Articles tagged with Genomic Dna
Researchers have developed a practical strategy to recover biosynthetic information from fragmented metagenomic data, identifying promising natural-product candidates with potential antibacterial or anticancer activity. The study prioritizes candidates using known biosynthetic gene clusters as guides, enabling the reconstruction of can...
Researchers will sequence genomes of 250 Antarctic species and 600 ecosystem samples to understand life's resilience to extreme conditions. The project aims to uncover genetic principles governing adaptation and inform biotechnology innovations.
A new DNA test has been developed to identify the genetic causes of inherited muscle disease, offering hope for diagnosis and treatment for thousands of Australians. The test, which uses long-read sequencing, screens over 300 genes and detects complex genetic changes that older tests miss.
A recent study published in Biological Diversity reveals that ecological selection drives population differentiation and local adaptation in Capsella bursa-pastoris, a widely distributed annual herb. Genome-wide scans identified 54 candidate genes under positive selection related to energy metabolism and other processes.
Researchers analyzed over 600 tumors from 544 patients and found distinct genomic signatures of DNA changes linked to different chemotherapies. These patterns appeared as early as 91 days after treatment began, allowing clinicians to track treatment-resistant tumours and potentially reduce toxic effects. The study could lead to a more ...
Researchers used AI and single-cell technology to study the 3D genome in brain cells from individuals with Alzheimer's disease. They found increased compartment mingling, reduced gene activity, and altered brain cell organization. The study identifies 3D genome organization as a key layer of Alzheimer's biology.
Evo 2 analyzes and generates DNA sequences across various forms of life, marking a major step toward unified AI for biology. The model can predict harmful genetic variants and generate biologically realistic DNA.
Researchers Dfam and Repbase collaborate to create a unified open platform for transposable element annotation, providing decades of expertly curated data freely available. The integration will support large-scale genome annotation, evolutionary research, and biomedical applications.
Researchers at Niigata University conducted the first comprehensive reappraisal of Alzheimer's disease risk in Japanese APOE-e4 homozygotes, finding a substantially lower risk than previously cited estimates. The study suggests that the risk is comparable to estimates reported in large studies of people with European ancestry.
A new study analyzing ancient DNA alongside archaeological data suggests that population movement along Peru's Pacific coast began at least 800 years ago, centuries before the rise of the Inca Empire. Genetic evidence reveals mixed ancestry between people from different coastal regions over subsequent generations.
A research team has identified two distinct genetic lineages corresponding to low- and high-altitude habitats in Capsella bursa-pastoris. Genome-wide scans detected 54 candidate genes under positive selection, highlighting temperature seasonality and precipitation as key drivers of adaptive divergence.
J. Craig Venter's pioneering work in expressed sequence tags revolutionized brain-expressed genes identification, while his synthetic cells paved the way for synthetic biology as a working discipline. His legacy has reshaped our understanding of genomes and their functions.
A new study reveals that selfish chromosomes exploit the Overdrive gene to destroy rival sperm, boosting their chances of passing into the next generation. The gene acts as a quality control checkpoint during sperm development, normally eliminating abnormal sperm cells, but selfish chromosomes hijack the system to kill competitors.
The partnership aims to support conservation genetics efforts globally by sequencing up to 4,000 unique animal samples across 1,300 species. The project will provide valuable genomic insights to inform conservation management decisions and promote ecological resilience.
The Assessing Genetic Diversity in Africa (AGENDA) project has generated whole-genome sequence data from over 1000 individuals from underrepresented communities, aiming to correct the imbalance in global genomic datasets. This effort will help predict disease risk and tailor treatments more effectively for African populations.
Researchers at John Innes Centre and Earlham Institute developed a powerful single-cell visualisation technique to understand wheat spike development. The study reveals distinct expression patterns across spikes, shedding light on why basal spikelets fail to achieve full size.
A nationwide pilot study tested for 10 medically actionable genes in 10,000 Australians aged 18-40, finding an estimated 1 in 50 carries a high risk genetic variant. Researchers urge government funding to progress a national preventive genomic testing program that could be available to all adult Australians.
A recent genomic study by Dr. Mayana Zatz and colleagues reveals that Brazil's admixed population may hold the key to understanding exceptional aging. The study identifies over 8 million novel genetic variants in the Brazilian population, with potential protective mechanisms against age-related diseases.
Researchers created detailed maps of the human genome's three-dimensional organization across time and space, revealing how genes interact and fold as cells function. The study provides a powerful framework for predicting which genes are likely to be affected by pathogenic variants.
Researchers at Arizona State University introduce powerful tools to analyze microbial family trees and biological data, strengthening microbiome research, disease tracking and environmental monitoring. The new software library scikit-bio provides a foundation for analyzing large biological datasets.
