A global study found a significant increase in diabetic ketoacidosis cases among children diagnosed with type 1 diabetes during the COVID-19 pandemic. The observed prevalence was significantly higher than predicted, highlighting the need for better public awareness and screening programs.
A study published in Diabetes Care found that trigger finger is more prevalent among individuals with diabetes, particularly those with poorly regulated blood sugar. The risk of trigger finger increases with poor HbA1C levels, highlighting the potential link between blood sugar dysregulation and this condition.
A long-term study on infants and young children with increased genetic risk of type 1 diabetes found that metabolic changes occur much earlier than previously assumed. Blood sugar levels were found to be higher in children who developed autoimmunity, suggesting a potential indicator for islet cell dysfunction.
Researchers have discovered that the bacterial protein BefA stimulates insulin-producing cells to replicate, potentially leading to new treatments for Type 1 diabetes. This finding suggests that the gut microbiome plays a crucial role in regulating beta cell development and preventing autoimmunity.
The bionic pancreas, an automated insulin delivery system, showed significant improvements in blood glucose control among participants with type 1 diabetes. It reduced the need for manual insulin adjustments and carbohydrate counting, making it easier to manage the condition.
A new study found that women diagnosed with type 1 diabetes at a younger age are more likely to experience early menopause. The research analyzed over 11,000 women and discovered an association between early diagnosis of type 1 diabetes and later age at natural menopause.
A new clinical trial found that the bionic pancreas device was more effective at maintaining blood glucose levels within normal range than standard-of-care management among people with type 1 diabetes. The device requires minimal user input and provides more automation, resulting in improved glycemic control.
A bionic pancreas, which automatically delivers insulin based on blood glucose levels, was more effective than standard care at maintaining normal blood sugar levels. The study, funded by NIDDK and conducted at Nemours Children's Health, Jacksonville, found the device to require less user input and provide more automation.
SourceNemours·JournalNew England Journal of Medicine·TypeRandomized controlled/clinical trial·DateSep 28, 2022
Researchers found that knocking out TXNIP in alpha cells improves diabetes-associated hyperglycemia and hyperglucagonemia. This discovery suggests a new potential treatment for Type 1 diabetes.
A recent study has found an association between SARS-CoV-2 infection and new-onset type 1 diabetes among pediatric patients. The study analyzed data from electronic health records and found that children who contracted COVID-19 were more likely to develop new type 1 diabetes compared to those with other respiratory infections.
A new study found that children infected with COVID-19 have a substantially higher risk of developing type 1 diabetes, with a 72% increase in new diagnoses in the six months following COVID diagnosis. Pediatricians and families should be alert for symptoms of diabetes following COVID.
Research finds strong association between enterovirus infection and type 1 diabetes; individuals with T1D eight times more likely to have an enterovirus infection than others. Vaccines aimed at preventing enterovirus infection may help prevent T1D development.
A nationwide study of 1.2 million children in Norway suggests a possible association between COVID-19 and new-onset type 1 diabetes. The study found that children who contracted COVID-19 were more likely to develop type 1 diabetes, but the absolute risk remains low.
A new Scottish study found no direct association between COVID-19 infection and increased type 1 diabetes risk in adults and children under 35, suggesting testing explanations for the observed link. Increased testing around the time of diagnosis may be partly responsible for the observed increase.
A new study found that placing a monthly cap on out-of-pocket costs for commercially insured patients could lower their highest monthly healthcare bills by 50-60%. A $500 monthly limit would affect about 25% of enrollees and reduce in-network OOP costs over a year by 46%, while a $250 limit would show a 51% reduction.
The T1D Index, a data simulation tool, measures the human and public health impact of type 1 diabetes globally. Simulations suggest over 3.86 million 'missing people' and 32 healthy years lost due to T1D, highlighting the need for interventions such as timely diagnosis, accessible care, and research funding.
A study at the University of Helsinki found that periodontitis has a particular link with diabetes and accelerates its progression. The research highlights the importance of considering general and oral health as a whole in healthcare to achieve better treatment outcomes.
A new study estimates that up to 17.5 million people worldwide will live with Type 1 Diabetes by 2040, with the highest burden in low- and middle-income countries. The modeling study predicts a significant increase in global deaths due to T1D, highlighting the need for improved surveillance, diagnosis, and care.
SourceThe Lancet·JournalThe Lancet Diabetes & Endocrinology·TypeComputational simulation/modeling·DateSep 21, 2022
A systematic review of children and teens with type 1 diabetes found that girls have poorer metabolic control, are more likely to be hospitalized with serious complications, and require higher insulin doses. The study highlights the need for targeted efforts to improve awareness and care for young females with type 1 diabetes.
