Articles tagged with Pseudogenes
Researchers explore the role of pseudogene-derived lncRNAs in governing cancer stem cell biology, highlighting their mechanisms and therapeutic targeting. These non-coding RNAs modulate CSC dynamics through various pathways, influencing tumor initiation and progression.
The CRISPR tool was successfully used to correct a genetic defect in cells affected by chronic granulomatous disease. However, the repair process also introduced new genetic defects, highlighting the need for caution when using CRISPR technology in clinical settings.
Researchers at Rice University have made a groundbreaking discovery about protein evolution, revealing that pseudogenes can provide clues to the evolutionary journey of proteins. The team found that certain mutations can stabilize the folding of pseudogenes, but also disrupt their biological functions.
Researchers at Beth Israel Deaconess Medical Center found that the non-coding BRAF pseudogene contributes to the development of an aggressive lymphoma-like cancer in animal models. The study suggests that pseudogenes may play a primary role in various diseases and could significantly expand the functional genome.
A study published in Nature Communications found that pseudogene expression profiles can help explain how cancer occurs and aid in discovering new biomarkers. This knowledge is crucial for developing targeted therapies and predicting patient outcomes.
A new study reveals that pseudogenes can regulate cancer-related genes like PTEN, potentially leading to new treatments. The research found that pseudogenes sharing sequences with PTEN can control its activity in two ways.
Researchers at Karolinska Institutet have discovered a new pseudogene that regulates the tumour-suppressing PTEN gene, enabling its potential reversal. This finding could lead to more effective cancer treatments by reprogramming cancer cells and preventing resistance.
The Yale team's study reveals a hierarchical structure in the human genome, with regulatory networks that work together to regulate target genes. They also found that sex plays a role in genetic activity, allowing researchers to track the relative contributions of mom and dad.
A new study reveals that thousands of noncoding RNAs have a regulatory role independent of their protein-coding function, communicating with each other to influence cellular microRNAs. This discovery introduces 'competitive endogenous RNAs' and doubles the size of the functional genome, offering new insights into cancer and human disease.
Scientists at Children's Hospital of Pittsburgh found that a category of genes known as pseudogenes serve no function, bolstering the theory of evolution. The study contradicts previous claims made by Intelligent Design proponents and suggests that pseudogenes are evolutionary relics with no function.
Researchers found that humans lost genes related to the sense of smell, bitter taste, and immune response, which may have improved our ability to fight infections. The loss of the CASPASE12 gene, in particular, led to a stronger immune response, but also made it harder for humans to fight off severe bacterial infections.
A recent study found a correlation between the loss of olfactory receptor genes and the acquisition of full trichromatic color vision in primates. The research team analyzed 19 primate species, including humans, and discovered that Old World monkeys and apes had similar percentages of OR pseudogenes, while New World monkeys had lower p...
Scientists in Japan and UCSD have discovered a novel regulatory role for pseudogenes, which stabilizes a protein-coding gene on another chromosome. The study found that disabling the pseudogene led to abnormal kidneys and bones in laboratory mice, while re-introducing it resulted in normal development.