Articles tagged with Type 1 Diabetes
A Swedish study found that 43% of children with new-onset type 1 diabetes did not receive hospital treatment on the same day as primary care contact. Delayed care can lead to life-threatening conditions like diabetic ketoacidosis. Improved awareness and rapid treatment are crucial for preventing complications.
A new study reveals that the small protein MOTS-c prevents the destruction of insulin-producing pancreatic cells in mice with autoimmune diabetes. MOTS-c treatment supports regulatory T-cells and reduces the activation of killer T-cells, effectively preventing disease onset.
A low glycaemic diet has been shown to produce small but meaningful improvements in blood sugar levels, cholesterol, weight, and other risk factors in people with diabetes. The findings are based on a systematic review of 27 randomised controlled trials involving 1,617 participants with type 1 or 2 diabetes.
A synthetic hinge concept developed by Indiana University School of Medicine Professor Michael A. Weiss and his team could lead to a breakthrough in 'smart' insulin therapy. The invention exploits a natural mechanism that allows the insulin to adjust its activity based on blood glucose levels, which could transform diabetes care.
Rice University bioengineers are developing an insulin-producing implant to regulate blood glucose levels in Type 1 diabetics. The implant uses human stem cells and 3D printing to mimic the natural behavior of the pancreas, with the goal of achieving consistent target blood glucose levels.
A study by Anglia Ruskin University found that younger people with diabetes are significantly more concerned about COVID-19 risks and have a higher likelihood of reporting worries. Social support from family, friends, and healthcare teams plays a crucial role in managing these concerns.
A large-scale genetic study has identified new drug targets to treat type 1 diabetes by examining 61,427 participants and pinpointing 78 regions on the chromosomes that influence risk. The researchers found 36 previously unknown regions and specific gene variations that can be used to identify potential drug targets.
The University of South Florida has been awarded a four-year, $69.9 million NIH grant to continue its Type 1 Diabetes Research study. The study aims to identify environmental factors that influence autoimmune destruction of beta cells in young children with genetic susceptibility to type 1 diabetes.
Researchers discovered 47 lipids significantly different between rapid and slow kidney function decliners, providing a platform for risk stratification. The study's findings also suggest the underlying mechanism of progressive kidney disease, which could be a future target for therapeutic intervention.
Research reveals that epigenetic changes contribute to the development of type 1 diabetes, with DNA methylation and histone modifications playing a crucial role. The study suggests that epigenetic markers could be used to monitor disease progression and identify potential therapeutic targets.
Researchers at Salk Institute develop efficient method to produce insulin-producing cells from stem cells, bringing hope for type 1 diabetes treatment. The new approach resulted in beta cell yields of up to 80 percent and biologically functional transplanted cells in mouse model.
A clinical study found that injecting a protein GAD into lymph nodes can be effective in preserving insulin production in individuals with the HLA-DR3-DQ2 variant. This subgroup accounts for around half of patients with type 1 diabetes, who may benefit from a potential new treatment to slow or stop the immune system's attack.
By mapping the genetic underpinnings of type 1 diabetes, researchers have identified a predictive causal role for specific cell types, including pancreatic exocrine cells. This study provides a major leap in understanding the causes of type 1 diabetes and may lead to new treatments for reversing its course.
Researchers at Newcastle University discovered that tiny pieces of genetic material, miR-424-5p, increase in early stages of heart disease in type 1 diabetes patients. This biomarker has the potential to define additional therapeutic options to help patients with type 1 diabetes.
Type 1 diabetes and diabetic neuropathy contribute to various bone structure impacts but don't fully explain higher fracture risk in patients. Balance and muscle strength also play a role in increased fracture risk, according to new findings.
Experts at the University of Birmingham argue that patients with type one diabetes need clear professional guidance to use 'Do-It-Yourself' artificial pancreas systems. The lack of legal, regulatory, or ethical guidance for clinicians has led to doctors being cautious about discussing DIY APS with patients.
A new clinical study, SINT1A, is underway to prevent type 1 diabetes in children by administering a probiotic containing Bifidobacterium Infantis. The study aims to promote a healthy intestinal flora and reduce the risk of autoimmunity against insulin.
A study found that adults with type 1 diabetes who require in-hospital treatment of diabetic ketoacidosis have a high readmission rate, with 20.2% returning within 30 days. Factors such as gender, leaving against medical advice, anemia, and chronic kidney disease increase the risk of readmission.
Children with poorly controlled type 1 diabetes have a 10 times higher risk of COVID-19-related complications and death compared to those with well-controlled diabetes, according to a study. The findings will help families make informed decisions about in-person schooling during the pandemic.
A recent study found that children and teens with type 1 diabetes experienced better blood glucose levels when confined to home during the COVID-19 pandemic. The researchers noted that remote consultations and school pressures contributed to poorer glucose control in the past.
