Articles tagged with Genome Sequencing
Researchers sequenced the genome of a 5,310-year-old corn cob and found it was genetically more similar to modern maize than its wild ancestor. The study provides insights into the early stages of maize domestication and its dispersal across the Americas.
The Japanese morning glory genome has been fully decoded, revealing genes that determine flower and leaf shapes, as well as flower colors and patterns. The research also identified a gene involved in plant hormone biosynthesis disrupted by transposons in mutants.
The DOE JGI has selected 37 projects for its 2017 Community Science Program, focusing on sustainable biofuels, plant microbiomes, and biogeochemistry. Researchers will utilize the DOE's sequencing capabilities to study key areas such as reference genomes for plants relevant to bioenergy production.
A pioneering study by Gilad Evrony and colleagues found that every brain cell has a unique genome resulting from somatic mutations during development. These findings hold promise for understanding unexplained neurologic diseases such as epilepsy, autism, and schizophrenia.
HybPiper is a streamlined pipeline for processing target-enrichment data, extracting coding and intronic regions, and detecting duplicate gene copies. The tool allows researchers to quickly analyze large amounts of DNA sequencing data, facilitating accurate species relationships.
A new program called CrispRGold helps scientists identify the most effective and specific RNA sequences for CRISPR-Cas9 system. This allows for efficient inactivation of genes in primary cells, enabling researchers to discover new genes involved in immune cell regulation.
Scientists have sequenced the entire genome of Xenopus laevis, an African clawed frog that inherited two sets of chromosomes from different species. The study provides insights into vertebrate evolution and sheds light on how tetraploidy emerged in animals.
Researchers discovered that parasitic plants, such as broomrapes, can transfer genes from their host plants, making them more invasive and resistant. This horizontal gene transfer may lead to the development of resistant host plants to combat crop loss caused by these weeds.
The Xenopus laevis genome shows that hybridization between two extinct species led to a doubling of genes and the emergence of tetraploidy. Researchers found nearly a thousand non-functional genes, revealing insights into ancient genome duplication events in vertebrates.
Scientists sequenced the entire genome of Xenopus laevis, revealing it inherited two sets of chromosomes from different diploid ancestors. The discovery provides insights into vertebrate evolution and tetraploidy, a phenomenon where an organism has four sets of chromosomes.
A new genome assembly process allows for rapid access to genetic information in Cabernet Sauvignon, enabling researchers to identify genetic markers for breeding disease-resistant vines. This breakthrough paves the way for developing new wine grape varieties suitable for changing climate conditions.
A team of researchers has successfully isolated Zika virus from a semen sample, obtaining the first complete genome sequence of the virus in humans. The study provides valuable insights into potential sexual transmission of Zika virus, which was previously poorly understood.
Researchers found a phage carrying animal-like DNA related to the black widow spider toxin gene, which also shares DNA with animal genomes. This discovery may provide insights into genetic engineering Wolbachia to fight diseases.
Scientists have created a genetic catalog of the African diaspora in the Americas, revealing why certain diseases hit those with African ancestry harder. The study found changes in DNA that put Africans at higher risk for diseases, and highlights the importance of understanding population histories to tailor clinical care.
A Japanese research team has identified the causative gene for a common type of hearing loss, sensorineural hearing loss, which affects one in every 1000 infants. The gene, DIAPH1, is involved in actin filaments and their maintenance in auditory hair cells, leading to progressive deafness in transgenic mice.
Scientists are exploring the relationship between genome architecture and antigen variation in pathogens like Trypanosoma brucei. By analyzing the parasite's genomic structure, researchers aim to better understand how these pathogens evade the immune system and develop more effective vaccines.
Researchers studied rates of mutation in a range of organisms and found that males contribute more genetic mutations than females. This male mutation bias may arise from errors in DNA replication and is critical for understanding disease-associated mutations.
The ocean sunfish's unusually fast growth rate and large size may be attributed to altered genes that control growth hormone signalling. The fish's skeleton is largely made of cartilage, a trait that could provide insights into its development.
Researchers at TGen and NAU used deep DNA sequencing to recreate the anthrax genome from Sverdlovsk, Russia victims, providing a precise examination of the anthrax strain used in Soviet biological weapons development. The study's findings put the strain into a global context, enabling forensic tracking and identification.
Researchers sequenced the genome of C. geophilum and found specific adaptations that could help host trees be more resistant to drought stress. The fungus has a reduced number of plant cell wall degrading enzymes and a large set of symbiosis-induced lineage-specific genes, including water channel genes.
Researchers at Uppsala University sequenced the genomes of 11 flycatchers, estimating the mutation rate in birds for the first time. The study found that more common species have lower mutation rates.
