Articles tagged with Type 1 Diabetes
A new study published in BMJ found that blood glucose levels between 48-52mmol/mol do not provide additional protection against organ damage, whereas levels below 48 do not offer further reduced risk. Patients with low HbA1c values need to monitor for excessively low glucose levels and fluctuations.
A recent study at University of Eastern Finland discovered a novel T-cell subset, peripheral helper T cells, associated with the onset of type 1 diabetes. These cells were found to be more frequent in children who later developed the disease and those with autoantibodies indicating genetic risk.
A recent study published in Nature Communications found that children with high genetic risk of developing type 1 diabetes have distinct gut microbiomes compared to those with low risk. The research suggests a link between genetic predisposition and environmental factors, highlighting the importance of the gut flora in autoimmune disea...
Researchers will use human pluripotent stem cells, CRISPR and human organoids to dissect beta cell defects and create a human cell model of type 1 diabetes. The goal is to identify the cellular actions leading to disease onset and potentially rescue surviving beta cells.
Researchers discovered a blood signature predicting type 1 diabetes before its onset, enabling early identification of high-risk children. The study, led by the University of Turku, could lead to disease prevention.
Researchers found that montelukast can disrupt inflammatory signaling in diabetic retinopathy, reducing small blood vessel and nerve damage. The study offers an early approach to treat type 1 diabetes and suggests a potential new treatment for the disease.
A global study of 12 million people found that diabetes significantly increases the risk of heart failure, with women at greater risk than men. Type 1 and type 2 diabetes both pose a stronger risk for women, highlighting the need for sex-specific research into diabetes and its impact on heart health.
A global study of 12 million people found diabetes increases the risk of heart failure, with a significant increase for women. Women with type 1 diabetes have a 47% greater excess risk of heart failure compared to men, highlighting the need for sex-specific research.
Patients with Type 1 diabetes who are obese often face denied pancreas transplantation due to high infection risks. However, robotic pancreas transplantation has shown promising results, reducing blood loss and surgical complications while improving patient outcomes.
Researchers analyzed samples from over 1,000 type 1 diabetes patients for 50 years or longer and found a protective protein called RBP3. Injecting RBP3 into rodents blocked diabetic retinopathy without severe side effects.
A study from Joslin Diabetes Center found that a minority of patients treated for decades with type 1 diabetes may have monogenic diabetes, which can be treated with oral drugs. The research suggests screening for genetic mutations in young people diagnosed with type 1 diabetes to identify potential treatment options.
Researchers from the University of Barcelona and IDIBAPS identified a molecular target, PTP1B phosphatase, that promotes the creation of new blood vessels in transplanted pancreatic islets. This study aims to improve the revascularization process, increasing the viability of cells and restoring regular sugar levels and glucose tolerance.
A new study shows that children who received all doses of the rotavirus vaccine had a 33% lower risk of getting diagnosed with type 1 diabetes. The study, published in Scientific Reports, used nationwide health insurance data and found that the vaccine was associated with a 94% lower rate of hospitalization for rotavirus infection.
Researchers found substantial T cell infiltration and few surviving beta cells in a patient's pancreas after IC therapy, contradicting previous reports of elevated PD-L1 expression
Researchers found that children with type 1 diabetes had slower growth in brain areas associated with mild cognitive deficits compared to children without T1D. The study suggests that glycemic exposure may adversely impact the developing brain in children with early-onset T1D.
A clinical trial found that teplizumab, an immunotherapy drug, can delay the onset of type 1 diabetes in people at high risk. The study, published in the New England Journal of Medicine, showed a median delay of two years in children and adults.
Researchers found that an immunotherapy treatment, teplizumab, effectively delayed the progression to clinical type 1 diabetes in high-risk individuals. Participants who received teplizumab took longer to develop clinical disease, with a median time of 48 months compared to just over 24 months for those in the control group.
Researchers found near-normal glycemic profiles in five long-term islet transplant recipients, with improved time-in-range metrics and reduced glucose variability. The study demonstrates the potential of islet transplantation as a successful long-term cell therapy for select patients with type 1 diabetes.
A 10-week pilot study integrated health coaching and incentives into standard treatment for pediatric patients with type 1 diabetes, lowering A1c levels by an average of .5%. Health coaches received greater empathy and engagement, while families benefited from personalized feedback and support.
A newly discovered immune cell, the 'X cell', has been found to be a major driver of the autoimmune response believed to cause type 1 diabetes. The X cell can act as both a B cell and a T cell, amplifying the autoimmune response.
