A team of researchers has determined that a gene on chromosome 12, previously suspected to be a strong genetic risk factor for Alzheimer's disease, cannot be replicated. Despite the initial findings, there is strong evidence for another genetic defect elsewhere on the chromosome that causes Alzheimer's disease.
Researchers used genetically modified mice to elucidate the mechanism underlying hereditary breast cancer. The study found that mutations in the BRCA-1 gene lead to genetic instability, favouring further mutations and tumour growth.
Magnetic patterns on Mars indicate ancient plate tectonics system, with implications for understanding of the planet's topography. The team found evidence of symmetrical mirror-image stripes, similar to those on Earth, which could be remnants of a long-lost plate tectonics system.
The completion of a high-density integrated genetic linkage and radiation hybrid map for the laboratory rat is a landmark in genomic science. The maps provide an integrated reference to more than 3,000 genes and ESTs, enabling researchers to connect disorders to their underlying genetic components.
Two studies published in Science suggest that parasites, specifically Riberoria trematodes, are responsible for some frog deformities. Laboratory and field experiments found that parasite infections cause mirror-image limb deformities, distinct from the thigh-knee-thigh-knee pattern caused by retinoids.
USGS scientists Mike Fisher and Art Frankel will discuss the potential effects of major quakes in Seattle using data from last year's SHIPS project. Scientists from other organizations will also describe the probabilities for a large earthquake in the Puget Sound area.
The study found that misexpression of Tbx4 in the forelimb region leads to leg-like structures, while misexpression of Tbx5 in the hindlimb region results in wing-like structures. These findings suggest that Tbx4 and Tbx5 play crucial roles in determining fore- and hindlimb identity.
Scientists at Penn School Medicine found that chaperonins, huge protein molecules, catch and unfold misfolded proteins to protect cells. This process takes place within 13 seconds and helps prevent cellular harm caused by protein misfolding disorders like mad cow's disease.
Researchers found that most hepatitis B virus infections in adult humans are uncomplicated and do not result in large-scale destruction of infected liver cells. A new noncytolytic process targets the virus' ability to reproduce, leaving the liver relatively unscathed.
Scientists have discovered magnetic stripes on Mars, similar to those found on Earth, suggesting the planet was once magnetized and had a global magnetic field. These findings provide insights into Mars' formation and evolution, shedding light on its potential for hosting liquid water.
Researchers found that axillary lymph node dissection, a common surgery used to determine the extent of disease in early stage breast cancer patients, may not benefit a large number of them. The study concluded that knowing lymph node status was unlikely to affect survival and may not be worth the risks associated with the surgery.
Researchers found a reciprocal relationship between emotional and cognitive areas of the brain in depressed individuals, with blood flow decreasing in cortical regions and increasing in limbic regions. The study provides new insights into the neural interplay between mood and cognition in depression.
Researchers have shown that four drugs, known as angiogenesis inhibitors, can effectively treat spontaneous tumors at distinct stages of progression in mice. The study provides evidence for the potential of these drugs to act against tumors in a mouse model that more closely resembles human tumor development.
Researchers at TSRI demonstrate that the immune system can cure viral infections without destroying infected cells. Nondestructive antiviral mechanisms triggered by inflammatory cytokines contribute to viral clearance, preserving organ function.
Rudolph's application of physiology to congenital heart disease significantly advanced understanding of normal and abnormal heart development in newborn humans. His research led to the development of new diagnostic and treatment methods for congenital heart defects.