Articles tagged with Genome Sequencing
Researchers at Uppsala University sequenced the genomes of 11 flycatchers, estimating the mutation rate in birds for the first time. The study found that more common species have lower mutation rates.
Researchers found misregulated imprinting at play in hybrid seeds from South American wild tomato species, affecting core gene regulation and contributing to seed failure. Genome-wide shifts occurred that favored maternal expression, suggesting a key role for epigenetic genomic imprinting in explaining differences in seed viability.
Researchers have reconstructed the first high-quality genome of the Justinianic strain of Yersinia pestis, shedding light on the evolutionary history of the plague bacterium. The study provides new insights into the genetic diversity of the pathogen and its human impact.
Researchers sequenced and analyzed the genomes of 38 wild snub-nosed monkeys from four endangered species, revealing reduced genetic diversity and a similar number of harmful mutations. The study identified hypoxia-related genes that enable these primates to thrive in high-altitude environments.
Researchers at the DOE JGI have discovered over 125,000 viral genomes infecting microbes, increasing the number of known microbial phyla by a factor of 16. The study provides a unique resource for viral sequence information and has implications for understanding global cycles and energy challenges.
The Soybean Knowledge Base (SoyKB) uses high-performance computing to analyze soybean genetic data, promoting deeper understanding for scientists improving crops. Over 2,000 unique users log on monthly, with over 10,000 utilizing the platform since its development in 2010.
MGH researchers discovered the role of DDI-1 and PNG-1 in sensing proteasome stress, with potential applications in cancer treatment and Alzheimer's disease. The findings suggest boosting proteasome activity could help treat conditions characterized by abnormal protein deposits.
The sequencing of the tobacco hornworm moth's genome has opened new avenues for research, including understanding insect physiology, biochemistry, and molecular biology. The study identified over 600 genes involved in defense against pathogens, highlighting the potential for genetic insights into this important agricultural pest.
A recent study has uncovered evidence of HIV-related retroviruses dating back 60 million years, challenging previous estimates of their origin. The research, led by Daniel Elleder, analyzed genomic data from the Malayan flying lemur and reconstructed ancient viral genomes.
A new Autism Speaks MSSNG study has expanded understanding of autism's complex causes, highlighting the role of non-coding DNA and environmental factors in gene changes. The research found a clear difference between de novo mutations from the mother and father, with clustered mutations from the mother linked to copy number variations.
A team of researchers sequenced 264 complete genomes from Richard Lenski's long-term evolution experiment (LTEE) to examine how E. coli bacteria changed over 50,000 generations. They found more than 14,000 changes across 12 populations, with mutations concentrated in genes that gave the bacteria a competitive edge.
A team of researchers studied four filamentous Ascomycete fungi to understand their role in carbon degradation. They identified a wide variety of carbohydrate-active enzymes that can directly oxidize labile and recalcitrant carbon, suggesting these species play a key role in lignocellulose conversion.
A team of researchers has successfully sequenced the genome of 6,000-year-old Chalcolithic barley grains, revealing genetic similarities with present-day barley grown in the Southern Levant. The study provides new insights into the origins of barley domestication and suggests that it occurred in the Upper Jordan Valley.
A comprehensive study has mapped the genetic underpinnings of type 2 diabetes, revealing over a dozen risk genes and pinpointing specific protein sequences that contribute to disease development. The findings highlight the complexity of the condition and emphasize the need for personalized treatment approaches.
Researchers have identified 84 potential inherited gene mutations that may contribute to severe forms of bipolar disorder. The study used advanced genome sequencing techniques to analyze DNA from 36 family members with the disease, finding rare genetic variations that were overrepresented in those with bipolar disorder.
Researchers at Hospital for Special Surgery discovered a potential genetic trigger of systemic autoimmune disease, linking virus-like elements to two autoimmune diseases. The study found that abnormal expression of genetic elements known as LINE-1 retroelements may contribute to the development of lupus and Sjogren's syndrome.
Researchers have successfully sequenced the genome of Hevea brasiliensis, the natural rubber tree, uncovering key genes responsible for its unique properties. The study identifies a cluster of genes related to rubber biosynthesis and disease resistance, which may contribute to the tree's high latex production.
Scientists at KIT discovered that the synchronized repair of two single-strand breaks consistently leads to tandem duplications of shorter sequences near the break locations. Using CRISPR/Cas system like molecular scissors, they found a new mechanism for the formation of tandem repeat DNA sequences in plant genomes.
The USGA is collaborating with the Donald Danforth Plant Science Center to study seashore paspalum's salt tolerance. The research aims to develop more robust turfgrass varieties that require less fresh water and fewer chemical treatments, increasing environmental sustainability in the golf industry.
