Researchers discovered common mutations and dysfunction in myotonic dystrophy type 1 and Rett syndrome using brain organoids. The study suggests that targeting NMDA receptors may ameliorate cognitive impairments in young patients with DM1.
A new study found record-high demand for abortion medications in the US following the leaked Supreme Court draft ruling. Searches for abortion medications spiked 162% during the 72-hour period after the leak, with significantly more searches in states with restrictive reproductive rights. The team urges prioritizing accessible informat...
A longitudinal study found that supervisors perceived as engaged leaders enhanced employee engagement via boosted personal psychological resources and team effectiveness. Engaged leaders also fostered a shared perception of available resources, leading to improved job performance.
A new study found that road fatalities and injuries kill more young people than communicable and non-communicable diseases or self-harm. The number of deaths attributed to road fatalities for adolescents has increased in some countries, particularly in low and low-middle income countries.
Researchers at Rensselaer Polytechnic Institute have made critical advances in nanostructures to improve battery performance. The team demonstrated that combining micro-particles with nanostructures can lead to longer battery life, faster charging times, and improved storage capacity.
Researchers have identified a neural circuit responsible for detecting 'affective' touch and influencing social behavior in mice. Activation of this circuit triggers social bonding, while disruption leads to reduced social interaction.
Researchers analyzed ancient DNA from over 400 equids in Celtic and Roman settlements, finding mule remains only in the Roman sites. Mules were valued by Romans for their pack and work capabilities due to their strength, endurance, and resistance to diseases.
A team of scientists developed a board game, Diamond: The Game, to inspire secondary school students to consider STEM careers. Players experience the reality of working in scientific research and collaboration is emphasized as key to modern science.
A new series published in The Lancet analyzes the growing problem of road traffic injuries, highlighting opportunities for prevention. Up to 540,000 lives could be saved worldwide by implementing proven road safety interventions on speed, drunk driving, helmet use, and seatbelt use.
A study published by researchers at the University of Colorado Anschutz Medical Campus found that psychiatric drugs imipramine and olanzapine can improve symptoms of Alzheimer's disease, including boosting cognition and reversing clinical diagnoses.
Researchers at the University of Innsbruck developed a new technique to track levitated nanoparticles with improved precision. By using the reflected light of a mirror, they outperformed state-of-the-art detection methods and opened up new possibilities for nanoparticle-based sensing applications.
Boston University School of Medicine researchers have developed a promising anti-cancer compound, Factor Quinolinone Inhibitors (FQIs), that specifically impede LSF's DNA-binding and transactivation activities. The study shows that FQI treatment can significantly reduce tumor growth in experimental models.
A new study from NYU Tandon School of Engineering uses a spatio-temporal model to predict firearm prevalence on a state-by-state level. The researchers found that combining data from background checks per capita and suicides committed with a firearm in a given state can provide precise information regarding firearm ownership.
A Danish research study has made significant discoveries about the CRISPR/Cas9 protein and its gRNA component, enabling more accurate gene modification. The findings aim to optimize the effectiveness of gene editing, addressing concerns over 'off-target effects'.
Two researchers argue that hyperpartisanship has led to a decline in political apologies, making it difficult for politicians to acknowledge wrongdoing and seek redemption. This shift away from apology is attributed to the influence of social media and partisan echo chambers, which reward silence over accountability.
A new therapeutic target for melioidosis has been identified by researchers at the Leibniz Institute for Natural Product Research and Infection Biology. The enzyme BurG synthesizes a toxic molecule central to infection, and inhibiting it could make bacteria less virulent.
Researchers at the University of British Columbia identified a new high-salt receptor, IR7c, in fruit flies that governs their ability to detect dangerously high concentrations of salt. This discovery provides insights into how animals sense and avoid excessive salt, which is essential for survival but can be toxic in high amounts.
A new study published in JAMA Network Open found that patients who received lactated Ringer solution instead of normal saline for IV fluids had a lower risk of kidney injury and death. The study, which included nearly 150,000 hospital patients, showed a 2.2% reduced risk of major adverse kidney events.
Researchers evaluated 435 employed adults with mild traumatic brain injury over 12 months, finding a significant association between return to work and improved economic outcomes. The study suggests that employer assistance plays a crucial role in supporting workers' transitions back to the workforce.
New research reveals NHS weight policies are associated with a decline in knee replacement surgery rates, disproportionately affecting less affluent groups. The study found that regions introducing BMI-based policies saw a decrease in surgery, potentially worsening health inequalities.