Children with type 1 diabetes experience a 20% reduction in medication adherence during school holidays, weekends, and public holidays. This can have serious consequences for their health, increasing demand on healthcare systems and potentially leading to hospitalization and mortality.
Researchers identified a critical role for hypoxia-inducible factor 1-alpha (HIF-1A) in increasing the risk of type 1 diabetes after viral infections. The study suggests that exposure to coxsackievirus and other environmental triggers can lead to β-cell death and increased incidence of type 1 diabetes.
Researchers have identified protective factors that play a strong role in preventing diabetic kidney disease. The study found that certain enzymes, including PKM2, are present in people with good kidney function and may be used as biomarkers and targets for personalized clinical intervention.
Immunologists from The University of Texas at Austin captured a first-ever video of T-cells undergoing assassin-training in the body's safety test. The new imaging technique holds promise for improving human health by better understanding T-cell development and function in autoimmune disorders like Type 1 diabetes.
A new study reveals that over 25% of Quebec children diagnosed with type 1 diabetes already have diabetic ketoacidosis, a life-threatening complication. The number of cases has increased by two percent per year since 2001, highlighting the need for awareness campaigns and earlier diagnosis.
Researchers have discovered that transplanted islets in the anterior chamber of the eye exhibit early signs of inflammation before type 1 diabetes symptoms appear, suggesting a potential biomarker for predicting disease development. Early intervention with immunosuppressive treatments may halt disease progression, and future studies ai...
Transplanting islets of Langerhans into mice reveals early autoimmune markers of type 1 diabetes, allowing for intervention before beta cell destruction. The study's findings offer hope for developing new drugs and clinical transplantation strategies to prevent damage.
Researchers at Joslin Diabetes Center found that increasing beta cell growth before signs of type 1 diabetes can halt the disease. In animal models, continuous generation of new insulin-producing beta-cells protected against autoimmune reactions.
A study by the University of Exeter found that 38% of patients with type 1 diabetes over 30 were initially treated as type 2. Half of those misdiagnosed remained so 13 years later. Insulin treatment is crucial for type 1 diabetes diagnosis.
Research at Karolinska Institutet links high HbA1c levels during pregnancy to increased preterm birth risk, affecting up to 22% of infants born to women with type 1 diabetes. The study also identifies risks of other complications for newborns, including respiratory problems and low blood sugar.
A new study led by McGill University Health Centre researchers found that children born to mothers with gestational diabetes are nearly twice as likely to develop type 1 diabetes before the age of 22. Early detection is crucial in preventing complications like diabetic ketoacidosis.
A new study suggests that obesity may play a role in reproductive problems in women with type 1 diabetes. Menstrual irregularities were seen in 47% of those with the disease, and polycystic ovary syndrome (PCOS) was found in 14%, increasing the risk of miscarriages and stillbirths.
A recent study found that nearly one-fifth of first-time users of a new hybrid closed loop insulin pump stopped using the device due to difficulties meeting technical demands. Patients required calibration between their continuous blood glucose monitor and fingerstick blood tests, leading to frustration.
Researchers found that older adults with type 1 diabetes spend more than an hour per day in the hypoglycemic range, increasing their risk of severe complications. This study highlights the need for interventions to reduce the risk of severe hypoglycemia in this age group.
Researchers developed a simple and inexpensive way to measure C-peptide, allowing clinicians to accurately diagnose type of diabetes and tailor treatment. The test has been used on over 750 patients with Type 1 diabetes diagnosis and shown that some have other types of diabetes, enabling them to stop insulin treatment.
A recent AI study identified high long-term blood sugar levels, kidney dysfunction, and excess bad cholesterol as the strongest predictors of cardiovascular disease and death in type 1 diabetes patients. The study also found that keeping these risk factors under control can lead to lower risks of cardiovascular events.
A new study suggests the Affordable Care Act's requirements on pre-existing conditions and age clauses had a significant impact on adults with diabetes. The percentage of people with private health insurance who had diabetes increased after the ACA provisions began, especially among those in their 50s.
Researchers have made significant progress with UVA's artificial pancreas, a device that automates blood-sugar level monitoring and insulin injection. The International Diabetes Closed Loop Trial has provided early results from its nationwide clinical trial, examining the algorithm's use in smartphone apps and embedded devices.
A new study published in JAMA found that children with type 1 diabetes outperform their peers in math and reading tests. The research reviewed over 630,000 Danish students' test results and adjusted for socioeconomic status.
A study of over 630,000 Danish children with and without type 1 diabetes found no significant differences in reading and math scores. The findings suggest that the relationship between type 1 diabetes and poor academic performance may not be universal.
