Articles tagged with Type 1 Diabetes
A study published in the Endocrine Society's Journal of the Endocrine Society finds higher rates of type 1 diabetes in areas with a high proportion of fast food restaurants and convenience stores. The research suggests that an adverse food environment may contribute to the development of type 1 diabetes, particularly among adults.
A study found that continuous glucose monitors (CGMs) improve blood glucose control, reduce hypoglycemia episodes, and increase quality of life for patients with type 1 diabetes. The use of CGMs is cost-effective over manual testing with strips, with savings of $3,796 per year.
Children with regular healthcare are less likely to develop life-threatening diabetic ketoacidosis, a complication of type 1 diabetes. Adolescents with a regular family physician or pediatrician have a significantly reduced risk of DKA, highlighting the importance of primary care for children.
A study in mice suggests that protective immune cells forming outside the thymus may defend against autoimmune diabetes. Gut microbes affecting this cell population may also protect against disease.
Researchers calculated genetic scores from over 30 genes in 3000 children with no family history of type 1 diabetes. The upper quartile of scores was associated with a greater than 10% risk for pre-symptomatic stage of multiple islet autoantibodies by age 6.
A Phase 3 clinical trial funded by the National Institute of Allergy and Infectious Diseases found consistent and dramatic improvements in quality of life among participants with type 1 diabetes who had frequent severe hypoglycemia. Islet recipients also reported better overall health status despite needing lifelong treatment.
A new study suggests that providing free insulin and blood glucose test strips to low- and middle-income families in India significantly improves blood-sugar control. The study also found that patients' knowledge of diabetes improved, especially those with higher education and urban dwellings.
Researchers developed a wearable heart rate monitor that detected hypoglycemia using beat-to-beat variation in heart rate. The device showed promise for timely detection of impending hypoglycemia, but requires further refinement to increase accuracy and precision.
A new study by The Endocrine Society shows that an insulin pump system can improve glycemic outcomes in children with type 1 diabetes starting from age 7. The MiniMed 670G system also demonstrates effectiveness in adults and adolescents, leading to significant improvements in time spent within target glucose ranges and reduced A1c levels.
Research analysis of blood mediators in type 1 diabetes and kidney disease patients reveals 10 elevated proteins, with TNF-alpha family and IL-6 significantly impacting 40% of patients. This study suggests personalized medicine approach to target specific inflammatory mediators for effective treatment.
A new classification of diabetes has been discovered, which can predict the risk of serious complications and provide tailored treatment suggestions. The study, published in The Lancet Diabetes & Endocrinology, reveals that type 2 diabetes consists of several subgroups, each with unique characteristics.
Researchers identified five distinct subtypes of type 2 diabetes and one autoimmune type, each with unique characteristics and associated complications. These findings may enable tailored treatment approaches for patients with diabetes, moving towards precision medicine.
Scientists have identified progenitor cells within the human pancreas that can be stimulated to develop into glucose-responsive beta cells. These findings open the door to developing regenerative cell therapies for those living with type 1 diabetes.
Researchers discovered that a common blood pressure medication, methyldopa, can prevent the onset of type 1 diabetes in up to 60% of those at risk by blocking a specific molecule. The study used a supercomputer and found that methyldopa not only blocks the DQ8 molecule but also doesn't harm other immune cells.
Researchers identified six novel chromosomal regions associated with type 1 diabetes, enabling the discovery of more genes that cause the disease. The study also found different genetic markers for early detection of autoantibodies in patients at risk.
A new study found that both type 2 and type 1 diabetes are associated with complications during pregnancy, including stillbirths, emergency Caesarean sections, and infant mortality. The research also found a significant increase in high birth weight and preterm delivery among babies born to mothers with diabetes.
Researchers at Helmholtz Munich successfully halted an autoimmune reaction in the early stages of islet autoimmunity, a key step in developing potential treatments for type 1 diabetes. The study reveals that inhibiting the miRNA181a/NFAT5 axis can increase Treg formation and reduce immune activation.
A recent study found a rapid increase in type 1 diabetes cases among children in China over the past two decades. The majority of new cases are diagnosed in adults, highlighting the need for more resources to improve care for adult-onset type 1 diabetes.
A new removable implant has been developed to control type 1 diabetes, with hundreds of thousands of islet cells protected by a thin hydrogel coating and attached to a polymer thread. This therapy could replace daily insulin injections and offer a more effective management solution for the disease.
A large-scale international randomized trial showed that weaning to an extensively hydrolyzed casein formula during infancy did not reduce the incidence of type 1 diabetes. The study, TRIGR Study, followed infants for at least 10 years and found no evidence to revise current dietary recommendations.
