Articles tagged with Type 1 Diabetes
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Researchers have discovered that transplanted islets in the anterior chamber of the eye exhibit early signs of inflammation before type 1 diabetes symptoms appear, suggesting a potential biomarker for predicting disease development. Early intervention with immunosuppressive treatments may halt disease progression, and future studies ai...
Transplanting islets of Langerhans into mice reveals early autoimmune markers of type 1 diabetes, allowing for intervention before beta cell destruction. The study's findings offer hope for developing new drugs and clinical transplantation strategies to prevent damage.
A new study reveals that over 25% of Quebec children diagnosed with type 1 diabetes already have diabetic ketoacidosis, a life-threatening complication. The number of cases has increased by two percent per year since 2001, highlighting the need for awareness campaigns and earlier diagnosis.
Researchers at Joslin Diabetes Center found that increasing beta cell growth before signs of type 1 diabetes can halt the disease. In animal models, continuous generation of new insulin-producing beta-cells protected against autoimmune reactions.
A study by the University of Exeter found that 38% of patients with type 1 diabetes over 30 were initially treated as type 2. Half of those misdiagnosed remained so 13 years later. Insulin treatment is crucial for type 1 diabetes diagnosis.
Research at Karolinska Institutet links high HbA1c levels during pregnancy to increased preterm birth risk, affecting up to 22% of infants born to women with type 1 diabetes. The study also identifies risks of other complications for newborns, including respiratory problems and low blood sugar.
A new study led by McGill University Health Centre researchers found that children born to mothers with gestational diabetes are nearly twice as likely to develop type 1 diabetes before the age of 22. Early detection is crucial in preventing complications like diabetic ketoacidosis.
Researchers found that older adults with type 1 diabetes spend more than an hour per day in the hypoglycemic range, increasing their risk of severe complications. This study highlights the need for interventions to reduce the risk of severe hypoglycemia in this age group.
A new study suggests that obesity may play a role in reproductive problems in women with type 1 diabetes. Menstrual irregularities were seen in 47% of those with the disease, and polycystic ovary syndrome (PCOS) was found in 14%, increasing the risk of miscarriages and stillbirths.
A recent study found that nearly one-fifth of first-time users of a new hybrid closed loop insulin pump stopped using the device due to difficulties meeting technical demands. Patients required calibration between their continuous blood glucose monitor and fingerstick blood tests, leading to frustration.
A recent AI study identified high long-term blood sugar levels, kidney dysfunction, and excess bad cholesterol as the strongest predictors of cardiovascular disease and death in type 1 diabetes patients. The study also found that keeping these risk factors under control can lead to lower risks of cardiovascular events.
Researchers developed a simple and inexpensive way to measure C-peptide, allowing clinicians to accurately diagnose type of diabetes and tailor treatment. The test has been used on over 750 patients with Type 1 diabetes diagnosis and shown that some have other types of diabetes, enabling them to stop insulin treatment.
A new study suggests the Affordable Care Act's requirements on pre-existing conditions and age clauses had a significant impact on adults with diabetes. The percentage of people with private health insurance who had diabetes increased after the ACA provisions began, especially among those in their 50s.
Researchers have made significant progress with UVA's artificial pancreas, a device that automates blood-sugar level monitoring and insulin injection. The International Diabetes Closed Loop Trial has provided early results from its nationwide clinical trial, examining the algorithm's use in smartphone apps and embedded devices.
A new study published in JAMA found that children with type 1 diabetes outperform their peers in math and reading tests. The research reviewed over 630,000 Danish students' test results and adjusted for socioeconomic status.
A study of over 630,000 Danish children with and without type 1 diabetes found no significant differences in reading and math scores. The findings suggest that the relationship between type 1 diabetes and poor academic performance may not be universal.
Researchers at the Diabetes Research Institute have successfully transplanted islets into the eye of experimental recipients, achieving long-term immunosuppression-free survival. This approach also shows promise for inducing peripheral immune tolerance, allowing for reduced or eliminated anti-rejection therapy.
Researchers have found a short anti-rejection therapy that can protect transplanted pancreatic islets in diabetic animals, enabling long-term survival and function without the need for life-long immune suppression. This breakthrough could lead to an effective treatment of type 1 diabetes with fewer side effects.
The National Institutes of Health has awarded a grant to develop and evaluate an artificial pancreas for pregnant women with type 1 diabetes. The project aims to improve patient and fetal outcomes by adapting automated insulin delivery technology.
A new study found that only a minority of US adults with type 1 diabetes achieve target hemoglobin A1c levels, indicating poor blood glucose management. The study revealed increasing HbA1c levels in young adults and teens over the past 5 years.