Researchers create new tool to define metabolic differences between individuals, paving the way for precision medicine. By combining genetic and protein data, scientists can better understand how patients respond to medication and tailor treatments accordingly.
The study reveals that the petunia has a complicated genetic history, having undergone one whole genome triplication shared with all the Solanaceae family. The released parental petunia genomes will be a valuable resource for scientists studying symbiosis, self-fertilization and circadian rhythms.
A study published in Molecular Biology and Evolution identifies ultraconserved elements (UCEs) essential for animal development. Researchers found that UCEs act as hubs to allow genome access for multiple proteins, contributing to the extreme DNA sequence conservation observed.
Researchers will focus on ion channels and their role in producing electrical pulses, with potential applications in understanding heritable diseases of the nervous system. The study aims to identify genetic changes that enable fast or slow channel operation.
Researchers from the DOE JGI call for a National Microbiome Data Center to manage accumulated microbiome data and metadata, enabling larger-scale comparative analyses. The center would harness all available data to address global challenges in energy, environment, health, and agriculture.
The study discovered 70 genes that show multiple signs of adaptation, including unique amino-acid-sequence substitutions and positive natural selection. These adaptations are linked to the development of the giraffe's cardiovascular system, blood pressure, and long neck and legs.
Scientists have developed a web-based system to track the spread of antibiotic-resistant MRSA and other superbugs across Europe, providing valuable insights for infection control teams. The tool, Microreact.org, uses whole-genome sequencing to identify patterns of resistance and help policymakers implement prevention strategies.
Scientists at Scripps Research Institute have received a grant to design precision drug candidates targeting disease-associated RNAs, aiming to develop patient-specific therapies for neurological diseases and cancer.
Researchers have sequenced the mitochondrial genome of the Hispaniolan solenodon, revealing that it diverged from other living mammals 78 million years ago. The venomous mammal survived asteroid impact and human colonization, but is now threatened by habitat loss and introduced predators.
Genomic analysis of Ebola virus samples from Liberia in June 2015 indicates a re-emergence of a persistently infected source, highlighting the risk of disease flare-ups even after an outbreak is declared over. The study's findings suggest that the virus replicates at a lower rate during persistent infections.
Researchers from Scripps Translational Science Institute discovered a higher-than-normal presence of genetic variants offering protection from cognitive decline in the 'Wellderly' study. These variants were found to be associated with long-term cognitive health and protection from chronic diseases, including cancer and heart disease.
Researchers at TSRI have integrated biomedical data into Wikidata, enabling easy access and linking of genes, proteins, and more. The project aims to create a comprehensive, uniform database that can be searched and updated by anyone.
The Mount Sinai Hospital and Sage Bionetworks conducted a genome study of over 589,000 adults to identify individuals resistant to severe Mendelian childhood diseases. Thirteen healthy people with associated genetic variants were found, but limitations in the original studies' informed consent policies hinder further analysis.
Researchers have discovered over 1,000 new types of bacteria and Archaea, dramatically expanding the tree of life. The newly added organisms come from diverse environments and are characterized by their genome sequences, offering a new perspective on microbiology and its implications for our understanding of biology.
A 2010 outbreak in Maryland was caused by Vibrio parahaemolyticus, a strain sourced from raw oysters from Asian restaurants. Whole genome sequencing helped identify the pathogen's origin and introduced techniques for future outbreaks.
A novel virus, Tilapia Lake Virus (TiLV), has been identified as the cause of massive tilapia die-offs in Israel and Ecuador, with significant implications for the global aquaculture industry. The discovery provides critical genomic and protein sequences necessary for disease detection, containment, and vaccine development.
Scientists discovered that microorganisms recognize multiple codons for the rare amino acid selenocysteine, expanding our understanding of the genetic vocabulary. The findings also highlight the context-dependency of the genetic code and its potential plasticity.
Scientists at Kyoto University have sequenced the buckwheat genome, identifying genes that could improve cultivation and taste. The team found genes related to 'mochi-ness', which give foods a soft, chewy texture, and those that synthesize proanthocyanidins, making buckwheat darker in color.
Researchers sequenced Zika virus genomes from Brazil to estimate a single entry point into the Americas, likely between May and December 2013. This timing correlates with major cultural events and increased air travel from Zika-endemic regions.
Researchers analyzed the genetic makeup of Zika viruses in Brazil, finding a single introduction date of May-December 2013. The study suggests a correlation between Zika virus and microcephaly cases, but more research is needed to establish causation.