Research at Karolinska Institutet shows that people with diabetes have lower levels of psoriasin, a key peptide that weakens the bladder's protective barrier function. This increases the risk of urinary tract infections. Oestrogen therapy may help regulate the immune response to UTIs in patients with diabetes.
Researchers investigated direction of attentional focus in prosthetic training to improve motor learning in individuals with lower limb loss. The study suggests that current practice can be refined to enhance rehabilitation outcomes for amputees.
A new Dutch study found that lockdowns caused significant mental health impacts on people with pancreas or islet transplants for type 1 diabetes. Glycaemic control worsened during the lockdown period due to reduced physical activity and increased insulin use, while anxiety and stress levels rose significantly among transplant patients.
A six-country European survey found that people with diabetes living in Italy and the UK, women, and those younger than 45 have the highest prevalence of anxiety. The study also suggests a link between blood sugar management and anxiety severity.
Researchers found that standard scoring tools missed cases of depression in teenagers with Type 1 diabetes, leading to lower sensitivity. They recommend adjusting cut-off scores to detect depressive symptoms more accurately.
Researchers at Nagoya University have discovered a new treatment for type 1 diabetes that uses leptin to improve insulin-alternative effects in mice. The combination of leptin and a PTP1B inhibitor normalizes blood glucose levels without the need for insulin, reducing hypoglycemia risk.
A study from Linköping University shows that individuals with type 1 diabetes should keep their mean long-term sugar level below 53 mmol/mol (7.0%) to avoid serious damage. The risk of eye- and kidney complications increases as the level increases.
Research confirms ethnicity as a key risk factor for kidney disease in people with Type 1 diabetes, particularly among African-Caribbean individuals. The study found nearly 60% greater risk of advanced kidney disease in this population.
Researchers at CeMM have discovered that targeting SMNDC1 in alpha cells can induce insulin production, a potential new approach for treating diabetes. The study identified a key molecular mechanism regulating insulin hormone production and its essential role in the treatment of diabetes.
A study published in Nature Communications suggests that better glucose control can improve brain structure and function in youth with Type 1 diabetes. The findings indicate that participants using a hybrid closed-loop insulin delivery system showed significant improvement in key brain metrics compared to those receiving standard care.
Researchers found that participants who received cooking education showed improvements in eating more vegetables, fewer carbohydrates, and lower A1C levels. The study also highlighted the importance of addressing food insecurity in diabetes management.
A new study found a correlation between colder temperatures and northern regions in the US and an increased risk of diabetes diagnoses in dogs. Diabetes diagnoses were more common in winter and in the North compared to other seasons and regions.
A double-blind study found that 12.5% of placebo-treated individuals and 1% of BCG-treated individuals met criteria for confirmed COVID-19, indicating a 92% vaccine effectiveness. The BCG-vaccinated group also displayed protective effects against other infectious diseases, including fewer symptoms and reduced disease events.
A recent JAMA study found a positive association between high insulin dosage and cancer incidence among patients with type 1 diabetes. The study suggests that clinicians may need to balance cancer risk when treating patients on high insulin doses, with improving insulin sensitivity potentially being a preferred approach.
A new study published in JAMA Oncology has found a significant association between daily insulin dose and increased cancer risk in patients with type 1 diabetes. The research, led by Yuanjie Mao, investigated the relationships between various risk factors and cancer incidence in this population.
A study of 2.7 million children in Ontario found no overall increase in new diabetes diagnoses during the pandemic, but a possible delay in diagnosis and a catch-up effect later on. The researchers also discovered that fewer cases were documented early on in the pandemic.
Researchers at Joslin Diabetes Center identified a human gut bacterium that makes a protein mimicking the insulin peptide targeted by the immune system in type 1 diabetes. The presence of this bacterium accelerates the onset of diabetes in a mouse model and is linked to its development in children at genetic risk.
Researchers at UNIGE have found that the S100A9 protein can significantly improve insulin metabolism in diabetic patients, reducing the risk of severe side effects associated with insulin therapy. The protein's anti-inflammatory effect may also help to normalize ketone production and prevent life-threatening conditions.
The Brigham and Women's Hospital will implement and evaluate an integrated service delivery model (PEN-Plus) for severe chronic noncommunicable diseases, such as type 1 diabetes and rheumatic heart disease, in eight low- and lower-middle-income countries. The initiative aims to enable one million of the world's poorest children and you...
Researchers at the University of Chicago have made a breakthrough in understanding the development of type 1 diabetes by targeting the role of pancreatic beta cells. Deleting a gene called Alox15 in mice preserved their beta cells, reduced immune T cell infiltration, and prevented diabetes from developing.
