Articles tagged with Genetic Mapping
A team of researchers has discovered genetic associations with blood pressure that could guide future treatments for patients with hypertension. Over 250 new genetic variants and 400 new genes associated with blood pressure were identified, suggesting existing drugs may be used to lower blood pressure.
Scientists at deCODE genetics in Iceland have published the first genetic map of the human genome developed using whole-genome sequence data. The study reveals that recombination and de novo mutation are linked mechanisms generating human diversity.
Researchers mapped bee colonies' entire genetic make-up to identify emerging diseases threatening native populations. The study found that native bees may survive better in cooler climates than southern European relatives.
A genetic map of garden asparagus has been created, allowing researchers to identify the chromosome that determines the plant's sex. The map is a significant breakthrough in understanding this dioecious species and will enable the development of new varieties with improved characteristics.
Eric S. Lander, a pioneer in the study of the human genome and Human Genome Project, has been honored with the William Allan Award for his substantial and far-reaching scientific contributions to human genetics. The award recognizes his work on genetic mapping, genome-wide association studies, and cancer genomics.
Researchers created a 3D map of enhancer-gene interactions that play a key role in cardiovascular disease. The map identifies the most important genes for developing new treatments for heart attacks, heart failure, and heart rhythm disorders.
Researchers at the University of Central Florida have discovered a link between Mycobacterium avium subspecies paratuberculosis (MAP) and rheumatoid arthritis. The bacteria, commonly found in milk and beef, can trigger autoimmune responses in genetically predisposed individuals.
Researchers have developed a more detailed map of the human brain's cellular diversity, identifying 35 subtypes of neurons and glial cells linked to various brain disorders. The study provides insights into genetic risk factors for diseases like Alzheimer's, Parkinson's, schizophrenia, and bipolar disorder.
A study published in PLOS Genetics found that lethal genetic disorders are more common than expected due to factors such as balancing selection, disease severity, and errors in estimates. This research may help identify overlooked mutations causing these disorders.
Researchers from the Wellcome Trust Sanger Institute and their collaborators have created a high-resolution map of the disease, pinpointing 18 genetic variants with over 95% certainty. This breakthrough has significant implications for the development of new treatments and personalized medicine for IBD.
A team of French and Argentinian scientists identified a genetic mutation responsible for fleece variation in domesticated sheep. The study mapped and functionally validated the mutation using genomic sequencing data from over 2,000 lambs, shedding light on an ancient gene mechanism that may have occurred.
A four-year genetic research effort has mapped the major landmarks in the evolution of dinoflagellates, a key species in the environment. The study found that nonphotosynthetic dinoflagellates have retained vital metabolic functions and could lead to a better understanding of bioluminescence and toxic algal blooms.
Researchers at UNH have created a linkage map of Fragaria iinumae, a wild ancestor of the cultivated strawberry. This breakthrough provides a valuable resource for assembly of a reference genomic sequence, which will aid in breeding for desirable traits such as fruit quality and disease resistance.
A team of researchers has created the first comprehensive in vivo fitness landscape of a gene, which provides a way to visualize and predict evolution. The findings show that about 1 percent of point mutations are beneficial to an organism, while 42 percent are harmful, and two harmful mutations interacting can lead to more harm.
Researchers at NYU Abu Dhabi have developed a map of genetic changes across the genome of date palms, shedding light on their origin and diversification. The study also identifies genes important for fruit ripening, disease resistance, and fruit color.
A team led by University of Pennsylvania professor Theodore Schurr has discovered that many Caribbean communities retain significant indigenous ancestry. Using DNA samples from over 88 participants in Trinidad and St. Vincent, the researchers found 42% of maternal and 28% of paternal genetic heritage.
Researchers have developed genetic maps that reveal ancient migration patterns of black bears in North America, providing insights into their evolution and distribution. The study identifies four glacial refugia where bears retreated during ice ages and shows how they dispersed into different regions.
Scientists at Kansas State University have developed a haplotype map of wheat that provides a detailed description of genetic differences in worldwide wheat lines. This study enables the precise mapping of genes and increases the selection of best lines for breeding, leading to faster release times for new varieties.
A new study mapping the genetic makeup of the British Isles reveals distinct groups clustered by geography, contradicting traditional Celtic identity. The research found separate genetic groups in Cornwall and Devon, as well as a single homogeneous group in eastern, central, and southern England.
