Articles tagged with Genome Sequencing
A Pittsburgh-based surveillance system detected a drug-resistant Pseudomonas aeruginosa infection linked to artificial tears months before the national public health alert. The findings demonstrate the effectiveness of whole genome sequencing-based surveillance in detecting outbreaks and preventing nationwide cases.
Researchers sequenced genomes of key cultivated and wild pepper species to identify genes associated with critical traits like fruit shape, flavor, and stress responses. The study provides valuable genomic resources for future functional studies and breeding efforts.
Australian researchers analyzed over 1,300 Golden staph strains, linking specific genes to antibiotic resistance and the bacteria's ability to linger in the bloodstream. The study highlights the diagnostic power of integrating clinical and genomic data to develop targeted solutions for deadly superbug infections.
A new study has shed light on the origins of St Helena's 'liberated' Africans, who were brought to the island between 1840 and 1867. The research reveals that they most likely originated from areas between northern Angola and Gabon in West Central Africa.
The team successfully completed the sequencing of the Y chromosome using long-read sequencing technology and innovative computational assembly methods. This achievement adds 41 additional protein-coding genes and provides crucial insight into reproduction, evolution, and population change.
Implementing whole genome sequencing (WGS) can prevent bacterial healthcare-associated infections, saving the NHS £480 million annually. The technology has major implications for health policymakers and healthcare leaders, with potential benefits including reduced antimicrobial resistance.
A new study reveals that Ötzi had a Mediterranean-European skin tone and little to no Eastern European ancestry. His hair was likely sparse, with a predisposition to baldness. The research team used advanced sequencing technology to analyze Ötzi's genome, which has more Anatolian farmer ancestry than any of his European contemporaries.
Researchers from four countries sequenced genomes of 100 infants with unexplained seizures to better understand the potential strengths of early genome sequencing for infantile epilepsy. The study found that 43% received a diagnosis within weeks, and this impacted prognosis in nearly 90% of cases.
A research group at Kyoto University has successfully developed a self-fertile buckwheat variety and a new type of the crop with a sticky texture. This breakthrough could contribute to the efficient breeding of less-common orphan crops, addressing the world's growing food demands.
Researchers at the University of Missouri have developed a new method using nanopores to advance discoveries in neuroscience and medical applications. The technique allows for real-time detection of dynamic aptamer-small molecule interactions, which can aid in understanding DNA and RNA diseases and drug discovery.
Research by the Peter Doherty Institute found that inflammation alters plasma composition, hindering parasite maturation. This work reveals a new mechanism slowing down malaria parasite development in the bloodstream.
Researchers sequenced einkorn wheat's genome, tracing its evolutionary history and identifying resilient properties that can be reintroduced into modern bread wheat. The study's findings provide insight into human migration and settlement, as well as potential solutions to protect the world's food supply.
Biologists argue that building on genomic sequencing momentum is critical in society's response to future pandemics. The technology improved during the COVID-19 pandemic, but gaps remain in global infrastructure and data sharing.
Professor Coppedè's appointment aims to enhance the journal's focus on cutting-edge genomics research, covering topics like genome sequencing and functional genomics. He will lead Current Genomics to greater success by staying at the forefront of genomics discoveries and advancements.
A new national study found whole genome sequencing to be nearly twice as effective as a targeted gene sequencing test at identifying genetic disorders in newborns and infants. The targeted panel missed 40% of diagnoses that WGS captured, while also revealing 134 new genetic diagnoses.
Researchers at Hokkaido University unveil unprecedented carrier protein-mediated ring-forming step in actinopyridazone biosynthesis. The dihydropyridazinone ring is formed through a novel machinery involving Apy3, Apy4, and Apy6 proteins.
A study by Professor Tongming Yin's team reveals the proposed role of MSL-lncRNAs in causing sex lability of female poplars. The researchers detected multiple cis-activating elements in the MSL gene, which generated long non-coding RNAs promoting maleness and leading to female lability.
A new study from the University of Illinois reveals a wealth of untapped diversity in popcorn's genetic code, with over 308,000 variations across the genome. The research may help improve the agronomic performance of the crop and uncover its long history of movement across North America.
Researchers confirm Bachman's warbler as a distinct species by sequencing its genome from museum specimens. The study reveals a new candidate gene involved in feather pigmentation in the group. Comparing the genomes of the extinct warbler with living sister species highlights the crucial role of museum collections in science.
The American College of Medical Genetics and Genomics has released its updated Secondary Findings Gene List (SF v3.2) with three new cardiovascular genes added, including CALM1, CALM2, and CALM3. The list provides guidance on reporting incidental findings in clinical exome and genome sequencing.
