Articles tagged with Antibodies
Researchers developed a dual action immunotherapy using CAR-T cells targeting CD19 and CD22 proteins in B-ALL cancer cells, increasing the efficacy of treatment and reducing relapse rates.
The new Epigraph vaccine developed by University of Nebraska-Lincoln virologist Eric Weaver protects against H1N1 swine flu and can also protect against influenza in humans and birds. The vaccine significantly outperformed commercial vaccines, providing protection for up to a decade.
Scientists have engineered a monoclonal antibody that protects mice from a lethal dose of influenza A with sticky staying power. The new molecule combines specificity and broad binding capacity, adhering to the lung lining and blocking infection in mice.
Researchers at Scripps Research used computer modeling to illustrate how antibodies recognize lipids in the HIV virus, highlighting a potential new approach for vaccine design. The study identified two key structural features on the antibodies that enable them to target well-defined membrane features.
A clinical trial is underway to assess the effectiveness of sipavibart, a long-acting monoclonal antibody, in treating Long COVID symptoms. The study aims to improve patients' health and restore them to full health.
A topical BRAF-inhibiting gel, LUT014, improved acneiform rash in 69% of patients with grade 2 or 3 rash and received an EGFR-targeted antibody. The treatment also showed a 33% success rate for the placebo arm, but was associated with similar adverse events.
The CoVaRR-Net network successfully bridged critical research and public health gaps exposed by the COVID-19 pandemic through interdisciplinary collaboration and innovative approaches like wastewater surveillance. Its achievements include 139 peer-reviewed publications, evidence-based public health decisions, and a global leader in ear...
A new study from Scripps Research finds that a higher ratio of antibodies to viral protein better engages two specific types of immune cells, including phagocytes and natural killer cells. This discovery has implications for the development of experimental HIV vaccines and other drugs.
Researchers developed fluorescent polyionic nanoclays that can be customized for medical imaging, sensor technology, and environmental protection. These tiny clay-based materials exhibit high brightness and versatility, enabling precise tuning of optical properties.
Researchers have shed light on how a new type of antibody treatment works against ovarian cancer by reactivating patients' immune cells. The study shows that MOv18 IgE reverses the suppression of immune cells and induces them to kill cancer cells, providing new insights into this therapy.
A new point-of-care technology developed by Northwestern University scientists can detect multiple HIV antigens at high sensitivity in a matter of minutes. The technology uses a nanomechanical platform and tiny cantilevers to measure the binding of p24 antigens to surface antibodies, demonstrating high specificity.
A study estimated the epidemiology of hepatitis D virus (HDV) in China, finding a prevalence of HDV antibody positivity among 4,936 patients with chronic HBV infection. The rate was 0.24%, with only one patient having both anti-HDV antibody and HDV RNA positivity.
A new study by researchers at McGill University found that annual COVID-19 vaccine booster doses help avoid breakthrough infections in people with immune-mediated inflammatory diseases. The study tracked 366 patients across Canada and used saliva PCR tests and antibody measurements, offering a more precise picture of infection risks.
A new study by UNC Charlotte researchers reveals the H5N1 influenza virus is adapting to escape human immunity, increasing the risk of transmission in humans. The team's computational modeling finds a worsening trend in antibody affinity to more recent viral isolates, indicating a greater risk to human health.
Researchers at the University of Zurich have developed a technology to test 25 antibodies simultaneously in a single mouse, greatly reducing the number of laboratory animals required. The method uses protein fragments as barcodes for analysis, allowing for high-quality preclinical data on multiple antibody candidates.
A study has established the importance of immunoglobulin A in generating a response to pneumonia vaccines. The research found that poor regulation of gut microbiota can lead to an inadequate immune response, leaving individuals vulnerable to respiratory infections.
A new type of antibody that stimulates the immune system to target cancer cells has shown promise in reducing tumor growth in treatment-resistant breast and ovarian cancers. The study found that the antibody, IgE, uniquely stimulated otherwise inactive immune cells to directly target HER2-expressing cancer cells.
A recent study published in the Journal of Experimental Medicine reveals that plasma cells are programmed from birth to migrate to protected sites in the body, where they produce large amounts of antibodies. High expression of integrin β7 is an excellent marker for these cells' ability to home to the bone marrow.
Research finds that certain viral antibodies and genetic risk factors can increase MS risk, with elevated antibody levels combined with a specific gene variant associated with strong increased risk. The study also identifies potential biomarkers for early diagnosis.
A new study has discovered how antibodies help protect against Strep A infections and is contributing to the development of a Strep A vaccine. The research used the world's only human challenge model for Strep A, which uncovered the power and potential for this model to accelerate vaccine development.
