Articles tagged with Genetic Variation
A systematic study confirms the potential of pharmacogenomics to improve drug therapies by selecting treatments based on a patient's genetic profile. However, the practice faces significant challenges, including inadequate training, funding, and concerns about racial inequities.
Researchers found that HBV polymerase mutations can restore viral replication rate while maintaining drug resistance, affecting treatment efficacy. Entecavir proved effective against even the most vigorous drug-resistant mutants, offering a promising alternative to lamivudine.
Studies found human evolution led to a decrease in high-risk genetic variants associated with these diseases, instead increasing protective e2 and e3 variants. Analysis suggests advantageous mutations may have driven this shift.
A study by Duke University Medical Center researchers has found a possible genetic link determining which heart patients are more likely to suffer kidney damage after surgery. The research team found that the E-4 variant of the apolipoprotein APO gene, already implicated in Alzheimer's disease, appears to offer protection to the kidneys.
A genetic variant of HIV linked to rapid disease progression in the US and Europe is rare in Africa, according to a new study. The findings may impact the design of HIV vaccines and therapies for underdeveloped regions where the epidemic is expanding.
Research suggests that people with E-4 variant of the apo gene are at high risk for developing Alzheimer's disease and vascular diseases. The study found significant differences in brain volume and white matter abnormalities between those with and without the gene variant, suggesting a link to silent strokes and cognitive decline.
Researchers at the University of Chicago have discovered a molecular mechanism that allows organisms to evolve new traits in response to environmental stress. The mechanism involves the protein heat shock protein 90 (Hsp 90), which normally keeps genetic variations silent but can reveal them during times of stress.
Researchers at Wake Forest University Baptist Medical Center demonstrated a gene-diet interaction that affects cholesterol absorption in humans. The study found that individuals with the apo A-IV-2 gene variant absorbed less cholesterol than those without the variant, particularly on diets high in polyunsaturated fat.
Scientists have discovered two new variants of the APC gene associated with an increased risk of bowel cancer. These variants, found in a study published in the Proceedings of the National Academy of Sciences, may be more common than previously thought and increase susceptibility to pre-cancerous polyps.
Researchers have identified a genetic risk factor for late-onset Alzheimer's disease, combining the E4 variant of apolipoprotein E with the butyrylcholinesterase K variant. This combination significantly increases the risk of developing Alzheimer's disease in people over 65 years old.
A study found that certain genetic variants next to the human obesity (OB) gene are associated with obesity in young women, as well as depression and anxiety. The results suggest a direct link between the OB gene variants and depression, rather than just secondary effects.
A University at Buffalo study finds that certain genetic variants near the human obesity gene are associated with obesity in young women, as well as depression and anxiety. The study also suggests that these genes may contribute to the development of behavioral disorders in young women.