Articles tagged with Type 1 Diabetes
Researchers identified six novel chromosomal regions associated with type 1 diabetes, enabling the discovery of more genes that cause the disease. The study also found different genetic markers for early detection of autoantibodies in patients at risk.
A new study found that both type 2 and type 1 diabetes are associated with complications during pregnancy, including stillbirths, emergency Caesarean sections, and infant mortality. The research also found a significant increase in high birth weight and preterm delivery among babies born to mothers with diabetes.
Researchers at Helmholtz Munich successfully halted an autoimmune reaction in the early stages of islet autoimmunity, a key step in developing potential treatments for type 1 diabetes. The study reveals that inhibiting the miRNA181a/NFAT5 axis can increase Treg formation and reduce immune activation.
A recent study found a rapid increase in type 1 diabetes cases among children in China over the past two decades. The majority of new cases are diagnosed in adults, highlighting the need for more resources to improve care for adult-onset type 1 diabetes.
A large-scale international randomized trial showed that weaning to an extensively hydrolyzed casein formula during infancy did not reduce the incidence of type 1 diabetes. The study, TRIGR Study, followed infants for at least 10 years and found no evidence to revise current dietary recommendations.
A large-scale international trial found that modifying baby formula to reduce cow's milk proteins didn't decrease the risk of type 1 diabetes. The study followed 2,159 infants with a family member affected by type 1 diabetes and genetic risk for years to determine which developed diabetes.
A new removable implant has been developed to control type 1 diabetes, with hundreds of thousands of islet cells protected by a thin hydrogel coating and attached to a polymer thread. This therapy could replace daily insulin injections and offer a more effective management solution for the disease.
A new nationwide clinical trial aims to make managing type 1 diabetes easier for patients using the world's first hybrid closed-loop system automated insulin delivery device. The trial, funded by Medtronic, will monitor blood glucose levels and adjust insulin doses continuously to help patients maintain stable blood sugar levels.
Researchers have developed tiny bilirubin-filled capsules that can improve the survival rates of transplanted pancreatic islet cells. This breakthrough has implications for treating Type 1 diabetes in both canine and human patients, with a potential treatment program for dogs that could lead to improved treatments for humans.
Researchers at Seattle Children's are exploring therapies that reprogram T cells to calm down an overactive immune response, which may hold promise for curing type 1 diabetes. The goal is to develop a treatment that could protect new patients from the life-long requirement for insulin therapy.
Research published in the Lancet Diabetes & Endocrinology found that over 40% of type 1 diabetes cases occur after age 30, and many adults are initially misdiagnosed with type 2. Type 1 diabetes requires insulin treatment to control blood sugar levels, while type 2 can often be managed with diet and medication.
A study published in the Journal of Clinical Endocrinology & Metabolism found that continuous glucose monitors can protect against hypoglycemia episodes, even when the body's defense mechanisms are impaired. The devices raised awareness of low blood sugar threats and reduced severe episodes.
A daily insulin pill did not slow down or prevent type 1 diabetes development among individuals with a higher risk of developing the disease. The trial involved 560 participants who received either oral insulin or a placebo, and found that time to diagnosis was not significantly different between groups.
Scientists developed an enterovirus vaccine that protects against virus-induced diabetes in a mouse model for Type 1 diabetes. The study suggests the potential role of enteroviruses in human Type 1 diabetes and offers a new preventative treatment option.
Researchers from Wake Forest Institute for Regenerative Medicine discovered that sodium percarbonate and calcium peroxide improved insulin-producing cell function and viability in lab-built bioartificial pancreas. Oxygen-generating materials could potentially supplement cells' high oxygen needs, aiding in diabetes treatment.
Researchers at Boston Children's Hospital have successfully reversed type 1 diabetes in a mouse model by infusing pre-treated blood stem cells. The treated cells curbed the autoimmune reaction and reversed hyperglycemia in diabetic mice, with almost all mice cured of diabetes in the short term and one third maintaining normal blood sug...
A recent study from UC Davis researchers refutes the use of an anti-malaria drug to create new insulin-producing cells for Type 1 diabetes treatment. The findings highlight the crucial need for reproducibility in scientific research, contradicting a previous report that sparked excitement in the field.
A new study reveals that up to 97.3% of people with pancreatic disease are misdiagnosed with Type 2 diabetes, instead of the correct condition, Type 3c diabetes. This can lead to delayed treatment and devastating long-term effects for patients.
A study found that adequate vitamin D levels during infancy and childhood are associated with a reduced risk of islet autoimmunity, a precursor to type 1 diabetes. Vitamin D status varies by latitude, and higher childhood levels are significantly linked to decreased risk of IA.
