Articles tagged with Type 1 Diabetes
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Research suggests that universal screening for type 1 diabetes at two ages could predict most cases of T1D by age 15. Dr. Emily K. Sims emphasizes the importance of identifying individuals with early, presymptomatic stages of disease to prevent life-threatening episodes and improve outcomes.
A phase 1/2 study shows that a stem cell-derived islet therapy has improved blood sugar control in all six adult patients with type 1 diabetes. Three patients achieved insulin independence and showed sustained improvements in blood glucose levels.
A recent US study has found that food insecurity significantly increases the risk of severe hypoglycaemia in adults with diabetes. The study, which analyzed data from over 1,000 participants, revealed that those experiencing food insecurity were nearly twice as likely to experience severe hypoglycaemic events.
A study of over 1 million Swedish men found that high blood pressure at age 18 was associated with a higher risk of major cardiovascular events, including heart failure, heart attacks, and strokes. Early intervention for hypertension may be critical to reducing later cardiovascular events.
The study found that type 1 diabetes incidence slightly increased overall, while type 2 diabetes significantly increased after the COVID-19 pandemic. Non-Hispanic Black and Hispanic youth were disproportionately affected.
Researchers have designed an implantable device that carries hundreds of thousands of insulin-producing islet cells and has its own on-board oxygen factory, generating oxygen by splitting water vapor. The device was tested in diabetic mice and maintained normal blood glucose levels for at least a month.
A new study found that islet transplantation significantly reduces the risk of kidney transplant failure and mortality in patients with type 1 diabetes. The study compared the long-term outcomes of patients who received an islet transplantation with those who underwent kidney transplantation and managed their diabetes with insulin alone.
A recent study published in the Journal of Diabetes Science and Technology found that HbA1c levels are markedly higher in young black youth compared to whites with type 1 diabetes. This disparity can lead to increased risk of hypoglycemia and long-term complications if primarily used for insulin management.
Research shows a significant decline in death rates after a first heart attack for individuals without diabetes and those with type 2 diabetes. However, this trend is absent in people with type 1 diabetes. The study suggests that improved standard care following a heart attack may contribute to the observed differences.
A small study found that treating newly diagnosed Type 1 diabetes patients with semaglutide significantly reduced their need for insulin. The medication's ability to stimulate insulin secretion from the beta cells of the pancreas allowed for the elimination of mealtime and basal insulin doses in most patients.
Scientists at CeMM and Max Perutz Labs have reclassified approximately 200 rare immune system disorders using a network-based approach. The study reveals strong similarities between rare diseases and autoimmune conditions, enabling the prediction of treatment efficacy and personalized approaches for diagnosis and treatment.
Researchers found that verapamil prevents the decline of insulin-like growth factor 1 (IGF-1) in Type 1 diabetes patients and promotes IGF-1 signaling in pancreatic beta cells. This mechanism may contribute to the beneficial effects of verapamil on preserving beta-cell function in Type 1 diabetes.
A recent study by Pennington Biomedical Research Center identifies GDF15 as a protein that acts as a cellular signal to enhance insulin secretion. High-intensity exercise training in patients with type 2 diabetes was found to have elevated levels of GDF15, associated with improved glycemic control.
A new study reveals that being divorced is associated with a two-thirds higher risk of lower limb amputation (LLA) in individuals with diabetes compared to those who are married. Additionally, men have a 57% higher risk of LLA than women. The study also found that obesity has a less-than-half the risk of LLA for people with normal weight.
Researchers have identified four metabolism-related biomarkers linked to an increased risk of metastatic prostate cancer in Black men. These biomarkers could lead to improved testing and treatments for this high-risk population, who are more than twice as likely to die from the disease.
Researchers aim to investigate the link between gut microbes and Type 1 diabetes. Emrah Altindis's lab seeks to understand how a protein found in certain bacteria may trigger the onset of T1D.
A recent study found that patients with type 1 diabetes using insulin pumps for extended periods do not exhibit significantly more pathology in their skin compared to short-term users. Despite this, researchers still struggle to understand the underlying causes of skin damage and inflammation at infusion sites.
A $3 million NIH award will support an intervention aimed at improving health outcomes in Black youth with type 1 diabetes. The project aims to optimize family interactions related to diabetes care through mobile health technology, potentially reducing disparities in health outcomes for this vulnerable population.
A Scripps Research study has developed a method to analyze T cells in blood samples to detect early signs of autoimmune disease that could lead to type 1 diabetes. This approach has shown 100% accuracy in identifying at-risk patients and may be used for personalized treatment.
A comprehensive review of biochemical markers for bone fragility in diabetes identifies low bone turnover and alterations in bone quality as key factors. The study suggests that glycemic control, AGEs, and serum IGF-1 may have predictive value for fracture risk in patients with diabetes.
