Articles tagged with Type 1 Diabetes
Researchers have developed a novel biomaterial that promotes immune tolerance and allows islets to survive after transplant without the need for long-term immunosuppression. This breakthrough enables patients with type 1 diabetes to control their blood sugar levels without lifelong medication.
Researchers at University of Missouri, Georgia Tech and Harvard University have successfully demonstrated a new Type 1 diabetes treatment in large animal models. By transplanting pancreatic islet cells with a molecule called FasL, they prevent rogue immune cells from destroying the transplanted cells.
A new biomaterial-based technique has improved islet transplants for type 1 diabetes treatment by inducing permanent immune acceptance. The microgels educate the immune system to accept the graft, making it possible to regulate blood glucose levels without chronic immunosuppression.
Researchers from Osaka University have discovered that mesenchymal stem cells can prevent the onset of type 1 diabetes associated with immune checkpoint cancer therapy. MSCs secrete factors that protect pancreatic cells against immune attack, suggesting a new approach to preventing this debilitating side effect.
A recent study published in PLOS Medicine found that having a parent with type 1 diabetes may be linked to lower school performance in children. The research involved over 622,000 Danish children and suggested a negative association between parental type 1 diabetes and cognitive development.
Researchers analyzed genomic profiles of over one million cells from 1,000 people, identifying a link between specific genes and immune cell types in autoimmune diseases. The discovery could lead to tailored treatments and refine clinical trials.
A new study found that Black people with diabetes were more likely to develop life-threatening complications like diabetic ketoacidosis during the pandemic. The disparity persisted even before the COVID-19 pandemic and was present in 45% of Black people, compared to 16% of White people.
Researchers at Karolinska Institutet have identified a new antidiabetic substance that preserves beta cell activity and prevents high blood glucose in mice. This approach may prevent the exhaustion of beta cells and improve long-term diabetes treatment.
A new study suggests that people with type 1 diabetes who have high levels of psychological resilience are more likely to manage their condition successfully. The research found that those with low resilience also had poorer blood sugar control after two years.
Researchers developed a compound consisting of insulin bound to an antioxidant group, improving glucose consumption and brain function in mice with type 1 diabetes. The combination therapy showed better cognitive performance than individual treatments alone.
A large cohort study found that babies born to men who took metformin during sperm development were at increased risk for genital defects in boys. Diabetes control affects sperm quality, so men should discuss alternative treatments with their doctors before conception. The findings suggest a need for further study on treatment of prosp...
Researchers used a contrast pattern mining algorithm on publicly available data from 16,000 participants in the T1D Exchange Clinic Registry. The study found individuals with an immediate family history of Type 1 diabetes were more frequently diagnosed with hypertension and other co-occurring conditions.
Researchers have identified early-onset epigenetic changes linked to an increased risk of developing type 1 diabetes. These findings offer new opportunities for identifying children at genetic risk, potentially allowing for earlier intervention and prevention.
Eiji Yoshihara receives prestigious JDRF Career Development Award for innovative research on type 1 diabetes. The Lundquist Institute investigator has made significant contributions to understanding the disease.
Researchers developed genetic modifications to increase stress resistance and immune evasion in stem cell-derived beta cells, leading to improved survival rates. The study suggests a potential breakthrough for treating type 1 diabetes through transplantation of these cells.
Researchers found that verapamil treatment delayed disease progression, lowered insulin requirements, and preserved some beta cell function in patients with Type 1 diabetes. The study used proteomics analysis and RNA sequencing to examine changes in circulating proteins in response to verapamil treatment.
Scientists have successfully produced fully functional pancreatic beta cells from stem cells for the first time, offering a breakthrough in treating type 1 diabetes. The study's findings demonstrate that these stem cell-derived beta cells can regulate insulin secretion and manage glucose metabolism in both cell cultures and mice studies.
Researchers have revealed that during Type 1 Diabetes development, pancreatic duct cells reprogram to suppress autoimmune T cell responses. This discovery advances understanding of the disease by creating a map of pancreatic islet cells over time.
A recent study found that early detection of type 1 diabetes in children can effectively monitor and treat the disease. The cost analysis shows that standard screening could reduce costs from 28 euros to 22 euros per child, while also preventing metabolic derailments and their consequences.
A new study published in Nature Communications identifies a harmful cellular pathway that causes pancreatic beta cell death, leading to type 1 diabetes. Blocking this pathway preserved beta cells, increased insulin production, and prevented or delayed diabetes in mice models.
A new study found that female adults who heavily used cannabis had a lower incidence of diabetes compared to those who did not use cannabis. In contrast, light cannabis use among females and male adults with any level or no cannabis use showed no association with diabetes diagnosis.
