Research on how genomes change over time. Covers hidden DNA structure, chromosome bursts in cancer, plant pangenomes, and microbial adaptation.
Scientists identified a highly conserved type IV secretion system in Rickettsia, linked to virulence, and discovered gene duplication and additional contributing genes. The study provides insight into the evolution of Rickettsia virulence and sheds light on its potential as emerging infectious agents.
Researchers have rediscovered a dormant human gene, IRGM, which was thought to be extinct for millions of years. The study, published in PLOS Genetics, reveals that the gene was resurrected through a complex series of structural events, suggesting its potential importance in fighting new or resistant infectious agents.
Dr. Sara Sawyer will use a $120,000 grant to study how HIV and its host cells have evolved together over time. By analyzing the genomes of primates, she aims to identify critical genes and proteins that could lead to new antiviral drug targets.
A global survey of salivary microbes found that the oral microbiome diversity among individuals is similar to that among people from different parts of the world. The study, led by Dr. Mark Stoneking, analyzed bacterial gene sequences from saliva samples from 120 healthy subjects across six geographic areas and compared them with a dat...
Researchers found that fruit fly females' genes are activated similarly to an immune reaction when they mate, leading to a heightened defense system. The cost of mating is also revealed to be high, as females produce fewer offspring due to male harassment and toxic sperm fluid.
African populations are still evolving due to natural selection, with lactose tolerance and genetic variation influenced by diseases like malaria. Penn genetics researcher Sarah Tishkoff presents her findings on human evolutionary history in Africa.
Researchers at the University of California, Santa Cruz, have found evidence that mobile repetitive elements, or 'jumping genes,' significantly impact the evolution of gene regulatory networks. At least five percent of the human genome has been under negative selection during most of mammalian evolution, indicating functional importance.
Researchers at ASU have discovered that humans have a unique genetic adaptation to starch consumption, with high-starch diets associated with more copies of the AMY1 gene. This finding provides insight into why certain populations may be better equipped to handle diarrheal diseases.
Researchers from Max Planck Institute and 454 Life Sciences Corp. have completed a draft version of the Neandertal genome, providing insights into their genetic relationship with modern humans. The study reveals significant differences between the Neandertal and human genomes, shedding light on how our species diverged.
Researchers found a surge in duplicated sequences containing rapidly evolving genes in the genomes of humans and great apes, with most differences occurring prior to the speciation of chimpanzees. The study suggests that genetic differences contribute significantly to the distinctiveness between humans and chimps, and that these region...
Researchers develop feature frequency profiles technique for organizing large sets of data, including nucleotide base sequences, books, and images. The method provides more comprehensive analysis over standard tools, correctly grouping works by category and author, and shedding new light on Shakespeare's authorship.
A study by the Wellcome Trust Sanger Institute suggests that around 1 in 200 human genes may be unnecessary for human health. The researchers found that single-letter changes in genetic code can disrupt proteins, leading to variations that are either beneficial or have little consequence.
Researchers at Instituto Gulbenkian de Ciência discover mechanism to silence transposable elements in sperm cells, preventing harmful mutations. The technique, developed by Jörg Becker's team, uses small interfering RNA to target and silence these DNA elements.
A rapidly evolving gene contributes to the origin of new species by driving an evolutionary arms race inside cells. The Nup160 and Nup96 genes, which code for gatekeepers of a cell's nucleus, have become incompatible between closely related fruit fly species.
Researchers compared four different strains of Coxiella burnetii to build a comprehensive picture of its genetic architecture and content. They found that strain virulence was associated with a smaller genome and the loss of genes, possibly due to pseudogene formation.
A new class of nonprotein coding genes, known as lincRNAs, has been discovered in mammals with critical regulatory roles in health and disease. The study reveals that these long RNAs play important roles in regulating cellular processes such as cell proliferation, immune signaling, and stem cell biology.
Researchers at Helmholtz Zentrum München sequenced sorghum's genome, gaining insights into its drought tolerance and C4 photosynthesis. The analysis provides new information on the evolution of crop plant genomes.
Researchers have developed a new method for comparing whole genome sequences, revealing new genetic relationships and surprising discoveries. This technique can compare entire genomes, not just selected genes, and has classified previously enigmatic bacteria and viruses.
Researchers at Uppsala University identified fast-evolving human genes with patterns of molecular evolution not driven by natural selection. Instead, biased gene conversion (BGC) speeds up the rate of evolution in certain genes, fixing harmful mutations.
Research by Drs. Bergman and Siegal explores evolutionary capacitance, a concept addressing stability of species under accumulated genetic variation. They found that most genes hold variation in reserve, releasing it when functionally compromised.
