Articles tagged with Human Genetics
Scientists have identified a region on human chromosome 1 that contributes to elevated blood triglyceride levels, increasing the risk of atherosclerosis and heart disease. Three genes, angiopoietin-like 3, leptin receptor, and sterol carrier protein 2, are promising candidates for further study.
Researchers found that up to one-third of genes are differentially expressed due to environment, with respiratory genes upregulated in urban populations. The study suggests that environmental factors play a large role in modulating gene expression, and that the same gene can be expressed differently depending on the environment.
A new study published in PLOS ONE found that female fruit flies often choose males who win fights, contradicting the assumption that aggression is key to successful mating. The researchers suggest that unexpected interactions between individuals, known as 'chemistry,' play a crucial role in mate selection.
A team of researchers created a functional human vascular system in mice by injecting spheroids of endothelial cells into the skin. The newly formed blood vessels are exclusively made of human endothelial cells and establish contact with mouse vessels, allowing for study of tumor growth and angiogenesis inhibitor effects.
Researchers discovered a gene in flies whose activity is controlled by protein and sugar intake, suggesting a second mechanism for glucose release under specific dietary conditions. The findings also reveal potential links between diet, insulin signaling, and life span, particularly with high-protein diets.
A team of scientists led by Dennis Jenkins found ancient human DNA in coprolites from the Paisley Caves in Oregon, dating back 14,300 years. The DNA belongs to Native Americans in haplogroups A2 and B2, common in Siberia and east Asia.
Researchers have refined the Y chromosome haplogroup tree using genetic variations, resolving branches and estimating time to ancestral common ancestors. The updated tree provides new interpretations on geographical origins of ancient sub-clades and sheds light on the ancestry of major haplogroups such as E, O, S, and T.
Researchers have produced the first detailed analysis of a hominoid-only gene, TBC1D3, which is linked to cancer. The study found that the protein helps turn on RAS, a protein active in a third of all human cancers. Further research aims to uncover the functions of human-only genes and their potential applications in fighting diseases.
A team of researchers, led by Ted Goebel and Michael R. Waters, revises the timeline of early American arrival, proposing a 15,000-year-old migration from Alaska. New data synthesizes genetic, archaeological, and skeletal evidence to explain the complex process of peopling America.
Researchers discuss developments in acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL), highlighting the potential of targeted drug therapies and cancer stem cell targeting. New molecular technologies aim to improve treatment outcomes and reduce toxic side effects.
Researchers at Monell Center found that fruit flies respond positively to most human-preferred sweeteners, highlighting the critical role of environment in shaping taste preferences. The study suggests convergent evolution in perceptual behavior, where similar environmental pressures led to similar taste responses.
Researchers at the University of Washington have identified 25 genes regulating lifespan in yeast and roundworms, with at least 15 having similar versions in humans. The study provides quantitative evidence that these genes have been conserved during evolution, suggesting potential targets for treating age-related diseases.
Researchers found evidence of donkey domestication around 5,000 years ago in Egypt, with skeletal remains showing joint wear and signs of load carrying. The study suggests that the process of domestication may be slower and more complicated than previously thought.
Scientists at Albert Einstein College of Medicine identify genetic variations influencing human longevity. The study found that female children of centenarians had higher IGF-I plasma levels, suggesting a possible compensation mechanism for impaired growth.
A research team led by the Genome Institute of Singapore found that a molecular alliance between specific proteins known as transcription factors sustains the pluripotent embryonic stem cell state. The team identified Klf2 and Klf5 as redundant molecules that substitute for Klf4, maintaining the ES cell state.
Psychologists Agneta Herlitz and Jenny Rehnman found significant sex differences in episodic memory, favoring women. Women excel in verbal episodic memory tasks and are better at remembering faces, especially of females.
The study provides a global analysis of human proteins interacting with viral and bacterial proteins, revealing possible intervention points for future therapeutics. Pathogens preferentially target high-impact human proteins called hubs and bottlenecks, which are involved in cancer pathways.
Researchers at the University of Oregon have discovered a previously unknown mechanism for cleft palate, a common birth defect. By studying a genetic mutation in zebrafish, they found that microRNA Mirn140 regulates the expression of Pdgf, a growth factor involved in cell signaling.
The study found that couples related at a third cousin level have the highest number of offspring, with an average of 4.04 children and 9.17 grandchildren. The correlation holds true across different eras and urbanization levels, suggesting a biological basis for the association.
A team at the University of Copenhagen discovered that people with blue eyes have a single common ancestor due to a genetic mutation in the OCA2 gene. This mutation resulted in reduced melanin production in the iris, effectively 'diluting' brown eyes to blue. Brown-eyed individuals exhibit more individual variation in their DNA.
