections.
A new DNA test has been developed to identify a range of hard-to-diagnose neurological and neuromuscular genetic diseases quicker and more accurately than existing tests. The test uses Nanopore sequencing technology to scan for abnormally long repeats within patients' genes, which are the hallmarks of disease.
Researchers at Massachusetts General Hospital identified genetic variants in fibrillar collagen genes that increase the risk of spontaneous coronary artery dissection (SCAD), a common cause of fatal heart attacks in young women. The study's findings provide a potential new target for therapies to prevent SCAD.
Researchers have discovered a genetic difference in the meniscus that makes about 50% of females more prone to developing knee osteoarthritis than males or other females. The study suggests potential for a blood test to identify high-risk individuals, allowing for early interventions and prevention strategies.
Researchers at Weill Cornell Medicine have identified a protein called HDP1 that plays a critical role in activating genes required for the development of male and female stages of the malaria parasite. Without HDP1, parasites are unable to assemble mature gametocytes, leading to their death and inability to infect mosquitoes.
A new study has identified the critical genes most likely to cause coronary heart disease and trigger heart attacks. The research provides a prioritized list of 162 genes, which will enable more accurate genetic testing and targeted therapies for patients at risk of coronary heart disease.
Researchers at UC Davis MIND Institute found a novel gene linked to autism spectrum disorder in newborns. The study analyzed DNA methylation signatures in the placenta, which reflected fetal brain development and early autism diagnosis.
Researchers at Mayo Clinic Cancer Center developed a machine learning algorithm that integrates genetic data from over 5,000 patients to predict patient benefit from chemotherapy and immunotherapy. A 32-gene molecular signature was identified, providing prognostic information and predicting patient response to immunotherapy.
University of Illinois researchers found a key gene responsible for increasing soybean protein content by approximately 2%. The discovery could lead to significant increases in protein production, addressing global food security issues. However, the gene's function is unclear and may involve the plant's circadian machinery.
Researchers at San Diego State University have discovered a novel way bacteria infect cells by producing long threads, which grows up to 100 times the size of a bacterium in 30 hours. This mechanism allows the bacteria to rapidly infect multiple cells and access more nutrients for growth.
The Purdue Research Foundation Office of Technology Commercialization has awarded more than $143,000 to three projects led by researchers in the College of Agriculture, Engineering and Veterinary Medicine. Guri Johal is developing a corn variant that could impact worldwide corn production with Trask funds supporting his project on clon...
A team of researchers at UMass Amherst identified the specific genes responsible for growth suppression in maize flowers, including GRASSY TILLERS1 and RAMOSA3. These findings provide insights into the evolution of life on earth and have implications for plant breeding, benefiting humans from apples to corn.
Researchers identified seven rare structural variants affecting 31 genes in severely ill COVID-19 patients, shedding light on individual responses to the virus. These genetic variations may help explain differences in illness severity and suggest potential targets for early intervention.
A study led by Clemson University geneticist Allison Hickman has identified 11 high-priority genes associated with uterine cancer. These genes are potential targets for drug therapies, offering new hope for effective treatment options.
A team of researchers at Harvard's Wyss Institute and ETH Zurich have developed a computational approach to identify genomic safe harbors (GSHs) with high potential for safe insertion of therapeutic genes. The study validated two GSH sites in adoptive T cell therapies and in vivo gene therapies for skin diseases.
Researchers found that some people's genes determine whether they store fat in a 'favourable' or 'unfavourable' way, affecting their risk of diseases. Even those with 'favourable adiposity' are still at risk for certain health issues.
A new study published in Mammalian Biology analyzed the life history data of 13 North Atlantic right whales using genetic samples and photo identification. The researchers found that four calves previously thought to be dead survived, revealing a significant variation in calf separation time from mothers and physical development.
A new machine learning model, RefMap, has identified 690 genetic risk factors for motor neurone disease, a five-fold increase from previous estimates. This discovery could lead to the development of new treatments and personalized medicine for patients with MND.
Researchers have identified a previously unknown gene, goldentouch, responsible for the golden coloration in Midas cichlids. The gene, found on chromosome 11, is present in two variants: one associated with dark coloration and the other with orange/yellow coloration.