Researchers at Stanford University have discovered a method to use two antibodies to effectively combat the constantly evolving virus, which could lead to longer-lasting treatments for COVID-19. The antibodies were shown to be effective against all SARS-CoV-2 variants in laboratory testing.
A longitudinal study found that EBV infection predisposes people to develop Crohn's disease, with a five-to-seven-year delay between exposure and diagnosis. The study suggests that EBV may alter the immune system leading to Crohn's disease.
Researchers developed a simple test that detects antibodies against four dengue virus serotypes and zika virus. The test achieved high sensitivity (87.8%) and specificity (91.4%), indicating its potential to monitor specific antibodies produced in response to exposure to the viruses.
A blood test has been found to identify personalized dietary triggers for patients with irritable bowel syndrome, resulting in improved abdominal pain relief. The study showed that 59.6% of participants who removed trigger foods experienced significant reduction in abdominal pain compared to 42.2% in the control group.
Researchers discover how an anticancer drug triggers an 'outside in' signal to get sucked into a cancer cell, providing insights into adhesion regulation and potential drug design targets. The study reveals a new mechanism for delivering drugs using P-cadherin protein.
Researchers developed MUNIS, a deep learning tool that predicts CD8+ T cell epitopes with high accuracy, potentially accelerating vaccine development. The tool was validated using experimental data from influenza, HIV, and EBV, demonstrating its potential to streamline vaccine design.
Scientists discovered that repetitive HIV vaccinations can lead to the production of antibodies targeting immune complexes already bound to the virus. This chain reaction was observed in follow-up experiments on HIV-vaccinated animals and may impact vaccine design strategies. Understanding this response could lead to improved vaccines ...
Researchers at Duke University developed an acoustofluidic integrated molecular diagnostics chip, AIMDx, that uses tiny vortexes to detect dangerous viruses. The vortexes trap cells, bacteria, and larger bioparticles, purifying samples for biomedical tests.
Researchers from McGill University and colleagues found that stunted children had lower levels of antibodies against measles by age five. The study suggests that combatting child hunger could help prevent measles outbreaks globally, as undernutrition may affect vaccine protection.
A consensus platform for antibody characterization has been developed to evaluate antibody specificity and tackle the challenge of non-specific antibodies in life sciences. The Open Science approach supports large-scale collaboration among competitors in the antibody industry, resulting in an estimated $1 billion annual savings.
A new hepatitis B vaccine, Heplisav-B, has been shown to be more effective than an older vaccine type in inducing a protective antibody response among people living with HIV who didn't respond to prior vaccination. The study found that up to 99.4% of subjects received the new vaccine showed protective levels of antibodies.
Researchers chart high-precision map of aging across various organs and reveal immunoglobulin's dual-edged sword effect on systemic aging. The study identifies key hallmarks of aging, including tissue structural disorder and loss of cellular identity.
The study analyzed antibody profiles from humans in three countries to reconstruct historical seasonal influenza patterns and individual lifetime infection histories. The findings revealed variation in incidence and antibody dynamics over the life course.
Research led by ISGlobal reveals that children younger than five months of age may benefit from the RTS,S and R21 malaria vaccines if they live in areas with low malaria transmission, where mothers have less antibodies to the parasite. The study analyzed blood samples from over 600 children and infants and found that high levels of mat...
Researchers developed a novel, homogeneous customizable OpenGUS immunoassay that detects target analytes quickly and effectively. The platform provides a hassle-free approach for biomarker detection in point-of-care diagnostics, high-throughput testing, and environmental monitoring.
Participants who received 2 doses of MVA-BN vaccine showed comparable or lower mpox antibody responses at 12 months compared to those receiving 1 dose. Protective immunity may be waning in individuals vaccinated with this vaccine, according to a recent study.
Researchers at Karolinska Institutet have identified a new potential risk marker for cardiovascular disease in older women. Low levels of an anti-inflammatory antibody are associated with a higher risk of heart attack and coronary heart disease, independent of other known risk factors.
A study by researchers at the University of Rochester Medical Center found that high levels of specific antibodies in breast milk provide protection against rotavirus, a common gastrointestinal disease. The findings highlight the importance of optimized breastfeeding practices to improve infant health globally.
Researchers from Osaka Metropolitan University have developed a method to detect coronavirus spike proteins quickly and selectively using a light-induced immunoassay. The technique uses a milliwatt-level laser and can complete the entire process in under 5 minutes.
