Articles tagged with Gene Targeting
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Researchers block DNA repair pathway in leukemia stem cells by targeting protein RAD52, which is crucial for fixing genetic mistakes. This approach may lead to a new strategy to overcome drug resistance in cancer patients.
A new study found that baby boomers' interest in health issues peaks in the early 50s and again near age 65. Health professionals are encouraged to target this generation with health messages at these times, as they are most receptive to hearing them.
Researchers suggest that causation may be the root of temporal binding, a phenomenon where events close in time are perceived as meaningful episodes. The study found that participants in experiments anticipating an event's flash showed significantly later predictions than those without causal understanding.
Researchers develop miR-TRAP, a new method to directly identify microRNA targets in cells. This technique allows scientists to understand the roles microRNAs play in human development and disease, bridging a gap in the RNA field.
A new gene-editing tool using TALENs has been developed, enabling researchers to target any DNA sequence with high accuracy. The FLASH system allows for the automated construction of up to 96 TALENs in a single day at a low cost.
Researchers at Winship Cancer Institute developed a technique to remove cancer cells' defenses against radiation by disabling their ability to repair DNA. The experimental method uses RNA molecules that shut down genes needed for DNA repair, making brain and lung cancer cells more sensitive to X-ray radiation.
Insect metamorphosis triggered by hormones, like puberty in humans, involves a global change of rules for gene expression. Researchers found that a specific gene and signaling pathway work together to control development at different stages.
Researchers at University of Missouri have found that targeting synthetic RNA to a specific gene can significantly lower the severity of Spinal Muscular Atrophy in mice. The study shows promising results with improved motor skills and increased weight in affected animals.
Researchers at the University of Illinois have identified 25 microRNAs associated with glioblastoma survival and discovered 20 new microRNAs linked to initiation or growth of other cancer types. These findings suggest common pathways that can be targeted with similar drugs, offering hope for improved treatment options.
Researchers perfect a method to temporarily turn off essential genes in adult mice without killing them, allowing for reversible gene silencing. This breakthrough enables testing of therapeutic targets and evaluation of their efficacy and side effects.
A CSHL-led team developed a powerful method to identify potent RNAi triggers, allowing biologists to fully exploit this natural mechanism. The approach revealed new insights into small RNA biogenesis and improved the recipe for creating potent RNAi triggers.
Scientists have discovered a genetic partnership between two proteins that enables nerve cells to connect correctly in the brain. The study suggests that similar mechanisms may play a role in human brain development and could lead to new therapies for developmental disorders.
A new study has identified DUO1, a genetic hierarchy that governs sperm cell production and fertility in flowering plants. The research found that DUO1 acts as a master switch to ensure twin fertile sperm cells are made in each pollen grain.
Scientists at Virginia Tech have identified a critical step in juvenile hormone signaling, which could lead to more targeted mosquito controls. The discovery of a protein partner for the juvenile hormone receptor has significant implications for understanding insect development and reproductive maturation.
A new approach called context-dependent assembly enables the rapid generation of powerful zinc-finger nucleases, which can efficiently correct gene mutations in humans. This innovation allows researchers to design ZFNs for specific genes with ease, overcoming limitations of previous methods.
Researchers have identified about a thousand brassinosteroid target genes, revealing molecular links between the steroid and various cellular functions. The study provides the first comprehensive action map for a plant hormone, accelerating basic plant science and crop research.
Researchers have identified a novel mechanism regulating circadian rhythms that could provide a new target for treating jet lag, shift work, sleep disturbances, diabetes, obesity, and some types of cancer. The discovery offers hope for modulating the body's core clock using synthetic ligands targeting nuclear receptors.
Antigene therapy utilizes a DNA-based drug that attaches directly to specific DNA sequences and is activated by light energy, effectively silencing targeted genes. This approach may offer new hope for treating diseases currently incurable or having limited success.
A new study reveals that CEP290 is crucial for maintaining the structural integrity of the ciliary gate, a key component of cilia. This discovery could lead to targeted gene therapy for cilia-related disorders, including Meckel syndrome and Joubert syndrome.
Researchers at the University of Utah have developed a procedure to delete specific genes from nematode worms, allowing them to infer the function of each gene and thereby understand human gene regulation. The technique, called MosDel, uses a transposon to cut out genes and exploit cell DNA repair mechanisms.
A team of researchers at Worcester Polytechnic Institute has developed a new model system to study fungal infections. The system can be used to identify promising targets for anti-fungal drugs, potentially leading to effective treatments for conditions like thrush and athlete's foot.
