The NIH granted Vion Pharmaceuticals a two-year, $750,000 Small Business Innovation and Research (SBIR) grant to enhance the anti-tumor efficacy of its TAPET bacterial vector. The goal is to deliver potent anti-cancer agents directly at the tumor site, leveraging TAPET's preferential replication in tumors.
A $4.1 million grant from the National Science Foundation is helping researchers link disparate databases and protect confidential data for economic and social scientists. The project aims to improve quality of the Census Bureau's surveys and enable better research on social issues like welfare-to-work and aging.
Researchers at the University of Toronto and CAMH have discovered a natural window for blocking dopamine receptors to treat schizophrenia without excessive side effects. This breakthrough allows for lower doses of antipsychotic medication, reducing negative symptoms and improving treatment outcomes.
Researchers discovered that viral load is a critical predictor of HIV transmission between men and women, regardless of gender. Individuals with low levels of the virus in their blood did not transmit the virus to their partner.
UW researchers find that oscillating magnetic fields can kill malaria parasites by damaging their iron-containing structures. The treatment could be inexpensive and simple, bypassing emerging drug resistance concerns.
Scientists have found a genetic switch that helps calm anxiety in mice, revealing the role of Crhr2 receptor in reducing stress response. The discovery provides an initial motivation for further dissecting potential drug discovery programs.
Researchers have detected significant speed-ups and slow-downs in the rotation rate of gases at the inner edge of a spherical shell known as the convection zone. The discovery is believed to shed light on the physical dynamics of the 11-year solar cycle that affects Earth.
Researchers at Harvard Medical School found a genetic protein that influences the brain's body map, contradicting previous thinking that neural input from the body's periphery shapes it. The discovery raises questions about individual differences in sensory function and potential genetic basis for variations in brain organization.
A North Carolina State University professor argues that a greater understanding of ancient medicine could provide modern doctors with new ways to treat diseases and identify potential dangers. He cites examples such as St. John's wort, which was initially used as an antiseptic but later found to have abortifacient effects.
Research published in the American Journal of Clinical Nutrition found that tea drinkers had a 5% greater mean BMD than non-tea drinkers, equating to a 10-20% decline in fracture risk. Isoflavonoids in tea are thought to contribute to this positive effect.
Researchers developed a novel method to improve polymers by changing their organization using small molecules as additives. The new method creates a gel-like material with enhanced mechanical and thermal properties, as well as unique optical properties, including birefringence and wavelength reflection.
A new iceberg has broken from Antarctica's Ross Ice Shelf, just east of one discovered on March 17. The new iceberg is approximately 130 km by 20 km and was detected using high-resolution satellite data provided by the Antarctic Meteorological Research Center.
A study led by Johns Hopkins found that patients with high blood pressure taking beta blockers were 28% more likely to develop diabetes than those not taking the medication. In contrast, thiazide diuretics were associated with a lower risk of diabetes.
A strain of mutant flies with a crippled light-reactive pigment maintains a steady clock under constant light. The fly cryptochrome dCRY is the only photoreceptor molecule regulating the fly's circadian rhythm.
A new study suggests that human aging and its associated diseases can be traced to gradual increases in cell division errors in tissues throughout the body. Altered gene expression results in cells with diminished function, leading to aging.