Articles tagged with Macrophages
Research at Washington University School of Medicine found that aging immune cells contribute to inflammation and abnormal blood vessel growth in macular degeneration, potentially leading to vision loss. The study identified microRNA-150 as a potential therapeutic target for preventing progression to advanced forms of the disease.
A Tokyo Medical and Dental University-led study found that a protein signaling pathway enhances expression of genes encoding inflammatory mediators in macrophages, contributing to colonic inflammation. The research may lead to novel targets for IBD therapy.
Researchers at Trinity College Dublin have discovered a potential 'off-switch' for inflammation by identifying the molecule itaconate, which can block production of inflammatory factors and protect against lethal inflammation. This breakthrough could lead to new anti-inflammatory medicines for diseases such as arthritis and heart disease.
Researchers at UAB identified a therapeutic target to prevent or delay heart failure by blocking early infiltration of macrophages into the heart. Macrophage targeting may also reduce inflammation and T-cell expansion in patients with pressure-overload hypertrophy.
The researchers developed a label-free multimodal microscopy platform that allows non-invasive study of cellular preparations. The platform enables the study of fine cellular processes, such as macrophage cells activation upon exposure to lipopolysaccharide (LPS), at single-cell level through phenotypic and molecular characterization.
Researchers have found that dermal macrophages capture and recapture tattoo pigment, allowing for continuous maintenance of tattoos. This process can be disrupted by killing off macrophages, potentially improving the effectiveness of laser surgery in removing unwanted tattoos.
Researchers at CNIC identified a function of the protease MT4-MMP, which increases surveillance activity of blood-patrolling monocytes. This blockade could potentiate treatments for infection or prevent metastasis, but its effects on later stages need analysis.
A Massachusetts General Hospital team discovered that macrophages, immune cells known for removing debris, are actively involved in the development of heart failure with preserved ejection fraction (HFpEF). Elevated levels of inflammatory cardiac macrophages were found in both mouse models and human patients with HFpEF.
Researchers at the University of Liverpool have found that macrophages express insulin-like growth factors (IGFs) 1 and 2, which support breast cancer metastasis. The study suggests a significant reduction in tumour cell growth and lung metastasis when IGFs are blocked with paclitaxel.
A new study establishes a decisive link between immune cells and systemic sclerosis, providing a starting point for developing new therapies. Hundreds of macrophage genes are identified as crucial for the development of the disease.
A Montreal team of researchers has discovered a new approach to combat tuberculosis by reprogramming immune cells. By training stem cells in the bone marrow, macrophages can be generated to kill TB-causing bacteria. The findings offer promising results for developing an effective vaccine against TB.
A team of Canadian researchers has discovered a way to re-program innate immune cells to kill tuberculosis. The innovative work aims to make vaccines more effective against TB and other infectious diseases like the flu. By targeting stem cells in the bone marrow, scientists were able to boost the killing efficiency of macrophages.
Researchers developed macrophage nanosponges that can safely absorb and remove endotoxins and pro-inflammatory cytokines from the bloodstream. These nanosponges improved survival rates in mice with sepsis by preventing systemic inflammation and reducing bacterial counts.
Researchers at Tokyo Medical and Dental University have discovered that overexpression of the MKL1 protein in macrophages contributes to inflammation development in IBD. Targeting this protein may hold potential for treating IBD, a condition with currently no cure.
Researchers at VIB-KU Leuven have identified Caveolin-1 as a key player in suppressing metastatic growth in lung tumors. By studying macrophages at metastasis sites, they revealed that upregulation of this protein hinders cancer progression.
Researchers at Stanford University School of Medicine have identified a second biological pathway that signals immune cells not to engulf and kill cancer cells. By blocking this newly discovered pathway, combining it with anti-CD47 antibody may enhance the immune system's ability to eradicate many types of cancers.
A study published in the Journal of Neuroscience reveals that neutrophils, a type of immune cell, play a significant role in clearing debris from damaged nerves. Without this cellular clearance mechanism, nerves cannot properly regenerate after injury.
Researchers found that an experimental drug stimulates alpha-7 nicotinic receptors, reducing inflammation and improving lung function in mice with chronic allergic conditions. The treatment also activated M2 macrophages, associated with tissue repair, and reduced pro-inflammatory molecules.
A study published in Cell Research found that intermittent fasting can be beneficial for the metabolism, reducing fat build-up and stabilizing glucose and insulin systems. After sixteen weeks of on-and-off fasting, mice weighed less and had lower body fat compared to control groups.
