Articles tagged with Type 1 Diabetes
A new subtype of diabetes has been identified in sub-Saharan Africa affecting nearly two-thirds of young people thought to have type 1 diabetes. This non-autoimmune form lacks typical features such as autoimmunity and genetic susceptibility, raising concerns about diagnosis and treatment.
Researchers have discovered a non-autoimmune form of type 1 diabetes prevalent in young people in Sub-Saharan Africa, differing from the typical autoimmune pattern seen in other regions. The study's findings also suggest an ancestral or genetic link between this subtype and African ancestry in the US.
A study found that automated insulin delivery pumps improved quality of life and reduced diabetes-related complications, with a cost-effectiveness ratio of 11,184 euros per quality-adjusted life-year. The technology is now supported for patients with type 1 diabetes in Finland.
A new study suggests that erythritol, commonly used in low-carb products, can alter the function of brain microvascular endothelial cells, leading to increased risk of stroke. The sugar substitute was found to constrict blood vessels and reduce the production of natural clot-busting compounds.
The Endocrine Society's new Scientific Statement identifies potential research directions to improve treatment options for people with type 1 diabetes. The statement highlights the need for population-based screening and more research into the causes of the disease.
Replacing animal products with plant-based foods, including ultra-processed ones, leads to significant weight loss and improved insulin sensitivity in people with type 1 diabetes. A secondary analysis of a randomized clinical trial found that the vegan group experienced reduced body weight and increased insulin sensitivity.
Researchers identify new group of immune cells driving autoimmune attack on insulin-producing cells in pancreas during cancer immunotherapy. JAK inhibitors, already FDA-approved for psoriasis and arthritis, show potential to prevent and even reverse type 1 diabetes in preclinical models.
Researchers have developed a novel treatment approach for autoimmune diseases by engineering a protein that holds closely together two signaling complexes on T cells, shutting down those T cells in a limited way. This approach shows promise for treating conditions such as Type-1 diabetes and multiple sclerosis.
A team of international scientists successfully 3D printed functional human islets using a novel bioink, paving the way for more effective and less invasive treatment options. The bioprinted constructs maintained their structure without clumping or breaking down and showed promising results in laboratory tests.
A clinical trial found that semaglutide, a Type 2 diabetes drug, improved blood sugar levels and weight loss in adult Type 1 diabetes patients who use automated insulin delivery systems. The study showed that 36% of patients taking semaglutide achieved target blood glucose levels and lost at least 5% of their body weight.
Researchers discovered that a protein called BNIP3 plays a critical role in preserving mitochondrial health and reducing immune responses in type 1 diabetes. Boosting BNIP3 activity may help preserve beta cell function and prevent cellular destruction.
A new clinical trial found that taking semaglutide once weekly significantly improves blood sugar levels and leads to substantial weight loss in adults with Type 1 diabetes. The study involved 72 participants across four medical centers and showed a 36% improvement rate compared to the placebo group.
Critical Path Institute's Translational Therapeutics Accelerator awards $250,000 to researchers advancing a promising therapeutic pathway for type 1 diabetes. The project aims to address key challenges in T1D treatment, including beta-cell preservation and immune system modulation.
A landmark review highlights how diabetes alters bone microarchitecture and increases fracture risk in people with type 2 diabetes, despite normal or elevated bone mineral density. The authors advocate for updated diagnostic tools, including a revised TBS algorithm, to more accurately reflect bone quality in individuals with central ob...
A new study published in npj Digital Medicine found that an interactive artificial pancreas system, using digital twins, improved blood sugar control and reduced hemoglobin A1c levels in type 1 diabetes patients. The system adapts to users' changing bodies and allows them to test changes to the system's parameters in a safe simulation ...
A new study from the University of Colorado Anschutz Medical Campus shows that primary care clinics can effectively introduce continuous glucose monitors (CGMs) into their practices. The study found that both self-guided and virtual CGM initiation services were successful, regardless of clinic size or diabetes expertise.
Researchers have discovered a key marker, FXYD2, that identifies functional maturity and heterogeneity of stem cell-derived islet organoids. This breakthrough enables quality control for production of transplantable islets, advancing the field toward safer and more effective islet replacement therapies.
Researchers developed a new approach to identify healed diabetic foot ulcers at risk of reopening based on trans-epidermal water loss measurements. High TEWL values were linked to increased wound recurrence and shorter time to recurrence, suggesting functional skin barrier defects are a critical factor in wound healing.
Researchers found that an inexpensive HIV drug can improve vision in patients with diabetic macular edema (DME) more effectively and at a lower cost than existing treatments. The drug, lamivudine, is taken orally and may represent a game-changing option for millions of patients worldwide.
Scientists have created a vascularized organoid model of hormone-secreting cells in the pancreas, promising to improve diabetes research and cell-based therapies. The model, developed by Max Delbrück Center researchers, contains greater numbers of mature beta cells and secretes more insulin than non-vascularized counterparts.
