Articles tagged with Type 1 Diabetes
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A recent study published in PLOS Medicine found that genetically determined vitamin D levels do not have a large effect on risk of type 1 diabetes among Europeans. The researchers used a Mendelian randomization design to examine the causal effect of vitamin D levels on the disease.
Researchers found that an experimental treatment converted cells to generate insulin, reducing diabetic symptoms and increasing insulin cell mass. The treatment showed promise for regenerating insulin-producing capacity and restoring normal blood glucose balance.
A new study published in Diabetes Care found that children with Type 1 Diabetes have lower brain volumes and IQ scores compared to non-diabetic children. The research suggests that hyperglycemia may adversely affect brain development, starting from childhood.
CU Anschutz researchers found a correlation between inflammatory T-cell responses to hybrid insulin peptides and worsening blood glucose measurements in genetically at-risk adolescents. This study provides an important advancement in identifying the risk of T1D early and potential for intervention.
The International Diabetes Closed-Loop (iDCL) Trial found that hybrid closed-loop insulin therapy significantly improved glycemic control in patients with type 1 diabetes. The use of this technology increased Time in Range by 13%, especially during nighttime hours, and reduced time spent at blood glucose levels above 180 mg/dL.
Researchers emphasize the need for addressing social determinants of health and providing community-based interventions to mitigate disparities. The University of Pennsylvania School of Nursing highlights its commitment to innovation in research, education, and practice to improve medical and economic equity.
A new study finds that Black patients are four times more likely to be hospitalized for diabetic ketoacidosis due to type 1 diabetes and COVID-19. The study also reveals disparities in the use of diabetes technology among minority patients.
A study found associations between retinal changes and memory problems in older people with type 1 diabetes. Researchers used routine eye scans to detect structural changes in the retina that may be linked to cognitive decline. The findings could lead to better understanding, diagnosis, and treatment of Alzheimer's disease and other co...
A study published in the Journal of Experimental Medicine reveals that inhibiting protein OCA-B protects mice from type 1 diabetes by limiting immune cell activity. The finding provides a proof-of-principle for OCA-B as a therapeutic target and could lead to further development of treatments.
Researchers found COVID-19 infected individuals with type 1 and type 2 diabetes are three times more likely to have severe illness or require hospitalization compared to those without diabetes. The study urges policymakers to prioritize these individuals for COVID-19 vaccination.
A novel T cell genetically engineered by University of Arizona Health Sciences researchers targets and attacks pathogenic T cells that cause Type 1 diabetes. The 5MCAR T cells, which mimic the evolutionary design of natural killer T cells, were tested in a non-obese diabetic mouse model with promising results.
Researchers from the University of Copenhagen have developed a new insulin molecule that can sense blood sugar levels and release insulin accordingly. This innovative approach aims to reduce the frequency of injections and monitoring required by people with type 1 diabetes, improving their quality of life.
A study published in PNAS reports a breakthrough treatment for type 1 diabetes in mice, utilizing a combination of haploidentical mixed chimersim and administration of gastrin and epidermal growth factor. This approach successfully reversed autoimmunity, augmented beta cell regeneration, and normalized blood glucose levels by reactivat...
A University of Gothenburg study found that continuous glucose monitoring (CGM) has favorable effects over several years, including a 4 mmol/mol decrease in average blood glucose levels and a 70% reduction in episodes with low blood sugar levels. Patients also reported improved comfort and reduced anxiety.
A new report from The Lancet Commission on Diabetes highlights the need for evidence-based interventions to close the gap in diabetes prevention and care. Implementing six key components can reduce cardiovascular-renal events by up to 40% and prevent premature deaths.
Children with multiple islet autoantibodies are more likely to progress to symptomatic type 1 diabetes than those who remain positive for a single autoantibody. Detailed information about the order, timing and type of autoantibodies appearing after the first autoantibody can significantly improve prediction of which children are most l...
A novel approach to measuring antibodies against SARS-CoV-2 has been developed, revealing a discrepancy between reported virus-positive cases and actual antibody prevalence. The study found that over 47% of antibody-positive children were asymptomatic, with significant geographic differences in antibody frequency across Bavaria.
A new agreement establishes a clear guideline for exercising safely with type 1 diabetes, covering carbohydrate consumption and safe glucose thresholds. The guidance is tailored for healthcare professionals to help patients manage blood sugar levels during physical activity.
Researchers at UAB have developed a biocompatible coating that delays allograft and autoimmune-mediated rejection in mouse models of T1D. The coating, consisting of multiple layers of tannic acid, protects transplanted islets from immune cells and oxidative stress.
