Articles tagged with Type 1 Diabetes
Research highlights racial-ethnic differences in pregnancy-related high blood pressure risk, with Pacific Islanders and Filipinos more likely to develop a hypertensive disorder. Early identification and treatment can help prevent serious complications for both pregnant individuals and their infants.
A study by Anglia Ruskin University found that patients with underlying conditions such as type 1 diabetes are at a significantly higher risk of complications from cosmetic botulinum toxin injections. The researchers recommend restricting administration to medically qualified professionals.
Researchers at the Medical University of South Carolina are developing a new therapy for Type 1 diabetes that combines stem cell biology, immunology, and transplantation science. The goal is to restore beta cell function and insulin production in people with T1D without using immunosuppressive drugs.
A study of over 300 stool samples found that gut-microbe-derived bile acids may play a role in shaping the immune system during early childhood. The findings suggest an imbalance in how gut microbes co-produce these compounds, which could link to signs of type 1 diabetes.
A genetic risk score test can predict who is at highest risk of developing type 1 diabetes and identify adults eligible for new drug teplizumab. The test identifies those in the top ten percent as eight times higher risk, enabling early intervention and treatment.
A large study found that people with type 1 and type 2 diabetes have a higher risk of sudden cardiac death, particularly in younger adults. The research also showed that sudden cardiac death contributes to shorter life expectancy for those with diabetes.
The UCF Health Mobile Health Clinic provides free high-quality healthcare services to underserved communities, serving as a real-world classroom for medical and nursing students. The clinic aims to reduce preventable conditions and improve long-term health through comprehensive screenings, chronic disease monitoring, and education.
A nationwide observational study from SWEDEHEART reveals that patients with type 1 diabetes have a significantly higher risk of stent complications compared to those without diabetes. The study emphasizes the need for adapted treatment and follow-up strategies for this patient group.
Researchers at University of Cologne identify p35-mediated CDK5 hyperactivity as a central mechanism limiting nerve regeneration in diabetes. Targeted interventions using peptides restore nerve fiber growth, leading to significant motor and sensory improvements.
Researchers explore innovative avenues for regenerating functional β-cells using stem cells and pancreatic progenitor cells. The dual approach of activating endogenous progenitors and transplanting externally differentiated cells represents a powerful, scalable strategy for T1D management.
The report emphasizes the importance of pairing research with policy partners and investing in mentorship and career advancement of Latino scientists and students. It also calls for implementing evidence-based practices, using telemedicine and AI equitably, and designing trauma-informed interventions that fit Latino family life.
A new study has caught immune cells 'in the act' in pancreatic lymph nodes, suggesting an early onset of Type 1 Diabetes. The researchers identified a unique subset of CD4 T cells that ramp up two proteins, NFKB1 and BACH2, turning genes on and off to rev up the immune attack on insulin-making cells.
Researchers found a significant link between type 1 diabetes and an increased risk of bladder cancer, with people being 4.29 times more likely to develop the disease. The new analysis controlled for tobacco smoking, a factor that obscured the heightened risk in earlier studies.
Researchers at Stanford Medicine have successfully transplanted a hybrid immune system into mice with Type 1 diabetes, preventing the disease from progressing. The approach involves adding a drug to the pre-transplant regimen, which resulted in all mice being cured or prevented from developing the disease.
A new insulin delivery technology has been found to improve glucose control during pregnancy for women with Type 1 diabetes, reducing the risk of complications for both mother and baby. The study, led by University of Calgary researchers, found that this technology resulted in a three-hour per day improvement in the desired glucose ran...
A new study reveals that sons born to mothers with type 1 diabetes show early signs of vascular dysfunction in their blood vessels, even before metabolic health is affected. The research suggests that this sex-specific effect could help clinicians assess risk and prevent cardiovascular disease earlier in life.
The POInT trial reveals promising secondary findings: oral insulin delays clinical type 1 diabetes progression, especially in children with high-risk insulin gene variants. This opens doors to targeted, personalized prevention strategies for a genetically defined subgroup of children.
Researchers found that prasugrel may offer an advantage over ticagrelor for individuals with Type 1 or Type 2 diabetes and complex coronary disease. This is because the two medications are not interchangeable, and treatment with prasugrel may provide better benefits in preventing blood clots and adverse cardiac events.
A new study found that maternal type 1 diabetes is associated with specific epigenetic marks in the child, which affect immune function and expression of genes involved in autoimmune diseases. These changes appear to protect against islet autoimmunity, a precursor to type 1 diabetes.
Researchers successfully converted human stomach cells into insulin-secreting cells in mice, helping to control blood sugar levels and alleviate diabetes. The approach could potentially be used to treat patients with lost or dysfunctional pancreatic beta cells.
