Articles tagged with Human Genetics
A Mayo Clinic study found that obese patients with specific genetic markers experienced greater weight loss when taking the medication sibutramine. Patients who lacked these genetic factors showed little to no weight loss during the 12-week trial.
Scientists have discovered a connection between Apobec3 and the production of neutralizing antibodies against HIV, potentially shedding light on why most people who contract the virus don't develop effective immunity. The study's findings could lead to new insights into developing HIV drugs and vaccines.
A study published in PLOS Biology suggests that sleep is crucial for brain function, allowing the brain to regroup after a hard day of learning. The research proposes that sleep enables the brain to consolidate new memories and 'forget' random impressions, making it essential for continued learning.
Dinoflagellates have evolved a unique way to pack their genetic material into compact chromosomes without using histones. This discovery raises questions about the evolution of chromosomes and whether dinoflagellates once had histones but lost them. The study provides new insights into the biochemical basis of chromosome formation.
A study on Trichoplax genome findings aids researchers in learning how groups of genes function in humans and other species. The genetic code of this simple saltwater creature reveals common genes among many species, helping scientists figure out their lineage and divergence.
New studies presented at the XVII International AIDS Conference confirm a clear threshold response for DNA damage caused by ethyl methanesulfonate (EMS) in Viracept. The research finds that patients exposed to elevated EMS levels are not at increased risk of cancer, despite levels below this threshold.
Researchers found evidence that humans fought back against an ancient retrovirus with a defense mechanism called APOBEC3G, which is still used to attack modern retroviruses. This discovery provides insight into the evolutionary battle between humans and viruses.
Emory University researchers have discovered that fluoroquinolone antibiotics can enhance the effectiveness of RNA interference, a gene-silencing technique, in laboratory settings. The most powerful enhancer was enoxacin, which has been used to treat bacterial infections.
Researchers discovered a relationship between long DNA sequences called palindromes and replication delays, which can lead to chromosomal breaks and cancer. Palindromes stall the replication machinery, causing DNA malfunction, and specific proteins may protect the genome from breaking at these sites.
A multi-disciplinary group proposes ten principles to guide the use of racial and ethnic categories in genetic research, minimizing misinterpretation and misuse of human genetic variation. The guidelines recognize that racial and ethnic categories are socio-political constructs that change over time.
Research published in Nature Genetics reveals that marsupials and humans share an identical genetic imprinting mechanism that evolved 150 million years ago. This discovery helps determine how the mechanism works and what can be done to prevent human diseases related to genetic imprinting.
Researchers identified 39 histone modifications and a core set of 17 associated with active genes. These combinations, known as 'backbone sets,' were found to be present in more than a quarter of promoter regions, suggesting specific meanings for specific patterns of modification.
Eco1 and its human homologue maintain sister chromatid cohesion by affecting Smc3, a key component of the cohesion protein complex. This process is critical for genome stability and cell survival.
Researchers have created the first outline of aortic arch development and identified the role of the gene unc45a in forming AVMs. The study provides new understanding into how these congenital circulatory defects develop, shedding light on genetic and physiological factors that contribute to their formation.
A new approach to archiving human genetic information is introduced through Gene Wiki, an online repository of human genes stored within Wikipedia. This community-annotated system allows for a flexible and organic accumulation of science, enabling all readers to edit and add to the gene wiki pages.
The study reveals hundreds of biological differences between male and female gene expression in the cerebral cortex, indicating a long-evolved signature of sex differences. These findings have implications for medical dosages and treatments of diseases or damage to the brain.
Researchers have pinpointed four proteins - apoA1, transthyretin, clusterin and albumin - that react strongly to bovine growth hormone, potentially serving as biomarkers for growth hormone activity in humans. The discovery could offer a wider testing window for detecting recombinant human growth hormone misuse.
The study found that the UK and Israel produced substantially more research in human embryonic stem cells than other fields. In contrast, Australia showed a modest result due to its mixed policy on stem cell research. The US is still the largest producer of research in this field but lags behind when compared to other similar fields.
Researchers have found a human virus in chimpanzees in Tanzania's Mahale Mountains National Park, which may be transmitted from visiting scientists and tourists. The discovery highlights the need for more research to establish a comfortable level of proof and protect the region through science-based changes.
A chromatin modifying enzyme helps compensate for the fact that males have only one copy of the sex chromosome X by binding differently to male and female sex chromosomes. This process, called dosage compensation, ensures that males produce the same amount of proteins as females despite their single X chromosome.