Researchers found misregulated imprinting at play in hybrid seeds from South American wild tomato species, affecting core gene regulation and contributing to seed failure. Genome-wide shifts occurred that favored maternal expression, suggesting a key role for epigenetic genomic imprinting in explaining differences in seed viability.
Researchers have reconstructed the first high-quality genome of the Justinianic strain of Yersinia pestis, shedding light on the evolutionary history of the plague bacterium. The study provides new insights into the genetic diversity of the pathogen and its human impact.
Researchers sequenced and analyzed the genomes of 38 wild snub-nosed monkeys from four endangered species, revealing reduced genetic diversity and a similar number of harmful mutations. The study identified hypoxia-related genes that enable these primates to thrive in high-altitude environments.
Researchers at the DOE JGI have discovered over 125,000 viral genomes infecting microbes, increasing the number of known microbial phyla by a factor of 16. The study provides a unique resource for viral sequence information and has implications for understanding global cycles and energy challenges.
The Soybean Knowledge Base (SoyKB) uses high-performance computing to analyze soybean genetic data, promoting deeper understanding for scientists improving crops. Over 2,000 unique users log on monthly, with over 10,000 utilizing the platform since its development in 2010.
MGH researchers discovered the role of DDI-1 and PNG-1 in sensing proteasome stress, with potential applications in cancer treatment and Alzheimer's disease. The findings suggest boosting proteasome activity could help treat conditions characterized by abnormal protein deposits.
The sequencing of the tobacco hornworm moth's genome has opened new avenues for research, including understanding insect physiology, biochemistry, and molecular biology. The study identified over 600 genes involved in defense against pathogens, highlighting the potential for genetic insights into this important agricultural pest.
A recent study has uncovered evidence of HIV-related retroviruses dating back 60 million years, challenging previous estimates of their origin. The research, led by Daniel Elleder, analyzed genomic data from the Malayan flying lemur and reconstructed ancient viral genomes.
A new Autism Speaks MSSNG study has expanded understanding of autism's complex causes, highlighting the role of non-coding DNA and environmental factors in gene changes. The research found a clear difference between de novo mutations from the mother and father, with clustered mutations from the mother linked to copy number variations.
A team of researchers sequenced 264 complete genomes from Richard Lenski's long-term evolution experiment (LTEE) to examine how E. coli bacteria changed over 50,000 generations. They found more than 14,000 changes across 12 populations, with mutations concentrated in genes that gave the bacteria a competitive edge.
A team of researchers studied four filamentous Ascomycete fungi to understand their role in carbon degradation. They identified a wide variety of carbohydrate-active enzymes that can directly oxidize labile and recalcitrant carbon, suggesting these species play a key role in lignocellulose conversion.
A team of researchers has successfully sequenced the genome of 6,000-year-old Chalcolithic barley grains, revealing genetic similarities with present-day barley grown in the Southern Levant. The study provides new insights into the origins of barley domestication and suggests that it occurred in the Upper Jordan Valley.
A comprehensive study has mapped the genetic underpinnings of type 2 diabetes, revealing over a dozen risk genes and pinpointing specific protein sequences that contribute to disease development. The findings highlight the complexity of the condition and emphasize the need for personalized treatment approaches.
Researchers at Hospital for Special Surgery discovered a potential genetic trigger of systemic autoimmune disease, linking virus-like elements to two autoimmune diseases. The study found that abnormal expression of genetic elements known as LINE-1 retroelements may contribute to the development of lupus and Sjogren's syndrome.
Researchers have identified 84 potential inherited gene mutations that may contribute to severe forms of bipolar disorder. The study used advanced genome sequencing techniques to analyze DNA from 36 family members with the disease, finding rare genetic variations that were overrepresented in those with bipolar disorder.
Researchers have successfully sequenced the genome of Hevea brasiliensis, the natural rubber tree, uncovering key genes responsible for its unique properties. The study identifies a cluster of genes related to rubber biosynthesis and disease resistance, which may contribute to the tree's high latex production.
Scientists at KIT discovered that the synchronized repair of two single-strand breaks consistently leads to tandem duplications of shorter sequences near the break locations. Using CRISPR/Cas system like molecular scissors, they found a new mechanism for the formation of tandem repeat DNA sequences in plant genomes.
The USGA is collaborating with the Donald Danforth Plant Science Center to study seashore paspalum's salt tolerance. The research aims to develop more robust turfgrass varieties that require less fresh water and fewer chemical treatments, increasing environmental sustainability in the golf industry.