Mice fed human diet exhibit distinct liver gene expression profiles compared to those on a chimpanzee diet, suggesting dietary influences on physiological differences between humans and other apes. This study replicates previous findings in mice fed different diets.
A molecular change found in human prostate cancers triggers growth of prostate cancer in mice and human cell lines. The overexpression of ERG transcription factor is thought to activate cell-invasion programs, displacing basal cells by neoplastic epithelium.
Researchers at the University of Saskatchewan have isolated a plant gene that helps plants resist environmental stresses. The study's findings could lead to the development of crops with improved tolerance to ultra-violet light and other types of radiation, ultimately benefiting agricultural productivity and ecosystem health.
A team from Duke University Medical Center isolated sex-determining genes from an ancient fungus, Phycomyces blakesleeanus, which contains insights into the evolution of human sexual differentiation. The findings suggest that HMG-domain proteins may have marked the beginning of sex determination in both fungi and humans.
Chimpanzees have been found to build 'cultures' through social learning, with different colonies adopting unique methods for food preparation and grooming. This discovery challenges the long-held assumption that culturally-learned behaviors are unique to humans.
Researchers found 26 losses of long-established genes in the human lineage, including 16 previously unknown cases. The study identified a gene for acyltransferase-3 that was lost in humans but still functional in chimpanzees and possibly gorillas.
A recent genome study found that positive selection has occurred at a rate roughly 100 times higher in the past 5,000 years compared to other periods of human evolution. The study, led by University of Wisconsin-Madison anthropologist John Hawks, identified 1,800 genes with recent genetic changes, driven by major cultural shifts such a...
Researchers have identified a gene variant associated with increased alcohol consumption in mice, which may provide new targets for developing treatments for alcohol dependence. The study suggests that glutamate pathways play a critical role in addiction and may be targeted by future drugs.
Researchers found that reducing FoxP2 levels impaired zebra finch song development, showing a critical role for the gene in vocal learning. This similarity with humans suggests shared molecular substrates for vocal learning across species.
A recent study published in Molecular Ecology reveals that the genetic distribution of brown bears was not solely determined by Ice Age isolation. Instead, human hunting and land use have had a significant impact on their genetics, allowing them to survive and thrive in central Europe during the coldest periods. This new understanding ...
A study published in Genome Biology uncovers a link between microRNA expression and retinal degeneration, potentially leading to new therapies for incurable forms of sight loss. Researchers used mutant mice that model the human eye disease retinitis pigmentosa, finding altered microRNA expression patterns.
The University of Washington's new DNA fin-printing project aims to create open-access databases for Pacific salmon populations, helping managers and scientists understand their ocean migration. By employing genetic markers, researchers can distinguish between individual fish and track population movements, informing conservation effor...
A recent study from the University of Toronto found significant differences in how genetic material is spliced to create proteins in humans and chimpanzees. The researchers discovered that six to eight per cent of alternative splicing events showed differences, which are associated with various diseases.
Research on human RecQ helicases reveals their role in regulating homologous recombination, a DNA repair pathway. Mutations in these enzymes cause cancer-predisposition syndromes, highlighting their importance in maintaining genomic stability.
Researchers at M. D. Anderson Cancer Center have identified a tumor-suppressor gene that suppresses lung tumors in mice and could provide new approaches for lung cancer prevention, diagnosis, and treatment. The GPRC5A gene is under-expressed in human lung cancer cells and its expression was found to be lower in 61% of human non-small c...
A study reveals that excess sugar consumption decreases SHGB production in the liver, a protein regulating sex steroid entry into tissues. This reduction is associated with increased fat palmitate levels and inhibited by inhibiting palmitate generation.
A team of Stanford University researchers has identified a gene responsible for giving dogs their black fur, revealing its potential connection to human stress adaptation and weight regulation. The discovery was made by analyzing DNA samples from hundreds of dog breeds, including boxers and Large Munsterlanders.
Researchers at Michigan State University have identified a new gene, JY-1, necessary for embryonic development in dairy cows. The discovery may offer insights into the cause of infertility in women, who also experience single egg release and individual births, unlike mice which release multiple eggs.
Scientists found that at least 1% of Neanderthals were likely redheads due to a point mutation in the MC1R gene. The discovery suggests that Neanderthals' pigmentation may be as varied as modern humans', with implications for understanding the evolution of human traits.
Scientists used a genetic tool to study human embryonic stem cell self-renewal and differentiation. They found that reducing or increasing the expression of oct4 gene induced differentiation, revealing a key difference in early human development regulation compared to mice.