A new research centre, PRESIS-DIA, will study the causes of diabetes development over a lifetime and integrate genetics, cell biology, and clinical information. The centre aims to develop customised, unique treatment for individuals, enabling better diagnosis and therapeutic strategies.
Researchers at Karolinska Institutet describe a new way of generating insulin-producing cells using a molecule that stimulates protein synthesis and boosts insulin production. The study shows promise for treating type 1 and 2 diabetes, potentially increasing the number of insulin-producing pancreatic β cells.
Researchers at McMaster University found that older adults with Type 1 diabetes are at a higher risk of reduced muscle strength and cardiovascular complications. They discovered abnormally low diastolic blood pressure in these patients, which may indicate early increased cardiovascular disease risk.
A comprehensive register study at the University of Gothenburg shows individuals with diabetes have a substantially increased risk of left-sided heart valve disease. Lowering blood pressure and reducing other risk factors may even reduce this risk more than current treatment targets suggest.
A nationwide study found a significant association between excessive BMI in late adolescence and the development of type 1 diabetes in young adulthood. The researchers analyzed data from over 1.4 million adolescents and found that those with obesity had double the risk of developing type 1 diabetes compared to those with optimal BMI.
A new Rutgers University study finds that diabetes weakens tooth enamel and dentin, making teeth more susceptible to decay. Researchers induced Type 1 diabetes in mice and observed significant softening of enamel and dentin after 12 weeks.
The Edmonton Protocol team has reported that islet transplantation is an effective therapy for patients with difficult-to-control Type 1 diabetes, with a high rate of graft survival and insulin independence. The procedure has been shown to stabilize blood sugar levels and improve quality of life for patients.
Researchers have developed a novel biomaterial that promotes immune tolerance and allows islets to survive after transplant without the need for long-term immunosuppression. This breakthrough enables patients with type 1 diabetes to control their blood sugar levels without lifelong medication.
Researchers at University of Missouri, Georgia Tech and Harvard University have successfully demonstrated a new Type 1 diabetes treatment in large animal models. By transplanting pancreatic islet cells with a molecule called FasL, they prevent rogue immune cells from destroying the transplanted cells.
A new biomaterial-based technique has improved islet transplants for type 1 diabetes treatment by inducing permanent immune acceptance. The microgels educate the immune system to accept the graft, making it possible to regulate blood glucose levels without chronic immunosuppression.
Researchers from Osaka University have discovered that mesenchymal stem cells can prevent the onset of type 1 diabetes associated with immune checkpoint cancer therapy. MSCs secrete factors that protect pancreatic cells against immune attack, suggesting a new approach to preventing this debilitating side effect.
A recent study published in PLOS Medicine found that having a parent with type 1 diabetes may be linked to lower school performance in children. The research involved over 622,000 Danish children and suggested a negative association between parental type 1 diabetes and cognitive development.
Researchers analyzed genomic profiles of over one million cells from 1,000 people, identifying a link between specific genes and immune cell types in autoimmune diseases. The discovery could lead to tailored treatments and refine clinical trials.
A new study found that Black people with diabetes were more likely to develop life-threatening complications like diabetic ketoacidosis during the pandemic. The disparity persisted even before the COVID-19 pandemic and was present in 45% of Black people, compared to 16% of White people.
Researchers at Karolinska Institutet have identified a new antidiabetic substance that preserves beta cell activity and prevents high blood glucose in mice. This approach may prevent the exhaustion of beta cells and improve long-term diabetes treatment.
A new study suggests that people with type 1 diabetes who have high levels of psychological resilience are more likely to manage their condition successfully. The research found that those with low resilience also had poorer blood sugar control after two years.
Researchers developed a compound consisting of insulin bound to an antioxidant group, improving glucose consumption and brain function in mice with type 1 diabetes. The combination therapy showed better cognitive performance than individual treatments alone.
A large cohort study found that babies born to men who took metformin during sperm development were at increased risk for genital defects in boys. Diabetes control affects sperm quality, so men should discuss alternative treatments with their doctors before conception. The findings suggest a need for further study on treatment of prosp...
Researchers used a contrast pattern mining algorithm on publicly available data from 16,000 participants in the T1D Exchange Clinic Registry. The study found individuals with an immediate family history of Type 1 diabetes were more frequently diagnosed with hypertension and other co-occurring conditions.
Researchers have identified early-onset epigenetic changes linked to an increased risk of developing type 1 diabetes. These findings offer new opportunities for identifying children at genetic risk, potentially allowing for earlier intervention and prevention.
Eiji Yoshihara receives prestigious JDRF Career Development Award for innovative research on type 1 diabetes. The Lundquist Institute investigator has made significant contributions to understanding the disease.