Researchers create new tool to define metabolic differences between individuals, paving the way for precision medicine. By combining genetic and protein data, scientists can better understand how patients respond to medication and tailor treatments accordingly.
The study reveals that the petunia has a complicated genetic history, having undergone one whole genome triplication shared with all the Solanaceae family. The released parental petunia genomes will be a valuable resource for scientists studying symbiosis, self-fertilization and circadian rhythms.
A study published in Molecular Biology and Evolution identifies ultraconserved elements (UCEs) essential for animal development. Researchers found that UCEs act as hubs to allow genome access for multiple proteins, contributing to the extreme DNA sequence conservation observed.
Researchers will focus on ion channels and their role in producing electrical pulses, with potential applications in understanding heritable diseases of the nervous system. The study aims to identify genetic changes that enable fast or slow channel operation.
Researchers from the DOE JGI call for a National Microbiome Data Center to manage accumulated microbiome data and metadata, enabling larger-scale comparative analyses. The center would harness all available data to address global challenges in energy, environment, health, and agriculture.
The study discovered 70 genes that show multiple signs of adaptation, including unique amino-acid-sequence substitutions and positive natural selection. These adaptations are linked to the development of the giraffe's cardiovascular system, blood pressure, and long neck and legs.
Scientists have developed a web-based system to track the spread of antibiotic-resistant MRSA and other superbugs across Europe, providing valuable insights for infection control teams. The tool, Microreact.org, uses whole-genome sequencing to identify patterns of resistance and help policymakers implement prevention strategies.
Scientists at Scripps Research Institute have received a grant to design precision drug candidates targeting disease-associated RNAs, aiming to develop patient-specific therapies for neurological diseases and cancer.
Researchers have sequenced the mitochondrial genome of the Hispaniolan solenodon, revealing that it diverged from other living mammals 78 million years ago. The venomous mammal survived asteroid impact and human colonization, but is now threatened by habitat loss and introduced predators.
Genomic analysis of Ebola virus samples from Liberia in June 2015 indicates a re-emergence of a persistently infected source, highlighting the risk of disease flare-ups even after an outbreak is declared over. The study's findings suggest that the virus replicates at a lower rate during persistent infections.
Researchers from Scripps Translational Science Institute discovered a higher-than-normal presence of genetic variants offering protection from cognitive decline in the 'Wellderly' study. These variants were found to be associated with long-term cognitive health and protection from chronic diseases, including cancer and heart disease.
Researchers at TSRI have integrated biomedical data into Wikidata, enabling easy access and linking of genes, proteins, and more. The project aims to create a comprehensive, uniform database that can be searched and updated by anyone.
The Mount Sinai Hospital and Sage Bionetworks conducted a genome study of over 589,000 adults to identify individuals resistant to severe Mendelian childhood diseases. Thirteen healthy people with associated genetic variants were found, but limitations in the original studies' informed consent policies hinder further analysis.
Researchers have discovered over 1,000 new types of bacteria and Archaea, dramatically expanding the tree of life. The newly added organisms come from diverse environments and are characterized by their genome sequences, offering a new perspective on microbiology and its implications for our understanding of biology.
A 2010 outbreak in Maryland was caused by Vibrio parahaemolyticus, a strain sourced from raw oysters from Asian restaurants. Whole genome sequencing helped identify the pathogen's origin and introduced techniques for future outbreaks.
A novel virus, Tilapia Lake Virus (TiLV), has been identified as the cause of massive tilapia die-offs in Israel and Ecuador, with significant implications for the global aquaculture industry. The discovery provides critical genomic and protein sequences necessary for disease detection, containment, and vaccine development.
Scientists discovered that microorganisms recognize multiple codons for the rare amino acid selenocysteine, expanding our understanding of the genetic vocabulary. The findings also highlight the context-dependency of the genetic code and its potential plasticity.
Scientists at Kyoto University have sequenced the buckwheat genome, identifying genes that could improve cultivation and taste. The team found genes related to 'mochi-ness', which give foods a soft, chewy texture, and those that synthesize proanthocyanidins, making buckwheat darker in color.
Researchers sequenced Zika virus genomes from Brazil to estimate a single entry point into the Americas, likely between May and December 2013. This timing correlates with major cultural events and increased air travel from Zika-endemic regions.
Researchers analyzed the genetic makeup of Zika viruses in Brazil, finding a single introduction date of May-December 2013. The study suggests a correlation between Zika virus and microcephaly cases, but more research is needed to establish causation.
MeCP2 binds genome-wide using DNA sequence features, revealing diverse modes of binding largely independent of methylation status. Local MeCP2 activities explain gene expression patterns in neurons.