The COVID-19 pandemic has led to a higher incidence of type 1 diabetes and diabetic ketoacidosis in children and adolescents, with increased resources needed for support. Future studies are necessary to assess the trend's persistence and possible underlying mechanisms.
Researchers identify altered proteins predicting islet autoimmunity, a precursor to Type 1 diabetes. The findings mark an important step forward in predicting the disease months before symptoms appear.
Scientists at the University of Bristol have shown that reinforcement learning significantly outperforms commercial blood glucose controllers in terms of safety and effectiveness. The new study improves on prior work by learning from patient records, achieving good blood glucose control through personalized insulin dosing strategies.
Researchers have made progress in generating stem cell-derived beta cells, but current methods are costly and labor-intense. A recent study has found a simple method to address these issues, enhancing maturation and functionality of sBCs.
A study found that even insured patients with diabetes use crowdfunding platforms like GoFundMe to cover excess medical expenses, including uncovered co-pays and life-saving care. Researchers urge policymakers to consider these needs when developing affordable diabetes care policies.
A new gene expression signature has been identified that can predict the rapid progression of type 1 diabetes. This signature may allow for earlier intervention and improved treatment plans.
Researchers at Weill Cornell Medicine have successfully converted human stomach stem cells into insulin-secreting cells, offering a promising approach to treating type 1 and severe type 2 diabetes. The transplants reversed disease signs in mouse models, suggesting good durability.
A study found that children with COVID-19 were 57% more likely to develop type 1 diabetes, with the increase occurring shortly after the virus diagnosis. The researchers hope to explore this correlation further using prospective cohorts of children.
Researchers have developed an algorithm that accounts for individual patient differences and validated a pump control algorithm that does not require meal announcement. This innovation simplifies the control problem, reduces delays, and increases the accuracy of insulin delivery, making diabetes management less burdensome for patients.
Rice University scientists developed a screening technique to identify high-performing biomaterials for encapsulating insulin-secreting cells, providing long-term blood sugar level control in diabetic mice. The study's findings have the potential to open the door to a more sustainable and self-regulating way to treat Type 1 diabetes.
A recent analysis of three clinical trials found that the UVA-developed artificial pancreas improved blood sugar control by 13 percentage points and decreased hemoglobin A1c levels. The device spent an average of 2.8 more hours per day in target blood sugar range, benefiting both kids and adults with diabetes.
A new study published in PLOS Medicine found that the sugary drink tax in Oakland reduced purchases by 26.8%, leading to improved health and significant cost savings. The researchers estimated that consuming fewer SSBs added 94 quality-adjusted life-years per 10,000 residents and saved the city over $100,000 in healthcare costs.
Researchers have developed a novel insulin formulation that can be switched on by glucose, offering improved regulation of blood sugar levels in patients with type 1 diabetes. The new formulation uses biocompatible lipid nanoparticles and achieves precise control of insulin release in response to fluctuations in blood sugar.
Researchers at the University of Gothenburg discovered that insulin can be stored at room temperature for four weeks, quadrupling its previous storage period. This finding has significant implications for global health, particularly in developing countries where insulin is often in short supply and expensive.
Two new subtypes of insulin-producing beta cells, ß <sub> HI </sub> and ß <sub> LO </sub>, have been identified with distinct characteristics. The study suggests epigenetic dosage as a driving force behind the decision of ß cells to become these subtypes, offering a new target for potential diabetes treatments.
A team of researchers at ETH Zurich has created an implantable fuel cell that uses excess blood sugar to generate electrical energy. The device powers artificial beta cells that produce insulin, effectively regulating blood glucose levels.
A study published in Lancet Diabetes & Endocrinology found that the incidence of type 1 diabetes among Finnish children increased by 16% during the pandemic. Researchers believe that social isolation and lockdowns rather than SARS-CoV-2 infection may have contributed to this increase.
A clinical study found that children ages 2 to 6 with type 1 diabetes using an artificial pancreas system spent more time in their target blood sugar range, reducing anxiety for families. The system improved nighttime blood glucose control and was used safely by participants.
A study of one family with monogenic diabetes reveals that insulin deficiency is the principal factor leading to a smaller pancreas. The Vanderbilt University Medical Center researchers discovered this through precise measurements of the pancreas taken from four family members.
A study has identified new microRNA biomarkers for the partial remission phase of type 1 diabetes and linked one of these microRNAs to immunoregulatory processes. The findings suggest a unique microRNA signature expression during this phase, which modulates regulatory T cell expansion and PD-1 expression.