Researchers at La Jolla Institute for Immunology discovered that even healthy individuals have high numbers of preproinsulin-specific T cells in their pancreas. These cells are believed to be the prime suspects in triggering the autoimmune response that causes type 1 diabetes.
A case series reports 5 patients developing type 1 diabetes after receiving immunotherapy, with rapid onset and serious risk for diabetic ketoacidosis. Monitoring glycemia does not predict diabetes occurrence, and GAD antibodies are present in half of these cases, warranting further investigation.
A recent study found that donor-conceived adults have a higher incidence of immunology diseases, including seven times more type 1 diabetes diagnoses and double the incidence of thyroid disease. The study suggests an altered immunological system may be driving these health conditions.
A global survey of over 7,000 patients with type 1 diabetes found that three-quarters would continue using online or telephone appointments with their doctors. Glucose control was positively associated with a positive perception of telemedicine, and age and education level did not appear to influence perceptions.
People with type 1 diabetes are at higher risk of severe COVID-19 clinical outcomes, especially older individuals with longer disease duration and worse glucose control. However, young people with or without diabetes are coping better with the infection, likely due to differences in anatomy, epidemiology, and gene expressions.
Among individuals with type 1 diabetes, those who stopped working during lockdown experienced improved blood sugar levels. This improvement was attributed to reduced opportunities for exercise and heightened psychological stress being replaced by a more regular lifestyle and increased focus on diabetes management.
A study led by UC Davis Health researchers found that diabetic ketoacidosis is associated with cognitive problems in children, including lower long-term memory and IQ. The study also showed that repeated episodes of DKA can lead to worsening cognitive deficits over time.
A new study confirms the existence of residual, non-functioning beta cells in living individuals with longstanding type 1 diabetes. Researchers used a non-invasive imaging technique to detect these cells, which may be restored if adequate treatments are available.
A new study suggests that people with type 1 diabetes will live almost 8 years less and those with type 2 diabetes will live almost 2 years less than the general population. The study used data from the UK National Diabetes Audit and Office for National Statistics to calculate life expectancy, finding a significant gap in mortality rat...
A recent study published in Diabetologia reveals that people with type 1 diabetes have a 33% higher risk of falls compared to the general population, while those with type 2 diabetes face a 19% increased risk. The research also identifies various risk factors for falls and fractures in individuals with diabetes.
Researchers have found pro-inflammatory lipids that precede Type 1 diabetes onset in a mouse model and high-risk children. The findings suggest that these lipids may serve as biomarkers for the disease and offer a therapeutic target to prevent its development.
Researchers at the University of Pennsylvania School of Nursing found that a text messaging intervention combined with MyDiaText improved self-care for adolescents with T1DM. The study showed persistent engagement and potential increase in glycemic control, suggesting a promising method to engage this population.
A new artificial pancreas system has been shown to prevent hypoglycemia during and after heavy exercise in people with type 1 diabetes. The study, published in the Journal of Clinical Endocrinology & Metabolism, found that the system performed well and was safe compared to standard therapy.
The Control-IQ system, manufactured by Tandem Diabetes Care, safely and effectively manages blood glucose levels in children with type 1 diabetes. The study found that the artificial pancreas did a better job keeping the children's blood glucose within the target range.
A new study from La Jolla Institute for Immunology found that blocking nerve signals to the pancreas could stop patients from ever developing type 1 diabetes. The researchers used a mouse model and discovered that blocking sympathetic nerve signals protected mice from beta cell death.
The study found that youth using the artificial pancreas system had significant improvements in blood glucose control, including a 7% improvement during the daytime and a 26% improvement at night. The technology improved overall time-in-range by nearly 11%, translating to more hours per day in a healthy range.
A clinical trial found that a new artificial pancreas system improved blood glucose control in children aged 6-13, achieving 7% daytime improvement and 26% nighttime control. The technology replaces traditional testing and insulin delivery, providing greater convenience and safety.
A new study aims to determine if sleep optimization interventions can help adults with Type 1 diabetes improve their sleep and glycemic control. Participants will receive a wearable sleep tracker and brief phone counseling sessions.
A new combined approach improves prediction of type 1 diabetes in high-risk children, allowing better risk counselling and early intervention. The test doubles the efficiency of newborn screening programmes to prevent life-threatening ketoacidosis.
Research suggests that bacterial infections, as indicated by antibiotic purchases, increase the risk of coronary heart disease in individuals with type 1 diabetes. Elevated levels of bacterial lipopolysaccharides also contribute to this increased risk.
Scientists at UCL have discovered new biomarkers that can identify people with Type 1 diabetes who are likely to respond to the immunotherapy drug Abatacept. The study found that certain immune cells, known as 'follicular helper T cells', play a key role in the disease.