Researchers have found a short anti-rejection therapy that can protect transplanted pancreatic islets in diabetic animals, enabling long-term survival and function without the need for life-long immune suppression. This breakthrough could lead to an effective treatment of type 1 diabetes with fewer side effects.
Researchers at the Diabetes Research Institute have successfully transplanted islets into the eye of experimental recipients, achieving long-term immunosuppression-free survival. This approach also shows promise for inducing peripheral immune tolerance, allowing for reduced or eliminated anti-rejection therapy.
The National Institutes of Health has awarded a grant to develop and evaluate an artificial pancreas for pregnant women with type 1 diabetes. The project aims to improve patient and fetal outcomes by adapting automated insulin delivery technology.
A study found a significant decrease in type 1 diabetes diagnoses in children aged 0-4 years after the introduction of the rotavirus vaccine in 2007. The researchers suggest that preventing rotavirus infection may also reduce the risk of type 1 diabetes.
A new study found that only a minority of US adults with type 1 diabetes achieve target hemoglobin A1c levels, indicating poor blood glucose management. The study revealed increasing HbA1c levels in young adults and teens over the past 5 years.
Researchers have developed a new risk score that takes into account genetic information to identify babies at high risk of type 1 diabetes. The score is nearly twice as efficient as existing methods and also effective at predicting type 1 diabetes in adults, helping with early diagnosis and treatment.
Patients with type 1 diabetes and poor blood sugar control face a higher risk of fragility fracture compared to those with good glycemic control. Good blood sugar control is an important goal for patients with diabetes, and research shows that it may help reduce the risk of fractures in type 1 diabetes patients.
Researchers found that trained alert dogs can detect hypoglycaemic episodes in 83% of cases, helping Type 1 patients regulate blood sugars non-invasively. The study provides the first large-scale evaluation of medical detection dogs in detecting hypoglycaemia.
The TEDDY study, following nearly 9,000 children over five years, aims to identify high-risk genes and environmental factors that contribute to type 1 diabetes. Early screening and intervention may be possible through analyzing autoantibodies in newborns and tracking changes in risk factors as children age.
Patients with type 1 diabetes exhibit altered brain connectivity patterns compared to healthy individuals, according to a new study published in PLOS ONE. The research, led by the University of Barcelona, employed fMRI techniques to investigate brain activity during working memory tasks.
A study published in JCI Insight found that a specific subset of immune B cells, CD19+IgM+, can delay the onset of type 1 diabetes in mice. This discovery opens up new possibilities for developing therapies targeting this disease subtype.
Research finds that socio-economic conditions in regions affect T1 diabetes treatment, with disadvantaged areas having higher blood glucose levels, lower use of pump therapy and CGMS, and better outcomes for severe hypoglycemia. Frequent use of pump therapy and CGMS could improve treatment outcomes in these regions.
A new study found a significant increase in type 1 diabetes cases across Europe, with rates rising by 3.4% per year. The study's findings have important implications for healthcare planning and delivery, highlighting the need for improved blood sugar control and increased support services.
An investigation by The BMJ found that tens of thousands of UK patients with type 1 diabetes are being denied access to flash glucose monitoring devices due to a postcode lottery. Despite NHS guidance, only 3-5% of patients have access to the devices, compared to 20-25% recommended by clinical commissioning groups.
A new $3.3 million grant will fund a high-resolution reference map of pancreatic cells to identify molecular changes leading to type 1 diabetes.
Researchers at Baylor College of Medicine found three distinct phases in infant gut microbiome development from 3-46 months of age. Partial breastfeeding was associated with higher abundance of probiotic bacteria, while cessation accelerated maturation and change in microbial diversity.
Scientists at Newcastle University have found that metformin can reduce the presence of microRNAs that contribute to heart disease in patients with Type 1 diabetes. By decreasing these microRNAs, metformin improves glucose levels and promotes blood vessel repair, opening up new treatment options for this vulnerable patient group.
A study highlights strategies to help teens with type 1 diabetes manage high cholesterol and blood pressure, including offering realistic guidance, encouraging regular exercise, and promoting healthy eating habits. The research emphasizes the importance of personalized approach and team effort in addressing these conditions.
A new study found that 21% of individuals with insulin-treated diabetes diagnosed after age 30 have severe insulin deficiency, characteristic of late-onset type 1 diabetes. These patients often experience delays in diagnosis and treatment due to misdiagnosis as type 2 diabetes.
A new hybrid closed-loop insulin delivery system was compared to sensor-augmented pump therapy for blood sugar control in patients with poorly controlled type 1 diabetes. The study found that the hybrid closed-loop system achieved significantly better glucose control and reduced the risk of hypoglycaemia.