A study found a significant decrease in type 1 diabetes diagnoses in children aged 0-4 years after the introduction of the rotavirus vaccine in 2007. The researchers suggest that preventing rotavirus infection may also reduce the risk of type 1 diabetes.
Researchers have developed a new risk score that takes into account genetic information to identify babies at high risk of type 1 diabetes. The score is nearly twice as efficient as existing methods and also effective at predicting type 1 diabetes in adults, helping with early diagnosis and treatment.
Patients with type 1 diabetes and poor blood sugar control face a higher risk of fragility fracture compared to those with good glycemic control. Good blood sugar control is an important goal for patients with diabetes, and research shows that it may help reduce the risk of fractures in type 1 diabetes patients.
Researchers found that trained alert dogs can detect hypoglycaemic episodes in 83% of cases, helping Type 1 patients regulate blood sugars non-invasively. The study provides the first large-scale evaluation of medical detection dogs in detecting hypoglycaemia.
The TEDDY study, following nearly 9,000 children over five years, aims to identify high-risk genes and environmental factors that contribute to type 1 diabetes. Early screening and intervention may be possible through analyzing autoantibodies in newborns and tracking changes in risk factors as children age.
Patients with type 1 diabetes exhibit altered brain connectivity patterns compared to healthy individuals, according to a new study published in PLOS ONE. The research, led by the University of Barcelona, employed fMRI techniques to investigate brain activity during working memory tasks.
A study published in JCI Insight found that a specific subset of immune B cells, CD19+IgM+, can delay the onset of type 1 diabetes in mice. This discovery opens up new possibilities for developing therapies targeting this disease subtype.
Research finds that socio-economic conditions in regions affect T1 diabetes treatment, with disadvantaged areas having higher blood glucose levels, lower use of pump therapy and CGMS, and better outcomes for severe hypoglycemia. Frequent use of pump therapy and CGMS could improve treatment outcomes in these regions.
A new study found a significant increase in type 1 diabetes cases across Europe, with rates rising by 3.4% per year. The study's findings have important implications for healthcare planning and delivery, highlighting the need for improved blood sugar control and increased support services.
An investigation by The BMJ found that tens of thousands of UK patients with type 1 diabetes are being denied access to flash glucose monitoring devices due to a postcode lottery. Despite NHS guidance, only 3-5% of patients have access to the devices, compared to 20-25% recommended by clinical commissioning groups.
Researchers at Baylor College of Medicine found three distinct phases in infant gut microbiome development from 3-46 months of age. Partial breastfeeding was associated with higher abundance of probiotic bacteria, while cessation accelerated maturation and change in microbial diversity.
A new $3.3 million grant will fund a high-resolution reference map of pancreatic cells to identify molecular changes leading to type 1 diabetes.
Scientists at Newcastle University have found that metformin can reduce the presence of microRNAs that contribute to heart disease in patients with Type 1 diabetes. By decreasing these microRNAs, metformin improves glucose levels and promotes blood vessel repair, opening up new treatment options for this vulnerable patient group.
A study highlights strategies to help teens with type 1 diabetes manage high cholesterol and blood pressure, including offering realistic guidance, encouraging regular exercise, and promoting healthy eating habits. The research emphasizes the importance of personalized approach and team effort in addressing these conditions.
A new study found that 21% of individuals with insulin-treated diabetes diagnosed after age 30 have severe insulin deficiency, characteristic of late-onset type 1 diabetes. These patients often experience delays in diagnosis and treatment due to misdiagnosis as type 2 diabetes.
A new hybrid closed-loop insulin delivery system was compared to sensor-augmented pump therapy for blood sugar control in patients with poorly controlled type 1 diabetes. The study found that the hybrid closed-loop system achieved significantly better glucose control and reduced the risk of hypoglycaemia.
The BCG vaccine, used to prevent tuberculosis, can reduce blood sugar levels in people with advanced type 1 diabetes by mimicking microbial exposures. The vaccine appears to reset abnormal metabolic functions, boosting the immune system to consume sugar and reduce blood glucose levels over time.
A high-gluten diet during pregnancy is associated with an increased risk of type 1 diabetes in children, according to a large observational study. The researchers found that the child's risk of developing type 1 diabetes increased proportionally with the mother's gluten intake during pregnancy.
A new study from the University of Iowa found that 8.5% of American adults have been diagnosed with type 2 diabetes, while 0.5% have type 1 diabetes. Type 2 diabetes is overwhelmingly more common, accounting for 91.2% of all diagnosed cases.
A study published in Frontiers in Immunology reveals that a specific immune checkpoint molecule, interleukin-10 (IL-10), is not functioning properly in mice with type 1 diabetes. This defect leads to an overactive immune response, attacking insulin-producing cells and causing the disease.