A study at the University of Gothenburg found that intensive treatment with remote monitoring of glucose levels and weekly healthcare contact significantly improved long-term blood glucose control in people with type 1 diabetes. The treatment also increased patient satisfaction and proved to be safe, with no serious events reported.
A new study published in JAMA demonstrates that an AI-powered lifestyle intervention app for prediabetes can reduce the risk of diabetes similarly to traditional, human-led programs. The app achieved higher rates of program initiation and completion compared to traditional programs.
A study found a significant increase in type 1 diabetes cases among children under five and young adult men in Sweden during the Covid-19 pandemic. The incidence of diabetes increased by 12% in 2021 and 9% in 2022 compared to previous years, with no clear connection between Covid-19 infection and diabetes.
A low-fat vegan diet has been shown to improve insulin sensitivity and reduce the amount of insulin needed in people with type 1 diabetes. This can lead to significant cost savings, with total insulin costs decreasing by 27% in a recent study.
Poor blood sugar control in adolescence increases the risk of painful future complications for people with type 1 diabetes. Children diagnosed with type 1 diabetes at a young age have trouble controlling their blood sugar as teens and are more likely to develop neuropathy in adulthood.
A new lab-designed protein has been discovered to regulate blood glucose levels, offering a potential new treatment avenue for people with Type 1 diabetes. The substance combines insulin and glucagon into one molecule, signaling the liver to respond naturally.
A daily pill of baricitinib, a Janus kinase inhibitor, preserves insulin-producing beta cell function and slows type 1 diabetes progression in people recently diagnosed with the condition. The treatment's therapeutic effect is lost when it's stopped, justifying its testing in earlier stages to prevent or delay clinical diagnosis.
A new trial has shown that a lower dose of the immunomodulatory drug ATG is safe and effective in preventing the progression of type 1 diabetes in young people. The study found that the drug was able to arrest or delay the progression of T1D at a dose as low as 0.5mg/kg, with a good safety profile.
The study predicts that 513,000 new cases of T1D will be diagnosed worldwide in 2025, with the greatest increases expected in Africa and the Middle East/North Africa. The analysis reveals substantial global inequities in diabetes care and outcomes.
The Ver-A-T1D trial suggests that verapamil could preserve beta-cell function in adults with newly diagnosed type 1 diabetes. The study demonstrated encouraging trends towards beta-cell preservation and well-established safety profile, but narrowly missed statistical significance.
A four-year NIH grant will support a study of type 1 diabetes, led by Dr. Shuibing Chen at Weill Cornell Medicine. The researchers will investigate the interplay between genetic and environmental triggers using advanced laboratory and computational tools.
Lantidra, the only FDA-approved therapy for brittle type 1 diabetes, allows patients to stop taking daily insulin injections. The treatment has been shown to preserve health and prevent complications associated with diabetes.
The Pennington Biomedical Research Center has opened a new Endocrinology and Diabetes Clinic in Baton Rouge, providing specialized care for patients managing diabetes and endocrine disorders. The clinic is led by Dr. Timothy Gilbert, who brings nearly 20 years of private practice experience to the region.
A new study found that younger men with type 2 diabetes are more likely to experience worse cardiovascular disease and mortality outcomes compared to those with type 1 diabetes. In contrast, women with type 1 diabetes face poorer health outcomes across all ages, particularly due to longer exposure to high blood sugar levels and less ag...
A large-scale study published in PLOS Medicine found no association between early life antibiotic exposure and the development of autoimmune diseases in children. Researchers analyzed data from over 4 million Korean children and discovered no increased risk of Type 1 diabetes, Juvenile idiopathic arthritis, or other autoimmune conditions.
Researchers at UVA Health System are developing AI-based systems that can automatically detect meals and deliver insulin doses. The goal is to create fully automated artificial pancreas systems that require minimal user interaction.
Researchers uncover a critical endocrine link between brown adipocytes and pancreatic β-cells, revealing the ZNF638-RBP4-retinol-ATRA pathway's role in T1D pathogenesis. Targeting this axis may halt disease progression.
A rapid increase in diabetes technology adoption led to improved glycemic control among type 1 diabetes patients, yet racial and socioeconomic disparities persisted. Notable racial and ethnic differences grew over time, highlighting the need for targeted interventions.
A study by Uppsala University found that parents of children with type 1 diabetes experience a significant drop in work-related incomes, particularly mothers. The impact is most pronounced for mothers of children diagnosed in preschool years. Long-term effects show that pension-qualifying incomes gradually decrease over time.
