Articles tagged with Human Genetics
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A new perspective article suggests that integrating environmental effects into genetic research is crucial to understand the intricate nature of gene-environment interactions. The authors propose expanding genome-wide association studies by incorporating environmental data, which could help mitigate deterministic thinking in genetics.
A new study from Uppsala University found that Stone Age hunter-gatherer communities in Western Europe deliberately formed distinct families to avoid inbreeding and maintain genetic diversity. The research analyzed the genomes of several individuals buried at iconic sites in France, dating back to around 6,700 years ago.
A team of researchers from Wayne State University and the Barbara Ann Karmanos Cancer Institute have received a five-year, $9.6 million grant to improve the identification and clinical management of hereditary and multiple primary cancers in African Americans. The study aims to overcome barriers to genetic testing in this population.
Researchers identified six ancient individuals with an extra copy of Chromosome 21 and another with three copies of Chromosome 18, indicating care and appreciation from their communities. These findings suggest that children with Down Syndrome and Edwards Syndrome were not stigmatized but rather recognized as part of their societies.
A new study found that genetic factors contribute around 33% to the variation in levels of trust among individuals, while life circumstances such as age, health, and relationship status also increase trust. The research used twin studies to disentangle genetic and environmental influences on trust.
Researchers found that parents' manifestation of neurodevelopmental and psychiatric traits can predict the prevalence and severity of disorders in children. The study analyzed 97,000 families and revealed a correlation between parental traits, suggesting that assortative mating may contribute to increased disease severity.
A new study reveals a larger number of transposable elements in the human genome than previously known, shedding light on their potential role in human diseases. The 'genomic time machine' approach allowed researchers to identify degenerate TEs that were missed in previous studies.
A new statistical model developed by UChicago researchers accurately identifies causal genes and variants for a disease. The tool reduces false positives and takes into account multiple genes and variants, leading to the discovery of 35 putative causal genes for LDL cholesterol levels.
Genetic material from Neanderthal ancestors may have influenced the preference for waking up early in some people. Studies found that introgressed genetic variants from Neanderthals are associated with increased morningness and a shorter circadian period, which is beneficial at higher latitudes.
The international consensus report on precision diabetes medicine highlights significant advancements in prevention, diagnosis, treatment, and prognosis. The report also sheds light on knowledge gaps and provides a framework for future research.
Researchers have successfully converted human retinal cells, specifically Muller glia, into neurons in a lab setting using an artificial fish-like genetic program. This breakthrough could potentially serve as a new source of neurons to treat vision loss caused by disease or trauma.
A study at Uppsala University found that infant face preference is influenced by genes and linked to later language development. The researchers analyzed over 500 infant twins and found that individual infants' preferences for faces could be largely explained by their genetics.
A new study found that the progeny of successive generations of old parents had significantly shorter lifespans than those from young parents in both Drosophila melanogaster and Caenorhabditis elegans. The researchers also discovered that switching to only one generation of younger parents improved the healthspan of the offspring.
Researchers analyzed genes and brain tissue of patients with Alzheimer's disease to find sex-specific differences in immune function, cellular metabolism, and communication between brain cells. The study suggests that these differences contribute to women's increased risk for the disease and its severity.
A qualitative study by City of Hope highlights the importance of proper patient preparation for unanticipated, inheritable genetic findings prior to tumor sequencing. The research emphasizes the need for scalable educational interventions that facilitate informed consent, such as online tools and applications.
Researchers found that rare gene variants associated with inflammatory bowel disease (IBD) are less prevalent in African Americans, suggesting a different genetic contribution to the disease. The study highlights the importance of considering genetic diversity and admixture in IBD research.
A recent study in Nature Communications has identified a gene cluster in wheat that produces triticein, an isoflavone compound with potential health benefits. This discovery offers opportunities for metabolic engineering efforts to improve wheat's nutritional quality and resistance to disease.
Researchers from the University of Konstanz and Tübingen have found genetic evidence of a woolly rhinoceros's presence in southern Germany during the late Middle Palaeolithic period. The analysis of hyena coprolites reveals that the animals preyed on and consumed woolly rhinoceroses, providing insights into prehistoric ecosystems.
Scientists at the La Jolla Institute for Immunology have uncovered a group of T cells known as mucosal-associated invariant T (MAIT) cells. These cells can recognize the same markers whether they come from humans or mice, opening up new possibilities for treating infectious diseases and improving cancer immunotherapies. The study also ...
Researchers have identified a crucial biological trigger of Huntington's disease, finding that methylation converts an important protein into waste. By targeting this process, they may develop effective therapies for other neurodegenerative diseases.