Researchers identified glucocorticoids as a key factor inhibiting cardiac regenerative capacity after heart attacks. The study showed that deleting or blocking the glucocorticoid receptor increased heart muscle cell replication and regeneration.
A new study found that the cognitive function of Cantabrian earthquake survivors who were initially resilient to trauma has recovered over time. The research, conducted eight years after the initial trauma, showed no significant differences in performance between the earthquake-exposed group and non-exposed participants.
A new study by the Yale Program on Climate Change Communication found that romantic partners can significantly influence each other's views on climate change, with only 38% alignment in climate beliefs and 31% alignment in behaviors. The study suggests that conversations about climate change can help shift public support and increase e...
Researchers from the University of Bern and NCCR PlanetS simulated the DART mission impact, finding that it could deform the asteroid near unrecognizably. The study's results suggest that the impact could eject large amounts of material and deflect the asteroid more strongly than previously thought.
A recent NTU Singapore study finds that climate change is a stronger driver of increasing atmospheric methane than expected, leading to more heat being trapped in the atmosphere. The research suggests that nature could be producing more and consuming less methane than previously realized, contributing to higher methane emissions.
Researchers at LSU Health Sciences Center have discovered a novel combination therapy that effectively treats chemo-resistant triple-negative breast cancer. The treatment combines two existing FDA-approved drugs, ceritinib and enzalutamide, to target the growth of cancer cells, showing promise for improving treatment outcomes.
A study by Emmanuelle Volle's group at the Paris Brain Institute has identified two semantic memory search processes involved in creativity: clustering and switching. Clustering is linked to divergent thinking, while switching relates to combining distant associations between concepts.
Researchers analyzed 4,000 Facebook posts to understand how clickbait influences user engagement. They found that both headlines and text can 'bait' users into interacting with a post, with some techniques more successful than others.
Engineers at University of Chicago have developed fire-safe, recyclable liquefied gas electrolytes for temperature-resilient lithium-metal batteries. The new technology broadens the choice of electrolyte solvent molecules, enabling excellent low-temperature performance and high-voltage cathodes.
Researchers have devised a way to deliver carbon monoxide to the body using stable foams that can be delivered to the digestive tract. The foams reduced inflammation of the colon and helped reverse acute liver failure in mice, offering a potential alternative to immunosuppressive treatments.
Researchers at the University of Kentucky have developed an online portal to visualize how biases in RNA sequences impact gene expression. The study found that over 3,000 genes exhibit variable ramp sequences, which correspond to increased gene expression in specific tissues and cells.
The study found that legislatures, rather than governors, played a crucial role in shaping data reporting practices. Standardized data collection protocols and comprehensive race and ethnicity data are essential for addressing health disparities and reducing information asymmetries.
Scientists at Indiana University School of Medicine discovered differences in FOXP3 isoforms controlling Treg cells and their impact on the immune system. These findings may lead to new treatments for autoimmune diseases and allergies.
Researchers at the University of Michigan developed a new approach to expand training data sets for robots, enabling faster learning and improved performance. The method uses 'fake' data generated through simulations, which are then used to train robots on real-world tasks.
Great White Sharks have been avoiding a South African coastal region due to the presence of Orcas. Long-term sightings and tagging data show that Great Whites flee areas with high Orca activity, adopting a 'flight' strategy reminiscent of wild dogs in response to increased lion presence.
New research from UC Santa Cruz shows improvements in autistic adult representation in media and advocacy websites, with a notable increase in adult representations in film and television. However, the study also highlights persistent issues with childlike portrayals and limited attention to intersectionality.
New research reveals that specific proteins in plant cells explain why plant defenses falter under high temperatures, leaving them susceptible to infections. Scientists have also discovered a way to reverse this effect by constantly activating the CBP60g master switch gene, which bolsters plant defenses without stunting growth.
A new Series published in The Lancet estimates that adopting proven road safety interventions targeting four key risk factors could prevent between 25% and 40% of all fatal road injuries worldwide every year. This could save up to half a million lives annually, with increased focus on low- and middle-income countries.
A study published by Oregon State University found that evening grosbeak numbers have declined by an average of 2.6% per year over the last four decades, with a significant decrease in migration stop-over sites on campus. The decline may be related to disease, climate change, or shifts in land use, but the exact cause is still unknown.
Researchers have discovered that a cancer drug could slow the progress of Duchenne muscular dystrophy in mice by increasing muscle fibre resilience. The findings suggest that the drug may help delay disease progression and improve mobility for patients, potentially serving as an adjunct to emerging gene therapy approaches.