A recent study published in The Journal of Clinical Endocrinology & Metabolism found that non-Hispanic black patients with Type 1 diabetes and COVID-19 are almost four times as likely to present with diabetic ketoacidosis compared to white patients. The study highlights the importance of addressing social determinants of health, includ...
A phase 2 trial led by La Jolla Institute for Immunology (LJI) shows a promising combination therapeutic candidate for adults with recent-onset type 1 diabetes. The treatment combines anti-IL-21 antibody with liraglutide and has been found to increase endogenous insulin secretion without safety concerns.
A new trial shows that immunotherapy drug teplizumab can delay the onset of Type 1 diabetes in people at high risk by an average of five years compared to a placebo. The study, published in Science Translational Medicine, found reduced T-cell damage and improved insulin-producing beta cells in those who received the treatment.
A recent study published in PLOS Medicine found that genetically determined vitamin D levels do not have a large effect on risk of type 1 diabetes among Europeans. The researchers used a Mendelian randomization design to examine the causal effect of vitamin D levels on the disease.
Researchers found that an experimental treatment converted cells to generate insulin, reducing diabetic symptoms and increasing insulin cell mass. The treatment showed promise for regenerating insulin-producing capacity and restoring normal blood glucose balance.
A new study published in Diabetes Care found that children with Type 1 Diabetes have lower brain volumes and IQ scores compared to non-diabetic children. The research suggests that hyperglycemia may adversely affect brain development, starting from childhood.
CU Anschutz researchers found a correlation between inflammatory T-cell responses to hybrid insulin peptides and worsening blood glucose measurements in genetically at-risk adolescents. This study provides an important advancement in identifying the risk of T1D early and potential for intervention.
The International Diabetes Closed-Loop (iDCL) Trial found that hybrid closed-loop insulin therapy significantly improved glycemic control in patients with type 1 diabetes. The use of this technology increased Time in Range by 13%, especially during nighttime hours, and reduced time spent at blood glucose levels above 180 mg/dL.
Researchers emphasize the need for addressing social determinants of health and providing community-based interventions to mitigate disparities. The University of Pennsylvania School of Nursing highlights its commitment to innovation in research, education, and practice to improve medical and economic equity.
A new study finds that Black patients are four times more likely to be hospitalized for diabetic ketoacidosis due to type 1 diabetes and COVID-19. The study also reveals disparities in the use of diabetes technology among minority patients.
A study found associations between retinal changes and memory problems in older people with type 1 diabetes. Researchers used routine eye scans to detect structural changes in the retina that may be linked to cognitive decline. The findings could lead to better understanding, diagnosis, and treatment of Alzheimer's disease and other co...
A study published in the Journal of Experimental Medicine reveals that inhibiting protein OCA-B protects mice from type 1 diabetes by limiting immune cell activity. The finding provides a proof-of-principle for OCA-B as a therapeutic target and could lead to further development of treatments.
Researchers found COVID-19 infected individuals with type 1 and type 2 diabetes are three times more likely to have severe illness or require hospitalization compared to those without diabetes. The study urges policymakers to prioritize these individuals for COVID-19 vaccination.
A novel T cell genetically engineered by University of Arizona Health Sciences researchers targets and attacks pathogenic T cells that cause Type 1 diabetes. The 5MCAR T cells, which mimic the evolutionary design of natural killer T cells, were tested in a non-obese diabetic mouse model with promising results.
Researchers from the University of Copenhagen have developed a new insulin molecule that can sense blood sugar levels and release insulin accordingly. This innovative approach aims to reduce the frequency of injections and monitoring required by people with type 1 diabetes, improving their quality of life.
A study published in PNAS reports a breakthrough treatment for type 1 diabetes in mice, utilizing a combination of haploidentical mixed chimersim and administration of gastrin and epidermal growth factor. This approach successfully reversed autoimmunity, augmented beta cell regeneration, and normalized blood glucose levels by reactivat...
A University of Gothenburg study found that continuous glucose monitoring (CGM) has favorable effects over several years, including a 4 mmol/mol decrease in average blood glucose levels and a 70% reduction in episodes with low blood sugar levels. Patients also reported improved comfort and reduced anxiety.
A new report from The Lancet Commission on Diabetes highlights the need for evidence-based interventions to close the gap in diabetes prevention and care. Implementing six key components can reduce cardiovascular-renal events by up to 40% and prevent premature deaths.
A novel approach to measuring antibodies against SARS-CoV-2 has been developed, revealing a discrepancy between reported virus-positive cases and actual antibody prevalence. The study found that over 47% of antibody-positive children were asymptomatic, with significant geographic differences in antibody frequency across Bavaria.