Researchers at the University of Georgia discovered that natural selection on gene function is driving the evolution of LTR retrotransposons in plant genomes. The study found strong purifying selection across all gene regions, but rare episodes of positive selection and adaptation to host genomes.
Researchers have developed a new method to prioritize disease-associated SNPs by analyzing genes with high differential expression rates. This approach, called fitSNPs, successfully distinguished true disease genes from false positives in genome-wide association studies, and can serve as a powerful tool for prioritizing disease genes.
A new theory in evolutionary biology proposes that sex promotes genes' ability to perform well with many partners rather than just one specific set of genes. This idea, called genetic mixability, finds that sexual reproduction favors genes that work well across multiple variations.
Researchers at McGill University have found a molecular mechanism that maintains social harmony in ants by limiting their fertility. This discovery supports Charles Darwin's theory of natural selection and provides insight into the evolution of eusocial organisms like ants.
Researchers discover a single gene, FLO1, that enables yeast cells to cooperate and protect each other from stress and harm. Cells expressing FLO1 form flocs, shielding inner cells from danger while excluding 'cheaters' that do not express the gene.
Researchers compared many human and chimpanzee genomes to identify duplicated or lost regions during evolution, finding similar patterns in copy number variation but key gene differences. CNVs affected genes involved in inflammation and cell proliferation, with one gene linked to HIV susceptibility found to have reduced numbers in chimps.
Researchers at the Genome Institute of Singapore found that 'junk' DNA plays a crucial role in distinguishing humans from other species. These repeats provide a source of evolutionary variability and may hold the key to understanding physical differences between humans and other organisms.
A study by Tomislav Domazet-Lošo and Diethard Tautz reveals that most disease-associated genes originated before the first cells emerged, with only recently evolved genes showing no link to human diseases. This discovery sheds light on the evolutionary origins of genetic diseases affecting humans and other living organisms.
Researchers at Stanford University School of Medicine discovered ultraconserved DNA regions that have been highly conserved throughout evolution. Despite being deleted in laboratory animals, these regions are less likely to be lost in primates and rodents, suggesting a possible role in fundamental biological processes.
A recent study published in Genome Research found that ultraconserved elements, identical between humans and animals, play a crucial role in the natural evolution of species. These elements account for less than 2% of the human genome but are essential for the survival of many species.
A new computer program trains itself to predict genes in fungal DNA sequences, improving accuracy and efficiency. The program uses a probabilistic mathematical model to pinpoint boundaries between coding and non-coding sequences.
The Pristionchus pacificus worm genome is substantially larger and more complex than C. elegans, containing nearly 170,000 chemical bases and 23,500 protein-coding genes. The genome supports the theory that P. pacificus might be a precursor to parasitic worms.
The Pristionchus pacificus genome consists of a large number of genes, some with unexpected functions, providing clues to understanding complex interactions between host and parasite. The discovery sheds light on the evolution of parasitism and has potential implications for our understanding of host-parasite relationships.
Researchers have identified the genomic origins of Saccharomyces pastorianus, a hybrid yeast used in lager brewing. The study reveals two independent origins of today's extant S. pastorianus strains, suggesting that each group derived its Saccharomyces cerevisiae portion from distinct ale yeasts.
Researchers identified a genetic contributor to fundamental morphological differences between humans and apes, finding that changes in 'junk DNA' activated genes in primordial thumb and big toe in developing mouse embryos. This study suggests non-coding regions of the genome play a crucial role in human development.
The Trichoplax genome sequence provides a 'Rosetta Stone' for understanding the origins of animal-specific pathways. It shares over 80% of its genes with humans and defines Trichoplax as a branching point of animal evolution.
Researchers characterize grapevine transposons, finding they capture and amplify gene sequences, influencing gene evolution. The study also reveals 'domesticated' transposons with cellular roles, contributing to genetic diversity.
A new resource called Proteopedia links written information with interactive 3D images of biomacromolecules, enabling easy creation and editing by users. By integrating 3D structures with descriptive text, Proteopedia aims to make complex structural information comprehensible to all.
The analysis of Trichoplax adhaerens' genome sheds light on the ancestral relationship between placozoans and other animals, revealing a complex suite of genes and signaling pathways. The findings also suggest that placozoans may have played a more significant role in animal evolution than previously thought.
A study on Trichoplax genome findings aids researchers in learning how groups of genes function in humans and other species. The genetic code of this simple saltwater creature reveals common genes among many species, helping scientists figure out their lineage and divergence.
