Articles tagged with Type 1 Diabetes
EDENT1FI has screened 100,000 children across Europe for early-stage type 1 diabetes, using standardized screening programs and harmonized data collection. The initiative aims to empower families to manage life with type 1 diabetes effectively and support children and adolescents with early-stage detection.
Researchers at Kyoto University developed a PET tracer to quantify beta cell mass in type 1 diabetes patients, revealing lower uptake in those with the disease. This measurement was inversely related to hemoglobin A1c and total daily insulin dose, suggesting its potential as a noninvasive readout of residual beta cell mass.
A $3.4 million NIH grant will fund a semi-automated feedback system to support people tracking diet, exercise, and weight in weight-management programs. The system aims to provide personalized feedback to increase tracking and weight loss success.
A study from the University of Limerick found that supportive partners play a crucial role in women's experiences of gestational diabetes, with inadequate support increasing the burden of the condition. The research suggests that knowledge, communication, and cultural context are essential factors in determining the effectiveness of pa...
A Pennington Biomedical researcher published an editorial on the benefits of fruit intake for vascular health, citing a study on increasing fruit intake with avocados and mangos. The findings suggest that diets rich in fruits can improve nutrient status and health outcomes, aligning with the goals of the Food Is Medicine initiative.
A UCF researcher is pursuing innovative approaches to treat diabetic neuropathy without relying on pain pills and anti-depressants. Dr. Jim Nichols is investigating overlooked mechanisms in the body that may show how insulin deficiency affects sensation in limbs.
Syzygium jambolanum extracts demonstrate significant protective and antidiabetic effects, improving glycaemic control and metabolic health. The study reveals a systemic protective effect beyond glucose lowering alone.
The ESE and ESPE have launched a landmark Joint Clinical Practice Guidance to support structured and effective transition of young people with endocrine conditions. The Guidance provides practical, evidence-based recommendations to ensure continuity, safety and quality of care during this critical phase in a patient's life.
Researchers developed an oxygen-delivering gel to heal chronic wounds that fail to heal for more than a month. The gel conforms to the wound's shape and provides continuous oxygen levels, helping transform nonhealing wounds into normal injuries.
A new global study finds that physical inactivity is a significant driver of diabetes complications, with up to 10% of cases potentially preventable. The research emphasizes the need for tailored approaches to promote physical activity among people with diabetes, particularly addressing social and gender inequalities.
Scientists at the University of Florida and Linköping University discovered protein markers in umbilical cord blood associated with future insulin-dependent diabetes. The study suggests that these markers can be used to predict type 1 diabetes in early childhood, potentially allowing for targeted interventions and lifestyle changes.
A produce prescription program improved nutrition security among Medicaid patients with diabetes, increasing it from 23.2% to 38.7%. The program also improved food security, with 42.9% of participants reporting secure access to healthy foods after completion.
A UK-wide childhood screening program for type 1 diabetes has been shown to be effective in detecting early stages of the disease. By identifying children at risk, families can prepare for a potential diagnosis and receive timely treatment, reducing the need for emergency hospitalizations.
A groundbreaking study reveals B cells' detrimental role in progressing Type 1 diabetes by interfering with regulatory T cells. The findings suggest targeting B cell-Treg interactions could offer new therapeutic strategies for preserving beta cells and improving patient outcomes.
Research highlights racial-ethnic differences in pregnancy-related high blood pressure risk, with Pacific Islanders and Filipinos more likely to develop a hypertensive disorder. Early identification and treatment can help prevent serious complications for both pregnant individuals and their infants.
A study by Anglia Ruskin University found that patients with underlying conditions such as type 1 diabetes are at a significantly higher risk of complications from cosmetic botulinum toxin injections. The researchers recommend restricting administration to medically qualified professionals.
A study of over 300 stool samples found that gut-microbe-derived bile acids may play a role in shaping the immune system during early childhood. The findings suggest an imbalance in how gut microbes co-produce these compounds, which could link to signs of type 1 diabetes.
Researchers at the Medical University of South Carolina are developing a new therapy for Type 1 diabetes that combines stem cell biology, immunology, and transplantation science. The goal is to restore beta cell function and insulin production in people with T1D without using immunosuppressive drugs.
A genetic risk score test can predict who is at highest risk of developing type 1 diabetes and identify adults eligible for new drug teplizumab. The test identifies those in the top ten percent as eight times higher risk, enabling early intervention and treatment.
The UCF Health Mobile Health Clinic provides free high-quality healthcare services to underserved communities, serving as a real-world classroom for medical and nursing students. The clinic aims to reduce preventable conditions and improve long-term health through comprehensive screenings, chronic disease monitoring, and education.