A recent study published in Cell Reports Medicine has discovered an important immune component that offers protection against MRSA infection. The researchers found that IgM antibodies are required for clearance of S. aureus during an infection, suggesting a new direction for future vaccine strategies and therapies.
A recent study has revealed that oral bacteria, specifically Aggregatibacter actinomycetemcomitans, can exacerbate rheumatoid arthritis. The study found that the infection led to increased inflammation and joint damage in animal models.
Researchers at UC Santa Barbara discovered that macrophages can be programmed to respond to light, triggering an increase in their appetite and improving the effectiveness of cancer immunotherapies. The findings offer a new way to enhance trained immunity, a type of memory exhibited in the innate immune system.
Researchers at La Jolla Institute for Immunology have discovered immune cells, such as tissue resident memory cells, in the upper airway that can fight infections and build long-term immunity. These findings may lead to better vaccines and a deeper understanding of immunity against respiratory pathogens.
Researchers found that the recent SARS-CoV-2 variants BA.2.86 and JN.1 have only minor changes in immune evasion compared to their predecessor Omicron, contradicting initial public health concerns.
A new study reveals that about two percent of the population develop autoantibodies against type 1 interferons, making them more susceptible to severe viral infections. The autoantibodies remain detectable in the blood for life and are associated with a compromised type 1 interferon system.
A recent study published in Allergy found that COVID-19 leads to long-term changes in the immune system, even in mild cases. The research team identified significant reductions in immune cells and alterations in cytokine levels, suggesting an impaired immune response to new challenges.
Patients with 18q deletion syndrome exhibit both cellular and humoral immunodeficiency, characterized by low immunoglobulin levels and impaired T-cell function. Regular testing for both cellular and humoral immunity can allow for early detection of combined immune deficiencies and improve clinical outcomes.
Researchers discovered a correlation between higher COVID-19 vaccination rates and lower symptomatic child asthma prevalence. The study suggests that COVID-19 vaccination may provide protection against other human coronaviruses through cross-reactive antibody responses.
Researchers have discovered how a neutralizing antibody blocks measles virus infection by arresting the fusion process. The study's findings may also be relevant to other viruses with pandemic potential, such as Nipah and parainfluenza viruses.
Researchers at Lund University developed a hybrid antibody that significantly improves immune function despite weaker binding to antigens. The new antibody's longer stem enhances mobility and signaling capacity, leading to better protection against SARS-CoV-2 and streptococcal bacteria.
Researchers found auto-antibodies against type I interferons in severe and critical COVID-19 patients, compromising their immune response. This discovery highlights the importance of detecting these auto-antibodies in regular health checkups to better prepare for viral infections.
Researchers develop fully human antibodies that can neutralize the alpha-latrotoxin of the European black widow, a neurotoxin causing severe pain and hypertension. The study uses in vitro methods to create recombinant human antibodies, offering a safer treatment alternative with potential cross-reactive properties.
A new study led by UCSF found that COVID-19 vaccine side effects like headache and tiredness indicate a strong immune response. Those with more symptoms had nearly double the antibody levels of those without, suggesting the vaccine is effective in preventing infection.
Researchers identified two groups of follicular helper lymphocytes that produce different types of antibodies in response to virus infections and allergies. This discovery could lead to new treatments for allergy diseases without affecting immune responses to infections.
Scientists have designed a synthetic antigen that can stimulate antibody production against cancer cells. The approach uses a natural protein called serum albumin to carry the antigen, reducing the need for bulky carriers and side effects.
Researchers develop a new method using gold nanoparticle decorated polymers (GNDP) to improve detection of antigen-antibody reactions in infectious diseases. This approach results in higher optical density and improved sensitivity compared to traditional methods.
Researchers found that Mpox antibodies decrease significantly within a year of MVA-BN vaccination, especially in individuals without prior smallpox vaccination. In contrast, antibody levels remained high in those with childhood smallpox vaccination, suggesting long-term protection.
Researchers developed an improved method for G4 landscape determination, revealing that sequence property-specific constraints in the nuclear environment mitigate G4 formation. The technique, AbC G4-ChIP, captures G4s efficiently without bias, showing that depletion of a repeat-binding protein enhances net G4 capture at specific sites.
Researchers investigated the role of long-lived plasma cells in COVID-19 infection, finding deficient generation of spike-specific antibodies. The study suggests that inadequate long-lived plasma cell production may be responsible for short-lived protective antibody responses to SARS-CoV-2.
A competition among researchers predicted B. pertussis vaccine responses based on a simple correlation between calendar age and antibody responses. The result highlights the need for further research to understand variability in vaccination outcomes.