Articles tagged with Genetic Variation
Two large-scale genomic studies reveal new genetic variations in multiple sclerosis and suggest a link to other autoimmune diseases. The IL-7R receptor is identified as a critical factor in the disease's pathogenesis.
Researchers found that the genetic variation in laboratory mice is vastly greater than previously thought, with 8.3 million variations described. The pedigrees of the 15 mouse strains studied differ from each other to a far greater degree than previously assumed.
Researchers have identified two gene variants associated with immune system capacity against HIV, and a third variant linked to immune damage. These findings may lead to more targeted vaccines and tailored treatments.
Researchers have confirmed six new genetic variants that increase the likelihood of developing coronary artery disease. These variants, found in chromosomes 2, 6, 10 and 15, as well as two on chromosome 1 and one on chromosome 9, are common in white Europeans and explain a significant proportion of heart attacks.
Researchers found a genetic variant linked to an increased risk of developing COPD in smokers, suggesting a gene-environment interaction. The study suggests that genetic factors play a role in the development of COPD, alongside environmental exposure to cigarette smoke.
A common genetic variation on chromosome 9p21 is linked to a substantial increase in risk for heart attack, with individuals carrying the variation having a 1.64-fold greater risk of suffering a heart attack. The study found that approximately 21 percent of individuals of European descent carry two copies of the genetic variation.
Researchers have identified at least four new genetic variants associated with increased risk of diabetes and confirmed the existence of six more, boosting the number of known genetic variants to 10. These findings may lead to personalized medicine approaches by exploring how these genetic factors interact with lifestyle factors.
A recent study on chimpanzee genetics reveals three distinct groups with considerable genetic variation, which has important implications for conservation efforts. The research team found that the traditional geography-based sorting of chimps into western, central, and eastern populations is supported by significant genetic differences.
Researchers identify three genetic variants associated with an increased risk of Crohn's disease, including PHOX2B, NCF4, and ATG16L1. These discoveries offer new insights into the biological pathways underlying the disease and may lead to more effective therapies.
A recent study failed to validate the association of 85 genetic variants with increased risk for acute coronary syndromes (ACS), including heart attack and angina. The research included 811 patients with ACS, but found no conclusive evidence supporting the use of these gene variants as risk factors in clinical care.
A study led by the National Human Genome Research Institute identified a key genetic variant associated with small size in dogs. The IGF-1 gene was found to play a strong role in regulating body size across various breeds, offering potential insights into skeletal body size programming in humans and disease susceptibility.
Research suggests that genetic variations in MMP1 and vitamin D synthesis genes are associated with a higher risk of complications after hip replacement surgery. Patients with specific genetic variations were more likely to experience aseptic loosening and deep infection.
Researchers at Johns Hopkins Medicine have identified 34 unique genetic variations associated with sporadic ALS, bringing them closer to developing treatments. The study scanned the entire genome of 276 subjects with ALS and found that these genetic variants are more common in individuals with the disease.
Researchers have identified a genetic variation associated with a mild form of schizophrenia, which also confers improved overall survival. The HOPA12pb gene variation affects dopamine-releasing neurons and may hold the key to developing new treatments for schizophrenia and other related illnesses.
A global survey of genetic variation shows that at least 10-20% of heritable variation in gene activity is due to copy number variations (CNVs), affecting the activity of over 1,000 genes. The study provides a first genome-wide view of how unique genetic variations lead to unique patterns of gene activity.
Female Antarctic fur seals travel long distances to mate with genetically diverse males, rather than local dominant males. This behavior enables species to maintain genetic diversity, crucial for resisting disease and parasites.
A study found 5 genetic variations associated with the risk of nonfatal venous thrombosis in postmenopausal women, highlighting potential new targets for prevention and treatment. The findings suggest that genetic factors may play a significant role in the development of this condition.
A study published in The American Journal of Human Genetics identifies the chitinase 3-like 1 gene as a potential risk factor for schizophrenia. Genetic variations in this gene were found to be associated with schizophrenia, suggesting that genes involved in biological response to adverse conditions may play a role in predisposition.
Researchers analyzed 1,200 genome-wide polymorphisms in 432 Indian individuals, revealing low levels of genetic divergence across geographically and linguistically diverse populations. The study provides a foundation for future research on the genetic basis of common diseases in Asian Indians.
A study in PLOS ONE finds that genetically variable wolves are more likely to be recruited into the breeding population, reducing the negative effects of inbreeding. This means the accumulation of inbreeding's negative effects will occur much slower than previously believed.