A new study identifies three groups of cancers distinguished by early developmental signatures, shedding light on their gene expression patterns. This research provides a reference framework for interpreting smaller-scale functional studies and has implications for understanding human disease from a 'macrobiological' approach.
Research suggests that schizophrenia may be a by-product of human brain evolution, driven by increased metabolic demands. The study found molecular mechanisms involved in the evolution of human cognitive abilities and identified changes in gene expression and metabolite concentrations in both healthy humans and individuals with schizop...
A new study by Claus Wilke and D. Allan Drummond found that genetic evolution prioritizes minimizing errors in protein production to prevent misfolded proteins, which can cause neurodegenerative diseases. The research may lead to better detection of genes with mutations leading to toxic proteins.
A Harvard University study reveals that genes have evolved to minimize protein production errors, which can cause neurodegenerative diseases like ALS. The research found that natural selection favors the development of genes that prevent misfolded proteins resulting from translation mistakes.
A multi-disciplinary group proposes ten principles to guide the use of racial and ethnic categories in genetic research, minimizing misinterpretation and misuse of human genetic variation. The guidelines recognize that racial and ethnic categories are socio-political constructs that change over time.
Researchers have discovered that choanoflagellates, single-celled organisms, possess similar levels of proteins used for cell communication in more complex organisms like humans. This finding confirms their role as an evolutionary link between single-celled and multi-cellular organisms.
A large-scale genome analysis reveals that birds did not evolve from a common ancestor as previously thought, but instead underwent multiple adaptations to diverse environments. The study's results challenge current classifications and provide valuable insights into the evolutionary history of birds.
A symposium in the Biological Bulletin highlights the powerful advantages of using gene catalogs to infer biological function in marine animals, including the sea urchin and tubeworm. By comparing their genomes with those of other organisms, researchers can gain new clues about how physiological systems evolved.
Researchers have developed a method to classify liver toxins using gene-expression profiling of blood samples, improving the precision of compound classification. The study highlights the importance of 'phenotypic anchoring' in linking gene expression data analysis to traditional measures of toxicology.
A newly sequenced lancelet genome confirms a 40-year-old theory that gene duplication drove vertebrate evolution. The study shows that genes quadrupled during the evolution of vertebrates, with most duplicate copies lost.
Researchers have discovered insights into vertebrate origins and the evolution of immune systems, nervous system development, and cell signaling through the analysis of the amphioxus genome. The study reveals conserved genes and DNA elements between amphioxus and humans, suggesting a common ancestor with vertebrates.
A new study investigates the evolution of genomic imprinting in mammals, finding that different regions became imprinted at different times during mammalian evolution. This suggests that changes were in response to selection pressures and are adaptive.
Researchers can now contribute to large-scale community protein annotation, enhancing comprehensive coverage of biomedical knowledge. WikiProteins combines existing authoritative databases with mined scientific papers, creating over one million concept clouds called 'Knowlets', which can be annotated by experts.
Researchers have discovered a critical flaw in the standard method for analyzing gene evolution, particularly for genes encoding multi-domain proteins. A new tool called Neighborhood Correlation has been developed to correctly identify gene ancestry, which is essential for understanding gene function and regulatory circuitry. The tool ...
A consortium of scientists including CSHL's Gregory J. Hannon report findings about mammalian evolution gleaned from comparative study of small-RNA function in platypus, revealing unique characteristics such as egg-laying and venom delivery. The platypus genome also shows conserved small-RNA roles across species.
The first duck-billed platypus genome analysis reveals clues about early mammalian genome organization and the evolution of unique characteristics. The study found that the platypus shares more than 80% of its genes with other mammals, but also has distinct genetic features associated with reptilian and avian traits.
The platypus genome provides insights into the evolution of venom components and a bird-like sex-determination system in mammalian ancestors. Researchers have found that platypus venom genes evolved by gene duplication of antimicrobial beta-defensins, mirroring an independent evolutionary pathway in reptiles.
The platypus genome provides a comprehensive understanding of the animal's mix of features, including duck-billed snout, venomous spur, and electroreceptors. The analysis compares the platypus genome with other mammals and birds, revealing conserved genes and traits, as well as unique characteristics such as odor receptor expansion.
The genome sequence of Podospora anserina shows the fungus has a large set of genes involved in breaking down complex carbon sources, including cellulose and lignin. This discovery may lead to novel regulatory mechanisms during growth and reproduction, with potential applications in biotechnology.
Researchers analyzed genomic data to reveal the evolution of rickettsial genomes and their diversity. The study provides an ideal resource for developing vaccines, diagnostics, and therapeutics for Rickettsia diseases.