A new agreement establishes a clear guideline for exercising safely with type 1 diabetes, covering carbohydrate consumption and safe glucose thresholds. The guidance is tailored for healthcare professionals to help patients manage blood sugar levels during physical activity.
Children with multiple islet autoantibodies are more likely to progress to symptomatic type 1 diabetes than those who remain positive for a single autoantibody. Detailed information about the order, timing and type of autoantibodies appearing after the first autoantibody can significantly improve prediction of which children are most l...
Researchers at UAB have developed a biocompatible coating that delays allograft and autoimmune-mediated rejection in mouse models of T1D. The coating, consisting of multiple layers of tannic acid, protects transplanted islets from immune cells and oxidative stress.
Researchers at La Jolla Institute for Immunology discovered that even healthy individuals have high numbers of preproinsulin-specific T cells in their pancreas. These cells are believed to be the prime suspects in triggering the autoimmune response that causes type 1 diabetes.
A case series reports 5 patients developing type 1 diabetes after receiving immunotherapy, with rapid onset and serious risk for diabetic ketoacidosis. Monitoring glycemia does not predict diabetes occurrence, and GAD antibodies are present in half of these cases, warranting further investigation.
A recent study found that donor-conceived adults have a higher incidence of immunology diseases, including seven times more type 1 diabetes diagnoses and double the incidence of thyroid disease. The study suggests an altered immunological system may be driving these health conditions.
People with type 1 diabetes are at higher risk of severe COVID-19 clinical outcomes, especially older individuals with longer disease duration and worse glucose control. However, young people with or without diabetes are coping better with the infection, likely due to differences in anatomy, epidemiology, and gene expressions.
Among individuals with type 1 diabetes, those who stopped working during lockdown experienced improved blood sugar levels. This improvement was attributed to reduced opportunities for exercise and heightened psychological stress being replaced by a more regular lifestyle and increased focus on diabetes management.
A study led by UC Davis Health researchers found that diabetic ketoacidosis is associated with cognitive problems in children, including lower long-term memory and IQ. The study also showed that repeated episodes of DKA can lead to worsening cognitive deficits over time.
A global survey of over 7,000 patients with type 1 diabetes found that three-quarters would continue using online or telephone appointments with their doctors. Glucose control was positively associated with a positive perception of telemedicine, and age and education level did not appear to influence perceptions.
A new study suggests that people with type 1 diabetes will live almost 8 years less and those with type 2 diabetes will live almost 2 years less than the general population. The study used data from the UK National Diabetes Audit and Office for National Statistics to calculate life expectancy, finding a significant gap in mortality rat...
A new study confirms the existence of residual, non-functioning beta cells in living individuals with longstanding type 1 diabetes. Researchers used a non-invasive imaging technique to detect these cells, which may be restored if adequate treatments are available.
A recent study published in Diabetologia reveals that people with type 1 diabetes have a 33% higher risk of falls compared to the general population, while those with type 2 diabetes face a 19% increased risk. The research also identifies various risk factors for falls and fractures in individuals with diabetes.
Researchers have found pro-inflammatory lipids that precede Type 1 diabetes onset in a mouse model and high-risk children. The findings suggest that these lipids may serve as biomarkers for the disease and offer a therapeutic target to prevent its development.
Researchers at the University of Pennsylvania School of Nursing found that a text messaging intervention combined with MyDiaText improved self-care for adolescents with T1DM. The study showed persistent engagement and potential increase in glycemic control, suggesting a promising method to engage this population.
A new artificial pancreas system has been shown to prevent hypoglycemia during and after heavy exercise in people with type 1 diabetes. The study, published in the Journal of Clinical Endocrinology & Metabolism, found that the system performed well and was safe compared to standard therapy.
The Control-IQ system, manufactured by Tandem Diabetes Care, safely and effectively manages blood glucose levels in children with type 1 diabetes. The study found that the artificial pancreas did a better job keeping the children's blood glucose within the target range.
A new study from La Jolla Institute for Immunology found that blocking nerve signals to the pancreas could stop patients from ever developing type 1 diabetes. The researchers used a mouse model and discovered that blocking sympathetic nerve signals protected mice from beta cell death.
The study found that youth using the artificial pancreas system had significant improvements in blood glucose control, including a 7% improvement during the daytime and a 26% improvement at night. The technology improved overall time-in-range by nearly 11%, translating to more hours per day in a healthy range.
A clinical trial found that a new artificial pancreas system improved blood glucose control in children aged 6-13, achieving 7% daytime improvement and 26% nighttime control. The technology replaces traditional testing and insulin delivery, providing greater convenience and safety.
A new study aims to determine if sleep optimization interventions can help adults with Type 1 diabetes improve their sleep and glycemic control. Participants will receive a wearable sleep tracker and brief phone counseling sessions.