A new collagen-based treatment has shown promise for reversing Type 1 diabetes in both humans and dogs, offering a minimally invasive alternative to traditional therapies. The treatment involves injecting a solution containing pancreatic cells mixed with collagen, which can restore insulin independence for at least 90 days.
Research reveals women with type 1 diabetes diagnosed before age 10 experience significantly reduced life expectancy, with heart attacks occurring 90 times more frequently than in non-diabetic individuals.
People with younger-onset type 1 diabetes have a higher risk of cardiovascular complications and premature death. The study found that those diagnosed before the age of 10 had a 30-times greater risk of serious cardiovascular outcomes than those in the general population.
A single course of antibiotics early in childhood may increase the risk for Type 1 diabetes, according to a study published in eLife. The research found that four bacterial species groups were significantly more abundant in the guts of mice treated with the antibiotic, and likely involved in driving progression of the disease.
A large study found that children of mothers with type 1 diabetes have a significantly higher body mass index, waist circumference, and fasting blood glucose level. The researchers suggest that pediatricians should monitor these children for early warning signs of the condition.
Researchers found that proteins in saliva reflect high blood sugar levels in young patients with type 1 diabetes, allowing for early prediction of complications. A potential new preventive treatment has been identified using gene database searching.
A new clinical trial will assess the impact of high-dose omega-3 fatty acids and vitamin D supplementation on halting type 1 diabetes progression. The POSEIDON Study aims to reduce inflammation, increase insulin secretion, and promote a potential cure for this autoimmune disease.
A breakthrough discovery by RMIT University could enable early detection of Type 1 diabetes in newborns, potentially delaying or preventing the onset of the disease. The collaboration combines lab-on-a-chip technologies with biomarker detection to identify early loss of beta cells.
A new study found that one in four working-age adults with type 1 diabetes experienced at least one gap of 30 days or more in their private health insurance, leading to a five-fold increase in emergency room visits and hospital stays. The gaps resulted in higher blood sugar levels and decreased satisfaction with life.
A human clinical trial revealed verapamil as a safe and effective therapy to reduce insulin requirements and hypoglycemic episodes in adult subjects with recent onset Type 1 diabetes. The study found that regular oral administration of verapamil enabled patients to produce higher levels of their own insulin.
A study by Karolinska Institutet found a clear correlation between elevated blood glucose levels in mothers and the risk of heart defects in their babies. Pregnant women with type 1 diabetes are at a higher risk, especially those with high blood glucose levels during early pregnancy.
Women with well-controlled type 1 diabetes often give birth to babies that are large for their gestational age, despite excellent glycemic control throughout pregnancy. Continuous glucose monitoring revealed elevated fetal weight and abdominal circumference percentages.
A recent study has linked increased risk of autism spectrum disorder (ASD) in children born to mothers with the three main types of diabetes. The research, published in JAMA Network, suggests a higher risk for children exposed in utero to maternal preexisting type 1 diabetes and gestational diabetes diagnosed by 26 weeks.
Long-term follow-up of BCG vaccine trial participants shows significant clinical benefits, including near-normal blood sugar levels, which persist for up to five years. The study reveals a novel metabolic mechanism that increases cellular glucose consumption, leading to improved insulin sensitivity.
A study by McGill University Health Centre found that two-thirds of teenagers and young adults with type 1 diabetes experience stigma, which can lead to neglecting treatment and severe hypoglycemia. The study also highlights the need for social support and resiliency programs to help individuals manage their condition.
A study published in Diabetes Care found that the rapid decline in insulin production associated with Type 1 diabetes follows a two-phase pattern: an initial exponential fall and a subsequent stable phase. This discovery suggests that people with Type 1 diabetes may retain some working beta-cells for seven years after diagnosis.
A study by Joslin Diabetes Center researchers has found a correlation between long-term type 1 diabetes and mild cognitive decline, particularly in memory. The decline is also associated with an increased risk of cardiovascular disease.
Researchers have developed a new approach using synthetic hydrogel particles to educate the immune system to accept transplanted insulin-producing islets. The technique could allow for an 'off-the-shelf' therapy for type 1 diabetes without long-term immune suppression, potentially treating millions of people worldwide.
A survey of patients with type 1 diabetes on a very-low-carbohydrate diet found exceptional blood-sugar control with few complications, including lower rates of hypoglycemia and diabetic ketoacidosis. The researchers call for controlled clinical trials to test the diet's safety and efficacy.
A new study found structural and functional changes in the muscles of young adults with Type 1 diabetes, leading to reduced metabolism and greater difficulty controlling blood glucose levels. The study suggests revising exercise guidelines for those with Type 1 diabetes to prevent muscle damage.