A new study analyzing lice genetic diversity found that head lice arrived in the Americas twice – once with early human migrants and again during European colonization. This discovery supports existing theories on human migration and provides insights into how lice have evolved alongside humans.
A new study found that residents of neighborhoods with more greenspace tend to have longer telomeres, indicating better cellular health. However, the positive impact of greenspace is not enough to compensate for other environmental challenges like air pollution and racial segregation.
A new study reveals a multi-drug resistant strain of E.coli, MDR ST131, can outcompete and displace other strains in the human gut. The research provides evidence that certain types of E.coli are more prone to developing antibiotic resistance, posing significant health risks.
A recent NIH grant will support research into the genetic factors contributing to cardiac arrhythmia, a condition affecting millions of Americans. The study aims to identify specific genes linked to arrhythmia risk and develop novel therapeutic approaches.
Researchers discovered that people carrying three Neanderthal gene variants in the SCN9A gene are more sensitive to certain types of pain. The study found an association between the variants and a lower pain threshold in response to skin pricking after prior exposure to mustard oil.
Researchers have found that spermatozoa do not have mitochondrial DNA and lack a crucial transcription factor A mitochondrial (TFAM), explaining why it's only inherited from the mother. This discovery has important implications for human fertility and germ cell therapy.
AlphaMissense, a machine-learning algorithm, uses structure prediction to classify missense mutations and predict disease-causing genes. The tool has been shown to accurately predict the pathogenicity of 71 million possible single amino acid changes across 19,233 human proteins.
A study of nearly 500,000 participants found that smoking shortens telomere length in white blood cells, a indicator of aging and cell regeneration. The more cigarettes smoked, the stronger the shortening effect, suggesting a link between smoking and accelerated aging.
A new genetic study revealed the link between type 2 diabetes, lung disorders, and the gastrointestinal tract. The research suggests that individual responses to GLP-1R agonist drugs depend on DNA variants in the target gene, and high blood sugar levels can directly cause lung complications.
A team of Chinese and UK researchers has identified superoxide dismutase 1 (SOD1) as a potential target for reversing drug resistance in ovarian cancer. By using nanoparticles to deliver siRNA that reduces SOD1 levels, the study showed reduced growth and decreased resistance to cisplatin in female mice.
A massive genetic study has identified specific DNA changes that increase the risk of developing epilepsy. The research found 26 distinct areas in our DNA involved in epilepsy and proposed alternative drugs targeting these genes. The findings may inform better diagnosis, classification, and treatment strategies for epilepsy.
A new dictionary provides a comprehensive overview of Shakespeare's language, revealing words with reduced mental ability and plant hybrids. The Arden Encyclopedia of Shakespeare's Language offers insights into the linguistic thumbprints of plays and characters, as well as the networks of character interaction.
A recent NIH-supported study found a significant association between a genetic variant in people of African ancestry and an increased risk of developing Parkinson's disease. The variant, in the GBA1 gene, is associated with a higher risk of 3.5 times for those carrying two copies.
Researchers have identified genetic variants and structural patterns that contribute to the development of Bartter syndrome type 3, a rare kidney disease. The study's findings may lead to better diagnostic and treatment options for affected individuals.
A new study published in Nature Genetics has identified over 4,000 genetic variants linked to brain structure, revealing how the brain's organization is shaped by genetics. The research found that different sets of genes contribute to folding and size of the cortex, with some genes linked to larger or smaller head sizes.
A new study reveals that Ötzi had a Mediterranean-European skin tone and little to no Eastern European ancestry. His hair was likely sparse, with a predisposition to baldness. The research team used advanced sequencing technology to analyze Ötzi's genome, which has more Anatolian farmer ancestry than any of his European contemporaries.
A new study has identified thousands of shared genetic variants between patients with irritable bowel syndrome (IBS) and psychiatric disorders such as bipolar disorder, schizophrenia, depression, and anxiety. This discovery provides a new understanding of the brain-gut axis and holds promise for developing effective treatments for IBS.
A new study has identified four genetic variants associated with the direction of human scalp hair whorls, revealing a polygenic inheritance pattern. The findings may help unravel biological processes related to abnormal neurological development.
A new study revealed that people in the UK have facial skin with more DNA damaged from the sun than those in Singapore, leading to a higher risk of developing keratinocyte skin cancers. This is despite lower UV light exposure levels in the UK.