A team at Massachusetts General Hospital developed a method to transplant pancreatic islets onto the omentum, a fatty tissue, and demonstrated its effectiveness in reversing type 1 diabetes in nonhuman primates. The approach normalizes blood glucose levels and restores insulin secretion.
A clinical study by Indiana University School of Medicine researchers found that oral verapamil can improve pancreatic beta cell function in children with new-onset type 1 diabetes, with a 30% increase in insulin secretion over the first year. The trial involved 88 participants and was published in JAMA.
A new study published in Diabetologia found that childhood obesity is associated with a higher risk of four out of the five recently proposed subtypes of adult-onset diabetes. The study used Mendelian randomization to investigate the link between childhood body size and the risk of different diabetes subtypes occurring in adults.
A University of Minnesota-led study shows that verapamil can increase pancreatic insulin secretion by 30% in children with newly-diagnosed type 1 diabetes. The treatment was well-tolerated and had a favorable safety profile, making it an appealing option for children and adults with the condition.
Dr. David McDougal's research project aims to find better therapies to prevent hypoglycemic episodes in people with type 1 diabetes, focusing on the role of leptin in regulating blood sugar responses. The grant-funded study seeks to identify novel treatments for preventing low blood glucose in these patients.
A new clinical trial has shown safety and tolerability of oral GABA and reduced serum glucagon levels in children with recent onset Type 1 diabetes. The study focused on the potential of GABA and GAD to preserve insulin-secreting beta cells and attenuate excessive glucagon release.
A recent study found that adults with type 1 diabetes are at a high risk of being overweight or obese, but only half receive lifestyle recommendations to manage their weight. The study also highlighted the importance of individualized patient education in improving weight management for these patients.
A new study found that 62% of adults with type 1 diabetes are overweight or obese, similar to the general population. The high rate is attributed to the lack of evidence-based weight-management strategies for type 1 diabetes patients.
Researchers discovered microexons, short DNA sequences that play a vital role in insulin secretion and glucose homeostasis. The study found that genetic variants affecting microexon inclusion are linked to type-2 diabetes risk and fasting blood sugar levels.
Researchers found that continuous glucose monitors and wearable devices pose challenges for patients and caregivers, including issues with hardware, software, and device use. Nearly three-quarters of participants experienced low blood sugar levels, highlighting the need for improved technology to manage diabetes effectively.
Researchers have identified serine as a key contributor to peripheral neuropathy in diabetes, a condition that affects approximately half of people with type 1 or type 2 diabetes. Supplementing diabetic mice with serine alleviated neuropathy symptoms, suggesting a potential treatment option.
A new study published in Journal of Diabetes Investigation found a significant link between self-stigma and suboptimal glycated hemoglobin (HbA1c) levels in adults with type 1 diabetes. The research highlights the importance of eliminating self-stigma in managing the condition.
A novel treatment involving ACE2-producing probiotic Lactobacillus paracasei may prevent or reverse diabetic retinopathy in Type 1 diabetes patients. The study found that human subjects with retinopathy had a dysregulated systemic RAS and profound gut permeability defects, which were reversed by the probiotic treatment.
A wafer-thin device called NICHE has been developed to treat Type 1 diabetes by delivering islet cells and immunotherapy directly into the body. The device restored healthy glucose levels and eliminated symptoms for over 150 days, avoiding severe adverse effects of anti-rejection therapy.
Research published in Developmental Medicine & Child Neurology reveals a link between maternal diabetes and neurodevelopmental disorders such as autism, ADHD, and intellectual disability in children. Type 1 and type 2 diabetes were associated with increased risks of these conditions, while gestational diabetes was linked to autism spec...
WEHI researchers have visualized how a non-insulin molecule can mimic the role of insulin, opening new avenues for an oral insulin pill. The study confirms alternative molecules can be used to turn on blood glucose uptake, bypassing insulin needs.
A study found that antibodies to common antibiotic gentamicin are associated with an increased risk of progression to type 1 diabetes in children already genetically at risk. The researchers also identified an association between the FUT2 gene and the production of these antibodies, which may be compounding risks for type 1 diabetes.
Insulin pump use has grown over two decades but disparities persist among racial, ethnic, and socioeconomic groups. Youth from lower-income backgrounds and minority groups are less likely to use insulin pumps.
Researchers have developed a preventative therapeutic approach that prevents stress-induced cell death in pancreatic cells, a hallmark of type 1 diabetes. The treatment targets the GLIS3-MANF pathway common to both major types of diabetes.
A study published in the Hypertension journal suggests that bromocriptine, a Parkinson's disease medication, may help prevent heart disease in youth with Type 1 diabetes. The research found that teens with Type 1 diabetes who took bromocriptine had lower blood pressure and less stiff arteries after one month of treatment.