A new drug candidate, SRI-37330, has been discovered to improve four detrimental characteristics of diabetes: high blood sugar, glucagon elevation, excessive glucose production by the liver, and fatty liver. The compound is non-toxic, orally bioavailable, and highly effective in human islets and mouse models.
Joslin Diabetes Center researchers discover targeting renalase protein strengthens beta cells against stress and autoimmune attack. An FDA-approved drug, pargyline, is shown to protect human cells, potentially slowing disease progression in a clinical trial.
A national cost-sharing cap on insulin can help reduce the financial burden on families of children and young adults with type 1 diabetes. The study found that approximately 60% of patients would benefit from a $25 cap, with average savings of almost $480 per year.
Case studies published by Physicians Committee for Responsible Medicine found that plant-based diets rich in whole carbohydrates improved health markers in individuals with type 1 diabetes. The diets led to decreased insulin needs, stabilized blood sugar control, and reduced cholesterol levels.
A new study found that children with newly-diagnosed type 1 diabetes have a distinct gut microbiome composition associated with poorer blood sugar control. The researchers used machine learning analysis and genetic analysis to identify this link, highlighting the importance of gut health in disease development.
Researchers found persistent DNA methylation changes in blood cells and stem cells associated with metabolic memory and future diabetic complications. The study provides evidence of a link between epigenetics, glycemic history, and complication development, offering potential biomarkers for early intervention and prevention.
Researchers found that Cyclocarya paliurus polysaccharide modulates the gut microbiota and improves metabolic pathways, leading to a reduction in serum glucose levels and alleviating type 2 diabetes symptoms. The study provides new insights into the use of dietary polysaccharides for preventing or intervening in T2DM.
Research found a significant increase in insulin pump use and a decline in diabetic nephropathy, while pre-pregnancy obesity rose. The percentage of mothers with excess weight gain during pregnancy also increased. Despite this, the prevalence of very large babies born remained the same.
A clinical trial found that reducing uric acid levels with the medication allopurinol did not slow the progression of kidney disease in people with type 1 diabetes. Despite a significant drop in uric acid levels, participants showed no improvement in their kidney function.
A Phase 2 study led by UB pediatric endocrinologist Teresa Quattrin shows that golimumab, an anti-TNF therapy, preserved beta-cell function and reduced injected insulin required in children and young adults with newly diagnosed Type 1 diabetes. The study demonstrated a higher C-peptide level in patients treated with golimumab compared ...
A recent study published in the New England Journal of Medicine found that teplizumab significantly delayed the onset of type 1 diabetes by three years compared to a placebo. The trial involved individuals at high risk of developing T1D, and those treated with teplizumab showed higher rates of insulin secretion and C-peptide levels.
A new genetic risk score has been found to be effective in diagnosing type 1 diabetes in Indians, even in its current form based on European data. Genetic differences between Indian and European populations suggest that the test could be further improved to enhance outcomes.
Researchers at Oregon Health & Science University have developed an AI algorithm that uses data from continuous glucose monitors and wireless insulin pens to provide guidance on adjustments. The algorithm, paired with a smartphone app called DailyDose, generated recommendations in agreement with physicians 67.9% of the time.
Research by the University of Sheffield reveals people with diabetes are at a greater risk of bone fractures, especially hip fractures. Severity and length of time living with the condition also increase this risk.
A new study finds that people with Type 1 diabetes spend an average of $2,500 a year on healthcare costs, with diabetes-related supplies costing more than insulin. The study also highlights the importance of automating glucose monitoring and insulin delivery for young children and adolescents with Type 1 diabetes.
The CORONADO study found that 1 in 10 COVID-19 patients with diabetes died within 7 days of hospital admission, and 1 in 5 were intubated and mechanically ventilated. Poorer blood sugar control did not impact patient outcomes, but the presence of diabetic complications and increasing age increased mortality risk.
A study funded by JDRF, ADA, and Helmsley found all human and analog insulins in US pharmacies contained the expected amount of active insulin, posing no safety risks for people with diabetes.
A new study found that telehealth monitoring and technology can lead to better outcomes for patients with type 1 diabetes during the COVID-19 pandemic. By allowing for frequent insulin dose adjustments and improving glucose values, telehealth helped avoid hospital admissions for diabetic ketoacidosis.
Researchers at Karolinska Institutet and the universities of Jyväskylä and Tampere have produced a vaccine that protects against all six known strains of Coxsackie B virus, which may play a role in triggering type 1 diabetes. The vaccine was tested in animal models and showed promise, with plans to conduct human clinical trials.
Researchers have developed a vaccine that protects against the Coxsackie B virus, which may play a role in triggering type 1 diabetes. The vaccine was shown to be highly immunogenic and protective in animal models and non-human primates.