A new study found that adults diagnosed with type 1 diabetes after age 40 have a higher risk of cardiovascular disease and death compared to those diagnosed earlier. Poor glucose control, obesity, and smoking are the main risk factors identified in the study.
A new approach targeting inflammation may help prevent or slow the progression of Type 1 diabetes by blocking TYK2 protein signaling. Researchers found that inhibiting this protein reduced harmful inflammation in the pancreas and protected insulin-producing beta cells.
A systematic review of 46 clinical studies with 4,113 participants found that automated insulin delivery (AID) systems improved time in target range and reduced elevated glucose values compared to conventional pump therapy. However, low efficacy was observed during periods with very low glucose levels.
Researchers at Carnegie Mellon University have developed a novel FRESH bioprinting technique that enables the creation of microphysiologic systems entirely out of collagen, cells, and other proteins. This advancement expands the capabilities of studying disease and building tissues for therapy, such as Type 1 diabetes.
Researchers Schmidt and Selvin will explore the connections between cardiovascular disease and diabetes, with a focus on large white blood cells and wearable continuous glucose monitors. Their work aims to develop new treatment therapies and improve health outcomes for people with diabetes.
A study published in Diabetes, Obesity and Metabolism found that obesity rates among type 1 diabetes patients increased for all age groups and ethnicities from 2008 to 2023. GLP-1 receptor agonist use also rose sharply, with a sevenfold increase in severely obese youth with type 1 diabetes between 2008-11 and 2020-23.
Research in mice suggests that antibiotics during infancy can stunt insulin-producing cell growth and boost diabetes risk. Specific microorganisms, such as Candida dubliniensis, may help promote pancreatic cell development and improve metabolic function.
The Dexcom G7 CGM device demonstrated an accuracy of 8.0% in a study involving 130 adults with type 1 or type 2 diabetes, setting a new standard for continuous glucose monitoring devices.
The INHALE-3 extension study found that a regimen of inhaled technosphere insulin and insulin degludec reduced post-meal hyperglycemia in adults with type 1 diabetes. The treatment showed significant improvements in mean time in range, with 43% of participants expressing interest in continuing the regimen.
A new study from the University of Surrey found that healthcare professionals face difficulties in recognizing and addressing disordered eating in people with type 1 Diabetes due to lack of support and limited confidence. This can lead to delays in diagnosis and potentially life-threatening complications for patients.
A phase 1/2 clinical trial is exploring whether denosumab, an osteoporosis medication, can protect and regenerate beta cells in people with early type 1 diabetes. The study aims to improve blood sugar control by preserving beta cell function.
Researchers emphasize the importance of regular screenings and treatment to prevent vision loss in patients with diabetes. Current guidelines recommend eye exams for adults with type 1 and type 2 diabetes, while adolescents and young adults are at higher risk due to difficulty controlling their condition.
A new study from Washington State University finds automated insulin delivery systems safe and effective for older adults with type 1 diabetes, improving glucose control and reducing burden. The hybrid closed loop system proved most effective at keeping blood sugar in target range.
Research in mice found that early-life gut microbes shape insulin-producing cell development and reduce long-term changes in metabolism and diabetes risk. Exposure to a fungus called Candida dubliniensis during infancy may also promote lifelong metabolic health by supporting the growth of insulin-producing cells.
Researchers analyzed phage-bacteria communities in children's stool samples to understand their role in type 1 diabetes development. They found dynamic changes in phage and bacterial populations, suggesting an 'arms race' between the two, but no clear link to disease risk.
Researchers at the University of Colorado Anschutz Medical Campus found that primary care providers trained on advanced insulin technology or through telehealth can deliver similar positive results to specialists. The study focuses on Type 1 diabetes and highlights the potential for broader access to cutting-edge care.
Researchers identified GPR107 as a key regulator of COL4 levels in the kidney, finding that reduced GPR107 contributes to harmful COL4 accumulation and kidney damage. Strategies aimed at restoring or enhancing GPR107 function could represent a novel approach to preventing diabetic nephropathy progression.
Researchers developed reprogrammed vascular endothelial cells that provide strong support for islets, allowing them to survive and reverse diabetes long-term. The study showed that mice transplanted with islet cells plus R-VECs regained normal blood glucose control after 20 weeks.
A study comparing hybrid closed-loop and open-loop systems in young people with type 1 diabetes found that hybrid closed-loop systems offered improved long-term blood sugar values, a lower risk of hypoglycemic coma, but a higher rate of diabetic ketoacidosis. The results suggest that hybrid closed-loop therapies may be beneficial for i...
A new study published in JSCAI reveals a lower risk of cardiovascular events for people with Type 1 diabetes, compared to those with Type 2 diabetes. The research highlights the importance of distinguishing between the two types of diabetes and developing targeted treatment strategies.