A biologist at Binghamton University has developed a new method to uncover the parent species of hybrid plants and animals. By examining genomic patterns within these hybrids, researchers can identify distinct ancestries and determine the order in which chromosomes were inherited from their progenitor species.
Researchers found that giraffes on either side of the rift have not interbred for over 1,000 years, with females showing no signs of migration. The study suggests that Masai giraffes are more endangered than previously thought, requiring separate but coordinated conservation efforts.
International researchers have identified nutrient-rich black rice varieties with improved agronomic traits, including shorter stem length and early maturity. These findings provide important resources for crop bioengineers to improve pigmented rice for human health and sustainable agriculture.
CHOP researchers used deep sequencing to discover several previously undescribed genetic variants in vascular anomalies, capturing low-frequency mutations that were missed by conventional methods. The study found significant improvements in symptoms for over 63% of patients, enabling targeted therapies and improved quality of life.
A recent study has identified the specific gut bacteria that pose a threat to neonatal babies, particularly those with necrotising enterocolitis. Researchers analyzed genomic similarities in Clostridium perfringens and found a set of strains with lower disease-causing capacity, lacking genes responsible for toxin production.
Researchers have cloned the wheat rust resistance genes Lr9 and Sr43, revealing that they encode unusual kinase fusion proteins. This breakthrough enables new options for addressing disease resistance in bread wheat and could lead to heat-resistant versions of the Sr43 gene to adapt to climate change.
Three Amazonian Morpho butterfly species have been sequenced for the first time, revealing genetic differences that maintain reproductive isolation despite sympatry. The study found Z-chromosome rearrangements and genetic divergence among gene copies, suggesting a role in speciation.
Researchers at Michigan State University have created the first annotated Montmorency tart cherry genome, revealing the genetic code behind its complex structure. The discovery provides a foundation for studying bloom time and identifying genes associated with specific fruit traits.
A cutting-edge study in Mozambique found that the beta variant of SARS-CoV-2 was transmitted through regional migration from South Africa, while the delta variant entered mainly from the UK and India. The analysis also revealed that most introductions did not contribute to local spread.
Researchers at York University found more pathogens and parasites in urban bee populations, leading to inbreeding and reduced genetic diversity. Conservation efforts focused on green spaces and habitat connectors can help mitigate these effects.
Two NYGC research teams have been selected as grant recipients under the NIH Common Fund SMaHT Network. The first team will generate a high-quality somatic variant catalog leveraging three core sequencing assays, while the second team will develop innovative tools for studying somatic mosaicism using a single-cell multi-omics approach.
A new study led by Mass General Brigham researchers found that 88% of rare disease experts agree on the benefits of genomic sequencing in newborn screening. The experts recommended screening for over 600 genetic conditions, including those associated with hemophilia and retinoblastoma.
Researchers have identified 11 somatic mutations in the RAS/MAPK pathway that contribute to treatment-resistant adult epilepsy, suggesting the potential for repurposed anti-cancer agents as new treatments. This study provides insight into the genetic mechanisms underlying this form of epilepsy and opens up new avenues for targeted ther...
A climate-resilient bean genome unveiled potential to boost food security in drought-prone regions through improved genetic diversity and productivity. The sequencing of the hyacinth bean provides opportunities for targeted breeding to reduce anti-nutritional properties and increase its cultivation.
Researchers have identified mechanisms behind the emergence of new and contagious coronavirus variants by analyzing over three million genome sequences. The study found that concordant substitutions occurring at other sites influence the likelihood of a substitution occurring at a specific site, leading to unexpected variant emergence.
Scientists have found a rare yeast pathogen, Lodderomyces elongisporus, causing neonatal outbreaks in India despite strong disinfectant bleach. The fungus is rapidly evolving and has been linked to hospital equipment and apples treated with fungicides.
The study of Balto's genome provides new insights into the genetics of working dogs, revealing they were more genetically diverse and healthier than modern breeds. The analysis also identified beneficial adaptations in genes related to physical traits such as weight and skin thickness.
GPMeta accelerates pathogen detection in metagenomic sequencing (mNGS) tests, achieving higher accuracy while significantly reducing processing time. The approach uses a succinct hash index scheme and multi-GPU support to handle massive data sets.
Researchers have sequenced the genomes of two hornet species, revealing clues to their invasive success. The study found rapid genome evolution and genes related to communication and smell, which may help explain why hornets are successful as invasive species across the globe.
Two contagious cancers, devil facial tumour 1 (DFT1) and 2 (DFT2), affecting Tasmanian devils have been tracked to understand their origins and evolution. Researchers found DFT2 is a faster-growing cancer with rapid mutations, posing a significant threat to the species.
