Articles tagged with Genetic Mapping
Incipient sex chromosomes have been found in New Zealand's eponymous export, the kiwifruit. The genetic linkage map of the kiwifruit reveals that a subtelomeric region bears hallmarks of an early sex-determining locus.
A genome-wide association study has identified three genes associated with an increased risk of severe obesity in children and adults. The study, led by McGill scientists, found that these genes contribute to early-onset obesity in kids and morbid obesity in adults.
A research team led by M. D. Anderson Cancer Center scientists created a whole-organ genomic survey to chart the molecular journey from normal cell to invasive cancer in bladder tissue. They identified a crucial new category of genes, known as 'forerunner genes,' that launch the process of cancer development.
Biologists call for making detailed maps of biotech crops available to researchers, allowing them to analyze the effects on wildlife and water quality. The government's current data collection system is limited in spatial resolution, making it difficult to answer key questions about genetically engineered crops.
Researchers discovered a significant amount of variation in genetic recombination events among individuals, with some hotspots being used more by one sex. The study found heritable differences in recombination rate and hotspot use, which could provide insights into the evolution of recombination rates.
The Phase II HapMap contains over 3.1 million SNPs, three times more than the initial version, improving the detection of genetic variants involved in common diseases and exploring human genetic variation. Researchers have associated over 60 common DNA variants with risk of disease or related traits using this powerful new tool.
A computer program developed by Rensselaer Polytechnic Institute can trace genetic ancestry in minutes using just a cheek swab, with 99% accuracy. The algorithm uses single nucleotide polymorphisms (SNPs) and has potential applications for understanding complex diseases and tailoring medical treatments.
Researchers created a supermap of the H5N1 virus using genetic, geographic, and evolutionary data to predict future outbreaks. The map revealed no significant association between mutations in surface proteins HA and NA and specific host types.
The ivory trade is driving organized crime in Africa and Asia, with the black-market price rising to $750 per kilogram. Western nations must reinstate strong enforcement efforts to stop the trade and protect elephant populations.
Researchers created a detailed genetic map of the mouse genome using two groups of mice, tracking over 10,000 SNPs to identify patterns of inheritance. The study found variations in recombination rates across the genome, between sexes, and identified sequence motifs that may be representative of recombination hot spots.
Recent studies on PTSD are shedding light on its underlying causes, including the role of trauma, genetics, and neural circuitry. The condition affects approximately 5% of men and 10% of women, with a higher likelihood in children of trauma survivors.
A novel genome mapping method has been extended to humans, offering a faster and more cost-effective tool than traditional DNA sequencing. The algorithm makes it possible to optically map the human genome, revealing large-scale structure and detecting genomic abnormalities. This breakthrough may accelerate research in cancer biology.
Researchers at Baylor College of Medicine discovered that fruit flies' visual systems are genetically programmed and don't require neuronal activity for formation. This finding challenges the idea that brain wiring needs activity from neurons to function correctly.
Emory scientists have identified and mapped over 400,000 insertions and deletions (INDELs) in the human genome, providing an expanded view of human genetic differences. These variations differ from single nucleotide polymorphisms (SNPs) and are likely to impact human health and disease susceptibility.
The interactive 3D atlas provides highly accurate anatomical templates for researchers to map metabolically active brain regions and genetic expressions. The database contains 20 segmented structures from 10 adult male mice, including variability across the strain.
The HapMap project provides detailed information on genetic variations common in human populations, shedding light on the relationship between gene changes and diseases. Researchers have identified key sites of DNA recombination that may hold clues to understanding various conditions.
Researchers at Perlegen and Calit2 have developed a method to analyze whole-genome data, making it possible for genome-wide association studies to be performed on a reduced budget. The study reveals that most functional human genetic variation is not population-specific, with only 18% of SNPs segregating in one population sample.
A new mapping effort captures most common human genetic variation across European American, African American, and Han Chinese American ancestry. The research provides a tool for exploring the causal role of common DNA variation in complex human traits.
Researchers identified sex-specific differences in gene expression in various tissues, including liver, kidney, and reproductive organs. These differences were involved in drug and steroid metabolism, as well as regulation of fluid balance, with implications for understanding how males and females respond differently to drug treatments.
Researchers have created a genetic map of purebred dogs, revealing how breeds evolved and inherited traits. The study also found that similar trade-offs in genetics are present in both dogs and modern foxes.
Researchers mapped yeast genetic interaction networks, finding that genes interact in 'neighbourhoods' and predicting traits. The study provides new insights into how genes contribute to human disease.
The International HapMap Consortium has outlined its policies for rapidly releasing human genetic variation data to researchers worldwide. The $120 million project aims to create a public resource map of common human genetic patterns, facilitating the discovery of genes associated with diseases and response to medicines.
Researchers have successfully mapped the domestic turkey genome, which will aid in breeding birds with beneficial traits such as disease resistance and increased reproduction. This study leverages information from the chicken genome to improve turkey breeding practices.
Researchers at Rutgers University have developed a genetic road map that identifies sources of disease by analyzing single nucleotide polymorphisms (SNPs). The map, which is the first of its kind, provides detailed information on gene interactions and will enable scientists to conduct large-scale genotyping with greater efficiency.
The International Congress of Genetics will consider the implications of the genetics revolution on global food security, health care, and social justice. The event aims to provide representation from developing countries, which have the most to gain and lose from genetic advancements.