Researchers used chemoproteomics to profile 53 HDAC drugs and found many had additional targets beyond their intended HDACs. The study identified MBLAC2 as a common off-target protein that affects extracellular vesicle accumulation.
New research suggests that stalling improvements in cardiovascular diseases since 2010 could lead to significant economic costs. The study finds that reduced cardiovascular disease rates would result in £13 billion NHS healthcare costs, £1.5 billion social care costs, and £32 billion lost QALYs between 2020-2029.
Researchers at SUTD design a multiferroic van der Waals heterostructure combining magnetic and ferroelectric 2D materials, offering voltage switchable magnetism. This material can be used for ultracompact memory devices with minimal energy consumption.
A new study reveals that bottom burrowing animals were among the first to recover after the end-Permian mass extinction. The research, led by Dr. Xueqian Feng, used ancient sea bed burrows and trails to reconstruct the recovery stages of various animal groups.
A new study found that fine particulate matter (PM2.5) exposure is associated with an increased risk of having a cluster of multiple chronic diseases, particularly cardio-metabolic and respiratory conditions. The analysis revealed four distinct multimorbidity clusters, with lower PM2.5 exposure linked to musculoskeletal conditions.
A recent study by Virginia Commonwealth University researchers found that mindfulness in workplace interactions can bring about a more harmonious and healthy organization. The study explores how individuals bring mindfulness to work and its effects on relationships and group outcomes.
A team of scientists from A*STAR and NTU Singapore have developed technology to transform expired solar cells into enhanced thermoelectric material, which harvests heat and converts it into electricity. The technology achieved a record-high thermoelectric figure of merit of 0.45 at 873 K.
The thawing of permafrost soils could release massive amounts of greenhouse gases, exacerbating global warming. The Arctic regions are experiencing rapid changes in land and sea temperatures, threatening habitats and human populations.
A large clinical trial found treating anal precancerous lesions reduces the risk of developing anal cancer in people with HIV by 57%. The study highlights the need for screening and treating high-grade squamous intraepithelial lesions (HSIL) as the standard of care for older HIV+ individuals.
Researchers at Penn State have created a highly customizable microscale gas sensing device using laser writing and responsive sensor technologies. The device enables the simultaneous detection of multiple gases, including disease indicators and pollutants, in various environments and substrates.
The construction of dams and changes in land use have significantly impacted the amount of sediment rivers carry to oceans. Sediment transport has decreased by 49% globally due to dam construction, while increasing on 36% of rivers in the south, primarily driven by deforestation.
The American Heart Association has revised its cardiovascular health checklist to include sleep duration as a key factor in ideal heart and brain health. The new Life's Essential 8 score replaces the previous Life's Simple 7 and assesses factors such as diet, physical activity, nicotine exposure, and blood pressure.
A new design of sustainable cropping diversifications has been established to balance economic, food security, and environmental performances in the North China Plain. The study evaluated 30 crop rotations using PCA and HCA, and employed differential evolution and Pareto optimization models to optimize diversified cropping systems.
A large study found moderate protection against SARS-CoV-2 infection and symptomatic Covid-19 illness among vaccinated children, with greater protection observed in younger age subgroups. The research used Israel's Clalit Health Services database to control for confounding variables.
A new study found that dispute resolution outcomes in Texas were largely anchored to the median in-network allowed amount, rather than a higher alternative benchmark. This suggests that a market-based monetary benchmark can influence dispute outcomes and may result in significant savings for consumers.
A study finds that regulatory agencies are heavily influenced by industry money, leading to concerns about their independence. Experts call for structural changes and a watchdog agency to restore regulators' ability to make unbiased decisions.
Researchers with the Calgary Stroke Program have made a breakthrough in treating acute ischemic stroke with Tenectepele, a safe and well-tolerated drug that can be administered as a single dose. The study shows that TNK works better than current recommended drug tPA, restoring blood flow faster and for a longer period.
A recent study found that only under 30% of children and adolescents in the US have high cardiovascular health scores. The proportion of high CVH declined with increasing age, with 56% of 2-5-year-olds having high scores compared to 14% of 12-19-year-olds.
A new battery health assessment indicator SoNA was proposed to evaluate nonlinear aging in lithium batteries. The research developed a multidimensional grading system combining traditional SoH with SoNA to comprehensively assess battery safety and nonlinearity.
A study found that men exhibiting mild behavioural impairment symptoms are at risk of faster cognitive decline compared to women. Researchers identified key behavioral changes, such as apathy and false beliefs, which may help identify people at higher risk of developing dementia.