A large study found that people with type 1 and type 2 diabetes have a higher risk of sudden cardiac death, particularly in younger adults. The research also showed that sudden cardiac death contributes to shorter life expectancy for those with diabetes.
A nationwide observational study from SWEDEHEART reveals that patients with type 1 diabetes have a significantly higher risk of stent complications compared to those without diabetes. The study emphasizes the need for adapted treatment and follow-up strategies for this patient group.
Researchers explore innovative avenues for regenerating functional β-cells using stem cells and pancreatic progenitor cells. The dual approach of activating endogenous progenitors and transplanting externally differentiated cells represents a powerful, scalable strategy for T1D management.
Researchers at University of Cologne identify p35-mediated CDK5 hyperactivity as a central mechanism limiting nerve regeneration in diabetes. Targeted interventions using peptides restore nerve fiber growth, leading to significant motor and sensory improvements.
The report emphasizes the importance of pairing research with policy partners and investing in mentorship and career advancement of Latino scientists and students. It also calls for implementing evidence-based practices, using telemedicine and AI equitably, and designing trauma-informed interventions that fit Latino family life.
A new study has caught immune cells 'in the act' in pancreatic lymph nodes, suggesting an early onset of Type 1 Diabetes. The researchers identified a unique subset of CD4 T cells that ramp up two proteins, NFKB1 and BACH2, turning genes on and off to rev up the immune attack on insulin-making cells.
Researchers found a significant link between type 1 diabetes and an increased risk of bladder cancer, with people being 4.29 times more likely to develop the disease. The new analysis controlled for tobacco smoking, a factor that obscured the heightened risk in earlier studies.
Researchers at Stanford Medicine have successfully transplanted a hybrid immune system into mice with Type 1 diabetes, preventing the disease from progressing. The approach involves adding a drug to the pre-transplant regimen, which resulted in all mice being cured or prevented from developing the disease.
A new insulin delivery technology has been found to improve glucose control during pregnancy for women with Type 1 diabetes, reducing the risk of complications for both mother and baby. The study, led by University of Calgary researchers, found that this technology resulted in a three-hour per day improvement in the desired glucose ran...
A new study reveals that sons born to mothers with type 1 diabetes show early signs of vascular dysfunction in their blood vessels, even before metabolic health is affected. The research suggests that this sex-specific effect could help clinicians assess risk and prevent cardiovascular disease earlier in life.
The POInT trial reveals promising secondary findings: oral insulin delays clinical type 1 diabetes progression, especially in children with high-risk insulin gene variants. This opens doors to targeted, personalized prevention strategies for a genetically defined subgroup of children.
Researchers found that prasugrel may offer an advantage over ticagrelor for individuals with Type 1 or Type 2 diabetes and complex coronary disease. This is because the two medications are not interchangeable, and treatment with prasugrel may provide better benefits in preventing blood clots and adverse cardiac events.
Researchers successfully converted human stomach cells into insulin-secreting cells in mice, helping to control blood sugar levels and alleviate diabetes. The approach could potentially be used to treat patients with lost or dysfunctional pancreatic beta cells.
A new study found that maternal type 1 diabetes is associated with specific epigenetic marks in the child, which affect immune function and expression of genes involved in autoimmune diseases. These changes appear to protect against islet autoimmunity, a precursor to type 1 diabetes.
A study at the University of Gothenburg found that intensive treatment with remote monitoring of glucose levels and weekly healthcare contact significantly improved long-term blood glucose control in people with type 1 diabetes. The treatment also increased patient satisfaction and proved to be safe, with no serious events reported.
A new study published in JAMA demonstrates that an AI-powered lifestyle intervention app for prediabetes can reduce the risk of diabetes similarly to traditional, human-led programs. The app achieved higher rates of program initiation and completion compared to traditional programs.
A low-fat vegan diet has been shown to improve insulin sensitivity and reduce the amount of insulin needed in people with type 1 diabetes. This can lead to significant cost savings, with total insulin costs decreasing by 27% in a recent study.
A study found a significant increase in type 1 diabetes cases among children under five and young adult men in Sweden during the Covid-19 pandemic. The incidence of diabetes increased by 12% in 2021 and 9% in 2022 compared to previous years, with no clear connection between Covid-19 infection and diabetes.
A new lab-designed protein has been discovered to regulate blood glucose levels, offering a potential new treatment avenue for people with Type 1 diabetes. The substance combines insulin and glucagon into one molecule, signaling the liver to respond naturally.
Poor blood sugar control in adolescence increases the risk of painful future complications for people with type 1 diabetes. Children diagnosed with type 1 diabetes at a young age have trouble controlling their blood sugar as teens and are more likely to develop neuropathy in adulthood.