A groundbreaking analysis of historical DNA links tens of thousands of living individuals to enslaved and free African Americans at Catoctin Furnace. The study provides a new way to complement genealogical efforts and restore ancestral histories for African American communities.
Researchers reconstruct two massive family trees from ancient DNA data, shedding light on the lives of a prehistoric European Neolithic community. The study reveals a strong patrilineal pattern, large family sizes, and a potentially fluid exchange network comprising many groups.
Researchers have uncovered almost 500 genes linked to diet, shedding light on genetic basis of food preferences. The findings suggest a potential for using genetics to develop precision nutrition strategies tailored to individual tastes.
A groundbreaking Oxford study reveals a significant genetic component to people's probability of participating in genetic studies. The research identified detectable 'footprints' in genetics data that can be exploited statistically to enhance research accuracy for both participants and non-participants alike.
The Hastings Center's Institutional Review Board (IRB) has implemented an evidence-based intervention to address racism and promote equity in biomedical research. The IRB now requires researchers to define racial and ethnic classifications, state whether they are describing or explaining differences between groups, and provide justific...
A robotic system, WormPicker, autonomously detects and manipulates Caenorhabditis elegans for genetic research, increasing productivity for human researchers. The system accelerates studies in diverse areas of C. elegans biology.
A genome-wide association study found 150 genetic factors linked to diverticular disease of intestine (DivD), an overlooked and understudied disease. DivD is highly heritable, with 40% of risk inherited, according to researchers.
A new study from Aarhus University has found that applying AI predictions of protein structures enhances the CRISPR technology, making the cuts in a patient's DNA more precise. This discovery may lead to better treatments for patients with genetic disorders and potentially develop cures for various genetic diseases.
Scientists have identified a genetic locus associated with voice pitch, found in the ABCC9 gene, which influences voice characteristics in both men and women. The study also reveals links between voice pitch and cardiovascular health, highlighting the complex relationship between vocal traits and human biology.
A new study reveals a previously unknown way the immune system detects certain viruses, including SARS-Cov-2, using the inflammasome protein CARD8. Researchers found that CARD8 functions differently among various species and even varies between individuals in the human population.
Researchers developed a new biological age indicator, DNAmFitAge, that incorporates physical fitness parameters, showing a correlation with lower mortality risk, coronary heart disease risk reduction, and improved disease-free status in physically fit individuals.
A study by Florida Atlantic University and Duke University reveals that the malaria parasite's biological clock is 'in sync' with its human host's circadian clock. The researchers discovered a 'coupling' mechanism between the parasite and its host, which could lead to new treatments for this deadly disease.
A recent study has uncovered three previously unreported genetic loci associated with eyebrow thickness in Europeans, as well as rediscovering two of the four genetic loci previously found in non-Europeans. The research expands genetic knowledge on human eyebrow variation, with implications for dermatology and other fields.
A new international study reconstructs the legacy of Chile's largest indigenous community, the Mapuche, through genetics and linguistics. The research reveals distinct Mapuche lineages originated locally and have remained in relative isolation, punctuated by episodes of contact with other South American populations.
The study reveals new insights into primate evolution, genetic diversity, and the uniqueness of humans. It also highlights the importance of preserving primate species due to high genetic diversity, which enables adaptation to changing environments.
Researchers, led by Elizabeth King, aim to develop a knowledge base on complex genetic traits using fruit fly models. The project seeks to address the scientific knowledge gap in this field by focusing on interconnectedness among multiple factors.
Researchers have identified 16 genes associated with an increased risk of Spontaneous Coronary Artery Dissection (SCAD), a type of heart attack primarily affecting young to middle-aged women. The study also found that patients with SCAD have some genetic protection from the risk of conventional coronary artery disease.
Researchers analyzed a comprehensive dataset from Catholic parish records and genotype data to reveal how local topographies influenced French Canadian relatedness. They found that geographic features, particularly river networks, shaped Quebec's population structure and contributed significantly to the French Canadian gene pool.
A new study reveals a unique founder population structure in Newfoundland and Labrador, tracing the ancestry of European settlers from South-East Ireland and South-West England. The analysis found multiple population bottlenecks and strong associations between Catholic background and Irish genetic ancestry.
Scientists have developed a new method to deliver genetic information to stem cells using nanoparticles coated with a specific polymer, enabling more efficient control over cellular differentiation. This innovation has the potential to improve the efficiency and effectiveness of regenerative medicine treatments.
A new study led by UCL researchers finds that a particular gene affecting nose shape is inherited from Neanderthals and may have been influenced by natural selection. The study used data from over 6,000 volunteers and identified 33 genome regions associated with face shape.