Two scientists report a new type of mouse replaced an old type in Volo Bog between 1976 and 2001, with genetic differences apparent in just 25 years. The study suggests that environmental changes can drive rapid adaptation in animal populations, highlighting the need for conservation efforts.
A recent study reveals that Neandertals shared key changes with modern humans in the FOXP2 gene, which plays a crucial role in speech and language. This finding suggests that Neandertals may have possessed some prerequisites for language, challenging previous estimates of when human language emerged.
A team of researchers from Arizona State University has discovered the earliest evidence of modern human behavior in South Africa, dating back 164,000 years. The findings suggest that early humans expanded their diet to include shellfish and other marine resources, likely as a response to harsh environmental conditions.
Researchers at Baylor College of Medicine and Rice University have developed a molecular map of the influenza B virus's hemagglutinin protein. The study reveals similarities between the protein's sequence and function in flu A and B strains, suggesting that minor mutations could enable bird flu to spread among humans.
Scientists identified DMP1 as a tumor suppressor that activates Arf expression, inducing p53-dependent cell cycle arrest. DMP1 deletion or haploid insufficiency accelerates lung cancer development in K-ras mutated mice and patients, suggesting its potential as a target for drug therapy.
Scientists have discovered a new gene, Dmp1, linked to human lung cancer, which is often deleted in lung tumors. The study found that the non-functional Dmp1 gene leads to reduced activity of tumor suppressors p53 and Arf, allowing cancer cells to grow unchecked.
Human migration out of Africa and into Asia occurred in at least four pulses, driven by climate and sea level changes. The initial migration was thwarted, but subsequent pulses took advantage of stable climates and sea levels to expand into eastern Asia, Australia, and Melanesia.
A study on human, chimpanzee, and rhesus monkey genomes reveals that humans and rhesus monkeys have purged ERV-K copies from their genomes, while chimpanzees have retained a greater number of complete ERV-K copies. This finding suggests that genetic fluctuations due to bottlenecks and expansion play a role in shaping ERV-K dynamics.
People with a history of allergies have a nearly third lower risk of developing certain brain cancers, such as glioma. Meanwhile, genetic studies identified three locations on human chromosome 8q24 associated with an increased risk of prostate cancer.
New findings suggest that misfolded proinsulin can cause beta cell dysfunction and death, leading to an insulin shortage. This can result in the hallmark symptoms of diabetes, including high blood glucose levels.
A new DNA method developed at the University of Copenhagen uses hair samples to answer questions about human history, such as why mammoths died out. The technique also holds promise for forensic analysis in crime solving, providing faster results than traditional methods.
A team of researchers discovered a key protein in plants that creates drug resistance and is similar to proteins found in humans. This finding could help uncover new factors contributing to variable drug responses in humans and advance the understanding of drug sensitivity.
A brain system known to regulate food intake also controls fat storage and metabolism in the body completely independently of food consumption. The melanocortin system may be used to develop new medications to treat human obesity.
A new study has found that bats exhibit unparalleled genetic variation in the FOXP2 gene, which is linked to their unique ability of echolocation. This discovery adds weight to the theory that FOXP2 plays a crucial role in the sensory-motor coordination of vocalizations.
Researchers identified a consistent association between the TRAF1/C5 region and rheumatoid arthritis, suggesting a link to the inflammatory response. The study adds to accumulating evidence that this genetic region is associated with the disease, paving the way for further investigation into its role.
Researchers discovered that specific genetic variants of an odor receptor determine how people perceive pleasant or unpleasant odors. The study focused on two sex steroid-derived chemicals and found that different genetic variations led to varying reactions.
Researchers found humans carry more gene copies than ape relatives to produce more amylase enzyme, which digests starch. This discovery bolsters the idea that starch played a crucial role in early human diet and evolution.
A study published in Neuron found a link between the toxic brain protein Aâ peptide and neuronal overexcitation, leading to compensatory rewiring of brain circuitry. This overexcitation can contribute to cognitive deficits in Alzheimer's disease. Researchers suggest blocking this overexcitation may prevent such neurological deficits.
Researchers found that the genes responsible for color vision in aye-ayes are fully functional, contradicting the long-held theory that nocturnal mammals lose color vision over time. The study sheds light on the evolution of color vision and highlights the importance of examining rare and endangered species.
Researchers have created 3D images of fruit fly brains using optical projection tomography, shedding light on genetic research into Alzheimer's and other human diseases. The images allow scientists to visualize gene expression patterns and gain insights into the human brain.