A new review paper highlights the potential of fungal biotechnology to advance various industries. By manipulating fungal genomes, researchers can develop bioinformatic tools and create sustainable biomaterials, such as machine learning algorithms for predicting mycological patterns or fungal batteries.
A recent study reveals the first high-quality nuclear genome sequence and assembly of Babesia duncani, a neglected species until now. The parasite's evolution and mechanism of virulence have been identified, providing leads for the development of effective therapies.
A nationwide UK research study has diagnosed around 5,500 children with severe developmental disorders, identifying the genetic cause of their condition. The Deciphering Developmental Disorders study used genomic sequencing technology to provide diagnoses for families from across the UK and Ireland.
A team led by Bill Ballard has published a new study in GigaScience to propose Cooinda, an Alpine dingo, as the model specimen to represent a typical dingo. The study presents genomic and brain imaging data that sheds light on the evolutionary history of dingoes and their domestication process.
The giant faba bean genome has been successfully sequenced, providing a wealth of information on its genetic makeup. This breakthrough will facilitate varietal selection for traits related to protein content and yield potential, addressing global demand for plant-based proteins.
The study sheds light on Beethoven's health problems, including progressive hearing loss and chronic gastrointestinal complaints. Genetic risk factors for liver disease were identified, and evidence of a hepatitis B virus infection was found in the composer's final months.
An international research team analyzed over 400 Omnitrophota genomes, uncovering details about their biology and behavior. The study found that Omnitrophota are hyperactive with high metabolic rates, possibly as predators or parasites of other microorganisms.
Dr. Nara Sobreira has developed innovative tools like GeneMatcher and VariantMatcher to aid in rare disease diagnosis, earning her the 2023 Watson Genetic Medicine Innovation Award. She continues to work on expanding genome analysis accessibility through education and research initiatives.
A new snake family, Micrelapidae, was identified through an international study led by Tel Aviv University researcher Prof. Shai Meiri. The family includes only three species, two in Africa and one in Israel, and diverged from the rest of the evolutionary tree about 50 million years ago.
A new study by Institut Pasteur reveals that the 'bony-tongues' and 'eels' are genetically linked, shedding light on the evolutionary history of teleost fishes. The researchers sequenced genomes of several species and reconstructed relationships between different fish groups.
Researchers have created detailed genetic maps of green and leatherback sea turtle genomes, providing insights into their unique adaptations and evolutionary history. The study reveals that genetic differences between the two species are mainly found on microchromosomes, which may hold the key to each species' survival.
Lichen-forming fungi have evolved unique gene clusters to produce orange 'sunscreen' pigments, allowing them to thrive in sunny environments. The discovery of a critical ABC transporter gene within the pigment gene cluster provides a potential hypothesis for toxicity avoidance in these organisms.
A study published in JAMA Network Open found that single-locus genetic diseases were the most common cause of infant mortality, accounting for 41% of deaths. The research suggests that diagnostic whole genome sequencing may have prevented some deaths and that treatments for these conditions are available for 30% of cases.
An analysis of cases in Beijing found that two existing Omicron sub-variants, BA.5.2 and BF.7, accounted for more than 90% of local infections between November 14 and December 20, 2022. The study suggests these variants are chiefly responsible for the current surge in Beijing, likely China as a whole.
A research group at Nagoya University has sequenced 95.6% of the Nicotiana benthamiana genome using next-generation sequencing technology. The findings provide insight into the plant's ability to perform grafting, a rare phenomenon in plants.
Researchers used unconventional methods to study fruit fly phenotypes, finding that loss of epigenetic mark led to changes in behavior, gene expression, metabolism, and offspring production. This knowledge can aid in predicting ecological patterns of change in wild animal populations.
A new study found that E. coli K-12 has accumulated numerous genetic changes compared to its original isolated bacteria, making it less suitable as a model organism. This discovery highlights the rapid evolution of bacterial genomes and challenges the long-standing use of a single strain in research.
A transnational collaboration led to the characterization of Physostegia chlorotic mottle virus (PhCMoV), a plant disease first identified in Austria in 2018. The study revealed that PhCMoV can infect at least nine plant species, causing severe fruit symptoms on economically important crops.
A University of Maryland-led team deciphered the first comprehensive genome for a parasite responsible for transmitting Lyme disease and other serious infections. The researchers identified thousands of novel genes and new protein functions, including proteins associated with tick immunity and disease transmission.
Using genetically modified Aspergillus fungi, researchers have successfully converted polyethylene plastics into pharmacologically active compounds. The process breaks down the plastics quickly and efficiently, producing commercially viable yields of asperbenzaldehyde, citreoviridin, and mutilin.