A large-scale international trial found that modifying baby formula to reduce cow's milk proteins didn't decrease the risk of type 1 diabetes. The study followed 2,159 infants with a family member affected by type 1 diabetes and genetic risk for years to determine which developed diabetes.
A new nationwide clinical trial aims to make managing type 1 diabetes easier for patients using the world's first hybrid closed-loop system automated insulin delivery device. The trial, funded by Medtronic, will monitor blood glucose levels and adjust insulin doses continuously to help patients maintain stable blood sugar levels.
Researchers have developed tiny bilirubin-filled capsules that can improve the survival rates of transplanted pancreatic islet cells. This breakthrough has implications for treating Type 1 diabetes in both canine and human patients, with a potential treatment program for dogs that could lead to improved treatments for humans.
Researchers at Seattle Children's are exploring therapies that reprogram T cells to calm down an overactive immune response, which may hold promise for curing type 1 diabetes. The goal is to develop a treatment that could protect new patients from the life-long requirement for insulin therapy.
Research published in the Lancet Diabetes & Endocrinology found that over 40% of type 1 diabetes cases occur after age 30, and many adults are initially misdiagnosed with type 2. Type 1 diabetes requires insulin treatment to control blood sugar levels, while type 2 can often be managed with diet and medication.
A study published in the Journal of Clinical Endocrinology & Metabolism found that continuous glucose monitors can protect against hypoglycemia episodes, even when the body's defense mechanisms are impaired. The devices raised awareness of low blood sugar threats and reduced severe episodes.
A daily insulin pill did not slow down or prevent type 1 diabetes development among individuals with a higher risk of developing the disease. The trial involved 560 participants who received either oral insulin or a placebo, and found that time to diagnosis was not significantly different between groups.
Scientists developed an enterovirus vaccine that protects against virus-induced diabetes in a mouse model for Type 1 diabetes. The study suggests the potential role of enteroviruses in human Type 1 diabetes and offers a new preventative treatment option.
Researchers from Wake Forest Institute for Regenerative Medicine discovered that sodium percarbonate and calcium peroxide improved insulin-producing cell function and viability in lab-built bioartificial pancreas. Oxygen-generating materials could potentially supplement cells' high oxygen needs, aiding in diabetes treatment.
Researchers at Boston Children's Hospital have successfully reversed type 1 diabetes in a mouse model by infusing pre-treated blood stem cells. The treated cells curbed the autoimmune reaction and reversed hyperglycemia in diabetic mice, with almost all mice cured of diabetes in the short term and one third maintaining normal blood sug...
A recent study from UC Davis researchers refutes the use of an anti-malaria drug to create new insulin-producing cells for Type 1 diabetes treatment. The findings highlight the crucial need for reproducibility in scientific research, contradicting a previous report that sparked excitement in the field.
A study found that adequate vitamin D levels during infancy and childhood are associated with a reduced risk of islet autoimmunity, a precursor to type 1 diabetes. Vitamin D status varies by latitude, and higher childhood levels are significantly linked to decreased risk of IA.
A new study reveals that up to 97.3% of people with pancreatic disease are misdiagnosed with Type 2 diabetes, instead of the correct condition, Type 3c diabetes. This can lead to delayed treatment and devastating long-term effects for patients.
A study published in JAMA found that insulin pump therapy among young patients with type 1 diabetes was associated with lower rates of severe hypoglycemia and diabetic ketoacidosis compared to traditional injections. This innovative treatment approach offers improved clinical outcomes for this vulnerable population.
A new study of children from Sweden and Finland found that the swine flu vaccine Pandemrix did not increase the risk of developing autoantibodies against insulin-producing beta cells or type 1 diabetes. In fact, vaccinated children in Finland showed a reduced risk of developing autoantibodies and type 1 diabetes.
A new trial found that continuous glucose monitoring during pregnancy reduces the number of babies born larger than average, need for intensive care, and pre-eclampsia rates. Birth outcomes improved significantly for mothers using the device compared to traditional finger-prick tests.
A new biomarker, LRG1, can predict the occurrence of pre-eclampsia in pregnant women with type 1 diabetes, increasing their risk by 4 times. The study found that LRG1 levels were significantly higher in women who developed PE compared to those who did not.
A global study of over 800 patients with Type 1 diabetes found that dapagliflozin, a Type 2 diabetes medicine, significantly improved blood sugar levels. The results demonstrate the drug's efficacy as an adjunct therapy to insulin, reducing A1C levels by more than 0.5% without severe hypoglycemia.
Research shows that pregnancy outcomes remain poor for women with type 1 diabetes, especially those diagnosed at a young age. The study found higher rates of pre-eclampsia, stillbirth, and low birth weight among mothers with childhood-onset T1D.
