Articles tagged with Genome Sequencing
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
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Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Genetic analysis reveals dozens of chemical compounds associated with tomato flavor that have been lost in modern varieties. Selection for size and firmness has led to a reduction in sweetness and flavor content, highlighting the need to reintroduce flavor-infusing genes.
A team led by David Baker used metagenomic sequences to generate structural models for 614 proteins, including those from neglected families. The collaboration between the Baker lab and DOE JGI enabled a powerful way of predicting structures, increasing coverage of known protein families.
A national consortium of researchers is studying the pros and cons of genome sequencing for newborn health, raising questions about parental responsibility and child autonomy. The four studies across the US aim to develop evidence for guidelines on effectively incorporating new technology into newborn screening or care.
A national consortium of clinical geneticists is studying the use of genome sequencing for newborn health screenings, prevention, and prediction. The study aims to develop guidelines for incorporating this technology into newborn care.
Researchers used comparative genomics to study the giant panda and red panda, revealing 70 adaptively convergent genes involved in limb development, digestion, and pseudogenization. These findings provide insights into the genetic mechanisms underlying phenotype convergence in these species.
A team of researchers has identified genetic mutations that enable microalgae from the Southern Ocean to adapt to extreme and variable climates. The study provides insights into how polar organisms cope with environmental changes induced by human activity.
A comparative genomic analysis of Antarctic diatom Fragillariopsis cylindrus reveals its ability to adapt to extreme cold by selectively expressing variant genes. The study provides insights into the organism's genome structure and evolution, highlighting its unique genetic features that enable survival in harsh environments.
Researchers at the Earlham Institute have developed a new method for improving wheat crop yield quality using bioinformatics tools. The w2rap pipeline enables robust and efficient genome assembly, which will aid in precision breeding and increase global food security.
Researchers have created a novel method called RESA to identify mRNA-regulatory sequences in embryos, providing insights into the maternal-to-zygote transition and gene regulation. This breakthrough has broad applications for studying genetics and biology across various species.
Scientists have sequenced the ash tree genome, which aids the breeding of resistant trees against ash dieback fungus. The UK is home to over 1,000 species that rely on ash trees, making their conservation crucial.
A study sequencing genomes of Shigella sonnei isolates found two clusters of outbreaks, one causing severe gastrointestinal problems due to a toxin gene acquired from other Shigella species and another resistant to fluoroquinolone antibiotics. The findings provide insights into the bacteria's virulence and antibiotic resistance genes.
Researchers have sequenced the dry jujube genome, identifying key factors in sugar and acid content, and genes involved in breeding compatibility. This knowledge will aid breeders in creating improved jujube varieties.
A large genome study has identified potential virulence factors to discriminate new Francisella species from the deadly F. tularensis bacterium. The study provides a framework for identifying new isolates and environmental detections, improving disease diagnosis and bioweapon detection.
A new battery-powered detection system can identify 16 virulent pathogens with high sensitivity and provides positive identification from as few as 10 DNA sequences. The device is designed for use in remote locations where laboratory resources are lacking, addressing the lack of timely diagnosis and effective treatment.
The whitefly's genome has expanded families of detoxification genes and acquired 142 genes from bacteria or fungi that enable it to feed on diverse plants and evolve resistance to insecticides. This discovery will aid in the development of new control strategies using RNA interference to combat this global pest.
A international research collaboration sequenced the entire seahorse genome, revealing gene losses and duplications that enabled specialized traits such as male pregnancy and armored body. The study provides insights into evolutionary mechanisms driving biodiversity.
Researchers found Atlantic killifish adapting to toxic pollutants due to high genetic variation, making them more resilient than other species. This study suggests that genetic diversity is key to evolutionary adaptation and could inform strategies for human sensitivity to environmental chemicals.
A Chinese research group found that the Tibetan Mastiff's high-altitude adaptation is due to interbreeding with the Tibet grey wolf, introducing a DNA swap at two genomic hotspots. This process shares similarities with human evolution, highlighting ancient interbreeding as a key factor in adaptations.
The KAT tool analyzes K-mer datasets to identify error levels, biases, and contamination in sequencing data. It also checks genome assemblies for completeness and accuracy without external reference data.
A team of researchers has identified the genetic mechanisms driving the metamorphosis that transforms flounders from symmetrical larvae to asymmetrical adults. The discovery sheds new light on an evolutionary puzzle, but also has practical implications for the fishing industry, which faces significant losses in flounder aquaculture.
Researchers at the University of São Paulo developed a platform that analyzes clinical samples to diagnose infection by 416 viruses found in tropical regions. The tool is designed for reference laboratories and can detect pathogens with the potential to cause epidemics in humans.