A recent study reveals that Icelanders are more genetically diverse than previously thought, with higher rates of nucleotide differences and population admixture. This contradicts earlier claims of genetic homogeneity, which were largely based on flawed data and errors in publicly accessible databases.
A physical map of the mouse genome provides detailed organization and context to the draft sequence, aiding in gene discovery and understanding health and disease. This mapping effort also enables researchers to access specific regions of DNA for further study.
Researchers at University of Georgia have developed a new method to sequence genomes, called Cot-based Cloning and Sequencing (CBCS), which reduces the number of clones required from 119 million to 15 million, saving $354 million in funding.
A Rutgers computer research team is developing a genetic linkage map that may help scientists identify the DNA differences predisposing people to complex diseases. The map will analyze data from over 2,000 single nucleotide polymorphisms (SNPs) to track genes contributing to disease.
A study in mice found that genetic background influences blood-pressure response to acute alcohol exposure, with some strains experiencing increased blood pressure and others not. The findings suggest a predisposition to greater increases in blood pressure with alcohol consumption, potentially leading to hypertension.
Researchers at Harvard Medical School found a genetic protein that influences the brain's body map, contradicting previous thinking that neural input from the body's periphery shapes it. The discovery raises questions about individual differences in sensory function and potential genetic basis for variations in brain organization.
Renowned scientist J. Craig Venter will discuss his work on decoding the human genome at the American Chemical Society meeting. He co-founded Celera Genomics to sequence the entire human genome by 2001 and is this year's honoree for the David Perlman Memorial Lectureship.
Dr. Julie R. Korenberg's comprehensive map integrates three ways of looking at the human genome, marking critical points with fluorescent signposts for rapid translation of clinical problems into genome-based solutions. The guide has significant practical applications in cancer treatment and genetic diagnosis.
Researchers at NIAID have produced the first high-resolution genetic map of Plasmodium falciparum, the deadliest malaria parasite. The map provides a framework to accelerate genome sequencing efforts, enabling scientists to locate genes important for drug resistance and disease severity.
A PricewaterhouseCoopers study suggests that consumerism, e-commerce, and genetic mapping will transform the US healthcare system. The report highlights potential disruptions, including increased competition for capital investments and a shift towards preventive care through genomics.
Scientists have mapped the zebrafish genome using a radiation hybrid technique, allowing for matching of candidate genes with genetically mapped mutations. The map provides valuable insight into human development and has potential applications in understanding genetic diseases.
The Clemson University Genomics Institute is leading a three-year project with international partners to identify all 40,000 genes in rice and locate their position on 12 chromosomes.
A detailed map of the human genome will require locating at least half a million genetic markers to be useful for pharmaceutical research and development. According to Dr. Leonid Kruglyak, researchers need to locate more genetic markers to stay on track when chasing down genes that influence disease susceptibility and drug response.
A new color-coded chromosome mapping system devised by Julie R. Korenberg enables quick localization of known matching genes in humans using mouse DNA, greatly speeding up research into Down Syndrome and other human illnesses. The system has profound implications for the study of human diseases and the development of effective treatments.
The completion of a high-density integrated genetic linkage and radiation hybrid map for the laboratory rat is a landmark in genomic science. The maps provide an integrated reference to more than 3,000 genes and ESTs, enabling researchers to connect disorders to their underlying genetic components.
Cornell researchers have used genetic mapping to identify genes that boost rice yield and disease resistance in poor farmers. By introgressing genes from wild rice varieties into domesticated rice, they have increased crop production in unfavorable conditions.
David Botstein, Ronald Davis, and Eric Lander were awarded the Chiron Corporation Biotechnology Research Award for their pioneering work on genetic linkage analysis using molecular markers. Their research laid the foundation for the Human Genome Project and enabled the construction of human genetic maps.
Researchers at Purdue University have identified a genetic link to the aggressive stinging behavior in Africanized honey bees. By mapping genes associated with aggression, they hope to develop markers for selective breeding of gentle bees, which could improve pollination and reduce threats to beekeepers.
Scientists at Duke University discovered a genetic switch that governs prostate cancer progression. The switch controls the production of FGF-R2 receptors, which can lead to
African and Asian macaques' complicated lineages have been unraveled by genetic detective work at Columbia University. The study confirms that the genus is one of the oldest among Asian monkeys, dating to at least 7 million years ago.
A genetic map of dogs was constructed using 150 microsatellite markers, revealing the organization of genes and traits on the canine genome. The study has significant implications for understanding human diseases such as cancer, epilepsy, and bleeding disorders.
Researchers found a substantial genetic component underlying differences in fear response, particularly on chromosome 1, which may contain hundreds of genes. This discovery has implications for developing new pharmacological agents to target human genes implicated in fear-related disorders.
The new map reveals hot spots for genes and a large region where DNA remains intact across generations. It also identifies variations in chemical composition along the chromosome, shedding light on X's genetic code
The study confirms the Bornean rhino's genetic distinctness from other Sumatran rhinos, with a 1% difference in genetic code, making interbreeding unlikely. Only 50-100 animals remain, and conservation efforts are needed to protect them.
Researchers at Stanford Human Genome Center developed a powerful new computer program called Mapper to map thousands of genetic markers simultaneously. This allows for high-resolution maps with better local area resolution and rapid rebuilding process.