Research reveals that post-domestication wolf ancestry has shaped the evolution of dogs, influencing characteristics such as body size, sense of smell, and personality traits. The study found detectable levels of wolf ancestry in a wide range of dog breeds, including Shiloh shepherds and chihuahuas.
Researchers at Tohoku University shared key findings from their 10-year genome cohort study, highlighting effective techniques for analyzing and managing genomic data. The study's unique approaches to whole-genome sequencing, including qMiSeq and iDeal protocols, have been widely adopted by institutions worldwide.
The Gabriella Miller Kids First Data Resource Center has released its 37th study on extracranial germ cell tumors, a rare group of childhood cancers. The dataset comprises information from 393 children and young adults, including inherited genetic data and tumor-specific changes.
Researchers have unveiled the molecular mechanisms underlying L1's retrotransposition and integration into genomic DNA. The study reveals that ORF2p interacts primarily with the DNA backbone through electrostatic forces, enabling site-specific cleavage during retrotransposition.
A University of Hawaii study reveals how gut microbes interact with human genes, shaping disease risk, aging, and future medical treatments. The review highlights the potential for personalized medicine and precision health strategies tailored to each individual's unique microbial and epigenetic makeup.
The Gabriella Miller Kids First Pediatric Research Program has released its 36th study, introducing significant new data updates to two existing studies. These advances aim to uncover the genetic foundations of childhood cancers and congenital conditions. With over 110,000 data files available, researchers can explore publicly accessib...
A new study reveals that DNA damage in multiple myeloma initiates 2-4 decades before diagnosis, with key genomic events including IGH translocation and chr 1q gain. These findings may lead to new precision medicine treatment strategies for patients.
Researchers developed a strategy to predict multiple traits at once based on the whole genome, increasing predictive ability by 2-10 times. This method, called multi-trait genomic selection (MT-GS), combines genetic markers with known trait links for more accurate predictions, making it a promising tool for efficient and cost-effective...
Researchers analyzed centromeres in onion, garlic, and Welsh onion using CENH3-targeted antibody to map centromere regions. They found significant variations in size and position/mobility between species, challenging the static view of centromeres.
Despite using a large genetic dataset, scientists were unable to find a definitive explanation for the formation of distinct great white shark populations in the southern Indo-Pacific Ocean. A study published in Proceedings of the National Academy of Sciences suggests that genetic divergence began around 7,000 years ago.
ADLM 2025 will tackle urgent topics like clinical AI integration and fake medical news, as well as leveraging genomics for personalized healthcare. The meeting also explores the health threat of plastics and microbiome medicine to combat diseases.
Researchers have discovered a key role of centrosomes in signaling cells to proliferate despite DNA damage, enabling cancer resistance. The study suggests targeting Polo-like kinase 1 could prevent adaptation to therapy-induced DNA damage and drug resistance.
Researchers found that a single synonymous mutation in a gene drives cucumber elongation by altering RNA structure and function. This breakthrough has significant implications for crop breeding programs and may lead to the development of precision-crop improvement techniques.
Researchers at Stockholm University have uncovered the evolutionary history of the Norwegian lemming, revealing it to be one of the most recently evolved mammal species. The study found that the Norwegian and Siberian lemmings diverged approximately 35,000 years ago, with no evidence of interbreeding between them.
The Northwestern University-developed SOAR platform helps researchers understand diseases and find potential treatments by analyzing gene activity across various tissues. This tool enables prioritization of drugs to be sent to clinical studies, reducing development time.
A new AI tool developed by University of Missouri researchers can predict the 3D shape of chromosomes inside individual cells, providing a new view of how genes work. The tool helps identify unique differences in chromosome folding between cells, which controls gene activity and can lead to diseases like cancer.
Experts uncover biological secrets of Leonardo da Vinci through 30 years of genealogical research, revealing genetic continuity of the Da Vinci male line since the 15th generation. The study also confirms the existence of a Da Vinci family tomb and analyzes DNA samples from six living descendants.
Researchers have mapped a 7,000-year-old genetic mutation that provides protection against HIV, found in 18-25% of the Danish population. The mutation arose in an individual from the Black Sea region between 6,700 and 9,000 years ago.
The latest focus issue of Molecular Plant-Microbe Interactions explores the molecular, cellular, and genomic details of cereal crop diseases, highlighting key research on plant-pathogen interactions. Groundbreaking work has advanced the field, offering new insights into disease resistance and management strategies.
Researchers developed a new DNA-reading technology that identified more genomic imprinting in DNA, contributing to rare pediatric diseases. The study used HiFi long-read sequencing to analyze over 200 genetic samples and found widespread parent-of-origin effects on methylation at thousands of novel loci.