Idaho researchers have been awarded a three-year grant to explore novel approaches to gene therapies by targeting specific sections of chromosomes with locked nucleic acids. The team aims to improve targeting and show its impact on genes, potentially leading to new treatments for genetic diseases.
Researchers at Iowa State University have developed a new technique for making genetic changes in plant genes, allowing for targeted manipulations with high efficiency. This process harnesses homologous recombination to precisely introduce DNA at predetermined locations, enabling faster and safer gene editing for various crops.
A research team has used single-molecule fluorescence microscopy to follow magnetic nanoparticles as they transport genes or drugs into target cells in real-time. The study reveals bottlenecks in nanoferry transport and provides insights into optimizing existing systems, potentially leading to breakthroughs in gene therapy.
Johns Hopkins researchers have made a breakthrough in editing human stem cells, enabling the development of patient-specific therapies for rare blood diseases like paroxysmal nocturnal hemoglobinuria (PNH). The team successfully targeted and edited a gene responsible for causing PNH, improving on standard gene targeting technology.
Researchers develop method to target genes in Toxoplasma gondii, a parasite responsible for malaria and diarrhea. The breakthrough enables the creation of safe and effective genetically modified vaccines and drug therapies.
Researchers have discovered that microRNAs dampen target gene expression in specific cells by working in concert with other regulatory processes. Key muscle-regulatory miRNAs, such as miR-1 and miR-133, function to mediate actin organization in developing muscles.
A joint research study by IBM and the Genome Institute of Singapore found that microRNAs control stem cell differentiation through coding regions beyond the 3'UTR, challenging previous assumptions. The discovery has implications for novel diagnostics and therapeutics.
Researchers at Mount Sinai School of Medicine have developed a new gene silencing technology that can effectively suppress transcriptional expression of targeted genes in human cells, including those linked to various diseases. This breakthrough could pave the way for preventing diseases where gene dysfunction plays a role.
A new study reveals that p53 regulates cells by inhibiting the mTOR pathway, which regulates cell growth. The discovery of Sestrin1 and Sestrin2 as key players in this process may lead to novel cancer preventives and therapeutics.
A multi-institutional team has developed a powerful tool for genomic research and medicine, generating synthetic enzymes that can target specific DNA sequences for inactivation or repair. This new method, called OPEN, enables customized zinc-finger nucleases with high efficiency in many cell types.
The Michael J. Fox Foundation has awarded $2.4 million to nine research teams to validate potential therapeutic targets for Parkinson's disease. The funding aims to accumulate evidence and reduce the risk of investment for industry, ultimately accelerating PD drug development.
Researchers at UMass Chan Medical School have developed a new technique to target individual genes for inactivation in zebrafish embryos using engineered zinc-finger nucleases. This method has the potential to answer questions that were previously out of reach and will fundamentally change how researchers make knockouts in model organi...
Researchers discuss developments in acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL), highlighting the potential of targeted drug therapies and cancer stem cell targeting. New molecular technologies aim to improve treatment outcomes and reduce toxic side effects.
Researchers at Cold Spring Harbor Laboratory have discovered endothelial progenitor cells that regulate tumor growth and transform dormant lung metastases into life-threatening lesions. Targeting these cells may provide a novel approach to treating lung cancer.
Researchers at Ohio State University have successfully used TRAP to preserve the genetic diversity of ornamental geranium collections. The study resulted in a significant reduction of the collection size from approximately 800 plants to around 200, making it more manageable for breeders and researchers.
A computer program developed by Rensselaer Polytechnic Institute can trace genetic ancestry in minutes using just a cheek swab, with 99% accuracy. The algorithm uses single nucleotide polymorphisms (SNPs) and has potential applications for understanding complex diseases and tailoring medical treatments.
Researchers at the University of Alberta have found a new cause of blindness linked to a gene that regulates pH levels in the retina. The study suggests that targeting this process could lead to potential treatments for previously unknown causes of blindness, including hereditary vitreoretinal degenerations.
Researchers found that flies have a complex immune system regulated by AP-1 and STAT transcription factors, which edit and repress the immune response to prevent 'friendly fire'. This mechanism is evolutionarily conserved to maintain balanced immune responses.
A small percentage of CF patients with a rare genetic stop mutation responded positively to gentamicin treatment, suggesting potential targeted treatments for the disease. Gentamicin reversed stop codons and restored the CFTR protein, improving respiration in affected patients.