Researchers have developed a prototype insulin-loaded patch that comfortably sticks to the inside of a person's cheek, offering a less invasive way to manage blood sugar levels. The patch, activated by heat, releases insulin into the bloodstream several times faster than through skin, showing promise for diabetes treatment.
A new artificial pancreas system has been shown to be safe and effective in managing blood sugar levels in very young children with type 1 diabetes. The hybrid closed-loop system, CamAPS FX, reduced average blood sugar levels and improved glucose control without increasing the risk of hypoglycemia.
A new study published in Frontiers in Endocrinology has identified a promising target for an anti-hypoglycaemia drug by boosting the brain's AMPK fuel gauge. The researchers found that the compound increases the release of glucagon from the pancreas, defending against hypoglycaemia.
Researchers discovered a new hormone, fabkin, that regulates metabolism and controls insulin production in pancreatic beta cells. Blocking fabkin's activity prevented the development of both forms of diabetes in mice, suggesting its potential as a therapeutic target.
A multicenter clinical trial demonstrates insulin secretion from engrafted stem cells in patients with type 1 diabetes. The study shows 20% reduced insulin requirements and 13% more time spent in target blood glucose range over a one-year follow-up period.
A study by Katariina Koivusaari found that high cow's milk consumption is associated with a higher risk of developing preclinical type 1 diabetes in genetically predisposed children. The study also linked high-temperature treated infant formula to an increased risk of asthma in children.
A new study has identified the CCR2 gene as a key player in the progression of type 1 diabetes. The research found that lower blood levels of CCL-2, a ligand for CCR2, were associated with increased immune cell recruitment to the pancreas, leading to islet cell destruction.
Scientists have reversed new-onset type 1 diabetes in mice by injecting pyramid-like DNA molecules called tFNAs, which increased regulatory T cells and protected pancreatic β-cells. The treatment is one of the most promising candidates for type 1 diabetes immunotherapy.
Research found that adults with type 1 or type 2 diabetes and atrial fibrillation were less likely to notice irregular heartbeat symptoms, had a lower quality of life, and experienced more co-occurring health conditions than those without diabetes. This delay in diagnosis may lead to more complications such as stroke.
Researchers have discovered that a low-dose oral compound, HBI-002, can safely reduce oxidative stress and inflammation in the retina, common causes of diabetic retinopathy. The study suggests that small amounts of carbon monoxide may help protect vision in diabetes patients.
A five-year study aims to identify hormone responses in a population of Mexican Americans with prediabetes, Type 2 diabetes, and obesity. The research uses genetic data and physiologic testing to guide optimal treatments for diabetes, prediabetes, and related diseases.
The study analyzed data from 8,502 genetically high-risk children and found that half developed type 1 diabetes before age 6, while the other half developed it between ages 6 and 12. The findings suggest a different form of type 1 diabetes emerges in children as they grow older.
Research by Karolinska Institutet suggests that longer breastfeeding and later introduction to gluten may reduce the risk of developing type 1 diabetes. The study analyzed 5,935 articles and found a significant protective effect against the disease.
Researchers identified a pattern that links the accumulation of amyloid beta (Aβ) proteins with a reduction of serotonin, which may help predict who will develop late-life depression. The study found that individuals expressing this pattern had more severe depressive symptoms.
Active video games have been shown to give similar physiological effects to traditional exercise, such as jogging, in type 1 diabetics. The studies found that playing these games could help lower blood glucose levels and improve cardiovascular health.
A new comprehensive Consensus Report aims to capture best practice for managing type 1 diabetes. The report covers vital areas from a patient perspective, including psychosocial consequences, diagnosis, and treatment options. It also highlights the need for better research on preventing, diagnosing, and treating T1D.
A new review concludes that people with type 1 diabetes can manage their weight, but more research is needed to understand the specific needs of this patient group. The review explores strategies such as nutrition education, adjunct therapies like metformin and GLP-1 receptor agonists, and obesity surgery.
A comprehensive analysis of 33 studies reveals that COVID-19 lockdowns lead to improved blood sugar control in individuals with type 1 diabetes, while glycaemic control deteriorates and weight gain increases among those with type 2 diabetes. The study suggests that lockdown measures may have allowed people with type 1 diabetes to bette...
Research suggests that breastfeeding for at least 6-12 months significantly reduces the risk of developing type 1 diabetes. In contrast, higher consumption of cow's milk and dairy products during childhood is associated with a higher risk of islet autoimmunity and T1D.
A study found type 2 diabetes linked to higher mortality risk in hospitalised COVID patients than type 1; older age and high CRP also associated with increased risk. A model can predict which patients are at higher risk of death using age and CRP as variables.