New DNA analysis reveals that the original immigrants to Greenland came from a Siberian population, contradicting previous assumptions about their origins. The study found mitochondrial DNA similarities between ancient Greenlandic hair and eastern Siberia, suggesting a migration route via Alaska and Canada.
Genetic evidence reveals a significant shift in the timeline of human migration into Island Southeast Asia, forcing a reevaluation of existing theories. The research suggests that climate change and sea-level rise drove population expansions across the region, rather than agriculture-driven 'Out of Taiwan' model.
A team of scientists discovered that Vpx protein enables the AIDS virus to reproduce by facilitating reverse transcription in the simian virus life-cycle. The findings are significant as they suggest potential new strategies to prevent replication.
A new statistical approach has been developed to study genetic variation, allowing for a finer detail of human migration history. The technique analyzes shared parts of chromosomes across the entire human genome, identifying smaller genetic contributions and surprising findings such as Mongolian ancestry in Native American Pima people.
Researchers found that 22% of essential human genes are nonessential in mice, and this discrepancy affects waste management. The study's results suggest that efficient waste management became increasingly important as life span increased in humans, making certain genes more essential.
Scientists have developed a new way to estimate the total number of protein interactions in organisms, revealing that humans have approximately 10 times more protein interactions than fruit flies. This study contradicts previous comparisons based on gene numbers, which suggested that humans and fruit flies are relatively similar.
Researchers developed a genetic model of LQTS that mimics human arrhythmia, revealing underlying mechanisms and potential therapeutic targets. The study could lead to the development of new treatments for fatal arrhythmias, particularly in pre-menopausal women who are more sensitive to certain medications.
Atrazine, a widely used weedkiller, disrupts hormonal signaling in human cells, increasing the risk of abnormal birth weight and infertility. Exposure to atrazine has also been shown to 'feminize' zebrafish, with female fish outnumbering males at concentrations comparable to those found in agricultural runoff.
Researchers have developed a faster way to generate human monoclonal antibodies against influenza virus by tapping the immune system at peak powers. The method was tested on human volunteers and showed promising results, potentially finding broad application towards almost any infectious disease.
Scientists have identified a region on human chromosome 1 that contributes to elevated blood triglyceride levels, increasing the risk of atherosclerosis and heart disease. Three genes, angiopoietin-like 3, leptin receptor, and sterol carrier protein 2, are promising candidates for further study.
Researchers found that up to one-third of genes are differentially expressed due to environment, with respiratory genes upregulated in urban populations. The study suggests that environmental factors play a large role in modulating gene expression, and that the same gene can be expressed differently depending on the environment.
A new study published in PLOS ONE found that female fruit flies often choose males who win fights, contradicting the assumption that aggression is key to successful mating. The researchers suggest that unexpected interactions between individuals, known as 'chemistry,' play a crucial role in mate selection.
A team of researchers created a functional human vascular system in mice by injecting spheroids of endothelial cells into the skin. The newly formed blood vessels are exclusively made of human endothelial cells and establish contact with mouse vessels, allowing for study of tumor growth and angiogenesis inhibitor effects.
Researchers discovered a gene in flies whose activity is controlled by protein and sugar intake, suggesting a second mechanism for glucose release under specific dietary conditions. The findings also reveal potential links between diet, insulin signaling, and life span, particularly with high-protein diets.
A team of scientists led by Dennis Jenkins found ancient human DNA in coprolites from the Paisley Caves in Oregon, dating back 14,300 years. The DNA belongs to Native Americans in haplogroups A2 and B2, common in Siberia and east Asia.
Researchers have refined the Y chromosome haplogroup tree using genetic variations, resolving branches and estimating time to ancestral common ancestors. The updated tree provides new interpretations on geographical origins of ancient sub-clades and sheds light on the ancestry of major haplogroups such as E, O, S, and T.
Researchers have produced the first detailed analysis of a hominoid-only gene, TBC1D3, which is linked to cancer. The study found that the protein helps turn on RAS, a protein active in a third of all human cancers. Further research aims to uncover the functions of human-only genes and their potential applications in fighting diseases.
Researchers discuss developments in acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL), highlighting the potential of targeted drug therapies and cancer stem cell targeting. New molecular technologies aim to improve treatment outcomes and reduce toxic side effects.
A team of researchers, led by Ted Goebel and Michael R. Waters, revises the timeline of early American arrival, proposing a 15,000-year-old migration from Alaska. New data synthesizes genetic, archaeological, and skeletal evidence to explain the complex process of peopling America.
Researchers at Monell Center found that fruit flies respond positively to most human-preferred sweeteners, highlighting the critical role of environment in shaping taste preferences. The study suggests convergent evolution in perceptual behavior, where similar environmental pressures led to similar taste responses.
