Articles tagged with Type 1 Diabetes
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Scientists at the Diabetes Research Institute have successfully transplanted tissue-engineered islet cells into a patient with type 1 diabetes, achieving long-term insulin independence. The omentum tissue site has been found to be a viable alternative for islet implantation, minimizing inflammatory reactions.
Researchers at UT Health San Antonio have developed a gene-transfer technique that increases insulin-producing cells, potentially curing Type 1 and improving Type 2 diabetes. The therapy has cured diabetes in mice without side effects, offering a major advance over traditional insulin therapy.
Researchers discovered genetic influences in 'type 1.5' diabetes that may offer clues for more accurate diagnosis and treatment. The study found that LADA is closer to T1D than T2D, suggesting some patients with adult-onset type 2 diabetes may have late-onset type 1 diabetes.
A pilot study found that a University of Virginia-developed artificial pancreas helped young children with Type 1 diabetes better control their condition. The device automatically monitors and regulates blood-sugar levels, reducing the need for frequent finger pricks and insulin injections.
Researchers analyzed 24,000 retinal exams to develop a new screening schedule for people with type 1 diabetes. The findings suggest that adjusting the frequency of eye screenings based on risk could lead to lower costs and quicker diagnosis and treatment of advanced retinopathy.
The study found that incidence of type 1 diabetes increased by 1.8% annually from 2002 to 2012, while type 2 diabetes rose at a rate of 4.8%. Racial/ethnic minority groups experienced the most significant increases in new diagnosed cases.
A new study finds that an artificial pancreas system improves blood glucose control better than usual home management for children aged 5 to 8 years with type 1 diabetes. The wearable device uses computer algorithms to track blood sugar levels and adjust insulin dosing, resulting in a longer time in the target range.
Research found disparities in type 1 diabetes care among US military children, with white and officers' kids more likely to use insulin pumps and continuous glucose monitors. These technologies led to better glycemic control, but hospitalizations remained similar between pump users and those using multiple daily injections.
A new study found that a videoconferencing educational program equips rural primary care providers with the confidence to manage patients with complex diabetes. The program, called Endo ECHO, improves access to specialized care for large numbers of patients through weekly virtual clinics.
A diet high in short-chain fatty acids produced by gut bacteria has been found to protect against the onset of type 1 diabetes. The study, published in Nature Immunology, suggests that this special diet can improve immune tolerance and reduce inflammation.
A study found that only 65% of youths with type 1 diabetes and 42% of those with type 2 diabetes had undergone an eye examination by six years after initial diagnosis. Groups at reduced likelihood of screening include racial minorities and economically disadvantaged youth.
Researchers at UF Health have found a way to expand and preserve certain cord-blood cells, known as Tregs, which modulate the immune system and prevent autoimmune diseases like Type 1 diabetes. This discovery has important implications for patients with the disease and could potentially be used as a treatment or preventive measure.
The Critical Path Institute has launched a consortium to qualify islet autoimmunity antibodies as prognostic biomarkers for Type 1 Diabetes (T1D) research. The goal is to identify individuals at risk of disease progression and develop interventions to prevent or delay the onset of symptomatic T1D.
A recent study published in the Journal of the American Medical Association found that teens and young adults with type 2 diabetes are at a higher risk of developing kidney, nerve, and eye diseases. This study, funded by NIH and CDC, compared over 1,700 youth with type 1 and 272 youth with type 2 diabetes.
A recent study found that teenagers and young adults with type 2 diabetes are more likely to develop complications, such as diabetic kidney disease, retinopathy, and peripheral neuropathy, compared to those with type 1 diabetes. The study also revealed higher prevalence of hypertension in both groups.
Researchers at Linköping University conducted a pilot study showing promising results in treating type 1 diabetes. The study found stable insulin production in six patients who received GAD-alum injections, with significant improvements in blood sugar levels and reduced need for extra insulin.
The Joslin Diabetes Center is participating in two NIH-funded clinical trials to test artificial pancreas systems that automatically monitor and regulate blood glucose levels. If successful, the trials could lead to regulatory approval for use of these devices, improving glucose control and reducing diabetes self-management burden.
A pivotal trial demonstrated the safety and efficacy of a hybrid closed-loop insulin delivery system in home use, reducing HbA1c levels and preventing severe hypoglycemic events. The system showed significant improvements in glucose control for both adolescents and adults with type 1 diabetes.
Researchers discovered a subpopulation of beta cells that resists immune attack and acquires stemness to persist despite immune attack. This finding may lead to therapies targeting these cells to restore insulin production in type 1 diabetic patients.
The American Diabetes Association has awarded a $1.625-million grant to develop an animal model studying the connection between gut bacteria and autoimmune attack in type 1 diabetes. The research aims to identify mechanisms that may contribute to the disease and potentially lead to treatments that prevent it.