Researchers developed a mathematical model to analyze data from genome-wide association studies, pinpointing genetic variants that cause autoimmune diseases. The study found strong links between the immune system and neurologic disease MS, suggesting a primary role of the immune system in causing the disease.
Researchers are using multiparental populations to map complex trait genes in organisms such as mice, fruit flies, and maize. This approach enables the identification of specific gene regions associated with traits like nicotine resistance and toxicity of chemotherapy drugs.
Researchers at Aarhus University have sequenced the spider genome, providing a genetic map for future studies. The study reveals genes specific to spiders and sheds light on their incredible abilities, such as making silk and producing venom.
Researchers have developed a new tool that combines genetic and epigenetic data to identify the underlying causes of complex diseases. By analyzing overlapping patterns, scientists can pinpoint specific genetic variants linked to conditions such as cancer and metabolic disorders.
The study uses genome data from 1490 individuals to identify genetic mixing events between populations, dating back to historical events such as the Mongol Empire. The technique, called 'Globetrotter,' provides insight into past events and may have implications for public health and disease prevention.
Researchers at Curtin University have found a way to breed disease-resistant wheat, reducing yield loss due to Yellow Spot and other diseases. This new technology allows for improved disease resistance without affecting yields or increasing costs.
Scientists from the University of Chicago have developed a unique genetic map that identifies associations between single-gene diseases and complex diseases. The study analyzed over 120 million patient records and found statistically significant correlations between 2,909 disease pairs, including previously unknown comorbidities such a...
Researchers discovered 20 million base pairs of genetic sequence hidden in centromeres, a key finding that could aid in mapping the human genome. Latino genomes proved uniquely powerful in filling in uncharted regions due to their African ancestry.
Scientists have created a detailed map of the global connections within the brains of individuals with agenesis of the corpus callosum, a genetic cause of autism. The study reveals abnormal brain connectivity patterns and network topology, potentially leading to new imaging biomarkers for diagnosis and management.
Researchers discover at least four different modules in the brain dedicated to self-location, each with its own internal GPS-like mapping system. The discovery challenges previous understanding of how the brain organizes abstract functions and opens up new possibilities for memory formation.
Researchers developed a new method to track TB outbreaks by analyzing the genetic information of infected individuals, enabling faster response times and more targeted efforts. The approach has the potential to identify
A University of Minnesota scientist contributed to a landmark study mapping the barley genome, providing valuable tools for improving crop yields, resistance to pests and diseases, and nutritional value. The research will accelerate breeding efforts to help barley adapt to climate change, making it more resistant to drought and efficie...
Researchers at Tel Aviv University have developed a method for determining more precise geographical locations of an individual's ancestral origins using genetic traits. By analyzing DNA samples from 1,157 people across Europe, they were able to accurately determine two separate points on the map for an individual's mother and father.
Researchers have developed a new technology that allows for an individualized map of the DNA within a single sperm cell, providing insights into genetic diversity and potential applications in reproductive disorders. This technology could also be used to characterize differences in cancer cells taken from patients.
Researchers have developed a detailed genetic sequence and map of foxtail millet, a close relative of switchgrass and an important food crop in Asia. The study provides a powerful tool for scientists working to increase biofuel and crop yields by systematically searching for genes that influence desirable traits.
A national team of scientists has created the first atlas of the human brain surface based on genetic information, revealing distinct genetic divisions that differ from traditional brain maps. This atlas provides a new tool for understanding how genes influence brain development and function.
Researchers have completed the first high-resolution genetic map of miscanthus, a towering cane-like grass used as an energy crop. The mapping project has provided valuable markers to differentiate individual plants and improve breeding for faster and more efficient production.
Researchers from UCLA's Henry Samueli School of Engineering and Applied Science contributed to the development of a comprehensive genetic catalog of 17 strains of mice. The study provides a complete picture of genetic variation in these mouse strains, enabling scientists to accurately predict gene expression levels and identify variant...
Researchers have developed a method to dissect the genomes of polyploid crops like oilseed rape and bread wheat, allowing for predictive breeding. By integrating sequence data from different sources, they created genetic linkage maps that can identify useful genes and accelerate breeding in new traits.
Scientists have developed a genetic map of African-Americans, revealing distinct recombination patterns that differ from those in Europeans. The map holds promise for understanding the roots of disease and identifying new disease genes, particularly in African-American populations.
The study provides a detailed map of genetic recombination in African Americans, revealing distinct differences from European populations. The researchers identified over two million recombination events, shedding light on the genetic origins of congenital diseases more common in African Americans.