MeCP2 binds genome-wide using DNA sequence features, revealing diverse modes of binding largely independent of methylation status. Local MeCP2 activities explain gene expression patterns in neurons.
Researchers aim to collect and analyze 100,000 TB samples to create a database of MDR-TB genes, enabling faster diagnosis using whole genome sequencing. The project, CRyPTIC, will take around five years to complete and could potentially save lives by providing the right treatment.
Researchers at Stowers Institute have mapped where genetic recombination occurs in fruit flies, providing insights into understanding chromosomes and inheritance mechanisms. The study reveals separate mechanisms for crossovers and non-crossovers, with varying distributions and rules for each chromosome arm.
Researchers have created a robust method for comparing metagenome-coupled DNA sequences from all organisms in a sample, allowing for more effective and quick comparison of samples. This approach, based on k-mer frequencies, can detect previously unknown segments of DNA and improve the analysis of intestinal bacteria.
A study published in Genome Biology and Evolution sequenced the genome of Metaseiulus occidentalis, a predatory mite widely used to control plant pests. The research revealed completely atomized Hox genes and superdynamic intron evolution, highlighting the unique biology of this agriculturally important predator.
Researchers uncovered a group of retroviruses called ERV-Fc that affected 28 out of 50 modern mammal ancestors, spreading across every continent except Antarctica and Australia. The study also reveals patterns of evolutionary change and gene exchange between these viruses and other pathogens.
Researchers at TSRI successfully sequenced individual neuron genomes and produced live mice carrying neuronal genomes in all of their cells. They found that each neuron contained an average of more than 100 mutations and accumulated more mutations in genes used frequently.
A new software called EaSeq enables biomedical researchers to study and test hypotheses using their own data in a matter of hours. This analytical tool improves the analysis of ChIP sequencing data, which holds potential for clinical applications.
An Ibero-American team has sequenced the Mesoamerican common bean genome, which will aid in improving production and conserving genetic varieties. The discovery has significant implications for agriculture, as it will help identify genes involved in disease resistance, drought tolerance, and seed quality.
Scientists discovered that a wild plant from Bolivia is almost identical to the cultivated peanut species, dating back over 10,000 years. The hybridization of two wild species led to the formation of today's crop plant, with the new genome sequences providing access to 96% of all peanut genes.
Researchers confirm shelled mammal as armadillo's ancestor, revealing recent ancestral connections that have long fascinated biologists. The study sheds light on the glyptodont's place within the Xenarthra group and its extinction during the Ice Age.
An international team discovered how microorganisms, the Hadesarchaea, survive without oxygen and light, using carbon monoxide to gain energy. This finding expands our understanding of archaea that thrive in deep biosphere environments.
Dr. Eric S. Lander is awarded the 2015 Philip Hauge Abelson Prize for his contributions to genetics, molecular biology, and mathematics. He has made significant advancements in human genome sequencing and interpretation, which have transformed biological research.
Researchers at IBS created multiplex Digenome-seq to detect errors in CRISPR-Cas9 processes. The tool uses cell-free genomic DNA and sgRNA to identify on- and off-target sites, providing precise analysis results.
Researchers discovered that Dark-fly has a competitive advantage in reproduction over its wild-type counterpart when bred in the dark. The team sequenced the genome of Dark-fly and identified 28 genetic regions responsible for its unique adaptations, including genes involved in pheromone synthesis and circadian rhythms.
The seagrass genome has been sequenced, revealing evolutionary changes that enabled plants to thrive in the marine environment. The findings have significant implications for food security, climate change, and marine conservation.
Researchers developed a portable DNA sequencing system to monitor outbreaks, generating sequencing information in under an hour and providing crucial clues to epidemiologists. This technology has vast applications, including cancer research, and can impact response efforts during epidemics.
The bed bug's genome has been sequenced, offering insights into its unique biology and potential targets for controlling its resurgence. The study found that bed bugs have evolved multiple ways to resist insecticides, including barriers and detoxification genes.
Researchers sequenced a seagrass genome, revealing genes that enable plants to adapt to saline environments. The study provides insights into salt tolerance and could inform crop breeding to improve resilience in the face of climate change.
The San Diego Zoo Global has fully sequenced the 'Alalā, or Hawaiian crow's genome, which will help track genetic challenges in a species reduced to 20 birds. The sequencing is crucial for understanding how to reintroduce the species into prepared habitat on the island of Hawaii.
The great tit's reference genome shows epigenetic processes influencing learning and cognitive processes, with conserved patterns found in humans and other mammals. The study suggests a correlation between methylation levels and molecular evolution rate.