A new study found substantial increases in the use of continuous glucose monitoring and insulin delivery devices among children and adults with type 1 diabetes, resulting in improved blood-sugar control rates from 7% to 19% and 21% to 28%, respectively
A new analysis published in The Journal of Clinical Investigation reveals how leptin affects the brain and its potential use in future therapeutics for type 1 diabetes. Leptin helps regulate appetite and body weight, and insufficient levels lead the brain to activate circuits that mobilize energy sources, including glucose and ketones.
Researchers identified a sugar molecule called sialic acid that helps cancer cells evade the immune system. By engineering beta cells to produce this molecule, they found it possible to tolerate these cells and prevent their destruction. The study offers new hope for treating type 1 diabetes without immunosuppression.
A new study finds that living in rural areas in the first five years of life may be a risk factor for developing type 1 diabetes, whereas urban environments are associated with lower risk. The research identified significant high-risk clusters in rural areas and low-risk clusters in cities.
A UNLV study uses an mRNA cocktail to selectively route to the pancreas, reducing the risk of immune responses and side effects. The breakthrough offers new hope for treating pancreas-related diseases, including cancer and diabetes.
A new web-based tool, Coverage Checker, helps Michigan physicians navigate diabetes coverage and prior authorization. The tool shows care team members which insurance policies cover guideline-directed medical therapy and continuous glucose monitors, and the prior authorization steps required.
A study assessing the Enhanced Primary Care Diabetes model found that Black patients were less likely to meet diabetes care goals, despite more frequent nurse touchpoints. Younger age, insulin use, and fewer initial medication counts were associated with slower progress.
Researchers have discovered a non-autoimmune form of type 1 diabetes prevalent in young people in Sub-Saharan Africa, differing from the typical autoimmune pattern seen in other regions. The study's findings also suggest an ancestral or genetic link between this subtype and African ancestry in the US.
A new subtype of diabetes has been identified in sub-Saharan Africa affecting nearly two-thirds of young people thought to have type 1 diabetes. This non-autoimmune form lacks typical features such as autoimmunity and genetic susceptibility, raising concerns about diagnosis and treatment.
A study found that automated insulin delivery pumps improved quality of life and reduced diabetes-related complications, with a cost-effectiveness ratio of 11,184 euros per quality-adjusted life-year. The technology is now supported for patients with type 1 diabetes in Finland.
A new study suggests that erythritol, commonly used in low-carb products, can alter the function of brain microvascular endothelial cells, leading to increased risk of stroke. The sugar substitute was found to constrict blood vessels and reduce the production of natural clot-busting compounds.
The Endocrine Society's new Scientific Statement identifies potential research directions to improve treatment options for people with type 1 diabetes. The statement highlights the need for population-based screening and more research into the causes of the disease.
Replacing animal products with plant-based foods, including ultra-processed ones, leads to significant weight loss and improved insulin sensitivity in people with type 1 diabetes. A secondary analysis of a randomized clinical trial found that the vegan group experienced reduced body weight and increased insulin sensitivity.
Researchers identify new group of immune cells driving autoimmune attack on insulin-producing cells in pancreas during cancer immunotherapy. JAK inhibitors, already FDA-approved for psoriasis and arthritis, show potential to prevent and even reverse type 1 diabetes in preclinical models.
Researchers have developed a novel treatment approach for autoimmune diseases by engineering a protein that holds closely together two signaling complexes on T cells, shutting down those T cells in a limited way. This approach shows promise for treating conditions such as Type-1 diabetes and multiple sclerosis.
A team of international scientists successfully 3D printed functional human islets using a novel bioink, paving the way for more effective and less invasive treatment options. The bioprinted constructs maintained their structure without clumping or breaking down and showed promising results in laboratory tests.
A clinical trial found that semaglutide, a Type 2 diabetes drug, improved blood sugar levels and weight loss in adult Type 1 diabetes patients who use automated insulin delivery systems. The study showed that 36% of patients taking semaglutide achieved target blood glucose levels and lost at least 5% of their body weight.
A new clinical trial found that taking semaglutide once weekly significantly improves blood sugar levels and leads to substantial weight loss in adults with Type 1 diabetes. The study involved 72 participants across four medical centers and showed a 36% improvement rate compared to the placebo group.
Researchers discovered that a protein called BNIP3 plays a critical role in preserving mitochondrial health and reducing immune responses in type 1 diabetes. Boosting BNIP3 activity may help preserve beta cell function and prevent cellular destruction.
A landmark review highlights how diabetes alters bone microarchitecture and increases fracture risk in people with type 2 diabetes, despite normal or elevated bone mineral density. The authors advocate for updated diagnostic tools, including a revised TBS algorithm, to more accurately reflect bone quality in individuals with central ob...
Critical Path Institute's Translational Therapeutics Accelerator awards $250,000 to researchers advancing a promising therapeutic pathway for type 1 diabetes. The project aims to address key challenges in T1D treatment, including beta-cell preservation and immune system modulation.