A new trial has shown that a lower dose of the immunomodulatory drug ATG is safe and effective in preventing the progression of type 1 diabetes in young people. The study found that the drug was able to arrest or delay the progression of T1D at a dose as low as 0.5mg/kg, with a good safety profile.
The study predicts that 513,000 new cases of T1D will be diagnosed worldwide in 2025, with the greatest increases expected in Africa and the Middle East/North Africa. The analysis reveals substantial global inequities in diabetes care and outcomes.
The Ver-A-T1D trial suggests that verapamil could preserve beta-cell function in adults with newly diagnosed type 1 diabetes. The study demonstrated encouraging trends towards beta-cell preservation and well-established safety profile, but narrowly missed statistical significance.
A daily pill of baricitinib, a Janus kinase inhibitor, preserves insulin-producing beta cell function and slows type 1 diabetes progression in people recently diagnosed with the condition. The treatment's therapeutic effect is lost when it's stopped, justifying its testing in earlier stages to prevent or delay clinical diagnosis.
A four-year NIH grant will support a study of type 1 diabetes, led by Dr. Shuibing Chen at Weill Cornell Medicine. The researchers will investigate the interplay between genetic and environmental triggers using advanced laboratory and computational tools.
Lantidra, the only FDA-approved therapy for brittle type 1 diabetes, allows patients to stop taking daily insulin injections. The treatment has been shown to preserve health and prevent complications associated with diabetes.
The Pennington Biomedical Research Center has opened a new Endocrinology and Diabetes Clinic in Baton Rouge, providing specialized care for patients managing diabetes and endocrine disorders. The clinic is led by Dr. Timothy Gilbert, who brings nearly 20 years of private practice experience to the region.
A new study found that younger men with type 2 diabetes are more likely to experience worse cardiovascular disease and mortality outcomes compared to those with type 1 diabetes. In contrast, women with type 1 diabetes face poorer health outcomes across all ages, particularly due to longer exposure to high blood sugar levels and less ag...
A large-scale study published in PLOS Medicine found no association between early life antibiotic exposure and the development of autoimmune diseases in children. Researchers analyzed data from over 4 million Korean children and discovered no increased risk of Type 1 diabetes, Juvenile idiopathic arthritis, or other autoimmune conditions.
Researchers at UVA Health System are developing AI-based systems that can automatically detect meals and deliver insulin doses. The goal is to create fully automated artificial pancreas systems that require minimal user interaction.
Researchers uncover a critical endocrine link between brown adipocytes and pancreatic β-cells, revealing the ZNF638-RBP4-retinol-ATRA pathway's role in T1D pathogenesis. Targeting this axis may halt disease progression.
A study by Uppsala University found that parents of children with type 1 diabetes experience a significant drop in work-related incomes, particularly mothers. The impact is most pronounced for mothers of children diagnosed in preschool years. Long-term effects show that pension-qualifying incomes gradually decrease over time.
A new study found substantial increases in the use of continuous glucose monitoring and insulin delivery devices among children and adults with type 1 diabetes, resulting in improved blood-sugar control rates from 7% to 19% and 21% to 28%, respectively
A rapid increase in diabetes technology adoption led to improved glycemic control among type 1 diabetes patients, yet racial and socioeconomic disparities persisted. Notable racial and ethnic differences grew over time, highlighting the need for targeted interventions.
Researchers identified a sugar molecule called sialic acid that helps cancer cells evade the immune system. By engineering beta cells to produce this molecule, they found it possible to tolerate these cells and prevent their destruction. The study offers new hope for treating type 1 diabetes without immunosuppression.
A new study finds that living in rural areas in the first five years of life may be a risk factor for developing type 1 diabetes, whereas urban environments are associated with lower risk. The research identified significant high-risk clusters in rural areas and low-risk clusters in cities.
A new analysis published in The Journal of Clinical Investigation reveals how leptin affects the brain and its potential use in future therapeutics for type 1 diabetes. Leptin helps regulate appetite and body weight, and insufficient levels lead the brain to activate circuits that mobilize energy sources, including glucose and ketones.
A UNLV study uses an mRNA cocktail to selectively route to the pancreas, reducing the risk of immune responses and side effects. The breakthrough offers new hope for treating pancreas-related diseases, including cancer and diabetes.
A study assessing the Enhanced Primary Care Diabetes model found that Black patients were less likely to meet diabetes care goals, despite more frequent nurse touchpoints. Younger age, insulin use, and fewer initial medication counts were associated with slower progress.
A new web-based tool, Coverage Checker, helps Michigan physicians navigate diabetes coverage and prior authorization. The tool shows care team members which insurance policies cover guideline-directed medical therapy and continuous glucose monitors, and the prior authorization steps required.