An international team of researchers has identified a novel gene mutation linked to Crohn's disease and ulcerative colitis, which may offer a new pathway for tracking the disease process and potential drug treatments.
A recent study by Dartmouth researchers found that individuals with a specific genetic variation in their ODC gene are more likely to benefit from aspirin use in preventing colon cancer. These individuals were 23% less likely to develop new adenomas and 49% less likely to develop more advanced lesions.
A study pooled data from over 20 groups conducting breast cancer research, identifying 16 single nucleotide polymorphisms (SNPs) that may be linked to breast cancer risk. The authors found that five SNPs showed borderline statistical significance and could contribute to breast cancer incidence.
A Tulane University study suggests that bats may have been responsible for the origin of the deadly Marburg hemorrhagic fever outbreak in the Democratic Republic of Congo. The research identified multiple genetic variants of the virus, indicating repeated introductions from a primary reservoir rather than person-to-person spread.
A comprehensive scan of the human genome has identified 51 chromosomal regions linked to alcohol addiction. The study provides new tools for understanding the physiological foundation of addiction and identifying individuals at risk.
A genetic variant in the SERPINH1 gene has been identified as a potential cause of premature delivery in African-American women. The variant reduces collagen production, making membranes more prone to rupture. This discovery may help physicians identify high-risk patients and prevent serious pregnancy complications.
Researchers found an association between specific genetic variations and a 50-100% increased stroke risk in younger women, with particular emphasis on the PDE4D gene. The study suggests a potential genetic test to identify high-risk women who may benefit from more intensive screening and counseling.
A genetic variation in the CFH gene is associated with an increased risk of age-related macular degeneration (AMD). The study found that individuals with the mutation had a 48% cumulative risk of developing late AMD by age 95, while those without it had a lower risk.
The study found that environmental quality increases the heritability of birth weight, but selection strength weakens in better environments. This suggests that biologically realistic models are crucial for predicting evolution in wild populations.
The Broad Institute scientists will survey DNA of 50,000 individuals using large-scale genotyping technologies and advanced informatics to highlight genetic differences in specific genes. The project aims to accelerate the pace of identifying risk factors and genetic variants associated with human diseases.
Researchers found widespread evidence of evolution in all populations studied, with signals of positive selection detected in genes related to metabolism, skin pigmentation, and brain development. The study identified over 700 recently evolving genes, including the lactase gene, which enabled Europeans to digest milk into adulthood.
A study found that genetic variation in the leptin and leptin receptor genes is associated with an increased risk of developing breast cancer. Individuals with two copies of the polymorphism had a threefold higher risk of developing breast cancer than those without it.
The collaboration aims to uncover the genetic basis underlying important agricultural traits in rice. By identifying sequence variation between major rice varieties, researchers can associate DNA variations with traits like drought resistance or vitamin content, ultimately helping to breed more resilient and nutritious rice strains.
The Human HapMap project provides a powerful tool for exploring the root causes of common diseases. By mapping genetic variation across the entire genome, researchers can identify genetic contributions to diseases such as diabetes, cancer, and Alzheimer's disease more efficiently.
Researchers discovered genetic variations in the VKORC1 gene that affect warfarin dosing, allowing for more precise patient treatment. The study, supported by the NIH Pharmacogenetics Research Network, may enable doctors to set ideal doses quickly and precisely.
A genetic study found significant associations between two single nucleotide polymorphisms (SNPs) and alcohol dependence in a Russian population. The variations were in the GABRA2 receptor subtype, which is involved in regulating brain activity and can decrease activity of the entire brain and body.
Researchers found significant associations between two SNPs and alcohol dependence in a Russian population, similar to U.S. findings. The study suggests that the GABRA2 gene influences risk for alcoholism regardless of environmental factors.
African-American study participants with a genetic variant for the mood-elevating hormone norepinephrine are at higher risk of depression, anxiety, and hypertension. Elevated norepinephrine levels, heart rate, and blood pressure were observed in those with the genetic variant.
A new mapping effort captures most common human genetic variation across European American, African American, and Han Chinese American ancestry. The research provides a tool for exploring the causal role of common DNA variation in complex human traits.
Researchers found a genetic variant of the CYP1A1 gene associated with lower estrogen levels, higher bone resorption markers, and lower bone density in hip bones. This variant may serve as an important genetic marker for identifying women at high risk of osteoporosis.