A study published in JAMA found that insulin pump therapy among young patients with type 1 diabetes was associated with lower rates of severe hypoglycemia and diabetic ketoacidosis compared to traditional injections. This innovative treatment approach offers improved clinical outcomes for this vulnerable population.
A new study of children from Sweden and Finland found that the swine flu vaccine Pandemrix did not increase the risk of developing autoantibodies against insulin-producing beta cells or type 1 diabetes. In fact, vaccinated children in Finland showed a reduced risk of developing autoantibodies and type 1 diabetes.
A new trial found that continuous glucose monitoring during pregnancy reduces the number of babies born larger than average, need for intensive care, and pre-eclampsia rates. Birth outcomes improved significantly for mothers using the device compared to traditional finger-prick tests.
A global study of over 800 patients with Type 1 diabetes found that dapagliflozin, a Type 2 diabetes medicine, significantly improved blood sugar levels. The results demonstrate the drug's efficacy as an adjunct therapy to insulin, reducing A1C levels by more than 0.5% without severe hypoglycemia.
Research shows that pregnancy outcomes remain poor for women with type 1 diabetes, especially those diagnosed at a young age. The study found higher rates of pre-eclampsia, stillbirth, and low birth weight among mothers with childhood-onset T1D.
A new biomarker, LRG1, can predict the occurrence of pre-eclampsia in pregnant women with type 1 diabetes, increasing their risk by 4 times. The study found that LRG1 levels were significantly higher in women who developed PE compared to those who did not.
A University of Colorado Anschutz Medical Campus study finds sotagliflozin helps control glucose and reduces the need for insulin in patients with type 1 diabetes. Patients experienced a lower rate of confirmed severe hypoglycemia than observed in patients on placebo and also had weight loss.
Researchers developed a novel antibody detection technology that increases the sensitivity of Type 1 Diabetes tests, enabling screening for more autoimmune antibodies implicated in the disease. The technology holds promise for making populationwide screening practical and catching the disease earlier.
A nationwide Norwegian study found that H1N1 infected individuals, especially children under 15, were twice as likely to develop type 1 diabetes than the general population. Infection with H1N1 influenza virus was linked to a doubled risk of T1D in Norwegians aged 30 or younger.
A new study suggests that specific genetic variants increase the risk of developing type 1 diabetes in later life, including after the age of 30. The research found that individuals with certain HLA genotypes have a higher likelihood of developing late-onset T1D and being diagnosed at an older age.
Regulatory T-cells in adipose tissue increase in response to environmental stimuli, promoting heat production and fatty acid breakdown. This discovery highlights the complex interactions between immune cells and environment in maintaining metabolic balance.
Researchers at Westmead Institute for Medical Research have discovered a new approach to treating type 1 diabetes, using pancreatic islet transplants delivered into the quadriceps muscle. This method presents fewer risks than current clinical practice of transplanting islets into the liver via the portal vein.
Research in mice shows that gut bacteria play a crucial role in modulating the effects of a powerful protective gene against type 1 diabetes. The findings highlight the importance of early environmental exposures to a variety of germs in proper immune system development.
A new study from Karolinska Institutet found that CABG reduces the risk of fatal heart disease and myocardial infarction in patients with type 1 diabetes by 45% and 47% respectively, compared to PCI.
A recent study demonstrates the safety of immunotherapy in treating type 1 diabetes. The treatment showed metabolic effects without accelerating β-cell destruction, suggesting a viable option for patients.
A clinical trial has observed noticeable changes in the behavior of immune systems of type 1 diabetes patients treated with peptides. The treatment has a noticeable effect on the immune system and suggests a potential way to protect remaining beta cells.
Scientists have identified a molecular handle to purify cells destined to become insulin-producing cells, enabling a streamlined and cost-efficient process for generating glucose-responsive beta cells. The discovery aims to address safety and end product consistency challenges in cell therapy for type 1 diabetes.
A new study of adults with Type 1 diabetes for at least 50 years found that better glucose control is associated with a lower risk of cardiovascular disease. The research also discovered that exercise plays a significant role in lowering mortality rates from all causes in this population.
A new study suggests that certain viruses in the intestines may affect a person's chance of developing Type 1 diabetes. Children with less diverse gut viral communities are more likely to generate self-destructive antibodies, while those carrying a specific circovirus group are less likely to develop the disease.
A recent study published in Diabetes Care found that almost half of patients with type 1 diabetes for over ten years still produce some insulin. Higher levels of interleukin-35 were detected in these patients, suggesting a link between this protein and the regeneration of remaining insulin-producing cells.
Recurring gastrointestinal infections in early childhood significantly increase the risk of developing gluten intolerance, according to a new study. The research found a strong association between early respiratory tract infections and an elevated risk of celiac disease.