The ginkgo genome reveals extensive expansion of gene families for defensive mechanisms against pathogens and insects, as well as unique traits such as transposable elements. The sequence provides a genetic resource for studying early events in tree evolution and the history of demography and distribution.
Researchers sequenced coral genomes to model population histories and show that corals can recover after environmental disasters. The study confirms fossil evidence and suggests that current reef deterioration can be reversed by reducing environmental stresses.
Researchers sequenced the genome of a 5,310-year-old corn cob and found it was genetically more similar to modern maize than its wild ancestor. The study provides insights into the early stages of maize domestication and its dispersal across the Americas.
The American College of Medical Genetics and Genomics has released updated recommendations for reporting secondary findings in clinical exome and genome sequencing. The new list, ACMG SF v2.0, includes four additional genes and one removed gene, totaling 59 medically actionable genes recommended for return. The updates aim to provide s...
The Japanese morning glory genome has been fully decoded, revealing genes that determine flower and leaf shapes, as well as flower colors and patterns. The research also identified a gene involved in plant hormone biosynthesis disrupted by transposons in mutants.
A pioneering study by Gilad Evrony and colleagues found that every brain cell has a unique genome resulting from somatic mutations during development. These findings hold promise for understanding unexplained neurologic diseases such as epilepsy, autism, and schizophrenia.
The DOE JGI has selected 37 projects for its 2017 Community Science Program, focusing on sustainable biofuels, plant microbiomes, and biogeochemistry. Researchers will utilize the DOE's sequencing capabilities to study key areas such as reference genomes for plants relevant to bioenergy production.
HybPiper is a streamlined pipeline for processing target-enrichment data, extracting coding and intronic regions, and detecting duplicate gene copies. The tool allows researchers to quickly analyze large amounts of DNA sequencing data, facilitating accurate species relationships.
Scientists have sequenced the entire genome of Xenopus laevis, an African clawed frog that inherited two sets of chromosomes from different species. The study provides insights into vertebrate evolution and sheds light on how tetraploidy emerged in animals.
A new program called CrispRGold helps scientists identify the most effective and specific RNA sequences for CRISPR-Cas9 system. This allows for efficient inactivation of genes in primary cells, enabling researchers to discover new genes involved in immune cell regulation.
Researchers discovered that parasitic plants, such as broomrapes, can transfer genes from their host plants, making them more invasive and resistant. This horizontal gene transfer may lead to the development of resistant host plants to combat crop loss caused by these weeds.
The Xenopus laevis genome shows that hybridization between two extinct species led to a doubling of genes and the emergence of tetraploidy. Researchers found nearly a thousand non-functional genes, revealing insights into ancient genome duplication events in vertebrates.
Scientists sequenced the entire genome of Xenopus laevis, revealing it inherited two sets of chromosomes from different diploid ancestors. The discovery provides insights into vertebrate evolution and tetraploidy, a phenomenon where an organism has four sets of chromosomes.
A new genome assembly process allows for rapid access to genetic information in Cabernet Sauvignon, enabling researchers to identify genetic markers for breeding disease-resistant vines. This breakthrough paves the way for developing new wine grape varieties suitable for changing climate conditions.
A team of researchers has successfully isolated Zika virus from a semen sample, obtaining the first complete genome sequence of the virus in humans. The study provides valuable insights into potential sexual transmission of Zika virus, which was previously poorly understood.
Scientists have created a genetic catalog of the African diaspora in the Americas, revealing why certain diseases hit those with African ancestry harder. The study found changes in DNA that put Africans at higher risk for diseases, and highlights the importance of understanding population histories to tailor clinical care.
Researchers found a phage carrying animal-like DNA related to the black widow spider toxin gene, which also shares DNA with animal genomes. This discovery may provide insights into genetic engineering Wolbachia to fight diseases.
A Japanese research team has identified the causative gene for a common type of hearing loss, sensorineural hearing loss, which affects one in every 1000 infants. The gene, DIAPH1, is involved in actin filaments and their maintenance in auditory hair cells, leading to progressive deafness in transgenic mice.
Scientists are exploring the relationship between genome architecture and antigen variation in pathogens like Trypanosoma brucei. By analyzing the parasite's genomic structure, researchers aim to better understand how these pathogens evade the immune system and develop more effective vaccines.
Researchers studied rates of mutation in a range of organisms and found that males contribute more genetic mutations than females. This male mutation bias may arise from errors in DNA replication and is critical for understanding disease-associated mutations.