Four NIH-funded research projects aim to test and refine fully automated artificial pancreas systems, replacing traditional methods for managing type 1 diabetes. The studies will evaluate safety, efficacy, user-friendliness, and cost, with the goal of bringing these life-changing devices to those who need them.
A long-term study found that continuous glucose monitoring significantly lowers blood sugar levels in persons with type 1 diabetes, reducing the risk of complications. The treatment also leads to increased well-being and improved treatment satisfaction.
Two studies found that continuous glucose monitoring improved blood sugar levels and reduced hypoglycemia in type 1 diabetes patients using multiple daily insulin injections. The studies showed significant reductions in hemoglobin A1c levels and glycemic variability, with improved treatment satisfaction.
A set of international guidelines helps individuals with type 1 diabetes exercise safely, reducing the risk of hypoglycemia and improving overall health. The guidelines provide recommendations for glucose targets, nutritional and insulin dose adjustments to prevent blood sugar fluctuations during exercise.
A new study reveals that individuals with Type 1 diabetes exhibit distinct gut inflammation and microbiome changes compared to those without diabetes or celiac disease. The research found specific genes associated with gut inflammation and unique combinations of gut bacteria in patients with Type 1 diabetes.
Researchers identified a molecular signaling pathway that promotes sensory neuron growth and prevents or reverses peripheral neuropathy in cell and rodent models of type 1 and 2 diabetes, chemotherapy-induced neuropathy, and HIV. Anti-muscarinic drugs already approved for other conditions may offer new treatment options.
A new study published in Diabetologia suggests that enterovirus infections are associated with the onset of autoimmunity in children who develop type 1 diabetes. The study found a higher incidence of enterovirus infections in children with T1D compared to control children, particularly those who developed islet autoantibodies.
The Human Pancreas Analysis Program (HPAP) aims to study diabetes and pancreatic islets with unparalleled resolution. The program will procure and phenotype pancreatic tissues from individuals with or at risk for Type 1 diabetes.
A study found that type 1 diabetes patients with elevated albumin in their urine had triple the risk of life-threatening kidney and cardiac disease compared to those with normal levels. Copeptin levels were significantly higher in these patients, suggesting a new potential target for therapies.
Researchers at Helmholtz Munich have discovered proteins in the blood that can predict incipient type 1 diabetes, even before symptoms appear. The study identified 41 peptides from 26 proteins that distinguish children with autoantibodies from those without, including proteins associated with lipid metabolism.
Researchers at Wayne State University are developing a new material formulation to resist foreign body reactions in implantable devices, such as insulin infusion pumps. This project aims to improve the long-term use of these devices by reducing the need for replacements.
Scientists at Helmholtz Zentrum München have discovered a mechanism used by the immune system to prepare for attacks on insulin-producing cells in the pancreas. The team identified a signaling pathway triggered by miRNA92a, which leads to an increase in immune cells that promote autoimmunity. Targeted intervention using antagomirs may ...
Aerobic exercise improves glycemic control and reduces insulin requirements in T1D patients. The study found that physically active patients had more responsible behavior in monitoring their glucose levels, suggesting an educational program addressing diet, insulin injecting monitoring, and exercise could be highly advantageous.
A recent study found a connection between follicular T helper cells and the development of type 1 diabetes. The cells were increased in frequency close to disease onset, particularly in children with multiple autoantibodies.
Researchers at the University of Cambridge have developed a new treatment for type 1 diabetes that targets the immune system's damage, aiming to reduce or eliminate daily insulin injections. The treatment uses aldesleukin, a drug that enhances regulatory T cells to prevent autoimmunity.
A recent expert review from the International Osteoporosis Foundation confirms that both type 1 and type 2 diabetes increase the risk of bone fragility. The mechanisms behind this include hyperglycemia, oxidative stress, and microvascular complications, which alter bone turnover and material properties.
Teresa Mastracci, a Senior Scientist at IBRI, has received a $750,000 JDRF Career Development Award to investigate polyamine and hypusine biosynthesis in reversing type 1 diabetes. Her research aims to identify new drugs that preserve or regenerate healthy beta cells, slowing or halting disease progression.
Teresa Mastracci, a researcher at the Indiana Biosciences Research Institute, has received a $750,000 JDRF grant to study polyamine and hypusine biosynthesis for reversing the progression of type 1 diabetes. The goal is to identify new drugs that preserve or regenerate healthy beta cells.
A clinical trial has shown that metformin can promote a patient's ability to repair their own damaged blood vessels by increasing vascular stem cells. This could lead to improved treatment options for Type 1 diabetes patients at risk of developing heart disease.