The Texas Bison Herd is struggling due to inbreeding depression, a condition caused by lack of genetic variation. The herd's average age has increased, and birth rates are low, posing a threat to its survival.
A study found that genetic variations in taste receptors affect the way people perceive the bitterness of alcohol, influencing their drinking habits. Individuals who are supertasters and can't taste the bitterness of PROP may consume more alcohol than those who are nontasters.
The new center will provide tools for SNP selection, discovery, and analysis, enabling researchers to identify genetic markers associated with diseases. The center aims to make this capability accessible to many biomedical researchers, leading to a better understanding of human genetic variation and its association with disease.
Researchers at Washington University in St. Louis found that genetically distinct populations of brown lizards (Anolis sagrei) introduced to five countries can be traced back to Florida. The study, which analyzed DNA from over 600 individuals, suggests that the Sunshine State is a key site for species migration.
A recent study found that genetic variations in the HLA and TNF gene regions are associated with response to treatment in early rheumatoid arthritis patients. Patients with two copies of the shared epitope were four times more likely to achieve significant improvement in disease activity compared to those with one or no copies.
Researchers discovered strong evidence for natural selection at eight genes in European-American populations, likely related to environmental conditions. The study found connections between genetic variation and diseases such as diabetes, obesity, high blood pressure, kidney disease, and Alzheimer's.
A study found that genetic differences are the primary cause of variation in long-term average alcohol intake. Some genes affect both intake and dependence, while others influence only dependence. The research suggests that individuals can make lifestyle choices to improve their health and reduce risk, even with a family history of hea...
Researchers discovered a genetic marker, PTPN22, associated with a two-fold increased risk of rheumatoid arthritis. The variant impairs immune regulation, leading to hyperresponsiveness and inflammation.
A comprehensive DNA analysis of 744 healthy volunteers has identified 49 distinct genetic variants associated with increased risk of sudden cardiac death. These variants were found in specific ethnic groups and may impact diagnosis and testing for long QT syndrome, particularly among minority patients.
A new study identified three genetic variants associated with a 30% increase in prostate-specific antigen (PSA) levels. The discovery could lead to more accurate testing and fewer unnecessary biopsies, particularly for black men who are at higher risk of developing prostate cancer.
A recent study by A. A. Hoffmann et al. found that the fruit fly Drosophila birchii lacks genetic variation to adapt to changing thermal conditions, a concern for endangered species. UC Riverside's Derek Roff warns that global warming may exacerbate this issue, threatening the survival of already endangered species.
Researchers have found a potential genetic link between variations in the beta-2 receptor gene and a reduced risk of heart attack and death from coronary disease. The study, published by the American Heart Association, suggests that individuals with certain forms of the gene may be more resilient to cardiovascular disease.
Researchers found that cardiac surgery patients with the factor V Leiden gene variant lost less blood and required fewer transfusions than those without the mutation. The study suggests a new approach to personalized medicine, tailoring therapies based on individual genetic risk factors.
Researchers found that specific genetic variants, such as the val158met polymorphism in the COMT gene, influence an individual's sensitivity to pain. This genetic variation affects brain regions involved in pain perception and emotional regulation, leading to increased pain ratings and a more negative internal state.
A recent study found that individuals with two linked genetic variations are more likely to experience anxiety after consuming caffeine. The researchers validated a methodology that can identify individual differences in how people respond to major drugs, paving the way for future studies on other substances.
The HapMap project aims to chart genetic variation within the human genome by comparing differences among individuals. Researchers hope to create a tool to detect genetic contributions to many diseases, improving drug design and diagnostic tools.
A genetic variation in monoamine oxidase A (MAO A) enzyme may protect maltreated children against antisocial behavior, with a ninefold increased risk of aggression in those with low enzyme activity. In contrast, higher MAO A levels were associated with trauma resistance and reduced behavior problems.
A recent study published in Science finds that the genetic variation of the nene bird species decreased significantly between 160-850 years ago, likely due to human expansion on the island of Hawaii. The researchers used DNA analysis from ancient specimens and modern captive birds to draw this conclusion.
Researchers found that Hsp90 helps proteins fold properly by acting as a buffer for subtle genetic mutations. Lowering its function releases hidden genetic changes, which can lead to valuable new traits in plants and animals.
A study by Dr. David Veenstra at the University of Washington identified two genetic variants associated with an increased risk of severe bleeding incidents in patients taking warfarin. Patients with these variants required longer time to achieve stable dosing, suggesting potential for dose adjustment and closer monitoring.