A team of researchers has comprehensively predicted the location of non-B DNA structures in great apes using newly available telomere-to-telomere genomes. The study suggests that non-B DNA is enriched in these segments and may play a role in genetic diseases and cancer, with potential new functions discovered.
Researchers identify colibactin, a bacterial toxin that alters DNA, as a potential trigger for early-onset colorectal cancer. Exposure to colibactin in childhood may imprint a distinct genetic signature on colon cells, increasing the risk of developing cancer before age 50.
Researchers analyzed DNA from four generations of a large family to understand genetic mutations and their transmission. They found that the rate of de novo mutations varied by over twenty-fold depending on genome location.
A team of researchers has developed a comprehensive atlas of genetic change through generations, revealing that parts of the human genome change much faster than previously known. This discovery has significant implications for understanding human disease and evolution, including the roots of genetic diseases.
A recent preclinical study from Weill Cornell Medicine researchers suggests that three-dimensional gene hubs may promote brain cancer. The findings, published in Molecular Cell, offer a new way to think about cancer beyond gene mutations and highlight the importance of understanding DNA organization in tumor cells.
Researchers have developed a new method to genetically improve poplar trees without introducing foreign DNA into its genome. This breakthrough could accelerate the deployment of genetically enhanced trees with benefits for both the environment and the bio-based economy.
Researchers are exploring the use of immunotherapy drugs and a tumor-busting 'oncolytic' virus to tackle high-grade neuroendocrine tumors. A new clinical trial, led by Dr. Aman Chauhan, aims to unlock the mysteries of renal cell carcinoma through detailed laboratory and clinical studies.
Researchers developed a new method to measure changes in DNA that can help predict a person's age, focusing on how random chemical tags become over time. The study found that methylation entropy predicted age as accurately as traditional methods, with an average error of just five years.
A comprehensive review highlights growing concerns over cyber-biosecurity threats to next-generation DNA sequencing, which could be exploited for data breaches and biothreats. The study recommends practical solutions, including secure protocols, encrypted storage, and AI-powered anomaly detection.
Scientists at the University of Birmingham have made strides in understanding how cells repair DNA damage. Two studies identify key players and mechanisms involved in preventing excessive DNA signal overload, which could lead to refinements in future cancer therapies.
A new family of Ssn endonucleases was discovered, enabling targeted cuts in single-stranded DNA. This breakthrough sheds light on a crucial genetic mechanism with significant promise for biotechnology applications, including gene editing, DNA detection, and molecular diagnosis.
A new method for detecting cancer from blood samples has been developed, enabling the detection of extremely low concentrations of circulating tumor DNA. The technique, which combines whole-genome sequencing with error-correcting methods, shows high sensitivity and accuracy in identifying cancer mutations.
Researchers created an algorithm called PRRDetect to identify tumors with faulty DNA repair mechanisms, which are more sensitive to immunotherapy. The algorithm could help doctors tailor treatments to individual patients and improve treatment outcomes for cancers such as lung and brain tumors.
Researchers have discovered new interactions and identified potential targets for cancer therapy by analyzing the effects of inactivating DNA repair genes. By comprehensively studying the interactions between more than 500 crucial genes, the team gained important new insights into how cells maintain genome integrity.
Researchers at UTA uncovered how the flowerpot snake repairs its DNA and prevents harmful mutations, shedding light on genetic repair mechanisms that could deepen our understanding of human gene evolution. The study also reveals surprising findings about reproductive strategies and immune-related genes in reptiles.
Cells employ a protein network to repress TE activity and keep themselves healthy. O-GlcNAc transferase (OGT) is a lead choreographer in this process, protecting cells from genomic instability by restraining TET activity.
Researchers directly observed DNA formation into rod-shaped chromosomes during cell division, revealing the role of condensin complexes and their looping process in compaction. This discovery provides insights into the molecular mechanism of chromosome segregation.
The study provides a comprehensive genetic map of the pistachio genome, allowing for the creation of better-nutrition varieties. The research also identifies four key stages of nut growth from flower to harvest, providing insights into shell hardening and kernel growth.
A novel fluorescent biosensor captures spatio-temporal dynamics of STING activation in response to aberrant DNA, enabling visualization of single cell and population responses. This study reveals new insights into the immune response to chromosomally unstable tumours and potential avenues for treatment.
Thorny skates exhibit a unique size discrepancy, with small and large varieties coexisting along the North American coast. A new study reveals that COVID-19 restrictions led to an abundance of genetic data, allowing researchers to uncover the secret behind the size difference.