Researchers at the University of Washington have identified 25 genes regulating lifespan in yeast and roundworms, with at least 15 having similar versions in humans. The study provides quantitative evidence that these genes have been conserved during evolution, suggesting potential targets for treating age-related diseases.
Researchers found evidence of donkey domestication around 5,000 years ago in Egypt, with skeletal remains showing joint wear and signs of load carrying. The study suggests that the process of domestication may be slower and more complicated than previously thought.
A research team led by the Genome Institute of Singapore found that a molecular alliance between specific proteins known as transcription factors sustains the pluripotent embryonic stem cell state. The team identified Klf2 and Klf5 as redundant molecules that substitute for Klf4, maintaining the ES cell state.
Scientists at Albert Einstein College of Medicine identify genetic variations influencing human longevity. The study found that female children of centenarians had higher IGF-I plasma levels, suggesting a possible compensation mechanism for impaired growth.
Psychologists Agneta Herlitz and Jenny Rehnman found significant sex differences in episodic memory, favoring women. Women excel in verbal episodic memory tasks and are better at remembering faces, especially of females.
The study provides a global analysis of human proteins interacting with viral and bacterial proteins, revealing possible intervention points for future therapeutics. Pathogens preferentially target high-impact human proteins called hubs and bottlenecks, which are involved in cancer pathways.
Researchers at the University of Oregon have discovered a previously unknown mechanism for cleft palate, a common birth defect. By studying a genetic mutation in zebrafish, they found that microRNA Mirn140 regulates the expression of Pdgf, a growth factor involved in cell signaling.
The study found that couples related at a third cousin level have the highest number of offspring, with an average of 4.04 children and 9.17 grandchildren. The correlation holds true across different eras and urbanization levels, suggesting a biological basis for the association.
A team at the University of Copenhagen discovered that people with blue eyes have a single common ancestor due to a genetic mutation in the OCA2 gene. This mutation resulted in reduced melanin production in the iris, effectively 'diluting' brown eyes to blue. Brown-eyed individuals exhibit more individual variation in their DNA.
Mice fed human diet exhibit distinct liver gene expression profiles compared to those on a chimpanzee diet, suggesting dietary influences on physiological differences between humans and other apes. This study replicates previous findings in mice fed different diets.
A molecular change found in human prostate cancers triggers growth of prostate cancer in mice and human cell lines. The overexpression of ERG transcription factor is thought to activate cell-invasion programs, displacing basal cells by neoplastic epithelium.
Researchers at the University of Saskatchewan have isolated a plant gene that helps plants resist environmental stresses. The study's findings could lead to the development of crops with improved tolerance to ultra-violet light and other types of radiation, ultimately benefiting agricultural productivity and ecosystem health.
A team from Duke University Medical Center isolated sex-determining genes from an ancient fungus, Phycomyces blakesleeanus, which contains insights into the evolution of human sexual differentiation. The findings suggest that HMG-domain proteins may have marked the beginning of sex determination in both fungi and humans.
Chimpanzees have been found to build 'cultures' through social learning, with different colonies adopting unique methods for food preparation and grooming. This discovery challenges the long-held assumption that culturally-learned behaviors are unique to humans.
Researchers found 26 losses of long-established genes in the human lineage, including 16 previously unknown cases. The study identified a gene for acyltransferase-3 that was lost in humans but still functional in chimpanzees and possibly gorillas.
A recent genome study found that positive selection has occurred at a rate roughly 100 times higher in the past 5,000 years compared to other periods of human evolution. The study, led by University of Wisconsin-Madison anthropologist John Hawks, identified 1,800 genes with recent genetic changes, driven by major cultural shifts such a...
Researchers have identified a gene variant associated with increased alcohol consumption in mice, which may provide new targets for developing treatments for alcohol dependence. The study suggests that glutamate pathways play a critical role in addiction and may be targeted by future drugs.
Researchers found that reducing FoxP2 levels impaired zebra finch song development, showing a critical role for the gene in vocal learning. This similarity with humans suggests shared molecular substrates for vocal learning across species.
A recent study published in Molecular Ecology reveals that the genetic distribution of brown bears was not solely determined by Ice Age isolation. Instead, human hunting and land use have had a significant impact on their genetics, allowing them to survive and thrive in central Europe during the coldest periods. This new understanding ...
A study published in Genome Biology uncovers a link between microRNA expression and retinal degeneration, potentially leading to new therapies for incurable forms of sight loss. Researchers used mutant mice that model the human eye disease retinitis pigmentosa, finding altered microRNA expression patterns.