Researchers have identified two microRNAs, miR-294 and miR-721, that are upregulated in macrophages infected with Leishmania parasites, potentially inhibiting the immune system's response. By analyzing the expression of these microRNAs, scientists hope to identify molecular targets for developing new treatments against leishmaniasis.
A new study reveals how tuberculosis bacteria evade the immune system by hiding in macrophages. Researchers have found that only well-adapted mycobacteria avoid detection, suggesting a potential target for future treatments.
Researchers have engineered smart protein molecules called iSNAPS that can rewire macrophages to ignore a 'don't eat me' signal from cancer cells, allowing them to engulf and destroy cancer cells. This breakthrough could lead to a new method of re-engineering immune cells to fight cancer and infectious diseases.
Researchers discover nerve-associated macrophages that become inflamed with age and disrupt fat cell function. Lowering inflammation in these cells restores normal fat metabolism in older mice.
A new drug targeting technique has been developed to target specific cells in the body, potentially improving therapies for immune-related diseases. The approach preferentially targets harmful macrophages while leaving healing cells unaffected, offering a promising solution for conditions such as arthritis and inflammatory bowel diseases.
A study found that macrophages can produce Interleukin-10 (IL-10), a healing factor, which promotes wound repair in the intestine. This discovery could lead to new treatments for inflammatory bowel disease (IBD). The researchers used a colonoscope with biopsy forceps to create a wound in mice and observed its healing process.
Researchers identify MARCO as a key adenovirus receptor on macrophage cells, enabling viral invasion and triggering an inflammatory response. This discovery has implications for gene therapy and the development of medications to block the receptor
Recent research from NTNU found that omega-3 fatty acids can dampen harmful inflammatory reactions in the body, particularly by activating autophagy and inhibiting interferon response factors. This may be beneficial for patients with conditions driven or aggravated by strong inflammatory responses.
Researchers at Penn State College of Medicine discovered that certain viruses evade the innate immune system by spreading to blood and being fought off in organs like the liver and spleen. This finding could lead to better treatments for viral infections like Zika, dengue, and measles.
Two types of testicular macrophages have been identified, one found in interstitial spaces and another on the surface of seminiferous tubules. These macrophages prevent other immune system agents from entering the testes by releasing specific molecules.
Researchers discovered that a single protein from Group A Streptococcus bacteria can wipe out macrophages but not other immune cells, triggering an early warning system. This finding has implications for vaccine design and treatment of toxic shock syndrome.
Researchers developed a new approach to model human immune variation, identifying gene markers that correlate with human disease outcomes. The study found that accounting for immune diversity is critical for predicting disease outcomes.
Researchers at Penn have developed a new approach to targeting cancer cells using engineered macrophages, which distinguish between healthy and cancerous cells. The treatment shows promise in regressing human tumors without toxicity.
Scientists at Imperial College London discovered a way to reprogram macrophages, immune cells that cause inflammation, by blocking a single enzyme. By targeting this broken metabolism, they reduced inflammation in rats and mice with human-like diseases.
A new study reveals that particle-induced cell death depends on multiple redundant cathepsins, which can be blocked by inhibiting or silencing these enzymes in macrophages. The researchers found that several key proinflammatory events induced by sterile particles are blocked, including cell death.
A study published in the Journal of Clinical Investigation reveals a mechanism to reverse disease in arteries by targeting an immune reaction. Researchers at NYU Langone Health discovered that certain immune cells can switch from promoting inflammation to healing, which can lead to reduced plaque growth and improved cardiovascular health.
Research reveals a defective immune cell's sweet tooth predisposes people to shingles, exacerbating heart disease. The connection shows how the same mechanism disabling immune response to viral infections also affects heart conditions.
Macrophages, known as the Pac-Man of the immune system, promote healing by regrowing severed nerves in rats, offering a promising alternative to current treatments like autografts. The approach uses biological signals to recruit younger, undifferentiated cells destined to become pro-healing macrophages.
Macrophages from CAD patients suppress T cell activation, driven by pyruvate and PD-L1. This mechanism may contribute to immune dysfunction and reactivation of long-latent viruses like varicella zoster virus.
Trehalose boosts autophagy in macrophages, allowing them to reduce atherosclerotic plaque. The study shows promise for treating atherosclerosis and other metabolic conditions.
Researchers found that radiation therapy can improve the delivery of cancer nanomedicines up to 600% by attracting macrophages to tumor blood vessels, leading to increased nanoparticle uptake. This combination strategy shows promise for enhanced treatment efficacy and could be tested in clinical trials quickly.