A new clinical trial at UVA is testing an innovative AI-powered device designed to improve automated insulin delivery, aiming to simplify diabetes management. The trial will evaluate the 'Bolus Priming System with Reinforcement Learning' technology in adult participants with Type 1 Diabetes.
A new study found that yo-yo dieting significantly increases the risk of kidney disease in people with type 1 diabetes. Participants who experienced greater weight fluctuations had a 40% decline in estimated glomerular filtration rate and were more likely to exhibit increased albuminuria.
Researchers found that time in safe blood-sugar range can predict diabetes complications as accurately as hemoglobin A1c levels. The study used advanced machine learning techniques to analyze landmark diabetes data from the DCCT trial.
A new study from Aarhus University Hospital shows that fecal microbiota transplantation can be a safe and effective treatment for patients with type 1 diabetes and gastroenteropathy. The treatment has significantly improved quality of life and symptoms for participants, offering hope to those with debilitating symptoms.
A Stanford Medicine study found that AI can help researchers quickly evaluate large amounts of medical data, identifying trends and patterns. The tool was trained on notes from 1,201 children with ADHD, allowing researchers to pinpoint gaps in follow-up care and identify tactics to improve ADHD management.
Researchers have found that loosening the grip of engineered chimeric antigen receptor (CAR) Tregs improves their function and effectiveness in treating autoimmune diseases. By adjusting the affinity of the CAR, the study shows that Tregs can suppress immune responses while reducing pro-inflammatory consequences.
Mount Sinai researchers have made significant progress in understanding how human beta cell regenerative drugs work, potentially leading to a cure for diabetes. The study suggests that these drugs may be able to induce lineage conversion in human pancreatic islets, providing a new source of beta cells.
Scientists at UCSF have developed engineered T cells that act as immune referees to soothe overreacting immune responses and mope up inflammatory molecules. These cells could improve treatment for organ transplants, type 1 diabetes and other autoimmune conditions by reducing the need for harsh immunosuppressant drugs.
A new study found that factors beyond carbohydrates, such as exercise and hormones, play a substantial role in regulating blood glucose levels in people with Type 1 Diabetes. The research highlights the complexity of glucose regulation and the need for personalized insulin dosing approaches.
Lantidra is the only FDA-approved treatment for brittle type 1 diabetes, a more severe form of the disease. The therapy involves pancreatic islet cell transplantation and has shown promising results in clinical trials, with most patients no longer requiring insulin one year after the procedure.
Researchers at Medical University of South Carolina and University of Florida developed a novel approach to treat type 1 diabetes using tagged beta cell transplant with localized immune protection. The study, published in Cell Reports, shows promise for creating an off-the-shelf solution for T1D treatment.
A new research grant aims to develop kinase inhibitors for treating type 1 diabetes, with a focus on preventing and reversing the condition. The grant is made through C-Path's TRxA program in partnership with The Leona M. and Harry B. Helmsley Charitable Trust.
A new system combining high-speed video and an AI algorithm can detect high blood pressure and Type 1 or Type 2 diabetes from subtle changes in blood flow, potentially leading to early detection and treatment. The technology is still in its preliminary stages but holds promise for non-invasive monitoring of health at home.
The TEDDY study aims to understand the causes of type 1 diabetes in children, finding a connection between enterovirus infection, autoantibodies, and disease development. Probiotics may also reduce risk in infants at high danger of developing diabetes-related antibodies.
Researchers developed a screening technique to filter out low-quality data in wearable sensors, improving the performance of smartwatches for noninvasive blood glucose estimation. The approach enhances accuracy by discarding data with high phase errors and approximating missing values.
The use of GLP-1 receptor agonists (GLP-1RAs) and SGLT2 inhibitors in people with type 1 diabetes has significantly increased between 2010 and 2023. This trend is driven by their benefits in weight management and cardiorenal protection, but caution is advised due to concerns about euglycemic diabetic ketoacidosis.
A McGill University study reveals that vitamin D deficiency early in life can lead to a higher risk of autoimmune diseases like Type 1 diabetes. The research found that an aging thymus causes the immune system to become less effective, increasing the risk of misdirected immune cells attacking healthy tissues.
Cognitive-behavioral therapy (CBT) is a promising intervention for addressing medical non-adherence in pediatric patients with chronic illnesses. CBT successfully integrates principles of learning theory and cognitive science to address behavioral and emotional challenges that affect health outcomes.
Researchers at University of Gothenburg propose inhibiting somatostatin to restore glucagon release and prevent dangerous blood sugar levels. This approach has the potential to save lives and is supported by experimental results in mice with type 1 diabetes.
A large study found that women with premature ovarian insufficiency are 2.6 times more likely to have an autoimmune disorder, with some conditions increasing the risk by 26 times. The study suggests a strong link between POI and severe autoimmune diseases, highlighting the need for medical professionals to be aware of this increased risk.