Researchers have developed a simplified blood test that increases overall screening efficiency for type 1 diabetes. The study, led by Melbourne researchers, found that a single finger prick blood test can predict clinical diagnosis with high accuracy.
A 20-year study shows a 40% decrease in amputation rates among people with type 1 diabetes in Sweden. Improved treatment of risk factors such as blood sugar levels and kidney function contributed to the trend reversal.
Researchers at Vanderbilt University Medical Center developed a standardized MRI protocol for pancreatic imaging, enabling reproducible measurements across different MRI hardware and software. The study demonstrates potential for incorporating MRI into multisite clinical trials, advancing diabetes research and treatment.
Using human stem cells and small molecules, researchers successfully differentiated them into insulin-producing pancreatic beta cells. This breakthrough could lead to a personalized treatment option for type 1 diabetes, reducing costs and increasing accessibility for those affected.
The prevalence of type 1 and type 2 diabetes among US children and teens rose significantly from 2001 to 2017. Researchers estimated an increase in diabetes cases across all age groups during this period, with the largest increases seen among younger populations.
A Swedish study found that 43% of children with new-onset type 1 diabetes did not receive hospital treatment on the same day as primary care contact. Delayed care can lead to life-threatening conditions like diabetic ketoacidosis. Improved awareness and rapid treatment are crucial for preventing complications.
The Milken Institute has released a roadmap to increase autoantibody screening for Type 1 Diabetes, with the support of The Leona M. and Harry B. Helmsley Charitable Trust. The goal is to ensure effective screening, which can diagnose T1D early, prevent life-threatening conditions like diabetic ketoacidosis, and develop therapeutics.
A new study reveals that the small protein MOTS-c prevents the destruction of insulin-producing pancreatic cells in mice with autoimmune diabetes. MOTS-c treatment supports regulatory T-cells and reduces the activation of killer T-cells, effectively preventing disease onset.
A low glycaemic diet has been shown to produce small but meaningful improvements in blood sugar levels, cholesterol, weight, and other risk factors in people with diabetes. The findings are based on a systematic review of 27 randomised controlled trials involving 1,617 participants with type 1 or 2 diabetes.
A synthetic hinge concept developed by Indiana University School of Medicine Professor Michael A. Weiss and his team could lead to a breakthrough in 'smart' insulin therapy. The invention exploits a natural mechanism that allows the insulin to adjust its activity based on blood glucose levels, which could transform diabetes care.
A study by Anglia Ruskin University found that younger people with diabetes are significantly more concerned about COVID-19 risks and have a higher likelihood of reporting worries. Social support from family, friends, and healthcare teams plays a crucial role in managing these concerns.
Rice University bioengineers are developing an insulin-producing implant to regulate blood glucose levels in Type 1 diabetics. The implant uses human stem cells and 3D printing to mimic the natural behavior of the pancreas, with the goal of achieving consistent target blood glucose levels.
A large-scale genetic study has identified new drug targets to treat type 1 diabetes by examining 61,427 participants and pinpointing 78 regions on the chromosomes that influence risk. The researchers found 36 previously unknown regions and specific gene variations that can be used to identify potential drug targets.
The University of South Florida has been awarded a four-year, $69.9 million NIH grant to continue its Type 1 Diabetes Research study. The study aims to identify environmental factors that influence autoimmune destruction of beta cells in young children with genetic susceptibility to type 1 diabetes.
Researchers discovered 47 lipids significantly different between rapid and slow kidney function decliners, providing a platform for risk stratification. The study's findings also suggest the underlying mechanism of progressive kidney disease, which could be a future target for therapeutic intervention.
Research reveals that epigenetic changes contribute to the development of type 1 diabetes, with DNA methylation and histone modifications playing a crucial role. The study suggests that epigenetic markers could be used to monitor disease progression and identify potential therapeutic targets.
Researchers at Salk Institute develop efficient method to produce insulin-producing cells from stem cells, bringing hope for type 1 diabetes treatment. The new approach resulted in beta cell yields of up to 80 percent and biologically functional transplanted cells in mouse model.
A clinical study found that injecting a protein GAD into lymph nodes can be effective in preserving insulin production in individuals with the HLA-DR3-DQ2 variant. This subgroup accounts for around half of patients with type 1 diabetes, who may benefit from a potential new treatment to slow or stop the immune system's attack.
By mapping the genetic underpinnings of type 1 diabetes, researchers have identified a predictive causal role for specific cell types, including pancreatic exocrine cells. This study provides a major leap in understanding the causes of type 1 diabetes and may lead to new treatments for reversing its course.