The Collaborative Cross mouse strains have been used to map causative loci for complex traits like body weight and white head-spotting, showcasing the power of ancestry-based approaches. The studies also revealed the scope of phenotypic variation present in the CC lines, providing insights into breeding effects on genetic structure.
Scientists have created a new map of the potato genome that could improve crop yields and nutritional content. The study's findings suggest that breeding potatoes with improved genes could help feed a growing global population.
Scientists have developed a new technique to map both connections and functions of nerve cells in the brain for the first time. The 'connectomics' approach aims to understand how perceptions, sensations, and thoughts are generated in the brain, with potential applications in diseases like Alzheimer's and schizophrenia.
The Boston College bioinformatics lab has created a detailed map of genomic structural variants, a layer of DNA that distinguishes individuals. This analysis of 185 human genomes supports the 1000 Genomes Project and provides new insights into genetic selection, variations, and disease susceptibility.
A team of scientists has mapped the genome of orangutans, providing a new tool for conservation efforts and shedding light on the evolution of primates. The study reveals unique features of the orangutan genome, including fast-evolving genes related to visual perception and metabolic processes.
Researchers used differential epistasis maps to study how genes interact in response to stress by DNA-damaging agents. The genetic network was found to completely reprogram itself, revealing functional relationships that would go undetected using other approaches.
The project produced a comprehensive map of human genetic variation using next-generation DNA sequencing technologies, containing approximately 15 million SNPs and over 20,000 structural variations. The database contains more than 95 percent of the currently measurable variants found in any individual.
The new HapMap adds more than 1 million SNPs, increasing resolution and helping researchers interpret genome studies. Non-African diversity is largely a subset of African diversity in the updated map.
Agricultural Research Service scientists have developed a new genetic map of switchgrass, which is expected to speed up the search for genes that make the perennial plant more viable as a biofuel source. The genetic map divides the switchgrass genome into 18 distinct groups of genes linked together on the same strand of DNA.
A new approach to boosting vitamin A levels in corn has been developed by US scientists, with potential to reduce child blindness and mortality in developing regions. The research identified genetic sequences linked to higher beta-carotene levels in corn and demonstrated an inexpensive method to identify and breed high-yielding varieties.
A genome mapping technique has been demonstrated to speed up the process of finding specific genes by quickly identifying genetic associations. This method compares DNA sequences across multiple individuals and identifies similarities that narrow the scope of the search for a particular gene.
A study published in PNAS found that genetics plays a role in the brain's back-burner setup for low-priority ideas. The default-mode network is linked to genetic factors, with over 40% of variance in functional connectivity under genetic control.
Researchers at UNC Chapel Hill created a first-of-its-kind map of the human genome's regulatory elements, revealing clusters specific to pancreatic islet cells. The study identified genetic variants associated with type II diabetes and found that certain genes are 'turned on' or 'off', opening new avenues for understanding the disease.
Scientists at the University of York have created a genetic map for Artemisia annua, which will enable rapid improvement of the species and development of high-yielding crops. The project aims to meet soaring demand for effective malaria treatments by 2012, when production is expected to double.
Researchers have sequenced 85% of the soybean genome, providing critical information to improve crop yields, disease resistance, and nutritional content. The discovery includes genes conferring resistance to a devastating disease and mutations that enhance digestibility and phosphorus absorption.
Scientists at the Genome Institute of Singapore have created a genetic map of the Han Chinese population based on genome-wide DNA variations in over 6,000 samples. The map reveals that northern inhabitants were genetically distinguishable from those in the south, consistent with historical migration patterns.
A new gene map has been developed to aid plant breeding efforts in maize, a major source of food and fuel worldwide. The map charts genetic diversity and recombination across the genome of 27 inbred lines, providing insights into complex traits.
Researchers linked genetic data to visualize H1N1 flu virus movement around the world using Google Earth. The resulting map represents the most comprehensive analysis of avian flu transmission among sites in Asia, Africa, and Europe.
A team of scientists at UCR has developed a high-density consensus genetic map of cowpea, accelerating conventional breeding and facilitating the production of new varieties. The map enables breeders to locate valuable genes and incorporate them into new varieties more efficiently.
Researchers create the largest map of human genome changes, identifying 75 regions that 'jump' between genomes and over 250 genes with duplicated copies. The study provides insights into evolutionary biology and offers a resource for researchers to explore genetic variation's role in human disease.