Researchers at University of Pennsylvania School of Medicine discovered targeting a single gene can inhibit bone decay while stimulating bone formation. This concept may lead to drug treatments for osteoporosis and other bone diseases.
A team of researchers has mapped the key root-development pathway in Arabidopsis using an advanced genomic technique, revealing eight direct targets and numerous indirectly affected genes. The study provides new insights into plant development and function, shedding light on the complex regulatory network governing root growth.
Researchers investigated how homeoproteins interact with DNA to determine their binding specificity. The findings reveal new insights into the mechanisms underlying these interactions.
Researchers discovered that MAML1 plays a crucial role in regulating muscle cell differentiation, with increased expression leading to enhanced myotube formation and muscle-specific gene expression. The study also found that MAML1 works together with MEF2C to 'turn on' genes required for muscle development.
In cluttered conditions, observers make more high-confidence errors due to increased background noise and reduced accuracy. The study's findings suggest far-reaching implications for complex cognitive tasks, including problem-solving and memory.
Researchers found that a modest decrease in Mdm2 protein expression prevents tumor formation and does not lead to premature aging. Inhibitors of Mdm2 may delay cancer in young individuals without detrimental side effects.
The research examines how the U.S. Supreme Court can assist powerful officials in achieving their ideological objectives through direct political action. Key findings include states as a crucial factor in generating national political support for judicial review and the importance of entrenched interests and fragmented coalitions in sh...
Scientists have discovered a way to treat Huntington's disease by targeting multiple proteins and genetic pathways simultaneously. This breakthrough has the potential to provide new hope for patients with this devastating neurodegenerative disorder.
Gene targeting allows researchers to design and produce knockout lab mice to study human disease, revolutionizing biomedical research and advancing genetic medicine. The award recognizes the breakthrough technology developed by Capecchi and Smithies, enabling scientists to address complex biological problems.
Gene targeting allows scientists to alter specific genes in cultured cells and transfer them to laboratory mice, enabling the study of human diseases. The technique has revolutionized biomedical research and is now practiced by thousands of scientists worldwide.
Scientists at Cold Spring Harbor Laboratory identified 130 genes that affect the replication of retrovirus-like elements in yeast. These genes have clear relatives or homologs in the human genome, providing a rich source for candidate host genes to develop new anti-retroviral therapeutics.
Researchers have discovered microRNA JAW that controls the development of flat leaves, a key characteristic in capturing sunlight and energy. The study reveals the importance of microRNA regulation in plant morphology, paving the way for new avenues in agricultural advancements.
Scientists have successfully silenced mutant genes without affecting normal gene copies using RNA interference, a promising approach for treating diseases like Machado-Joseph disease, Huntington's, and Alzheimer's. This breakthrough technique has the potential to selectively turn off disease-causing genes, preserving essential normal g...
Scientists have achieved germline transmission of 'gene knockdown' in mice by using genetic engineering to create mouse embryonic stem cells targeted with RNAi. This enables the manipulation of gene activity in specific tissues and allows for switching on and off at any time during development or adulthood.
Smithies' groundbreaking work on gene targeting has led to thousands of mouse models simulating human diseases, enabling rapid advances in diagnosis and treatment. His research using genetically altered mice has also shed light on high blood pressure, a major human problem.
Researchers have identified a brain region involved in planning movement, which also controls gain control of eye movements. This finding provides new insight into how the brain adjusts to moving objects, allowing for smooth image display.
Researchers Beau Lotto and Dale Purves suggest that the visual system perceives color based on reflectances and illuminances of past stimuli. In experiments, subjects adjusted colors to match perceived color differences, showing an increased difference when contexts suggested different objects or illumination.
Phase I clinical trials show CCI-779's potential as a cancer treatment, inhibiting tumor growth with minimal side effects. The drug targets the mTOR pathway, which may selectively arrest the development of certain cancer cells.
Researchers have discovered two targets for a new generation of cholesterol-lowering drugs that should allow greater precision in managing cholesterol levels. A key compound, LG268, has been shown to completely block the absorption of cholesterol in mice, while also enhancing the production of reverse cholesterol transporters.
Dr. Oliver Smithies has received the International Okamoto Award for his groundbreaking work in hypertensive and arteriosclerotic research using molecular genetics. He pioneered gene targeting techniques that have been widely adopted by researchers worldwide, leading to a better understanding of human genetic diseases.