The ocean sunfish's unusually fast growth rate and large size may be attributed to altered genes that control growth hormone signalling. The fish's skeleton is largely made of cartilage, a trait that could provide insights into its development.
Researchers sequenced the genome of C. geophilum and found specific adaptations that could help host trees be more resistant to drought stress. The fungus has a reduced number of plant cell wall degrading enzymes and a large set of symbiosis-induced lineage-specific genes, including water channel genes.
Researchers at TGen and NAU used deep DNA sequencing to recreate the anthrax genome from Sverdlovsk, Russia victims, providing a precise examination of the anthrax strain used in Soviet biological weapons development. The study's findings put the strain into a global context, enabling forensic tracking and identification.
Researchers found misregulated imprinting at play in hybrid seeds from South American wild tomato species, affecting core gene regulation and contributing to seed failure. Genome-wide shifts occurred that favored maternal expression, suggesting a key role for epigenetic genomic imprinting in explaining differences in seed viability.
Researchers at Uppsala University sequenced the genomes of 11 flycatchers, estimating the mutation rate in birds for the first time. The study found that more common species have lower mutation rates.
Researchers have reconstructed the first high-quality genome of the Justinianic strain of Yersinia pestis, shedding light on the evolutionary history of the plague bacterium. The study provides new insights into the genetic diversity of the pathogen and its human impact.
Researchers sequenced and analyzed the genomes of 38 wild snub-nosed monkeys from four endangered species, revealing reduced genetic diversity and a similar number of harmful mutations. The study identified hypoxia-related genes that enable these primates to thrive in high-altitude environments.
Researchers at the DOE JGI have discovered over 125,000 viral genomes infecting microbes, increasing the number of known microbial phyla by a factor of 16. The study provides a unique resource for viral sequence information and has implications for understanding global cycles and energy challenges.
The Soybean Knowledge Base (SoyKB) uses high-performance computing to analyze soybean genetic data, promoting deeper understanding for scientists improving crops. Over 2,000 unique users log on monthly, with over 10,000 utilizing the platform since its development in 2010.
MGH researchers discovered the role of DDI-1 and PNG-1 in sensing proteasome stress, with potential applications in cancer treatment and Alzheimer's disease. The findings suggest boosting proteasome activity could help treat conditions characterized by abnormal protein deposits.
The sequencing of the tobacco hornworm moth's genome has opened new avenues for research, including understanding insect physiology, biochemistry, and molecular biology. The study identified over 600 genes involved in defense against pathogens, highlighting the potential for genetic insights into this important agricultural pest.
A recent study has uncovered evidence of HIV-related retroviruses dating back 60 million years, challenging previous estimates of their origin. The research, led by Daniel Elleder, analyzed genomic data from the Malayan flying lemur and reconstructed ancient viral genomes.
A new Autism Speaks MSSNG study has expanded understanding of autism's complex causes, highlighting the role of non-coding DNA and environmental factors in gene changes. The research found a clear difference between de novo mutations from the mother and father, with clustered mutations from the mother linked to copy number variations.
A team of researchers sequenced 264 complete genomes from Richard Lenski's long-term evolution experiment (LTEE) to examine how E. coli bacteria changed over 50,000 generations. They found more than 14,000 changes across 12 populations, with mutations concentrated in genes that gave the bacteria a competitive edge.
A team of researchers studied four filamentous Ascomycete fungi to understand their role in carbon degradation. They identified a wide variety of carbohydrate-active enzymes that can directly oxidize labile and recalcitrant carbon, suggesting these species play a key role in lignocellulose conversion.
A team of researchers has successfully sequenced the genome of 6,000-year-old Chalcolithic barley grains, revealing genetic similarities with present-day barley grown in the Southern Levant. The study provides new insights into the origins of barley domestication and suggests that it occurred in the Upper Jordan Valley.
A comprehensive study has mapped the genetic underpinnings of type 2 diabetes, revealing over a dozen risk genes and pinpointing specific protein sequences that contribute to disease development. The findings highlight the complexity of the condition and emphasize the need for personalized treatment approaches.
Researchers have identified 84 potential inherited gene mutations that may contribute to severe forms of bipolar disorder. The study used advanced genome sequencing techniques to analyze DNA from 36 family members with the disease, finding rare genetic variations that were overrepresented in those with bipolar disorder.
Researchers at Hospital for Special Surgery discovered a potential genetic trigger of systemic autoimmune disease, linking virus-like elements to two autoimmune diseases. The study found that abnormal expression of genetic elements known as LINE-1 retroelements may contribute to the development of lupus and Sjogren's syndrome.