Research published in Nature Microbiology suggests that antibiotic treatment can alter the microbiome and increase the risk of developing type 1 diabetes. The study used NOD mice and found that short pulses of antibiotics increased disease incidence by 53% compared to control mice.
Researchers found that bilirubin supplementation significantly decreased islet cell death after isolation and nutrient deprivation. The study also showed that bilirubin suppressed the release of damage-associated molecular patterns (DAMPs), which are foreign cell-fighting immune cells.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that a combination of three medications—dapagliflozin, liraglutide, and insulin—helped people with Type 1 diabetes improve blood sugar control and lose weight. The therapy also showed impressive improvements in blood glucose management.
A recent study found that breastfeeding for over three months postpartum alters maternal metabolism, producing lower concentrations of branched-chain amino acids and phospholipids. This change in metabolites is linked to reduced insulin resistance and a lower risk of developing type 2 diabetes.
Researchers found that patients with a rare autoimmune disorder produce antibodies that limit immune-related diseases, including type 1 diabetes. These autoantibodies target proteins such as interferons and interleukins, potentially inhibiting the development of type 1 diabetes.
Researchers tracked daily physical activity in 90 pre- to early-teenage children with type 1 diabetes and found improvements in blood vessel structure and reduced risk factors for heart disease. The study highlights the importance of physical activity for children with type 1 diabetes.
Researchers discovered that isoprene, a common natural chemical found in human breath, increases significantly at hypoglycemia levels. This finding may lead to the development of new tests for detecting hypoglycaemia and reducing its risk of life-threatening complications.
A recent study found that children with Juvenile Inflammatory Arthritis (JIA) have a significantly higher prevalence of Type 1 diabetes compared to the general population. The research, which included over 9,000 patients, suggests that understanding this link may lead to new treatments and preventative interventions for both diseases.
The Fr1da study has detected an early stage of type 1 diabetes in 105 out of 26,760 children aged two to five years. The children have not shown signs of metabolic imbalance, suggesting a potential breakthrough in preventive healthcare. Families are being offered comprehensive support and care.
A commentary published in Diabetes Technology & Therapeutics suggests that insulin pump therapy can lead to better blood glucose control and may be beneficial for all patients with type 1 diabetes. The author highlights the importance of pump technology, including sensor-controlled feedback and artificial pancreas systems.
A recent study published in The Journal of Clinical Investigation found that certain bacteria can activate killer T-cells, which destroy insulin-producing cells and lead to type 1 diabetes. This discovery sheds light on the potential external factors contributing to the disease's development.
Scientists at Washington University School of Medicine and Harvard University have produced insulin-secreting cells from stem cells derived from patients with type 1 diabetes. The new cells can produce insulin in response to glucose and may offer a potential cure for the disease.
Researchers found a direct correlation between increased life expectancy and the rise in type 1 diabetes cases globally. The study suggests that advances in medical care have reduced natural selection, allowing the underlying genetics of the disease to be passed from one generation to the next.
A study by Helmholtz Munich researchers found that viral respiratory tract disorders during the first six months of life significantly increase the risk of children developing type 1 diabetes. The infection localization and timing were key factors in determining the increased risk.
A study published in Diabetes Research and Clinical Practice reveals that children with type 1 diabetes are at risk of low vitamin D levels, affecting bone health, glucose metabolism, and immune function. The research emphasizes the importance of vitamin D screening for all children with type 1 diabetes.
The adAPT trial is a clinical study evaluating the effectiveness of metformin in preventing type 1 diabetes. Researchers aim to identify children at high risk and examine the impact of administering metformin on beta cell stress.
Researchers found that islet transplantation prevents severe hypoglycemic events in people who experienced episodes despite expert care. After one year, 88% of participants were free of severe hypoglycemic events and had restored hypoglycemic awareness.
A clinical trial found that islet transplants effectively prevented severe hypoglycemic events and restored awareness in patients with Type 1 diabetes. The study also demonstrated excellent glycemic control, with nearly 88% of subjects remaining free from severe hypoglycemia at one year.
Scientists have found that the RGS1 gene affects the frequency of T follicular helper cells, which are important for B cell production and seem to be crucial for the disease. The study suggests that while inhibiting RGS1 did not prevent autoimmune diabetes, it changes the way cells move within lymph nodes and spleen.
Two new studies found that life expectancy for people with type 1 diabetes has not decreased compared to the general population over the past few decades. The gap in life expectancy remained constant, with an estimated 12-13 years less life expectancy at birth for those with T1D.
Researchers at TSRI isolated a unique Treg cell from a mouse model of type 1 diabetes and discovered it originates in the thymus, giving rise to two functional states: an nTreg with active FoxP3 and a pre-nTreg without. This discovery opens new avenues for developing novel therapies to prevent autoimmune diseases.