A new study presents data from an FDA-approved clinical trial testing the generic vaccine BCG to reverse advanced type 1 diabetes. The findings suggest that BCG may induce a permanent increase in expression of genes that restore beneficial regulatory T cells (Tregs) preventing autoimmune attacks on the body's own tissue.
Scientists at the Diabetes Research Institute have successfully transplanted tissue-engineered islet cells into a patient with type 1 diabetes, achieving long-term insulin independence. The omentum tissue site has been found to be a viable alternative for islet implantation, minimizing inflammatory reactions.
A comprehensive catalog of diseases associated with human leukocyte antigen (HLA) gene variations has been generated by researchers at Vanderbilt University Medical Center. The catalog identifies individuals at risk for certain autoimmune diseases and potential new associations with multiple sclerosis and cervical cancer.
Researchers at UT Health San Antonio have developed a gene-transfer technique that increases insulin-producing cells, potentially curing Type 1 and improving Type 2 diabetes. The therapy has cured diabetes in mice without side effects, offering a major advance over traditional insulin therapy.
Researchers discovered genetic influences in 'type 1.5' diabetes that may offer clues for more accurate diagnosis and treatment. The study found that LADA is closer to T1D than T2D, suggesting some patients with adult-onset type 2 diabetes may have late-onset type 1 diabetes.
A pilot study found that a University of Virginia-developed artificial pancreas helped young children with Type 1 diabetes better control their condition. The device automatically monitors and regulates blood-sugar levels, reducing the need for frequent finger pricks and insulin injections.
Researchers analyzed 24,000 retinal exams to develop a new screening schedule for people with type 1 diabetes. The findings suggest that adjusting the frequency of eye screenings based on risk could lead to lower costs and quicker diagnosis and treatment of advanced retinopathy.
The study found that incidence of type 1 diabetes increased by 1.8% annually from 2002 to 2012, while type 2 diabetes rose at a rate of 4.8%. Racial/ethnic minority groups experienced the most significant increases in new diagnosed cases.
A new study found that a videoconferencing educational program equips rural primary care providers with the confidence to manage patients with complex diabetes. The program, called Endo ECHO, improves access to specialized care for large numbers of patients through weekly virtual clinics.
A new study finds that an artificial pancreas system improves blood glucose control better than usual home management for children aged 5 to 8 years with type 1 diabetes. The wearable device uses computer algorithms to track blood sugar levels and adjust insulin dosing, resulting in a longer time in the target range.
Research found disparities in type 1 diabetes care among US military children, with white and officers' kids more likely to use insulin pumps and continuous glucose monitors. These technologies led to better glycemic control, but hospitalizations remained similar between pump users and those using multiple daily injections.
A diet high in short-chain fatty acids produced by gut bacteria has been found to protect against the onset of type 1 diabetes. The study, published in Nature Immunology, suggests that this special diet can improve immune tolerance and reduce inflammation.
A study found that only 65% of youths with type 1 diabetes and 42% of those with type 2 diabetes had undergone an eye examination by six years after initial diagnosis. Groups at reduced likelihood of screening include racial minorities and economically disadvantaged youth.
Researchers at UF Health have found a way to expand and preserve certain cord-blood cells, known as Tregs, which modulate the immune system and prevent autoimmune diseases like Type 1 diabetes. This discovery has important implications for patients with the disease and could potentially be used as a treatment or preventive measure.
The Critical Path Institute has launched a consortium to qualify islet autoimmunity antibodies as prognostic biomarkers for Type 1 Diabetes (T1D) research. The goal is to identify individuals at risk of disease progression and develop interventions to prevent or delay the onset of symptomatic T1D.
A recent study published in the Journal of the American Medical Association found that teens and young adults with type 2 diabetes are at a higher risk of developing kidney, nerve, and eye diseases. This study, funded by NIH and CDC, compared over 1,700 youth with type 1 and 272 youth with type 2 diabetes.
A recent study found that teenagers and young adults with type 2 diabetes are more likely to develop complications, such as diabetic kidney disease, retinopathy, and peripheral neuropathy, compared to those with type 1 diabetes. The study also revealed higher prevalence of hypertension in both groups.
Researchers at Linköping University conducted a pilot study showing promising results in treating type 1 diabetes. The study found stable insulin production in six patients who received GAD-alum injections, with significant improvements in blood sugar levels and reduced need for extra insulin.
The Joslin Diabetes Center is participating in two NIH-funded clinical trials to test artificial pancreas systems that automatically monitor and regulate blood glucose levels. If successful, the trials could lead to regulatory approval for use of these devices, improving glucose control and reducing diabetes self-management burden.
A pivotal trial demonstrated the safety and efficacy of a hybrid closed-loop insulin delivery system in home use, reducing HbA1c levels and preventing severe hypoglycemic events. The system showed significant improvements in glucose control for both adolescents and adults with type 1 diabetes.