Researchers at the University of Montreal Hospital Research Centre discovered a way to modify white blood cells to accelerate cutaneous healing. The treatment uses a special protein called MFG-E8 to control macrophage behavior, promoting anti-inflammatory and pro-reparatory reactions.
Researchers at the University of Kentucky discovered that macrophages play a crucial role in complex tissue regeneration in mammals. The team found that specific subtypes of macrophages are required for regeneration, which could lead to novel clinical approaches to restore damaged tissue in humans.
A compound called interleukin 4 helps macrophages kill parasites and promote healing in lung tissue by binding to a receptor called myosin 18A. This discovery could lead to better treatments for common infections, including those caused by parasitic worms that infect hundreds of millions of people worldwide.
Researchers discovered that tumor-associated macrophages steal checkpoint blockade antibodies from T cells, leading to improved responses in mouse models. Blocking FcγR receptors allows checkpoint inhibitors to effectively target cancer cells.
The KAIST team discovered a new molecular signal triggered by IPMK enzyme in mediating innate immune response to sepsis. This finding suggests a potential therapeutic target for treating serious medical conditions like neuroinflammation and polymicrobial sepsis.
Phagocytosis not only eliminates useless cells, but also 'educates' macrophages, the immune cells that carry it out. This process helps maintain tissues in a clean and healthy state. Researchers identified specific molecular toolkits for eliminating unwanted cells in each tissue.
Researchers created a new model to study how chlamydia interacts with the human immune system, identifying key players IRF5 and IL-10RA. The results suggest these genes could be drug targets for new treatments.
Researchers discovered that macrophages aggregate around cardiac cells to facilitate electrical conduction, helping the heart beat in rhythm. This finding suggests a new role for immune cells in electrophysiology and may lead to new therapeutics for heart disease.
A recent study has discovered that macrophages are essential for the normal functioning of the heart, helping conduct electric signals that coordinate heartbeat. The findings suggest that changes in macrophage numbers or properties may contribute to heart rhythm abnormalities.
Researchers at UNC School of Medicine have found that HIV persists in macrophage cells, a type of white blood cell, which has significant implications for HIV cure research. This discovery demonstrates that two types of cells may be targets for therapeutic intervention to eradicate the virus.
Researchers at NYU Langone Health have uncovered a critical pathway by which pancreatic cancer cells evade the immune system, involving high levels of two proteins - dectin-1 and galectin-9. The study found that blocking this interaction can increase survival in mice with pancreatic tumors.
Researchers found that inhibiting Toll-like receptor 4 activation can silence Ebola virus-infected macrophages, a potential treatment option. The study also suggests this approach could work for other hemorrhagic fever viruses.
Scientists discovered that obesity disrupts the balance of 'guardian immune cells,' which maintain a delicate balance between immune systems. In healthy states, these cells protect against inflammation and metabolic disease, but in obese individuals, they lose their regulatory function.
Researchers discovered that macrophages transmit messages between non-immune cells, such as pigment cells in fish, to facilitate complex patterns like stripes. This unique function of macrophages suggests they may play a broader role in intercellular communication, affecting tissue development, regeneration, and cancer.
Researchers found a previously unappreciated role for Abraxane in tumor immunology, suggesting ways to improve the drug and develop new combination treatments. Nab-paclitaxel enables macrophages to switch from immune-suppressing M2 cells back into M1 cells that amplify the body's effort to kill cancer cells.
Researchers develop 'release and kill' strategy to target M. tuberculosis in infected macrophages, potentially shortening TB treatment periods. The approach leverages selective apoptosis to release the bacteria from infected cells, making them susceptible to antibiotics.
A research group at Kobe University has discovered a potential new cancer treatment that activates cancer-engulfing cells. The treatment uses an antibody to activate macrophages, which can effectively eliminate cancer cells. This discovery could lead to the development of new and more effective cancer treatments.
Researchers from Geneva and Fribourg have developed a rapid screening method to select the most promising nanoparticles for medical applications. The new approach can determine biocompatibility in under two days, reducing the need for animal testing and enabling personalized treatment.
Researchers identified how HIV infects macrophages despite protective protein SAMHD1 being switched off. A treatment to maintain macrophage defences could be crucial for reaching an HIV cure.
ABX464 upregulates IL-22 and miR-124, showing strong anti-inflammatory effects in preclinical models. The compound also prevents intestinal inflammation and protects against colitis, with therapeutic effects lasting at least 6 weeks.