A nationwide Norwegian study found that H1N1 infected individuals, especially children under 15, were twice as likely to develop type 1 diabetes than the general population. Infection with H1N1 influenza virus was linked to a doubled risk of T1D in Norwegians aged 30 or younger.
A University of Colorado Anschutz Medical Campus study finds sotagliflozin helps control glucose and reduces the need for insulin in patients with type 1 diabetes. Patients experienced a lower rate of confirmed severe hypoglycemia than observed in patients on placebo and also had weight loss.
Researchers developed a novel antibody detection technology that increases the sensitivity of Type 1 Diabetes tests, enabling screening for more autoimmune antibodies implicated in the disease. The technology holds promise for making populationwide screening practical and catching the disease earlier.
A new study suggests that specific genetic variants increase the risk of developing type 1 diabetes in later life, including after the age of 30. The research found that individuals with certain HLA genotypes have a higher likelihood of developing late-onset T1D and being diagnosed at an older age.
Regulatory T-cells in adipose tissue increase in response to environmental stimuli, promoting heat production and fatty acid breakdown. This discovery highlights the complex interactions between immune cells and environment in maintaining metabolic balance.
Researchers at Westmead Institute for Medical Research have discovered a new approach to treating type 1 diabetes, using pancreatic islet transplants delivered into the quadriceps muscle. This method presents fewer risks than current clinical practice of transplanting islets into the liver via the portal vein.
Research in mice shows that gut bacteria play a crucial role in modulating the effects of a powerful protective gene against type 1 diabetes. The findings highlight the importance of early environmental exposures to a variety of germs in proper immune system development.
A new study from Karolinska Institutet found that CABG reduces the risk of fatal heart disease and myocardial infarction in patients with type 1 diabetes by 45% and 47% respectively, compared to PCI.
A clinical trial has observed noticeable changes in the behavior of immune systems of type 1 diabetes patients treated with peptides. The treatment has a noticeable effect on the immune system and suggests a potential way to protect remaining beta cells.
A recent study demonstrates the safety of immunotherapy in treating type 1 diabetes. The treatment showed metabolic effects without accelerating β-cell destruction, suggesting a viable option for patients.
Scientists have identified a molecular handle to purify cells destined to become insulin-producing cells, enabling a streamlined and cost-efficient process for generating glucose-responsive beta cells. The discovery aims to address safety and end product consistency challenges in cell therapy for type 1 diabetes.
A new study of adults with Type 1 diabetes for at least 50 years found that better glucose control is associated with a lower risk of cardiovascular disease. The research also discovered that exercise plays a significant role in lowering mortality rates from all causes in this population.
A new study suggests that certain viruses in the intestines may affect a person's chance of developing Type 1 diabetes. Children with less diverse gut viral communities are more likely to generate self-destructive antibodies, while those carrying a specific circovirus group are less likely to develop the disease.
A recent study published in Diabetes Care found that almost half of patients with type 1 diabetes for over ten years still produce some insulin. Higher levels of interleukin-35 were detected in these patients, suggesting a link between this protein and the regeneration of remaining insulin-producing cells.
Recurring gastrointestinal infections in early childhood significantly increase the risk of developing gluten intolerance, according to a new study. The research found a strong association between early respiratory tract infections and an elevated risk of celiac disease.
A new study presents data from an FDA-approved clinical trial testing the generic vaccine BCG to reverse advanced type 1 diabetes. The findings suggest that BCG may induce a permanent increase in expression of genes that restore beneficial regulatory T cells (Tregs) preventing autoimmune attacks on the body's own tissue.
Scientists at the Diabetes Research Institute have successfully transplanted tissue-engineered islet cells into a patient with type 1 diabetes, achieving long-term insulin independence. The omentum tissue site has been found to be a viable alternative for islet implantation, minimizing inflammatory reactions.
A comprehensive catalog of diseases associated with human leukocyte antigen (HLA) gene variations has been generated by researchers at Vanderbilt University Medical Center. The catalog identifies individuals at risk for certain autoimmune diseases and potential new associations with multiple sclerosis and cervical cancer.
Researchers at UT Health San Antonio have developed a gene-transfer technique that increases insulin-producing cells, potentially curing Type 1 and improving Type 2 diabetes. The therapy has cured diabetes in mice without side effects, offering a major advance over traditional insulin therapy.
Researchers discovered genetic influences in 'type 1.5' diabetes that may offer clues for more accurate diagnosis and treatment. The study found that LADA is closer to T1D than T2D, suggesting some patients with adult-onset type 2 diabetes may have late-onset type 1 diabetes.
A pilot study found that a University of Virginia-developed artificial pancreas helped young children with Type 1 diabetes better control their condition. The device automatically monitors and regulates blood-sugar levels, reducing the need for frequent finger pricks and insulin injections.